Proteolytic processing of the serine protease matriptase-2: Identification of the cleavage sites required for its autocatalytic release from the cell surface

Biochemical Journal

Volumn 430, Issue 1, 2010, Pages 87-95

  Stirnberg, Marit ^a   Maurer, Eva ^a   Horstmeyer, Angelika ^a   Kolp, Sonja ^a   Frank, Stefan ^a   Bald, Tobias ^a   Arenz, Katharina ^a   Janzer, Andreas ^a   Prager, Kai ^a   Wunderlich, Patrick ^a   Walter, Jochen ^a   Gütschow, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Autocatalysis; Cell surface shedding; Cleavage site determination; Matriptase 2; Proteolytic processing; Type II transmembrane serine protease (TTSP)

Indexed keywords

AUTOCATALYSIS; CELL SURFACE SHEDDING; CLEAVAGE SITE DETERMINATION; MATRIPTASE-2; PROTEOLYTIC PROCESSING; TYPE II TRANSMEMBRANE SERINE PROTEASE;

ACTIVATION ANALYSIS; AMINO ACIDS; CATALYST ACTIVITY; CELL MEMBRANES; CYTOLOGY; PHOSPHATASES;

ENZYME ACTIVITY;

MATRIPTASE; MATRIPTASE 2; MONOMER; POLYMER; UNCLASSIFIED DRUG; ENZYME PRECURSOR; MEMBRANE PROTEIN; SERINE PROTEINASE;

ARTICLE; CATALYSIS; CELL SURFACE; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; CELL LINE; CELL MEMBRANE; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYMOLOGY; EXTRACELLULAR SPACE; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING;

CATALYSIS; CATALYTIC DOMAIN; CELL LINE; CELL MEMBRANE; CULTURE MEDIA, CONDITIONED; ENZYME ACTIVATION; ENZYME PRECURSORS; EXTRACELLULAR SPACE; HUMANS; MEMBRANE PROTEINS; MUTATION; PROTEIN BINDING; SERINE ENDOPEPTIDASES; TRANSFECTION;

EID: 77955496853     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091565     Document Type: Article

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