Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene

Neurochemistry International

Volumn 74, Issue , 2014, Pages 74-83

  Nakai, Tsuyoshi ^a   Nagai, Taku ^a   Wang, Rui ^a   Yamada, Shinnosuke ^a   Kuroda, Keisuke ^a   Kaibuchi, Kozo ^a   Yamada, Kiyofumi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Disc1; Dopamine release; Methamphetamine; Parvalbumin positive interneuron; Schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; METHAMPHETAMINE; PARVALBUMIN; 4 AMINOBUTYRIC ACID A RECEPTOR; DISC1 PROTEIN, MOUSE; DOPAMINE; MESSENGER RNA; NERVE PROTEIN; PRIMER DNA;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; EXON; FEMALE; GABAERGIC SYSTEM; GENE DISRUPTION; GENE EXPRESSION; GENOTYPE; HIPPOCAMPUS; HYPERACTIVITY; INTERNEURON; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING; ANIMAL; GENETICS; METABOLISM; MICRODIALYSIS; MUTANT MOUSE STRAIN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; DOPAMINE; EXONS; FEMALE; GAMMA-AMINOBUTYRIC ACID; MALE; MICE; MICE, MUTANT STRAINS; MICRODIALYSIS; NERVE TISSUE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, DOPAMINE; RECEPTORS, GABA-A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84904167429     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.06.009     Document Type: Article

References (101)

1. 1 receptors and working memory in schizophrenia J. Neurosci. 22 2002 3708 3719 (Pubitemid 37465776)
2. D.N. Allen, G.P. Strauss, K.A. Barchard, M. Vertinski, W.T. Carpenter, and R.W. Buchanan Differences in developmental changes in academic and social premorbid adjustment between males and females with schizophrenia Schizophr. Res. 146 2013 132 137
3. C.P. Austin, L. Ma, B. Ky, J.A. Morris, and P.J. Shughrue DISC1 (disrupted in schizophrenia-1) is expressed in limbic regions of the primate brain NeuroReport 14 2003 951 954 (Pubitemid 36829770)
4. C.P. Austin, B. Ky, L. Ma, J.A. Morris, and P.J. Shughrue Expression of disrupted-in-schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development Neuroscience 124 2004 3 10 (Pubitemid 38186612)
5. Y. Ayhan, B. Abazyan, J. Nomura, R. Kim, B. Ladenheim, I.N. Krasnova, A. Sawa, R.L. Margolis, J.L. Cadet, S. Mori, M.W. Vogel, C.A. Ross, and M.V. Pletnikov Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice. evidence for neurodevelopmental origin of major psychiatric disorders Mol. Psychiatry 16 2011 293 306
6. A.M. Barr, V. Lehmann-Masten, M. Paulus, R.R. Gainetdinov, M.G. Caron, and M.A. Geyer The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice Neuropsychopharmacology 29 2004 221 228 (Pubitemid 38175141)
7. J.B. Becker Corresponding author contact information estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis Neurosci. Lett. 118 1990 169 171 (Pubitemid 20334872)
8. J.E. Belforte, V. Zsiros, E.R. Sklar, Z. Jiang, G. Yu, Y. Li, E.M. Quinlan, and K. Nakazawa Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes Nat. Neurosci. 13 2010 76 83
9. D.H. Blackwood, A. Fordyce, M.T. Walker, D.M. St Clair, D.J. Porteous, and W.J. Muir Schizophrenia and affective disorders - cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family Am. J. Hum. Genet. 69 2001 428 433 (Pubitemid 32695214)
10. M. Blurton-Jones, and M.H. Tuszynski Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats J. Comp. Neurol. 452 2002 276 287
11. C. Bocklisch, V. Pascoli, J.C. Wong, D.R. House, C. Yvon, M. de Roo, K.R. Tan, and C. Lüscher Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area Science 341 2013 1521 1525
12. N.J. Brandon, and A. Sawa Linking neurodevelopmental and synaptic theories of mental illness through DISC1 Nat. Rev. Neurosci. 12 2011 707 722
13. G. Brébion, V. Villalta-Gil, J. Autonell, J. Cervilla, M. Dolz, A. Foix, J.M. Haro, J. Usall, M. Vilaplana, and S. Ochoa Cognitive correlates of verbal memory and verbal fluency in schizophrenia, and differential effects of various clinical symptoms between male and female patients Schizophr. Res. 147 2013 81 85
14. G.F. Busatto, L.S. Pilowsky, D.C. Costa, P.J. Ell, A.S. David, J.V. Lucey, and R.W. Kerwin Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia Am. J. Psychiatry 154 1997 56 63 (Pubitemid 27020193)
15. A. Carlsson A paradigm shift in brain research Science 294 2001 1021 1024 (Pubitemid 33048804)
16. S.A. Castner, L. Xiao, and J.B. Becker Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies Brain Res. 610 1993 127 134 (Pubitemid 23144432)
17. 1 receptor stimulation Science 287 2000 2020 2022 (Pubitemid 30158679)
18. B. Chattopadhyaya, and G.D. Cristo GABAergic circuit dysfunctions in neurodevelopmental disorders Front. Psychiatry 3 2012 51
19. H.H. Chen, Y.K. Yang, T.L. Yeh, C.F. Cherng, H.C. Hsu, S.Y. Hsiao, and L. Yu Methamphetamine-induced conditioned place preference is facilitated by estradiol pretreatment in female mice Chin. J. Physiol. 46 2003 169 174 (Pubitemid 38028906)
20. J.E. Chubb, N.J. Bradshaw, D.C. Soares, D.J. Porteous, and J.K. Millar The DISC locus in psychiatric illness Mol. Psychiatry 13 2008 36 64
21. A.L. Collins, D. Ma, P.L. Whitehead, E.R. Martin, H.H. Wright, R.K. Abramson, J.P. Hussman, J.L. Haines, M.L. Cuccaro, J.R. Gilbert, and M.A. Pericak-Vance Investigation of autism and GABA receptor subunit genes in multiple ethnic groups Neurogenetics 7 2006 167 174 (Pubitemid 44078294)
22. R.S. Devon, S. Anderson, P.W. Teague, P. Burgess, T.M. Kipari, C.A. Semple, J.K. Millar, W.J. Muir, V. Murray, A.J. Pelosi, D.H. Blackwood, and D.J. Porteous Identification of polymorphisms within disrupted in schizophrenia 1 and disrupted in schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder Psychiatr. Genet. 11 2001 71 78 (Pubitemid 32686185)
23. G.S. Dichter, C.A. Damiano, and J.A. Allen Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings J. Neurodev. Disord. 4 2012 19
24. J. Ekelund, I. Hovatta, A. Parker, T. Paunio, T. Varilo, R. Martin, J. Suhonen, P. Ellonen, G. Chan, J.S. Sinsheimer, E. Sobel, H. Juvonen, R. Arajärvi, T. Partonen, J. Suvisaari, J. Lönnqvist, J. Meyer, and L. Peltonen Chromosome 1 loci in Finnish schizophrenia families Hum. Mol. Genet. 10 2001 1611 1617 (Pubitemid 32734313)
25. A. Enomoto, N. Asai, T. Namba, Y. Wang, T. Kato, M. Tanaka, H. Tatsumi, S. Taya, D. Tsuboi, K. Kuroda, N. Kaneko, K. Sawamoto, R. Miyamoto, M. Jijiwa, Y. Murakumo, M. Sokabe, T. Seki, K. Kaibuchi, and M. Takahashi Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus Neuron 63 2009 774 787
26. S.H. Fatemi, A.R. Halt, J.M. Stary, R. Kanodia, S.C. Schulz, and G.R. Realmuto Glutamic and decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices Biol. Psychiatry 52 2002 805 810
27. B receptors is altered in brains of subjects with autism Cerebellum 8 2009 64 69
28. L. Fester, J. Prange-Kiel, H. Jarry, and G.M. Rune Estrogen synthesis in the hippocampus Cell Tissue Res. 345 2011 285 294
29. S.B. Floresco, A.R. West, B. Ash, H. Moore, and A.A. Grace Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission Nat. Neurosci. 2003 968 973 (Pubitemid 37064759)
30. 2-autoreceptors in regulating dopamine neuron activity and transmission. Neuroscience, in press. http:\\dx.doi.org\10.1016/j.neuroscience.2014.01.025.
31. K.B.J. Franklin, and G. Paxinos The mouse brain in stereotaxic coordinates 1997 Academic Press San Diego
32. W.J. Friedman, L. Olson, and H. Persson Cells that express brain-derived neurotrophic factor mRNA in the developing postnatal rat brain Eur. J. Neurosci. 3 1991 688 697
33. A.I. Gilani, M.O. Chohan, M. Inan, S.A. Schobel, N.H. Chaudhury, S. Paskewitz, N. Chuhma, S. Glickstein, R.J. Merker, Q. Xu, S.A. Small, S.A. Anderson, M.E. Ross, and H. Moore Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition Proc. Natl. Acad. Sci. USA 111 2014 7450 7455
34. J.A. Girault, and P. Greengard The neurobiology of dopamine signaling Arch. Neurol. 61 2004 641 644 (Pubitemid 38637678)
35. B. Giros, M. Jaber, S.R. Jones, R.M. Wightman, and M.G. Caron Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter Nature 379 1996 606 612 (Pubitemid 26052818)
36. N. Gogolla, J.J. Leblanc, K.B. Quast, T.C. Südhof, M. Fagiolini, and T.K. Hensch Common circuit defect of excitatory-inhibitory balance in mouse models of autism J. Neurodev. Disord. 1 2009 172 181
37. O. Guillin, A. Abi-Dargham, and M. Laruelle Neurobiology of dopamine in schizophrenia Int. Rev. Neurobiol. 78 2007 1 39
38. H. Häfner, S. Behrens, J. De Vry, and W.F. Gattaz Oestradiol enhances the vulnerability threshold for schizophrenia in women by an early effect on dopaminergic neurotransmission. Evidence from an epidemiological study and from animal experiments Eur. Arch. Psychiatry Clin. Neurosci. 241 1991 65 68
39. T. Hashimoto, D.W. Volk, S.M. Eggan, K. Mirnics, J.N. Pierri, Z. Sun, A.R. Sampson, and D.A. Lewis Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia J. Neurosci. 23 2003 6315 6326 (Pubitemid 36875633)
40. W. Hennah, A. Tuulio-Henriksson, T. Paunio, J. Ekelund, T. Varilo, T. Partonen, T.D. Cannon, J. Lönnqvist, and L. Peltonen A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia Mol. Psychiatry 10 2005 1097 1103 (Pubitemid 43251099)
41. W. Hennah, P. Thomson, A. McQuillin, N. Bass, A. Loukola, A. Anjorin, D. Blackwood, D. Curtis, I.J. Deary, S.E. Harris, E.T. Isometsä, J. Lawrence, J. Lönnqvist, W. Muir, A. Palotie, T. Partonen, T. Paunio, E. Pylkkö, M. Robinson, and P. Soronen DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder Mol. Psychiatry 14 2009 865 873
42. T. Hikida, H. Jaaro-Peled, S. Seshadri, K. Oishi, C. Hookway, S. Kong, D. Wu, R. Xue, M. Andrade, S. Tankou, S. Tankou, S. Mori, M. Gallagher, K. Ishizuka, M. Pletnikov, S. Kida, and A. Sawa Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans Proc. Natl. Acad. Sci. USA 104 2007 14501 14506 (Pubitemid 350003290)
43. T. Hikida, N.J. Gamo, and A. Sawa DISC1 as a therapeutic target for mental illnesses Expert Opin. Ther. Targets 16 2012 1151 1160
44. C.A. Hodgkinson, D. Goldman, J. Jaeger, S. Persaud, J.M. Kane, R.H. Lipsky, and A.K. Malhotra Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder Am. J. Hum. Genet. 75 2004 862 872 (Pubitemid 39390493)
45. A. Honda, K. Miyoshi, K. Baba, M. Taniguchi, Y. Koyama, S. Kuroda, T. Katayama, and M. Tohyama Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain Mol. Brain Res. 122 2004 89 92 (Pubitemid 38264550)
46. S.E. Hyman, R.C. Malenka, and E.J. Nestler Neural mechanisms of addiction: the role of reward-related learning and memory Annu. Rev. Neurosci. 29 2006 565 598 (Pubitemid 44476856)
47. M. Inan, T.J. Petros, and S.A. Anderson Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia Neurobiol. Dis. 53 2013 36 48
48. S.D. Iversen, and L.L. Iversen Dopamine: 50 years in perspective Trends Neurosci. 30 2007 188 193 (Pubitemid 46654233)
49. H. Jaaro-Peled, M. Niwa, C.A. Foss, R. Murai, S. de Los Reyes, A. Kamiya, Y. Mateo, P. O'Donnell, N.G. Cascella, T. Nabeshima, T.R. Guilarte, M.G. Pomper, and A. Sawa Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging Hum. Mol. Genet. 22 2013 1574 1580
50. P. Jonas, J. Bischofberger, D. Fricker, and R. Miles Interneuron diversity series: fast in, fast out-temporal and spatial signal processing in hippocampal interneurons Trends Neurosci. 27 2004 30 40 (Pubitemid 38036976)
51. C.A. Jones, D.J.G. Watson, and K.C.F. Fone Animal models of schizophrenia Br. J. Pharmacol. 164 2011 1162 1194
52. A. Kamiya, K. Kubo, T. Tomoda, M. Takaki, R. Youn, Y. Ozeki, N. Sawamura, U. Park, C. Kudo, M. Okawa, C.A. Ross, M.E. Hatten, K. Nakajima, and A. Sawa A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development Nat. Cell Biol. 7 2005 1167 1178
53. 1 dopamine receptor binding in neuroleptic-naive patients with schizophrenia Am. J. Psychiatry 159 2002 761 767 (Pubitemid 34465049)
54. 3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography Biol. Psychiatry 68 2010 634 641
55. 2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning Neuron 49 2006 603 615 (Pubitemid 43221894)
56. H. Kilpinen, T. Ylisaukko-Oja, W. Hennah, O.M. Palo, T. Varilo, R. Vanhala, T. Nieminen-von Wendt, L. von Wendt, T. Paunio, and L. Peltonen Association of DISC1 with autism and Asperger syndrome Mol. Psychiatry 13 2008 187 196
57. J.Y. Kim, X. Duan, C.Y. Liu, M.H. Jang, J.U. Guo, N. Pow-anpongkul, E. Kang, H. Song, and G.L. Ming DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 Neuron 63 2009 761 773
58. J.Y. Kim, C.Y. Liu, F. Zhang, X. Duan, Z. Wen, J. Song, E. Feighery, B. Lu, D. Rujescu, D. St Clair, K. Christian, J.H. Callicott, D.R. Weinberger, H. Song, and G.L. Ming Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia Cell 148 2012 1051 1064
59. C. Konradi, C.K. Yang, E.I. Zimmerman, K.M. Lohmann, P. Gresch, H. Pantazopoulos, S. Berretta, and S. Heckers Hippocampal interneurons are abnormal in schizophrenia Schizophr. Res. 131 2011 165 173
60. T. Korotkova, E.C. Fuchs, A. Ponomarenko, J. von Engelhardt, and H. Monyer NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory Neuron 68 2010 557 569
61. M.F. Kritzer, and S.G. Kohama Ovarian hormones differentially influence immunoreactivity for dopamine beta-hydroxylase, choline acetyltransferase, and serotonin in the dorsolateral prefrontal cortex of adult rhesus monkeys J. Comp. Neurol. 409 1999 438 451 (Pubitemid 29262254)
62. K. Kuroda, S. Yamada, M. Tanaka, M. Iizuka, H. Yano, D. Mori, D. Tsuboi, T. Nishioka, T. Namba, Y. Iizuka, S. Kubota, T. Nagai, D. Ibi, R. Wang, A. Enomoto, M. Isotani-Sakakibara, N. Asai, K. Kimura, H. Kiyonari, T. Abe, A. Mizoguchi, M. Sokabe, M. Takahashi, K. Yamada, and K. Kaibuchi Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse Hum. Mol. Genet. 20 2011 4666 4683
63. S.R. Laviolette Dopamine modulation of emotional processing in cortical and subcortical neural circuits: evidence for a final common pathway in schizophrenia? Schizophr. Bull. 33 2007 971 981 (Pubitemid 47216650)
64. F.H. Lee, C.C. Zai, S.P. Cordes, J.C. Roder, and A.H. Wong Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice Mol. Brain 6 2013 1756-6606-6-20
65. M. Legault, P.P. Rompré, and R.A. Wise Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area J. Neurosci. 20 2000 1635 1642 (Pubitemid 30220442)
66. A. Leung, and P. Chue Sex differences in schizophrenia, a review of the literature Acta Psychiatr. Scand. Suppl. 401 2000 3 38 (Pubitemid 30412890)
67. D.A. Lewis, and G. González-Burgos Neuroplasticity of neocortical circuits in schizophrenia Neuropsychopharmacology 33 2008 141 165 (Pubitemid 350191315)
68. D.A. Lewis, T. Hashimoto, and D.W. Volk Cortical inhibitory neurons and schizophrenia Nat. Rev. Neurosci. 6 2005 312 324 (Pubitemid 40469985)
69. T.V. Lipina, M. Niwa, H. Jaaro-Peled, P.J. Fletcher, P. Seeman, A. Sawa, and J.C. Roder Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia Genes Brain Behav. 9 2010 777 789
70. -ΔΔCT method Methods 25 2001 402 408 (Pubitemid 34164012)
71. D.J. Lodge, and A.A. Grace Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia Trends Pharmacol. Sci. 32 2011 507 513
72. L. Ma, Y. Liu, P.J. Shughrue, C.P. Austin, and J.A. Morris Cloning and characterization of Disc1, the mouse ortholog of DISC1 (disrupted-in- schizophrenia 1) Genomics 80 2002 662 672 (Pubitemid 36062653)
73. Y. Mao, X. Ge, C.L. Frank, J.M. Madison, A.N. Koehler, M.K. Doud, C. Tassa, E.M. Berry, T. Soda, K.K. Singh, T. Biechele, T.L. Petryshen, R.T. Moon, S.J. Haggarty, and L.H. Tsai Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3β/β-catenin signaling Cell 136 2009 1017 1031
74. J.K. Millar, J.C. Wilson-Annan, S. Anderson, S. Christie, M.S. Taylor, C.A. Semple, R.S. Devon, D.M. St Clair, W.J. Muir, and D.H. Blackwood Disruption of two novel genes by a translocation co-segregating with schizophrenia Hum. Mol. Genet. 9 2000 1415 1423 (Pubitemid 30312490)
75. J.K. Millar, B.S. Pickard, S. Mackie, R. James, S. Christie, S.R. Buchanan, M.P. Malloy, J.E. Chubb, E. Huston, G.S. Baillie, P.A. Thomson, E.V. Hill, N.J. Brandon, J.C. Rain, L.M. Camargo, P.J. Whiting, M.D. Houslay, D.H. Blackwood, W.J. Muir, and D.J. Porteous DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling Science 310 2005 1187 1191 (Pubitemid 41681745)
76. K. Miyoshi, A. Honda, K. Baba, M. Taniguchi, K. Oono, T. Fujita, S. Kuroda, T. Katayama, and M. Tohyama Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth Mol. Psychiatry 8 2003 685 694 (Pubitemid 36976300)
77. A. Mouri, T. Nagai, D. Ibi, and K. Yamada Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules Neurobiol. Dis. 53 2013 61 74
78. T. Nagai, Y. Kitahara, A. Shiraki, T. Hikita, S. Taya, K. Kaibuchi, and K. Yamada Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice. an in vivo microdialysis study Neurosci. Lett. 470 2010 134 138
79. E.J. Nestler, and S.E. Hyman Animal models of neuropsychiatric disorders Nat. Neurosci. 13 2010 1161 1169
80. M. Niwa, A. Kamiya, R. Murai, K. Kubo, A.J. Gruber, K. Tomita, L. Lu, S. Tomisato, H. Jaaro-Peled, S. Seshadri, H. Hiyama, B. Huang, K. Kohda, Y. Noda, P. O'Donnell, K. Nakajima, A. Sawa, and T. Nabeshima Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits Neuron 65 2010 480 489
81. B receptors in the cingulate cortex and fusiform gyrus in autism J. Neurochem. 114 2010 1414 1423
82. 1 receptors in schizophrenia revealed by PET Nature 385 1997 634 636
83. A. Pillai Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia Neurosignals 16 2008 183 193 (Pubitemid 351263224)
84. M.V. Pletnikov, Y. Ayhan, O. Nikolskaia, Y. Xu, M.V. Ovanesov, H. Huang, S. Mori, T.H. Moran, and C.A. Ross Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia Mol. Psychiatry 13 173-186 2008 115
85. V.M. Pogorelov, J. Nomura, J. Kim, G. Kannan, Y. Ayhan, C. Yang, Y. Taniguchi, B. Abazyan, H. Valentine, I.N. Krasnova, A. Kamiya, J.L. Cadet, D.F. Wong, and M.V. Pletnikov Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model Neuropharmacology 62 2012 1242 1251
86. G.M. Rune, C. Lohse, J. Prange-Kiel, L. Fester, and M. Frotscher Synaptic plasticity in the hippocampus: effects of estrogen from the gonads or hippocampus? Neurochem. Res. 31 2006 145 155
87. M.G. Sanchez, M. Bourque, M. Morissette, and T. Di Paolo Steroids-dopamine interactions in the pathophysiology and treatment of CNS disorders CNS Neurosci. Ther. 16 2010 e43 e71
88. J. Schumacher, G. Laje, Abou, R. Jamra, T. Becker, T.W. Mühleisen, C. Vasilescu, M. Mattheisen, S. Herms, P. Hoffmann, A.M. Hillmer, A. Georgi, C. Herold, T.G. Schulze, P. Propping, M. Rietschel, F.J. McMahon, M.M. Nöthen, and S. Cichon The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations Hum. Mol. Genet. 18 2009 2719 2727
89. High receptors CNS Neurosci. Ther. 17 2011 118 132
90. S. Shen, B. Lang, C. Nakamoto, F. Zhang, J. Pu, S.L. Kuan, C. Chatzi, S. He, I. Mackie, N.J. Brandon, K.L. Marquis, M. Day, O. Hurko, C.D. McCaig, G. Riedel, and D. St Clair Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1 J. Neurosci. 28 2008 10893 10904
91. T. Shinoda, S. Taya, D. Tsuboi, T. Hikita, R. Matsuzawa, S. Kuroda, A. Iwamatsu, and K. Kaibuchi DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2 J. Neurosci. 27 2007 4 14 (Pubitemid 46089954)
92. K.K. Singh, X. Ge, Y. Mao, L. Drane, K. Meletis, B.A. Samuels, and L.H. Tsai Dixdc1 is a critical regulator of DISC1 and embryonic cortical development Neuron 67 2010 33 48
93. D. St Clair, D. Blackwood, W. Muir, A. Carothers, M. Walker, G. Spowart, C. Gosden, and H.J. Evans Association within a family of a balanced autosomal translocation with major mental illness Lancet 336 1990 13 16 (Pubitemid 20207869)
94. A. Streinecke, C. Gampe, C. Valkova, C. Kaether, and J. Bolz Disrupted-in-schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons J. Neurosci. 32 2012 738 745
95. M.K. Sun, and D.L. Alkon Differential gender-related vulnerability to depression induction and converging antidepressant responses in rats J. Pharmacol. Exp. Ther. 316 2006 926 932 (Pubitemid 43136539)
96. D.J. Surmeier, W. Shen, M. Day, T. Gertler, S. Chan, X. Tian, and J.L. Plotkin The role of dopamine in modulating the structure and function of striatal circuits Prog. Brain Res. 183 2010 149 167
97. J.M. Swanson, M. Kinsbourne, J. Nigg, B. Lanphear, G.A. Stefanatos, N. Volkow, E. Taylor, B.J. Casey, F.X. Castellanos, and P.D. Wadhwa Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis Neuropsychol. Rev. 17 2007 39 59 (Pubitemid 46355008)
98. S. Taya, T. Shinoda, D. Tsuboi, J. Asaki, K. Nagai, T. Hikita, S. Kuroda, K. Kuroda, M. Shimizu, S. Hirotsune, A. Iwamatsu, and K. Kaibuchi DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1 J. Neurosci. 27 2007 15 26 (Pubitemid 46089955)
99. C.S. Weickert, T.M. Hyde, B.K. Lipska, M.M. Herman, D.R. Weinberger, and J.E. Kleinman Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia Mol. Psychiatry 8 2003 592 610 (Pubitemid 36898018)
100. N.G. Weiland Glutamic acid decarboxylase messenger ribonucleic acid is regulated by estradiol and progesterone in the hippocampus Endocrinology 131 1992 2697 2702
101. J. Yip, J.J. Soghomonian, and G.J. Blatt Deceased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications Acta Neuropathol. 113 2007 559 568 (Pubitemid 46672602)