Striatal and extrastriatal dopamine D2/D3 receptors in schizophrenia evaluated with [18F]fallypride positron emission tomography

Biological Psychiatry

Volumn 68, Issue 7, 2010, Pages 634-641

  Kegeles, Lawrence S ^a   Slifstein, Mark ^a   Xu, Xiaoyan ^a   Urban, Nina ^a   Thompson, Judy L ^a   Moadel, Tiffany ^a   Harkavy Friedman, Jill M ^a   Gil, Roberto ^a   Laruelle, Marc ^a,b,c   Abi Dargham, Anissa ^a  

^a Columbia University ^*  (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Age related D2 D3 receptor loss; dopamine D 2 D3 receptor; extrastriatal regions; fallypride; partial volume correction; positron emission tomography; schizophrenia

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; FLUORODEOXYGLUCOSE F 18;

ADULT; ARTICLE; BRAIN REGION; BRAIN SCINTISCANNING; CAMERA; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NEOCORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCHIZOPHRENIA; STRIATE CORTEX; THALAMUS;

ADULT; AGE FACTORS; ANALYSIS OF VARIANCE; ANTIPSYCHOTIC AGENTS; BRAIN MAPPING; CASE-CONTROL STUDIES; CORPUS STRIATUM; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SCHIZOPHRENIA; YOUNG ADULT;

EID: 77956937214     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.05.027     Document Type: Article

References (54)

1. D.R. Weinberger, and M. Laruelle Neurochemical and neuropharmacological imaging in schizophrenia K.L. Davis, D.S. Charney, J.T. Coyle, C. Nemeroff, Neuropsychopharmacology: The Fifth Generation of Progress 2002 Lippincott, Williams, and Wilkins Philadelphia 883 885
2. M. Laruelle, A. Abi-Dargham, C.H. van Dyck, R. Gil, C.D. De Souza, and J. Erdos Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug free schizophrenic subjects Proc Natl Acad Sci U S A 93 1996 9235 9240
3. 125I]epidipride Brain Res 609 1993 237 343
4. 3H]raclopride Proc Natl Acad Sci U S A 86 1989 6412 6416 (Pubitemid 19210661)
5. A. Murray, H.L. Ryoo, E. Gurevich, and J.N. Joyce Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesofrontal regions of human forebrain Proc Natl Acad Sci U S A 91 1994 11271 11275
6. H. Hall, G. Sedvall, O. Magnusson, J. Kopp, C. Halldin, and L. Farde Distribution of D1- and D2-dopamine receptors, and dopamine and its metabolites in the human brain Neuropsychopharmacology 11 1994 245 256
7. J.N. Joyce, A. Janowsky, and K. Neve Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex in human brain J Pharmacol Exp Ther 257 1991 1253 2263
8. C. Halldin, L. Farde, T. Hogberg, N. Mohell, H. Hall, and T. Suhara Carbon-11-FLB 457: A radioligand for extrastriatal D2 dopamine receptors J Nucl Med 36 1995 1275 1281
9. J. Mukherjee, Z.Y. Yang, M.K. Das, and T. Brown Fluorinated benzamide neurolepticsIII Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F] fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer Nucl Med Biol 22 1995 283 296
10. M. Slifstein, D.-R. Hwang, Y. Huang, N. Guo, Y. Sudo, and R. Narendran In vivo affinity of [18F]fallypride for striatal and extrastriatal dopamine D2 receptors in nonhuman plrimates Psychopharmacology (Berl) 175 2004 274 286
11. G.P. Reynolds Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia Nature 305 1983 527 529
12. M. Akil, J.N. Pierri, R.E. Whitehead, C.L. Edgar, C. Mohila, A.R. Sampson, and D.A. Lewis Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects Am J Psychiatry 156 1999 1580 1589
13. M. Akil, C.L. Edgar, J.N. Pierri, S. Casali, and D.A. Lewis Decreased density of tyrosine hydroxylase-immunoreactive axons in the entorhinal cortex of schizophrenic subjects Biol Psychiatry 47 2000 361 370
14. J. Mukherjee, Z.Y. Yang, R. Lew, T. Brown, S. Kronmal, M.D. Cooper, and L.S. Seiden Evaluation of d-amphetamine effects on the binding of dopamine D-2 receptor radioligand, F-18-fallypride in nonhuman primates using positron emission tomography Synapse 27 1997 1 13
15. J.C. Price, S. Mason, B. Lopresti, D. Holt, N.R. Simpson, and W. Drevets PET measurements of endogenous neurotransmitter activity using high and low affinity radiotracers Neuroimage 5 1997 B77
16. D. Martinez, M. Slifstein, A. Broft, O. Mawlawi, D.R. Hwang, and Y. Huang Imaging human mesolimbic dopamine transmission with positron emission tomography Part II: Amphetamine-induced dopamine release in the functional subdivisions of the striatum J Cereb Blood Flow Metab 23 2003 285 300
17. A.B. Hollingshead Four Factor Index of Social Status 1975 Department of Sociology, Yale University New Haven, CT
18. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 1994 American Psychiatric Association Washington, DC
19. L.S. Kegeles, M. Slifstein, W.G. Frankle, X. Xu, E. Hackett, and S.A. Bae Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride Neuropsychopharmacology 33 2008 3111 3125
20. G. Brix, J. Zaers, L.E. Adam, M.E. Bellemann, H. Ostertag, and H. Trojan Performance evaluation of a whole-body PET scanner using the NEMA protocol National Electrical Manufacturers Association J Nucl Med 38 1997 1614 1623
21. A. Abi-Dargham, N. Simpson, L. Kegeles, R. Parsey, D.-R. Hwang, and S. Anjilvel PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756 Synapse 32 1999 93 109
22. K.J. Friston, A.P. Holmes, K.J. Worsley, J.-P. Poline, C.D. Frith, and R.S.J. Frakowiak Statistical parametric maps in functional imaging: A general linear approach Hum Brain Mapp 2 1995 189 210
23. A.A. Lammertsma, and S.P. Hume Simplified reference tissue model for PET receptor studies Neuroimage 4 1996 153 158
24. R.B. Innis, V.J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, and R.N. Gunn Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 2007 1533 1539
25. C.C. Meltzer, J.K. Zubieta, J.M. Links, P. Brakeman, M.J. Stumpf, and J.J. Frost MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution J Cereb Blood Flow Metab 16 1996 650 658
26. O.G. Rousset, Y. Ma, and A.C. Evans Correction for partial volume effects in PET: Principle and validation J Nucl Med 39 1998 904 911
27. O.G. Rousset, D.L. Collins, A. Rahmim, and D.F. Wong Design and implementation of an automated partial volume correction in PET: Application to dopamine receptor quantification in the normal human striatum J Nucl Med 49 2008 1097 1106
28. S.R. Kay, A. Fiszbein, and L.A. Opler The positive and negative syndrome scale (PANSS) for schizophrenia Schizophr Bull 13 1987 261 276
29. J.E. Overall, and D.R. Gorham The Brief Psychiatric Rating Scale Psychol Rep 10 1962 799 812
30. J.D. Cohen, S.D. Forman, T.S. Braver, B.J. Casey, D. Servan-Schreiber, and D.C. Noll Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI Hum Brain Mapp 1 1993 293 304
31. J.W. Newcomer Metabolic syndrome and mental illness Am J Manag Care 13 2007 S170 S177
32. J.M. Meyer, V.G. Davis, D.C. Goff, J.P. McEvoy, H.A. Nasrallah, and S.M. Davis Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: Prospective data from phase 1 Schizophr Res 101 2008 273 286
33. D.F. Wong, H.N. Wagner, R.F. Dannals, J.M. Links, J.J. Frost, and H.T. Ravert Effects of age on dopamine and serotonin receptors measured by positron emission tomography in the living brain Science 226 1984 1393 1396
34. 11C-raclopride Arch Neurol 50 1993 474 480 (Pubitemid 23143137)
35. 11C]raclopride J Cereb Blood Flow Metab 13 1993 310 314
36. D.F. Wong, H.N. Wagner Jr, L.E. Tune, R.F. Dannals, G.D. Pearlson, and J.M. Links Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics Science 234 1986 1558 1563
37. I. Ellison-Wright, D.C. Glahn, A.R. Laird, S.M. Thelen, and E. Bullmore The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis Am J Psychiatry 165 2008 1015 1023
38. T. Suhara, Y. Okubo, F. Yasuno, Y. Sudo, M. Inoue, and T. Ichimiya Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia Arch Gen Psychiatry 59 2002 25 30
39. H. Tuppurainen, J. Kuikka, H. Viinamaki, M. Husso-Saastamoinen, K. Bergstrom, and J. Tiihonen Extrastriatal dopamine D 2/3 receptor density and distribution in drug-naive schizophrenic patients Mol Psychiatry 8 2003 453 455
40. M.S. Buchsbaum, B.T. Christian, D.S. Lehrer, T.K. Narayanan, B. Shi, and J. Mantil D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia Schizophr Res 85 2006 232 244
41. F. Yasuno, T. Suhara, Y. Okubo, Y. Sudo, M. Inoue, and T. Ichimiya Low dopamine d(2) receptor binding in subregions of the thalamus in schizophrenia Am J Psychiatry 161 2004 1016 1022
42. M. Talvik, A.L. Nordstrom, H. Olsson, C. Halldin, and L. Farde Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: A PET study with [11C]FLB 457 Int J Neuropsychopharmacol 6 2003 361 370
43. B.Y. Glenthoj, T. Mackeprang, C. Svarer, H. Rasmussen, L.H. Pinborg, and L. Friberg Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender Biol Psychiatry 60 2006 621 629
44. R.M. Kessler, N.D. Woodward, P. Riccardi, R. Li, M.S. Ansari, and S. Anderson Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects Biol Psychiatry 65 2009 1024 1031
45. B. Pakkenberg Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics Arch Gen Psychiatry 47 1990 1023 1028
46. W. Byne, M.S. Buchsbaum, E. Kemether, E.A. Hazlett, A. Shinwari, V. Mitropoulou, and L.J. Siever Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder Arch Gen Psychiatry 58 2001 133 140 (Pubitemid 32142751)
47. W. Byne, M.S. Buchsbaum, L.A. Mattiace, E.A. Hazlett, E. Kemether, and S.L. Elhakem Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia Am J Psychiatry 159 2002 59 65
48. C.E. Stern, S.J. Sherman, B.A. Kirchhoff, and M.E. Hasselmo Medial temporal and prefrontal contributions to working memory tasks with novel and familiar stimuli Hippocampus 11 2001 337 346
49. M.K. van Vugt, A. Schulze-Bonhage, B. Litt, A. Brandt, and M.J. Kahana Hippocampal gamma oscillations increase with memory load J Neurosci 30 2010 2694 2699
50. V. Kaasinen, H. Vilkman, J. Hietala, K. Nagren, H. Helenius, and H. Olsson Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain Neurobiol Aging 21 2000 683 688
51. M. Inoue, T. Suhara, Y. Sudo, Y. Okubo, F. Yasuno, and T. Kishimoto Age-related reduction of extrastriatal dopamine D2 receptor measured by PET Life Sci 69 2001 1079 1084
52. A. Abi-Dargham, J. Rodenhiser, D. Printz, Y. Zea-Ponce, R. Gil, and L.S. Kegeles Increased baseline occupancy of D2 receptors by dopamine in schizophrenia Proc Natl Acad Sci U S A 97 2000 8104 8109
53. P. Riccardi, R. Li, M.S. Ansari, D. Zald, S. Park, and B. Dawant Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans Neuropsychopharmacology 31 2006 1016 1026
54. M. Slifstein, L.S. Kegeles, X. Xu, J.L. Thompson, N. Urban, and J. Castrillon Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride Synapse 64 2010 350 362