Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: Inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia

Journal of Cancer Research and Clinical Oncology

Volumn 130, Issue 3, 2004, Pages 135-145

  Tsukamoto, Tetsuya ^a   Inada, Kenichi ^a   Tanaka, Harunari ^a   Mizoshita, Tsutomu ^a   Mihara, Mami ^b   Ushijima, Toshikazu ^b   Yamamura, Yoshitaka ^a   Nakamura, Shigeo ^a   Tatematsu, Masae ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Cdx1; Cdx2; Gastric transcription factor; Gastric intestinal mixed intestinal metaplasia; HMG box; Homeobox genes; Intestinal transcription factor; Sox2

Indexed keywords

BIOCHEMICAL MARKER; CONCANAVALIN A; GASTRIC TRANSCRIPTION FACTOR; INTESTINE TRANSCRIPTION FACTOR; MUCIN 5AC; MUCIN 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VILLIN;

ARTICLE; CHRONIC GASTRITIS; ECTOPIC TISSUE; GENE EXPRESSION REGULATION; HIGH MOBILITY GROUP BOX DOMAIN; HOMEOBOX; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE ABSORPTION; INTESTINE METAPLASIA; INTESTINE MUCOSA; MOLECULAR MECHANICS; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH MUCOSA;

AVIAN PROTEINS; CONCANAVALIN A; DISEASE PROGRESSION; DNA-BINDING PROTEINS; DOWN-REGULATION; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; HMGB PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; INTESTINAL MUCOSA; METAPLASIA; MUCINS; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 1642319004     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-003-0519-6     Document Type: Article

References (65)

1. Allen A, Hutton DA, Pearson JP (1998) The MUC2 gene product: a human intestinal mucin. Int J Biochem Cell Biol 30:797-801
2. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolos C, David L (2003) Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 199:36-40
3. Bowles J, Schepers G, Koopman P (2000) Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 227:239-255
4. Correa P (1992) Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52:6735-6740
5. Domon-Dell C, Freund JN (2002) Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein. FEBS Lett 518:83-87
6. Drummond F, Sowden J, Morrison K, Edwards YH (1996) The caudal-type homeobox protein Cdx-2 binds to the colon promoter of the carbonic anhydrase 1 gene. Eur. J Biochem 236:670-681
7. Eda A, Osawa H, Yanaka I, Satoh K, Mutoh H, Kihira K, Sugano K (2002) Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol. 37:94-100
8. Escande F, Aubert JP, Porchet N, Buisine MP (2001) Human mucin gene MUC5AC: organization of its 5′-region and central repetitive region. Biochem J 358:763-772
9. Filipe MI, Ramachandra S (1995) The histochemistry of intestinal mucins: Changes in disease. In: Gastrointestinal and oesophageal pathology. Whitehead R (ed) Churchill Livingstone, Edinburgh, 73-95
10. Filipe MI, Potet F, Bogomoletz WV, Dawson PA, Fabiani B, Chauveinc P, Fenzy A, Gazzard B, Goldfain D, Zeegen R (1985) Incomplete sulphomucin- secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres. Gut 26:1319-1326
11. Filipe MI, Munoz N, Matko I, Kato I, Pompe-Kirn V, Jutersek A, Teuchmann S, Benz M, Prijon T (1994) Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer 57:324-329
12. Freund JN, Domon-Dell C, Kedinger M, Duluc I (1998) The Cdx-1 and Cdx-2 homeobox genes in the intestine. Biochem Cell Biol 76:957-969
13. Fujimitsu Y, Nakanishi H, Inada K, Yamachika T, Ichinose M, Fukami H, Tatematsu M (1996) Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts. Jpn J Cancer Res 87:1199-1203
14. Gum JR Jr, Hicks JW, Toribara NW, Siddiki B, Kim YS (1994) Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. J Biol Chem 269:2440-2446
15. Ho SB, Roberton AM, Shekels LL, Lyftogt CT, Niehans GA, Toribara NW (1995a) Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression. Gastroenterology 109:735-747
16. Ho SB, Shekels LL, Toribara NW, Kim YS, Lyftogt C, Cherwitz DL, Niehans GA (1995b) Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res 55:2681-2690
17. Inada K, Nakanishi H, Fujimitsu Y, Shimizu N, Ichinose M, Miki K, Nakamura S, Tatematsu M (1997) Gastric and intestinal mixed and solely intestinal types of intestinal metaplasia in the human stomach. Pathol Int 47:831-841
18. Inada K, Tanaka H, Nakanishi H, Tsukamoto T, Ikehara Y, Tatematsu K, Nakamura S, Porter EM, Tatematsu M (2001) Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach. Virchows Arch 439:14-20
19. Ishii Y, Rex M, Scotting PJ, Yasugi S (1998) Region-specific expression of chicken Sox2 in the developing gut and lung epithelium: regulation by epithelial-mesenchymal interactions. Dev Dyn 213:464-475
20. James R, Kazenwadel J (1991) Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem 266:3246-3251
21. Jass JR, Filipe MI (1979) A variant of intestinal metaplasia associated with gastric carcinoma: a histochemical study. Histopathology 3:191-199
22. Kato Y, Kitagawa T, Yanagisawa A, Kubo K, Utsude T, Hiratsuka H, Tamaki M, Sugano H (1992) Site-dependent development of complete and incomplete intestinal metaplasia types in the human stomach. Jpn J Cancer Res 83:178-183
23. Katsuyama T, Spicer SS (1978) Histochemical differentiation of complex carbohydrates with variants of the concanavalin A-horseradish peroxidase method. J Histochem Cytochem 26:233-250
24. Kawachi T, Kogure K, Tanaka N, Tokunaga A, Sugimura T (1974) Studies of intestinal metaplasia in the gastric mucosa by detection of disaccharidases with "Tes-Tape". J Natl Cancer Inst 53:19-30
25. Kawachi T, Kurisu M, Numanyu N, Sasajima K, Sano T (1976) Precancerous changes in the stomach. Cancer Res 36:2673-2677
26. Laborda J (1991) 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 19:3998
27. Lickert H, Domon C, Huls G, Wehrle C, Duluc I, Clevers H, Meyer BI, Freund JN, Kemler R (2000) Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development 127:3805-3813
28. Macdonald PM, Struhl G (1986) A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature 324:537-545
29. Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, Jordan BR, Dusetti NJ, Dagorn JC, Iovanna JL (1997) Molecular cloning, sequencing and expression of the mRNA encoding human Cdxl and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 74:35-44
30. Maroux S, Coudrier E, Feracci H, Gorvel JP, Louvard D (1988) Molecular organization of the intestinal brush border. Biochimie 70:1297-1306
31. Matsukuma A, Mori M, Enjoji M (1990) Sulphomucin-secreting intestinal metaplasia in the human gastric mucosa. An association with intestinal-type gastric carcinoma. Cancer 66:689-694
32. Matsukura N, Suzuki K, Kawachi T, Aoyagi M, Sugimura T, Kitaoka H, Numajiri H, Shirota A, Itabashi M, Hirota T (1980) Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation to complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J Natl. Cancer Inst. 65:231-240
33. Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, Kato T, Joh T, Itoh M, Tatematsu M (2001) Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa-with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer 4:185-191
34. Morson BC (1955) Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa. Br J Cancer 9:377-385
35. Mutoh H, Hakamata Y, Sato K, Eda A, Yanaka I, Honda S, Osawa H, Kaneko Y, Sugano K (2002) Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 294:470-479
36. Park J, Schulz S, Waldman SA (2000) Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx2. Gastroenterology 119:89-96
37. Rokkas T, Filipe MI, Sladen GE (1991) Detection of an increased incidence of early gastric cancer in patients with intestinal metaplasia type III who are closely followed up. Gut 32:1110-1113
38. Sakamoto N, Fukuda K, Watanuki K, Sakai D, Komano T, Scotting PJ, Yasugi S (2000) Role for cGATA-5 in transcriptional regulation of the embryonic chicken pepsinogen gene by epithelial-mesenchymal interactions in the developing chicken stomach. Dev Biol 223:103-113
39. Satoh K, Mutoh H, Eda A, Yanaka I, Osawa H, Honda S, Kawata H, Kihira K, Sugano K (2002) Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori. Helicobacter 7:192-198
40. Segura DI, Montera C (1983) Histochemical characterization of different types of intestinal metaplasia in gastric mucosa. Cancer 52:498-503
41. Seregni E, Botti C, Massaron S, Lombardo C, Capobianco A, Bogni A, Bombardieri E (1997) Structure, function and gene expression of epithelial mucins. Tumori 83:625-632
42. Silberg DG, Furth EE, Taylor JK, Schuck T, Chiou T, Traber PG (1997) CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology 113:478-486
43. Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, Sackett SD, Kaestner KH (2002) Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 122:689-696
44. Silva S, Filipe MI (1986) Intestinal metaplasia and its variants in the gastric mucosa of Portuguese subjects: a comparative analysis of biopsy and gastrectomy material. Hum Pathol 17:988-095
45. Soubeyran P, Andre F, Lissitzky JC, Mallo GV, Moucadel V, Roccabianca M, Rechreche H, Marvaldi J, Dikic I, Dagorn JC, Iovanna JL (1999) Cdx1 promotes differentiation in a rat intestinal epithelial cell line. Gastroenterology 117:1326-1338
46. Stemmermann GN, Hayashi T (1968) Intestinal metaplasia of the gastric mucosa: a gross and microscopic study of its distribution in various disease states. J Natl. Cancer Inst. 41:627-634
47. Stemmermann GN (1994) Intestinal metaplasia of the stomach. A status report. Cancer 74:556-564
48. Stevanovic M, Zuffardi O, Collignon J, Lovell-Badge R, Goodfellow P (1994) The cDNA sequence and chromosomal location of the human SOX2 gene. Mamm. Genome 5:640-642
49. Subramanian V, Meyer B, Evans GS (1998) The murine Cdx1 gene product localises to the proliferative compartment in the developing and regenerating intestinal epithelium. Differentiation 64:11-18
50. Suh E, Chen L, Taylor J, Traber PG (1994) A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 14:7340-7351
51. Suh E, Traber PG (1996) An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 16:619-625
52. Tatematsu M, Katsuyama T, Furihata C, Fukushima S, Shirai T, Kato T, Ito N (1990) Cellular differentiation and histogenesis of rat glandular stomach cancers. Jpn J Cancer Res 81:760-767
53. Tatematsu M, Masui T, Fukami H, Yamamoto M, Nakanishi H, Inada K, Kusakabe M, Sakakura T (1996) Primary monoclonal and secondary polyclonal growth of colon neoplastic lesions in C3H/HeN 〈-〉 BALB/c chimeric mice treated with 1,2-dimethylhydrazine immunohistochemical detection of C3H strain-specific antigen and simple sequence length polymorphism analysis of DNA. Int J Cancer 66:234-238
54. Teglbjaerg PS, Nielsen HO (1978) "Small intestinal type" and "colonic type" intestinal metaplasia of the human stomach, and their relationship to the histogenetic types of gastric adenocarcinoma. Acta Pathol Micro Biol Scand [A] 86A:351-355
55. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR Jr, Byrd JC, Siddiki B, Kim YS (1993) Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem 268:5879-5885
56. Troelsen JT, Mitchelmore C, Spodsberg N, Jensen AM, Noren O, Sjostrom H (1997) Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2. Biochem J 322 (Pt 3):833-838
57. Tsukamoto T, Kozaki K, Nishikawa Y, Yamamoto M, Fukami H, Inoue M, Wakabayashi K, Tatematsu M (1999) Development and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat large intestine. Jpn J Cancer Res 90:720-725
58. Tsukamoto T, Tanaka H, Fukami H, Inoue M, Takahashi M, Wakabayashi K, Tatematsu M (2000) More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats. Jpn J Cancer Res 91:792-796
59. Tsukamoto T, Fukami H, Yamanaka S, Yamaguchi A, Nakanishi H, Sakai H, Aoki I, Tatematsu M (2001) Hexosaminidase-altered aberrant crypts, carrying decreased hexosaminidase alpha and beta subunit mRNAs, in colon of 1,2-dimethylhydrazine-treated rats. Jpn J Cancer Res 92:109-118
60. Walker MM (2003) Is intestinal metaplasia of the stomach reversible? Gut 52:1-4
61. Wood HB, Episkopou V (1999) Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev 86:197-201
62. Yamamoto H, Bai YQ, Yuasa Y (2003) Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun 300:813-818
63. Yamamoto M, Furihata C, Ogiu T, Tsukamoto T, Inada K, Hirano K, Tatematsu M (2002) Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea. Cancer Lett 179:121-132
64. Yasugi S (2000) Epithelial cell differentiation during stomach development. Hum Cell 13:177-184
65. You WC, Blot WJ, Li JY, Chang YS, Jin ML, Kneller R, Zhang L, Han ZX, Zeng XR, Liu WD, Zhao L, Correa P, Fraumeni JJF, Xu GW (1993) Precancerous gastric lesions in a population at high risk of stomach cancer. Cancer Res 53:1317-1321