-
1
-
-
0035846933
-
Type II transmembrane serine proteases: Insights into an emerging class of cell surface proteolytic enzymes
-
Hooper JD, Clements JA, Quigley JP, et al. Type II transmembrane serine proteases: insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem 2001; 276: 857-60.
-
(2001)
J Biol Chem
, vol.276
, pp. 857-860
-
-
Hooper, J.D.1
Clements, J.A.2
Quigley, J.P.3
-
2
-
-
0037020169
-
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins
-
Velasco G, Cal S, Quesada V, et al. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem 2002; 277: 37637-46.
-
(2002)
J Biol Chem
, vol.277
, pp. 37637-37646
-
-
Velasco, G.1
Cal, S.2
Quesada, V.3
-
3
-
-
44449177930
-
The serine protease TMPRSS6 is required to sense iron deficiency
-
Du X, She E, Gelbart T, et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science 2008; 320: 1088-92.
-
(2008)
Science
, vol.320
, pp. 1088-1092
-
-
Du, X.1
She, E.2
Gelbart, T.3
-
4
-
-
54349096688
-
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
-
Folgueras AR, de Lara FM, Pendas AM, et al. Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 2008; 112: 2539-45.
-
(2008)
Blood
, vol.112
, pp. 2539-2545
-
-
Folgueras, A.R.1
De Lara, F.M.2
Pendas, A.M.3
-
5
-
-
79960674973
-
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
-
Meynard D, Vaja V, Sun CC, et al. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood 2011; 118: 747-56.
-
(2011)
Blood
, vol.118
, pp. 747-756
-
-
Meynard, D.1
Vaja, V.2
Sun, C.C.3
-
6
-
-
42649118442
-
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
-
Finberg KE, Heeney MM, Campagna DR, et al. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 2008; 40: 569-71.
-
(2008)
Nat Genet
, vol.40
, pp. 569-571
-
-
Finberg, K.E.1
Heeney, M.M.2
Campagna, D.R.3
-
7
-
-
54349094273
-
A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
-
Melis MA, Cau M, Congiu R, et al. A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica 2008; 93: 1473-9.
-
(2008)
Haematologica
, vol.93
, pp. 1473-1479
-
-
Melis, M.A.1
Cau, M.2
Congiu, R.3
-
8
-
-
52649096861
-
Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency
-
Guillem F, Lawson S, Kannengiesser C, et al. Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency. Blood 2008; 112: 2089-91.
-
(2008)
Blood
, vol.112
, pp. 2089-2091
-
-
Guillem, F.1
Lawson, S.2
Kannengiesser, C.3
-
9
-
-
56449096622
-
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
-
Silvestri L, Pagani A, Nai A, et al. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab 2008; 8: 502-11.
-
(2008)
Cell Metab
, vol.8
, pp. 502-511
-
-
Silvestri, L.1
Pagani, A.2
Nai, A.3
-
10
-
-
78649839347
-
Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression
-
Maxson JE, Chen J, Enns CA, et al. Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression. J Biol Chem 2010; 285: 39021-8.
-
(2010)
J Biol Chem
, vol.285
, pp. 39021-39028
-
-
Maxson, J.E.1
Chen, J.2
Enns, C.A.3
-
11
-
-
84867411483
-
Neogenin interacts with matriptase-2 to facilitate heojuvelin cleavage
-
Ens CA, Ahmed R, Zhang AS,. Neogenin interacts with matriptase-2 to facilitate heojuvelin cleavage. J Biol Chem 2012; 287: 35104-17.
-
(2012)
J Biol Chem
, vol.287
, pp. 35104-35117
-
-
Ens, C.A.1
Ahmed, R.2
Zhang, A.S.3
-
12
-
-
70350628958
-
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
-
Benyamin B, Ferreira MA, Willemsen G, et al. Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet 2009; 41: 1173-5.
-
(2009)
Nat Genet
, vol.41
, pp. 1173-1175
-
-
Benyamin, B.1
Ferreira, M.A.2
Willemsen, G.3
-
13
-
-
70350638919
-
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
-
Chambers JC, Zhang W, Li Y, et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet 2009; 41: 1170-2.
-
(2009)
Nat Genet
, vol.41
, pp. 1170-1172
-
-
Chambers, J.C.1
Zhang, W.2
Li, Y.3
-
14
-
-
70350646902
-
Multiple loci influence erythrocyte phenotypes in the CHARGE consortium
-
Ganesh SK, Zakai NA, van Rooij FJ, et al. Multiple loci influence erythrocyte phenotypes in the CHARGE consortium. Nat Genet 2009; 41: 1191-8.
-
(2009)
Nat Genet
, vol.41
, pp. 1191-1198
-
-
Ganesh, S.K.1
Zakai, N.A.2
Van Rooij, F.J.3
-
15
-
-
74949090955
-
A genome-wide association analysis of serum iron concentrations
-
Tanaka T, Roy CN, Yao W, et al. A genome-wide association analysis of serum iron concentrations. Blood 2010; 115: 94-6.
-
(2010)
Blood
, vol.115
, pp. 94-96
-
-
Tanaka, T.1
Roy, C.N.2
Yao, W.3
-
16
-
-
84862671571
-
Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations
-
McLaren CE, McLachlan S, Garner CP, et al. Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. PLoS One 2012; 7: e38339.
-
(2012)
PLoS One
, vol.7
-
-
McLaren, C.E.1
McLachlan, S.2
Garner, C.P.3
-
17
-
-
80155131215
-
An iron regulatory gene signature predicts outcome in breast cancer
-
Miller LD, Coffman LG, Chou JW, et al. An iron regulatory gene signature predicts outcome in breast cancer. Cancer Res 2011; 71: 6728-37.
-
(2011)
Cancer Res
, vol.71
, pp. 6728-6737
-
-
Miller, L.D.1
Coffman, L.G.2
Chou, J.W.3
-
18
-
-
33747594541
-
The mouse testis is the source of various serine proteases and serine proteinase inhibitors (SERPINs): Serine proteases and SERPINs identified in leydig cells are under gonadotropin regulation
-
Odet F, Verot A, Le Magueresse-Battistoni B,. The mouse testis is the source of various serine proteases and serine proteinase inhibitors (SERPINs): serine proteases and SERPINs identified in leydig cells are under gonadotropin regulation. Endocrinology 2006; 147: 4374-83.
-
(2006)
Endocrinology
, vol.147
, pp. 4374-4383
-
-
Odet, F.1
Verot, A.2
Le Magueresse-Battistoni, B.3
-
19
-
-
3242777139
-
Protease degradomics: Mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors
-
Overall CM, Tam EM, Kappelhoff R, et al. Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. Biol Chem 2004; 385: 493-504.
-
(2004)
Biol Chem
, vol.385
, pp. 493-504
-
-
Overall, C.M.1
Tam, E.M.2
Kappelhoff, R.3
-
20
-
-
34250777391
-
Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
-
Parr C, Sanders AJ, Davies G, et al. Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients. Clin Cancer Res 2007; 13: 3568-76.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3568-3576
-
-
Parr, C.1
Sanders, A.J.2
Davies, G.3
-
21
-
-
48749092358
-
Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation
-
Sanders AJ, Parr C, Martin TA, et al. Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation. J Cell Physiol 2008; 216: 780-9.
-
(2008)
J Cell Physiol
, vol.216
, pp. 780-789
-
-
Sanders, A.J.1
Parr, C.2
Martin, T.A.3
-
22
-
-
33645053497
-
Refinement of the 22q12-q13 breast cancer-associated region: Evidence of TMPRSS6 as a candidate gene in an eastern Finnish population
-
Hartikainen JM, Tuhkanen H, Kataja V, et al. Refinement of the 22q12-q13 breast cancer-associated region: evidence of TMPRSS6 as a candidate gene in an eastern Finnish population. Clin Cancer Res 2006; 12: 1454-62.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1454-1462
-
-
Hartikainen, J.M.1
Tuhkanen, H.2
Kataja, V.3
-
23
-
-
19944434383
-
An autosome-wide scan for linkage disequilibrium based association in sporadic breast cancer cases in Eastern Finland; Three regions found
-
Hartikainen J, Tuhkanen H, Kataja V, et al. An autosome-wide scan for linkage disequilibrium based association in sporadic breast cancer cases in Eastern Finland; three regions found. Cancer Epidemiol Biomarkers Prev 2005; 14: 75-80.
-
(2005)
Cancer Epidemiol Biomarkers Prev
, vol.14
, pp. 75-80
-
-
Hartikainen, J.1
Tuhkanen, H.2
Kataja, V.3
-
24
-
-
0037338643
-
P21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis
-
Pellikainen MJ, Pekola TT, Ropponen KM, et al. p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis. J Clin Pathol 2003; 56: 214-20.
-
(2003)
J Clin Pathol
, vol.56
, pp. 214-220
-
-
Pellikainen, M.J.1
Pekola, T.T.2
Ropponen, K.M.3
-
26
-
-
77956520950
-
ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival
-
Kauppinen JM, Kosma VM, Soini Y, et al. ST14 gene variant and decreased matriptase protein expression predict poor breast cancer survival. Cancer Epidemiol Biomarkers Prev 2010; 19: 2133-42.
-
(2010)
Cancer Epidemiol Biomarkers Prev
, vol.19
, pp. 2133-2142
-
-
Kauppinen, J.M.1
Kosma, V.M.2
Soini, Y.3
-
27
-
-
66949126902
-
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: Inverse correlation between HYAL1 and hyaluronan content
-
Nykopp TK, Rilla K, Sironen R, et al. Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. BMC Cancer 2009; 9: 143.
-
(2009)
BMC Cancer
, vol.9
, pp. 143
-
-
Nykopp, T.K.1
Rilla, K.2
Sironen, R.3
-
28
-
-
38349106695
-
Evaluation and validation of candidate endogenous control genes for real-time quantitative PCR studies of breast cancer
-
McNeill RE, Miller N, Kerin MJ,. Evaluation and validation of candidate endogenous control genes for real-time quantitative PCR studies of breast cancer. BMC Mol Biol 2007; 8: 107.
-
(2007)
BMC Mol Biol
, vol.8
, pp. 107
-
-
McNeill, R.E.1
Miller, N.2
Kerin, M.J.3
-
29
-
-
79952056705
-
Genetic variability of TMPRSS6 and its association with iron deficiency anaemia
-
Delbini P, Vaja V, Graziadei G, et al. Genetic variability of TMPRSS6 and its association with iron deficiency anaemia. Br J Haematol 2010; 151: 281-4.
-
(2010)
Br J Haematol
, vol.151
, pp. 281-284
-
-
Delbini, P.1
Vaja, V.2
Graziadei, G.3
-
30
-
-
33846071416
-
PolyDoms: A whole genome database for the identification of non-synonymous coding SNPs with the potential to impact disease
-
Jegga AG, Gowrisankar S, Chen J, et al. PolyDoms: a whole genome database for the identification of non-synonymous coding SNPs with the potential to impact disease. Nucleic Acids Res 2007; 35: D700-D706.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Jegga, A.G.1
Gowrisankar, S.2
Chen, J.3
-
31
-
-
77951640946
-
A method and server for predicting damaging missense mutations
-
Adzhubei IA, Schmidt S, Peshkin L, et al. A method and server for predicting damaging missense mutations. Nat Methods 2010; 7: 248-9.
-
(2010)
Nat Methods
, vol.7
, pp. 248-249
-
-
Adzhubei, I.A.1
Schmidt, S.2
Peshkin, L.3
-
32
-
-
0032545728
-
Loss of heterozygosity at loci from chromosome arm 22Q in human sporadic breast carcinomas
-
Allione F, Eisinger F, Parc P, et al. Loss of heterozygosity at loci from chromosome arm 22Q in human sporadic breast carcinomas. Int J Cancer 1998; 75: 181-6.
-
(1998)
Int J Cancer
, vol.75
, pp. 181-186
-
-
Allione, F.1
Eisinger, F.2
Parc, P.3
-
33
-
-
0031938046
-
Mapping of a new target region of allelic loss to a 2-cM interval at 22q13.1 in primary breast cancer
-
Iida A, Kurose K, Isobe R, et al. Mapping of a new target region of allelic loss to a 2-cM interval at 22q13.1 in primary breast cancer. Genes Chromosomes Cancer 1998; 21: 108-12.
-
(1998)
Genes Chromosomes Cancer
, vol.21
, pp. 108-112
-
-
Iida, A.1
Kurose, K.2
Isobe, R.3
-
34
-
-
0034214364
-
A region of deletion on chromosome 22q13 is common to human breast and colorectal cancers
-
Castells A, Gusella JF, Ramesh V, et al. A region of deletion on chromosome 22q13 is common to human breast and colorectal cancers. Cancer Res 2000; 60: 2836-9.
-
(2000)
Cancer Res
, vol.60
, pp. 2836-2839
-
-
Castells, A.1
Gusella, J.F.2
Ramesh, V.3
-
35
-
-
0034901808
-
Allelic losses of loci at 3p25.1, 8p22, 13q12, 17p13.3, and 22q13 correlate with postoperative recurrence in breast cancer
-
Hirano A, Emi M, Tsuneizumi M, et al. Allelic losses of loci at 3p25.1, 8p22, 13q12, 17p13.3, and 22q13 correlate with postoperative recurrence in breast cancer. Clin Cancer Res 2001; 7: 876-82.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 876-882
-
-
Hirano, A.1
Emi, M.2
Tsuneizumi, M.3
-
36
-
-
78751598932
-
Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: New link between hypoxia signaling and iron homeostasis
-
Lakhal S, Schodel J, Townsend AR, et al. Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. J Biol Chem 2011; 286: 4090-7.
-
(2011)
J Biol Chem
, vol.286
, pp. 4090-4097
-
-
Lakhal, S.1
Schodel, J.2
Townsend, A.R.3
-
37
-
-
34648815810
-
Emerging roles of proteases in tumour suppression
-
Lopez-Otin C, Matrisian LM,. Emerging roles of proteases in tumour suppression. Nat Rev Cancer 2007; 7: 800-8.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 800-808
-
-
Lopez-Otin, C.1
Matrisian, L.M.2
-
38
-
-
77953590859
-
Bone morphogenetic proteins in breast cancer: Dual role in tumourigenesis?
-
Alarmo EL, Kallioniemi A,. Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? Endocr Relat Cancer 2010; 17: R123-R139.
-
(2010)
Endocr Relat Cancer
, vol.17
-
-
Alarmo, E.L.1
Kallioniemi, A.2
-
39
-
-
84857132136
-
Tumor suppressor function of liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
-
Partanen JI, Tervonen TA, Myllynen M, et al. Tumor suppressor function of liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci USA 2012; 109: E388-E397.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Partanen, J.I.1
Tervonen, T.A.2
Myllynen, M.3
-
40
-
-
73549091040
-
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway
-
List K, Kosa P, Szabo R, et al. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol 2009; 175: 1453-63.
-
(2009)
Am J Pathol
, vol.175
, pp. 1453-1463
-
-
List, K.1
Kosa, P.2
Szabo, R.3
|