CDX2 autoregulation in human intestinal metaplasia of the stomach: Impact on the stability of the phenotype

Gut

Volumn 60, Issue 3, 2011, Pages 290-298

  Barros, Rita ^a   Da Costa, Luis Teixeira ^a,b   Pinto de Sousa, João ^c,d   Duluc, Isabelle ^e   Freund, Jean Noel ^e   David, Leonor ^a,d   Almeida, Raquel ^a,d  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF ÉVORA   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

^d University of Porto   (Portugal)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR CDX2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CARCINOMA CELL; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ILEUM; INTESTINAL METAPLASIA OF THE STOMACH; INTESTINE METAPLASIA; INTESTINE POLYP; MOUSE; NONHUMAN; PARANEOPLASTIC SYNDROME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADENOCARCINOMA; ANIMALS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HOMEOSTASIS; HUMANS; ILEUM; METAPLASIA; MICE; NEOPLASM PROTEINS; POINT MUTATION; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC; STOMACH; STOMACH NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 79851514659     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2010.222323     Document Type: Article

References (40)

1. Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006;118:3030-44.
2. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992;52:6735-40.
3. Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001;345:784-9.
4. Guarner J, Mohar A, Parsonnet J, et al. The association of Helicobacter pylori with gastric cancer and preneoplastic gastric lesions in Chiapas, Mexico. Cancer 1993;71:297-301. (Pubitemid 23021211)
5. de Vries AC, van Grieken NC, Looman CW, et al. Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands. Gastroenterology 2008;134:945-52. (Pubitemid 351451990)
6. Honda S, Fujioka T, Tokieda M, et al. Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils. Cancer Res 1998;58:4255-9. (Pubitemid 28450020)
7. Watanabe T, Tada M, Nagai H, et al. Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology 1998;115:642-8. (Pubitemid 28397299)
8. Zheng Q, Chen XY, Shi Y, et al. Development of gastric adenocarcinoma in Mongolian gerbils after long-term infection with Helicobacter pylori. J Gastroenterol Hepatol 2004;19:1192-8. (Pubitemid 39371264)
9. Mutoh H, Sakurai S, Satoh K, et al. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res 2004;64:7740-7. (Pubitemid 39446905)
10. Silberg DG, Swain GP, Suh ER, et al. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000;119:961-71.
11. Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 1996;16:619-25. (Pubitemid 26029101)
12. Almeida R, Silva E, Santos-Silva F, et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 2003;199:36-40. (Pubitemid 36054727)
13. Bai YQ, Yamamoto H, Akiyama Y, et al. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 2002;176:47-55. (Pubitemid 34085069)
14. Eda A, Osawa H, Satoh K, et al. Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. J Gastroenterol 2003;38:14-22. (Pubitemid 36267690)
15. Phillips RW, Frierson HF Jr, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 2003;27:1442-7. (Pubitemid 37315196)
16. Osawa H, Kita H, Satoh K, et al. Aberrant expression of CDX2 in the metaplastic epithelium and inflammatory mucosa of the gallbladder. Am J Surg Pathol 2004;28:1253-4. (Pubitemid 39121623)
17. Beck F, Chawengsaksophak K, Waring P, et al. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci USA 1999;96:7318-23. (Pubitemid 29299659)
18. Chawengsaksophak K, James R, Hammond VE, et al. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 1997;386:84-7. (Pubitemid 27130925)
19. Mutoh H, Hakamata Y, Sato K, et al. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 2002;294:470-9. (Pubitemid 34694118)
20. Silberg DG, Sullivan J, Kang E, et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002;122:689-96. (Pubitemid 34173821)
21. Mesquita P, Jonckheere N, Almeida R, et al. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 2003;278:51549-56. (Pubitemid 38020398)
22. Hinoi T, Lucas PC, Kuick R, et al. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 2002;123:1565-77. (Pubitemid 35231656)
23. Suh E, Chen L, Taylor J, et al. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 1994;14:7340-51. (Pubitemid 24326399)
24. Barros R, Pereira B, Duluc I, et al. Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. J Pathol 2008;215:411-20.
25. Barros R, Marcos N, Reis CA, et al. CDX2 expression is induced by Helicobacter pylori in AGS cells. Scand J Gastroenterol 2009;44:124-5.
26. Asfeldt AM, Steigen SE, Lochen ML, et al. The natural course of Helicobacter pylori infection on endoscopic findings in a population during 17 years of follow-up: the Sorreisa Gastrointestinal Disorder Study. Eur J Epidemiol 2009;24:649-58.
27. Wong BC, Lam SK, Wong WM, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 2004;291:187-94. (Pubitemid 38082812)
28. Barros R, Peleteiro B, Almeida R, et al. Relevance of high virulence Helicobacter pylori strains and futility of CDX2 expression for predicting intestinal metaplasia after eradication of infection. Scand J Gastroenterol 2010;45:828-34.
29. Xu F, Li H, Jin T. Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3. J Biol Chem 1999;274:34310-16. (Pubitemid 129511773)
30. Gartner F, David L, Seruca R, et al. Establishment and characterization of two cell lines derived from human diffuse gastric carcinomas xenografted in nude mice. Virchows Arch 1996;428:91-8. (Pubitemid 26177974)
31. Carrel S, Sordat B, Merenda C. Establishment of a cell line (Co-115) from a human colon carcinoma transplanted into nude mice. Cancer Res 1976;36:3978-84.
32. Benahmed F, Gross I, Gaunt SJ, et al. Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology 2008;135:1238-47. e1-3.
33. Modica S, Morgano A, Salvatore L, et al. Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut 2009;58:1250-9.
34. Margalit Y, Yarus S, Shapira E, et al. Isolation and characterization of target sequences of the chicken CdxA homeobox gene. Nucleic Acids Res 1993;21:4915-22. (Pubitemid 23330167)
35. da Costa LT, He TC, Yu J, et al. CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. Oncogene 1999;18:5010-14. (Pubitemid 29425309)
36. Prinos P, Joseph S, Oh K, et al. Multiple pathways governing Cdx1 expression during murine development. Dev Biol 2001;239:257-69. (Pubitemid 33108838)
37. Beland M, Pilon N, Houle M, et al. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. Mol Cell Biol 2004;24:5028-38. (Pubitemid 38668064)
38. Kong J, Nakagawa H, Isariyawongse BK, et al. Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis 2009;30:122-30.
39. Correa P, Fontham ET, Bravo JC, et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J Natl Cancer Inst 2000;92:1881-8. (Pubitemid 32036918)
40. Slack JM. Metaplasia and transdifferentiation: from pure biology to the clinic. Nat Rev Mol Cell Biol 2007;8:369-78. (Pubitemid 46643236)