CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1839, Issue 9, 2014, Pages 785-792

  Cobler, Lara ^a   Pera, Manuel ^a   Garrido, Marta ^a   Iglesias, Mar ^a   de Bolós, Carme ^a  

^a HOSPITAL DEL MAR   (Spain)

Author keywords

C JUN; CDX2; Gastric preneoplasic lesion; Interleukin 6; P STAT3

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN C JUN; PROTEIN TYROSINE PHOSPHATASE SHP 2; SHORT HAIRPIN RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CARCINOGENESIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; MUCOSA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH; STOMACH CELL; TRANSCRIPTION REGULATION; UPREGULATION;

C-JUN; CDX2; GASTRIC PRENEOPLASIC LESION; INTERLEUKIN-6; P-STAT3;

CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-6; PROTO-ONCOGENE PROTEINS C-JUN; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; STAT3 TRANSCRIPTION FACTOR;

EID: 84904127512     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2014.06.009     Document Type: Article

References (45)

1. Tsukamoto T., et al. Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia. J. Cancer Res. Clin. Oncol. 2004, 130:135-145.
2. Lennerz J.K., et al. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am. J. Pathol. 2010, 177:1514-1533.
3. Kang J.M., et al. CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer. J. Korean Med. Sci. 2011, 26:647-653.
4. Raghoebir L., et al. SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype. J. Mol. Cell Biol. 2012, 4:377-385.
5. Kuzmichev A.N., et al. Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells. Curr. Biol. 2012, 22:1705-1710.
6. Park E.T., et al. Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. Int. J. Cancer 2008, 122:1253-1260.
7. Tani Y., et al. Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. J. Cancer Res. Clin. Oncol. 2007, 133:263-269.
8. Tsukamoto T., et al. Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes. Histopathology 2005, 46:649-658.
9. Asonuma S., et al. Helicobacter pylori induces gastric mucosal intestinal metaplasia through the inhibition of interleukin-4-mediated HMG box protein Sox2 expression. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G312-G322.
10. Zhang X., et al. SOX2 in gastric carcinoma, but not Hath1, is related to patients' clinicopathological features and prognosis. J. Gastrointest. Surg. 2010, 14:1220-1226.
11. Matsuda K., et al. Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells. Scand. J. Gastroenterol. 2008, 43:25-33.
12. Camilo V., et al. Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. Carcinogenesis 2012, 33:1985-1992.
13. Otsubo T., et al. SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br. J. Cancer 2008, 98:824-831.
14. Mesquita P., et al. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J. Biol. Chem. 2003, 278:51549-51556.
15. Yamamoto H., et al. Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem. Biophys. Res. Commun. 2003, 300:813-818.
16. Shimada T., et al. Regulation of TFF3 expression by homeodomain protein CDX2. Regul. Pept. 2007, 140:81-87.
17. Mutoh H., et al. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem. Biophys. Res. Commun. 2002, 294:470-479.
18. Mutoh H., et al. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res. 2004, 64:7740-7747.
19. Almeida R., et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J. Pathol. 2003, 199:36-40.
20. Liu Q., et al. CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Mod. Pathol. 2007, 20:1286-1297.
21. Noach L.A., et al. Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection. Scand. J. Gastroenterol. 1994, 29:425-429.
22. Fan X.G., et al. Increased gastric production of interleukin-8 and tumour necrosis factor in patients with Helicobacter pylori infection. J. Clin. Pathol. 1995, 48:133-136.
23. Basso D., et al. Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2. Int. J. Clin. Lab. Res. 1996, 26:207-210.
24. Yamaoka Y., et al. Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut 1997, 41:442-451.
25. Wu W.K., et al. Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma. Biochem. Biophys. Res. Commun. 2008, 373:330-334.
26. Kanda N., et al. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene 2004, 23:4921-4929.
27. Gong W., et al. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin. Cancer Res. 2005, 11:1386-1393.
28. Yakata Y., et al. Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis. Int. J. Oncol. 2007, 30:437-442.
29. Mejias-Luque R., et al. Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors. Oncogene 2010, 29:1753-1762.
30. Hsu K.W., et al. Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. Carcinogenesis 2012, 33:1459-1467.
31. Tebbutt N.C., et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 2002, 8:1089-1097.
32. Jenkins B.J., et al. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat. Med. 2005, 11:845-852.
33. Mejias-Luque R., et al. IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. Biochim. Biophys. Acta 2008, 1783:1728-1736.
34. Barros R., et al. CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut 2011, 60:290-298.
35. Heinemeyer T., et al. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 1998, 26:362-367.
36. Uozaki H., et al. Transcriptional factor typing with SOX2, HNF4aP1, and CDX2 closely relates to tumor invasion and Epstein-Barr virus status in gastric cancer. Int. J. Clin. Exp. Pathol. 2011, 4:230-240.
37. Matsuoka J., et al. Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma. J. Surg. Res. 2012, 174:130-135.
38. Mutoh H., et al. Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa. Differentiation 2011, 81:92-98.
39. Stringer E.J., et al. Cdx2 determines the fate of postnatal intestinal endoderm. Development 2012, 139:465-474.
40. Aikou S., et al. Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening. Gastroenterology 2011, 141:837-845. (e1-7).
41. Keramari M., et al. Sox2 is essential for formation of trophectoderm in the preimplantation embryo. PLoS One 2010, 5:e13952.
42. Ikeda H., et al. Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis. Hepatol. Res. 2008, 38:1006-1017.
43. Kim S., et al. PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology 2002, 123:1163-1178.
44. Suzuki T., et al. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J. Biol. Chem. 2011, 286:31263-31271.
45. Krueger F., et al. Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. Cell. Signal. 2009, 21:1846-1856.