Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039

Radiation Research

Volumn 182, Issue 1, 2014, Pages 35-49

  Berhane, Hebist ^a   Shinde, Ashwin ^a   Kalash, Ronny ^a   Xu, Karen ^a   Epperly, Michael W ^a   Goff, Julie ^a   Franicola, Darcy ^a   Zhang, Xichen ^a   Dixon, Tracy ^a   Shields, Donna ^a   Wang, Hong ^a   Wipf, Peter ^b   Li, Song ^c   Gao, Xiang ^a   Greenberger, Joel S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Department of Chemistry ^*  (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FANCONI ANEMIA GROUP D2 PROTEIN; JP 4 039; NITROXIDE; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW SUPPRESSION; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; EXCISION; FANCONI ANEMIA; FEMUR; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HISTOPATHOLOGY; IRRADIATION; MOUSE; NONHUMAN; ORAL MUCOSITIS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIATION PROTECTION; STEREOTACTIC RADIOSURGERY; STRESS; TONGUE; TONGUE ULCER;

ANIMALS; BONE MARROW; CELL COUNT; CELL LINE; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FEMALE; FEMUR; HEAD; HEMATOPOIETIC STEM CELLS; LIPOSOMES; MALE; MICE; MOUTH; MUCOSITIS; NECK; NITROGEN OXIDES; RADIATION INJURIES, EXPERIMENTAL; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; RNA, MESSENGER;

EID: 84904136455     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13633.1     Document Type: Article

References (36)

1. Mehta PA, Harris RE, Davies SM, Kim MO, Mueller R, Lampkin B, et al. Numerical chromosomal changes and risk of development of myelodysplastic syndrome-acute myeloid leukemia in patients with Fanconi anemia. Cancer Genet Cytogenet 2010; 203:180-6.
2. Wang M, Chu H, Zhang Z, Wei Q. Molecular epidemiology of DNA repair gene polymorphism and head and neck cancer. J Biomed Res 2013; 27:179-92.
3. Alter BP. Fanconi's anemia and malignancies. Am J Hematol 1996; 53:99-110.
4. Dunn J, Potter M, Rees A, Runger TM. Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light. Cancer Res 2006; 66:11140-7.
5. Ceccaldi R, Parmar K, Mouly E, Delord M, Kim JM, Regairaz M, et al. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell 2012; 11:36-49.
6. Garcia-Higuera I, Tangiguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J, et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 2001; 7:249-62.
7. Birkeland AC, Auerbach AD, Sanborn E, Parashar B, Kuhel WI, Chandrasekharrapa SC, et al. Postoperative clinical radiosensitivity in patients with Fanconi anemia and head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2011; 37: 930-4.
8. Bremer M, Schindler E, Gross M, Dork T, Morlot S, Karstens JH. Fanconi's anemia and clinical radiosensitivity report on two adult patients with locally advanced solid tumors treated by radiotherapy. Strahlenther Onkol 2003; 179:748-53.
9. D'Andrea AD, Grompe M. The Fanconi Anemia/BRCA pathway. Nat Rev Cancer 2003; 3:22-40.
10. Knipscheer P, Raschie M, Smogorzewska A, et al. The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 2009; 326:1698-1701.
11. Alpi AF, Pace PE, Babu MM, Patel KJ. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. Mol Cell 2008; 32:767-77.
12. Joo W, Xu G, Persky NS, et al. Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science 2011; 333:312-6.
13. Garaycoechea JI, Patel KJ. Why does the bone marrow fail in Fanconi anemia? Blood 2014; 123:26-32.
14. Bernard ME, Kim H, Berhane H, Epperly MW, Franicola D, Zhang X, et al. GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi Anemia cell lines. Radiat Res 2011; 176:603-12.
15. Park JW, Pitot HC, Strati K, Spardy N, Duensing S, Grompe M, et al. Deficiencies in the Fanconi Anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. Cancer Res. 2010; 70:9959-68.
16. Berhane H, Epperly MW, Goff J, Kalash R, Cao S, Franicola D, et al. Radiobiologic differences between bone marrow stromal and hematopoietic progenitor cell lines form Fanconi Anemia (Fancd2-/-) mice. Radiat Res. 2014; 181: 76-89.
17. Guo H, Seixas-Silva JA, Epperly MW, Gretton JE, Shin DM, Bar-Sagi D, et al. Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res 2003; 159:361-70.
18. Epperly MW, Goff JP, Li S, Gao X, Wipf P, Dixon T, et al. Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. In Vivo 2010; 24:811-20.
19. Travlos GS. Histopathology of bone marrow. Toxicol Pathol 2006; 34:566-98.
20. Hall E, Giaccia A. Radiobiology for the radiologist. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2006.
21. Rajagopalan MS, Stone B, Rwigema J-C, Salimi U, Epperly MW, Goff J, et al. Intraesophageal manganese superoxide dismutaseplasmid liposomes ameliorates novel total body and thoracic irradiation sensitivity of homologous deletion recombinant negative nitric oxide synthase-1 (NOS1-/-) mice. Radiat Res 2010; 174:297-312.
22. Bolt MW, Mahoney PA. High-efficiency blotting of proteins of diverse sizes following sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal Biochem. 1997; 247:185-92.
23. Khan-Malek R, Wang Y. Statistical analysis of quantitative RTPCR results. Meth Mol Biol. 2011; 691:227-41.
24. Sonis ST. The biologic role for nuclear factor-kappaB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy. Crit Rev Oral Biol Med. 2002; 13:380-9.
25. Su X, Huang J. The Fanconi anemia pathway and DNA interstrand cross-link repair. Protein Cell 2011; 2:704-11.
26. Soulier J. Fanconi anemia. Hematology Am Soc. 2011; 2011:492-7.
27. Yang K, Moldovan GL, Vinciguerra P, Murai J, Takeda S, D'Andrea AD. Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev 2011; 25:1847-5.
28. Kee Y, D'Andrea A. Molecular pathogenesis and clinical management of Fanconi anemia. J Clin Invest. 2012; 122:3799-3806.
29. Dhanasekaran A, Kotamraju S, Karunakaran C, Kalivendi SV, Thomas S, Joseph J, et al. Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide. Free Radic Biol Med 2005; 39:567-83.
30. Jiang J, Kurnikov I, Belikova NA, Xiao J, Zhao Q, Vlasova IL, et al. Structural requirements for optimized delivery, inhibition of oxidative stress and anti-apoptotic activity of targeted nitroxides. J Pharmacol Exp Ther 2007; 320:1050-60.
31. Li S, Yan T, Yang JQ, Oberley TD, Oberley LW. The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res 2000; 60:3927-39.
32. Du W, Rani R, Sipple J, Schick J, Myers KC, Mehta P, et al. The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters. Blood 2012; 119:4142-51.
33. Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 2011; 475:53-60.
34. Garaycoechea JI, Crossan GP, Langevin F, Daly M, Arends MJ, Patel KJ. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature 2012; 489:571-8.
35. Hira A, Yabe H, Yoshida K, Okuno Y, Shiraishi Y, Chiba K, et al. Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. Blood 2013; 122:3206-12.
36. Kalash R, Berhane H, Yang Y, Epperly MW, Wang H, Dixon T, et al. Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam. In Vivo 2014; 28:1-12.