Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment

Journal of Biological Chemistry

Volumn 288, Issue 11, 2013, Pages 7867-7874

  Dong, Ningzheng ^a   Fang, Chaodong ^a   Jiang, Yizhi ^a   Zhou, Tiantian ^a   Liu, Meng ^a   Zhou, Jianping ^b   Shen, Jianzhong ^c,d   Fukuda, Koichi ^c   Qin, Jun ^c   Wu, Qingyu ^a,c  

^a SOOCHOW UNIVERSITY   (China)

^b Yancheng First People's Hospital   (China)

^c LERNER RESEARCH INSTITUTE   (United States)

^d PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN AMERICAN; ECTODOMAIN SHEDDING; HYPERTENSIVE PATIENTS; NATRIURETIC PEPTIDES; PROTEASE INHIBITOR; TRANSFECTED CELLS; WESTERN-BLOT ANALYSIS; ZYMOGEN ACTIVATION;

AMINO ACIDS; BLOOD PRESSURE; PEPTIDES;

GENES;

ARGININE; ATRIAL NATRIURETIC FACTOR; ENZYME PRECURSOR; SECRETED FRIZZLED RELATED PROTEIN 2;

ARTICLE; CONTROLLED STUDY; CORIN GENE; EMBRYO; ENZYME ACTIVATION; ENZYME ASSAY; EXON; GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HYPERTENSION; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; RESIDUE ANALYSIS; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; WESTERN BLOTTING;

BINDING SITES; ENZYME PRECURSORS; FEMALE; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; HYPERTENSION; MALE; MODELS, GENETIC; MODELS, MOLECULAR; MUTATION; PEPTIDES; PHYLOGENY; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, DNA; SERINE ENDOPEPTIDASES;

EID: 84875185502     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.411512     Document Type: Article

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