Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men

Journal of Gastroenterology and Hepatology (Australia)

Volumn 19, Issue 6, 2004, Pages 694-698

  Park, Seung Ha ^a   Kim, Byung Ik ^a   Yun, Jung Won ^a   Kim, Jeong Wook ^a   Park, Dong Il ^a   Cho, Yong Kyun ^a   Sung, In Kyung ^a   Park, Chang Young ^a   Sohn, Chong Il ^a   Jeon, Woo Kyu ^a   Kim, Hyang ^a   Rhee, Eun Jung ^a   Lee, Won Young ^a   Kim, Sun Woo ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

C reactive protein; Homeostasis model assessment; Inflammation; Insulin resistance; Non alcoholic fatty liver disease

Indexed keywords

ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN B; C REACTIVE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; URIC ACID;

ADULT; ALCOHOL ABUSE; ANAMNESIS; ASIA; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FATTY LIVER; HEPATITIS B; HEPATITIS C; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NONALCOHOLIC FATTY LIVER; OBESITY; PREDICTION; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR;

EID: 3042704673     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2004.03362.x     Document Type: Review

References (24)

1. Marchesini G, Brizi M, Morselli-Labate AM et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am. J. Med. 1999; 107: 450-5.
2. Pagano G, Pacini G, Musso G et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002; 35: 367-72.
3. Marchesini G, Brizi M, Bianchi G et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50: 1844-50.
4. Festa A, D'Agostino RDJ, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome. The insulin resistance atherosclerosis study (IRAS). Circulation 2000; 102: 42-7.
5. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler. Thromb. Vasc. Biol. 1999; 19: 972-8.
6. Hak AE, Pols HA, Stehouwer CD et al. Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study. J. Clin. Endocrinol. Metab. 2001; 86: 4398-405.
7. Juhan-Vague I, Thompson SG, Jespersen J. Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group. Arterioscler. Thromb. 1993; 13: 1865-73.
8. Lindahl B, Asplund K, Eliasson M, Evrin PE. Insulin resistance syndrome and fibrinolytic activity: the Northern Sweden MONICA Study. Int. J. Epidemiol. 1996; 25: 291-9.
9. Poehlman ET, Toth MJ, Gardner AW. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann. Intern. Med. 1995; 123: 673-5.
10. Tchernof A, Poehlman ET, Despres JP. Body fat distribution, the menopause transition, and hormone replacement therapy. Diabetes Metab. 2000; 26: 12-20.
11. Campos H, McNamara JR, Wilson PW, Ordovas JM, Schaefer EJ. Differences in LDL subfractions and apolipoproteins in premenopausal and postmenopausal women. J. Clin. Endocrinol. Metab. 1988; 67: 30-5.
12. Mathews DR, Hoskers JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment of insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-19.
13. Angulo P. Nonalcoholic fatty live disease. N. Engl. J. Med. 2002; 346: 1221-31.
14. McCullough AJ. Update on nonalcoholic fatty liver disease. J. Clin. Gastroenterol. 2000; 34: 255-62.
15. McKeigue PM, Pierpoint T, Ferrie JE, Marmot MG. Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in south Asians and Europeans. Diabetologia 1992; 35: 785-91.
16. Mather HM, Keen H. The Southall Diabetes Survey: prevalence of known diabetes in Asians and Europeans. Br. Med. J. 1985; 291: 1081-4.
17. Ramachandran A, Snehalatha C, Dharmaraj D, Viswanathan M. Prevalence of glucose intolerance in Asian Indians. Urban-rural difference and significance of upper body adiposity. Diabetes Care 1992; 15: 1348-55.
18. Singh RB, Niaz MA, Agarwal P, Beegum R, Rastogi SS, Singh NK. Epidemiologic study of central obesity, insulin resistance and associated disturbances in the urban population of North India. Acta Cardiol. 1995; 50: 215-25.
19. Knight TM, Smith Z, Whittles A et al. Insulin resistance, diabetes, and risk markers for ischaemic heart disease in Asian men and non-Asian in Bradford. Br. Heart J. 1992; 67: 343-50.
20. Day CP, James OFW. Steatohepatitis: a tale of two 'hits'? Gastroenterology 1998; 114: 842-5.
21. Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc. Natl Acad. Sci. USA 1997; 94: 2557-62.
22. Tsutsui H, Matsui K, Kawada N et al. IL-18 accounts for both TNF-alpha- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. J. Immunol. 1997; 159: 3961-7.
23. Dong W, Simeonova PP, Gallucci R et al. Cytokine expression in hepatocytes: role of oxidant stress. J. Interferon Cytokine Res. 1998; 18: 629-38.
24. Chikano S, Sawada K, Shimoyama T et al. IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner. Gut 2000; 47: 779-86.