Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors

Oncogene

Volumn 29, Issue 12, 2010, Pages 1753-1762

  Mejias Luque R ^a   Linden S K ^b   Garrido, M ^a   Tye, H ^c   Najdovska, M ^c   Jenkins, B J ^c   Iglesias, M ^a   Ernst, M ^d   De Bolos C ^a  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

Gastric tumors; IL 6 gp130; Inflammatory cytokines; Intestinal mucins

Indexed keywords

BETA ACTIN; I KAPPA B ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MUCIN 2; MUCIN 4; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CHRONIC INFLAMMATION; CONTROLLED STUDY; FEMALE; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GP130 GENE; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STAT3 GENE; STOMACH CANCER; STOMACH MUCOSA;

ANIMALS; CELL LINE, TUMOR; HUMANS; INFLAMMATION; MICE; MUCIN 5AC; MUCIN-2; MUCIN-4; NF-KAPPA B; SPECIES SPECIFICITY; STAT3 TRANSCRIPTION FACTOR; STOMACH NEOPLASMS;

HELICOBACTER PYLORI; MUS;

EID: 77950074333     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.467     Document Type: Article

References (33)

1. Ahn DH, Crawley SC, Hokari R, Kato S, Yang SC, Li JD et al. (2005). TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. Cell Physiol Biochem 15: 29-40.
2. Chaturvedi P, Singh AP, Batra SK. (2008). Structure, evolution, and biology of the MUC4 mucin. FASEB J 22: 966-981.
3. Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. (1991). Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 32: 1473-1477.
4. de Bolos C, Garrido M, Real FX. (1995). MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach. Gastroenterology 109: 723-734.
5. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C et al. (2006). Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313: 1960-1964.
6. Gartner F, David L, Seruca R, Machado JC, Sobrinho-Simoes M. (1996). Establishment and characterization of two cell lines derived from human diffuse gastric carcinomas xenografted in nude mice. Virchows Arch 428: 91-98.
7. Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD et al. (2005). Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res 11: 1386-1393.
8. Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB, Taupin D et al. (2008). Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcera-tive colitis. PLoS Med 5: e54.
9. Jackson CB, Judd LM, Menheniott TR, Kronborg I, Dow C, Yeomans ND et al. (2007). Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. J Pathol 213: 140-151.
10. Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P et al. (2005). Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med 11: 845-852.
11. Judd LM, Alderman BM, Howlett M, Shulkes A, Dow C, Moverley J et al. (2004). Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology 126: 196-207.
12. Judd LM, Bredin K, Kalantzis A, Jenkins BJ, Ernst M, Giraud AS. (2006). STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. Gastroenterology 131: 1073-1085.
13. Karin M. (2006). Nuclear factor-kappaB in cancer development and progression. Nature 441: 431-436.
14. Kim DY, Takeuchi K, Ishinaga H, Kishioka C, Suzuki S, Basbaum C et al. (2004). Roxithromycin suppresses mucin gene expression in epithelial cells. Pharmacology 72: 6-11.
15. Kimura YN, Watari K, Fotovati A, Hosoi F, Yasumoto K, Izumi H et al. (2007). Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis. Cancer Sci 98: 2009-2018.
16. Lee HW, Ahn DH, Crawley SC, Li JD, Gum Jr JR, Basbaum CB et al. (2002). Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B. J Biol Chem 277: 32624-32631.
17. Leung WK, Yu J, Chan FK, To KF, Chan MW, Ebert MP et al. (2002). Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues. J Pathol 197: 582-588.
18. Lidell ME, Bara J, Hansson GC. (2008). Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin. FEBS J 275: 481-489.
19. Linden SK, Florin TH, McGuckin MA. (2008). Mucin dynamics in intestinal bacterial infection. PLoS ONE 3: e3952.
20. Lopez-Ferrer A, Curull V, Barranco C, Garrido M, Lloreta J, Real FX et al. (2001). Mucins as differentiation markers in bronchial epithelium. Squamous cell carcinoma and adenocarcinoma display similar expression patterns. Am J Respir Cell Mol Biol 24: 22-29.
21. Lopez-Ferrer A, de Bolos C. (2002). The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins. Glycoconj J 19: 13-21.
22. Lopez-Ferrer A, de Bolos C, Barranco C, Garrido M, Isern J, Carlstedt I et al. (2000). Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium. Gut 47: 349-356.
23. Matsuda K, Yamauchi K, Matsumoto T, Sano K, Yamaoka Y, Ota H. (2008). Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells. Scand J Gastroenterol 43: 25-33.
24. Mejias-Luque R, Peiro S, Vincent A, Van SI, de Bolos C. (2008). IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. Biochim Biophys Acta 1783: 1728-1736.
25. Peek Jr RM, Crabtree JE. (2006). Helicobacter infection and gastric neoplasia. J Pathol 208: 233-248.
26. Piessen G, Jonckheere N, Vincent A, Hemon B, Ducourouble MP, Copin MC et al. (2007). Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesopha-geal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem J 402: 81-91.
27. Reis CA, David L, Correa P, Carneiro F, de Bolos C, Garcia E et al. (1999). Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer Res 59: 1003-1007.
28. Sell S, Max E. (2001). Immunology, Immunopathology, and Immunity, 6th edn. ASM Press: Washington DC.
29. Senapati S, Sharma P, Bafna S, Roy HK, Batra SK. (2008). The MUC gene family: their role in the diagnosis and prognosis of gastric cancer. Histol Histopathol 23: 1541-1552.
30. Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ et al. (2002). Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 8: 1089-1097.
31. Velcich A, Yang W, Heyer J, Fragale A, Nicholas C, Viani S et al. (2002). Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295: 1726-1729.
32. Yakata Y, Nakayama T, Yoshizaki A, Kusaba T, Inoue K, Sekine I. (2007). Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis. Int J Oncol 30: 437-442.
33. Yu H, Jove R. (2004). The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 4: 97-105.