Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2-/-) Mice

Radiation Research

Volumn 181, Issue 1, 2014, Pages 76-89

  Berhane, Hebist ^a   Epperly, Michael W ^a   Goff, Julie ^a   Kalash, Ronny ^a   Cao, Shaonan ^a   Franicola, Darcy ^a   Zhang, Xichen ^a   Shields, Donna ^a   Houghton, Frank ^a   Wang, Hong ^a   Wipf, Peter ^b   Parmar, Kalindi ^c   Greenberger, Joel S ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW CELL; BONE MARROW CULTURE; CLONOGENESIS; COMET ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE; FANCONI ANEMIA; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE PRODUCT; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IRRADIATION; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION PROTECTION; RADIOSENSITIVITY; SURVIVAL RATE;

ANIMALS; ANTIOXIDANTS; CELL CYCLE; CELL LINE; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FREE RADICAL SCAVENGERS; GRANULOCYTE-MACROPHAGE PROGENITOR CELLS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; MESENCHYMAL STROMAL CELLS; MICE; MITOCHONDRIA; NITROGEN OXIDES; OXIDATIVE STRESS; RADIATION TOLERANCE; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84893661594     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13405.1     Document Type: Article

References (30)

1. Kee Y, D'Andrea A. Molecular pathogenesis and clinical management of Fanconi anemia. J Clin Invest 2012; 122(11): 3799-3806.
2. Jenkins C, Kan J, Hoatlin ME. Targeting the Fanconi anemia pathway to identify tailored anticancer therapeutics. Anemia 2012; 2012: 1-7.
3. Alter BP. Fanconi's anemia and malignancies. Am J Hematol 1996; 53:99-110.
4. Bernard ME, Kim H, Berhane H, Epperly MW, Franicola D, Xichen Z, et al. GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines. Radiat Res 2011; 176:603-12.
5. Du W, Rani R, Sipple J, Schick J, Myers KC, Mehta P, et al. The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters. Blood 2012; 119(18):4142-51.
6. D'Andrea AD, Grompe M. Molecular biology of Fanconi anemia: implications for diagnosis and therapy. Blood 1997; 90(5): 1725-36.
7. Kalb R, Duerr M, Wagner M, Herterich S, Gross M, Digweed M, et al. Lack of sensitivity of primary fanconi's anemia fibroblasts to UV and ionizing radiation. Radiat Res 2004; 161(3): 318-25.
8. Kuhnert VM, Kachnic LA, Li L, Purschke M, Gheorghiu L, Lee R, et al. FancD2-deficient human fibroblasts are hypersensitive to ionizing radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions. Int J Radiat Biol 2009; 85(6): 523-31.
9. Fink MP, Macias CA, Xiao J, Tyurina YY, Delude RL, Greenberger JS, et al. Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants. chemical Pharmacology 2007; 74:801-09.
10. Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, et al. Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp 1. Stem Cells 2010; 28:1186-95.
11. Rajagopalan MS, Stone B, Rwigema J-C, Salimi U, Epperly MW, Goff J, et al. Intraesophageal manganese superoxide dismutaseplasmid liposomes ameliorates novel total body and thoracic irradiation sensitivity of homologous deletion recombinant negative nitric oxide synthase-1 (NOS1-/-) mice. Radiat Res 2010; 174:297-312.
12. O'Sullivan R, Greenberger JS, Goff J, Shields D, Epperly M, Glowacki J. Cell logic parameters of accelerated osteoporosis in SAMP6 mice are demonstrated in long-term bone marrow culture senescence and in the logy of bone marrow stromal cell lines. Exp Hematol 2012; 40:499-509.
13. Mauch P, Greenberger JS, Botnick L, Hannon E, Hellman S. Evidence for structured variation in self-renewal capacity within long-term bone marrow cultures. Proc Natl Acad Sci USA 1980; 77: 2927-30.
14. Sakakeeny MA, Greenberger JS. Granulopoiesis longevity in continuous bone marrow cultures and factor-dependent cell line generation: significant variation among 28 inbred mouse strains and outbred stocks. J Natl Cancer Inst 1982; 68:305-17.
15. Greenberger JS, Sakakeeny MA, Humphries KC, Eaves CG, Eckner RJ. Demonstration of permanent factor-dependent multipotential (erythroid/ neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci, USA 1983; 80:2931-35.
16. Van de Geijn J. Time-dose response of human tumors and normal tissues during and after fractionated radiation treatment. A new model. Radiother Oncol 1988; 2(1): 57-78.
17. Epperly MW, Gretton JE, Bernarding M, Nie S, Rasul B, Greenberger JS. Mitochondrial localization of superoxide dismutase is required for decreasing radiation induced cell damage. Radiat Res 2003; 160(5): 568-78.
18. Olive PL. Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to reductive drugs. I. Tirapzazmine. Br J Cancer 1995; 71:529-36.
19. Rwigema J-CM, Beck B, Wang W, Doemling A, Epperly MW, Shields D, et al. Two strategies for the development of mitochondrial-targeted small molecule radiation damage mitigators. Int J Radiat Oncol l Phys 2011; 80(3): 860-68.
20. Houghtaling S, Newell A, Akkari Y, Taniguchi T, Olson S, Grompe M. Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum Mol Genet 2005; 14(20): 3027-33.
21. Ceccaldi R, Parmar K, Mouly E, Delord M, Kim JM, Regairaz M, et al. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell 2012; 11(1): 36-49.
22. Kim H, Yang K, Dejsuphong D, D'Andrea AD. Regulation of Rev1 by the Fanconi anemia core complex. Nature Structural Molecular logy 2012; 19:164-70.
23. Guervilly JH, Macé-Aimé G, Rosselli F. Loss of CHK1 function impedes DNA damage-induced FancD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. Hum Mol Genet 2008; 17(5):679-89.
24. Hoehn H, Kalb R, Neveling K, Friedl R, Bechtold A, Herterich S, et al. Revertant Mosaicism in Fanconi Anemia: Natural Gene Therapy at Work. In: Monogr Hum Genet. Basel: Karger; 2007. P. 149-172.
25. Pawlik TM, Keyomarsi K. Role of Cell Cycle in Mediating Sensitivity to Radiotherapy. Int J Radiation Oncology l Phys 2004; 59(4): 928-42.
26. Djuzenova CS, Flentje M. Characterization of Fanconi anemia fibroblasts in terms of clonogenic survival and DNA damage assessed by the Comet assay. Med Sci Monit 2002; 8(10): BR421-30.
27. Hamanoue S, Yagasaki H, Tsuruta T, Oda T, Yabe H, Yabe M, et al. Myeloid lineage-selective growth of revertant cells in Fanconi anemia. Br J Haematol 2006; 132(5): 630-5.
28. Parmar K, D'Andrea AD. Stressed out: endogenous aldehydes damage hematopoietic stem cells. Cell Stem Cell 2012; 11:583-84.
29. Kuhnert VM, Kachnic LA, Li L, Purschke M, Gheorghiu L, Lee R, et al. FANCD2-deficient human fibroblasts are hypersensitive to ionizing radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions. Int J Radiat l 2009; 85(6): 523-31.
30. Rosselli F, Ridet A, Soussi T, Duchaud E, Alapetite C, Moustacchi E. p53-dependent pathway of radio-induced apoptosis is altered in Fanconi anemia. Oncogene 1995; 10:9-17.