Distributed, limbic gray matter atrophy in patients after bacterial meningitis

American Journal of Neuroradiology

Volumn 34, Issue 6, 2013, Pages 1164-1167

  Focke, N K ^a   Kallenberg, K ^a   Mohr, A ^a   Djukic, M ^b   Nau, R ^a,b   Schmidt, H ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Evangelisches Krankenhaus   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BACTERIAL MENINGITIS; BRAIN ATROPHY; BRAIN SIZE; CINGULATE GYRUS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GRAY MATTER; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; LIMBIC GRAY MATTER ATROPHY; LIMBIC SYSTEM; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; ORBITAL CORTEX; PARIETAL GYRUS; PARIETAL LOBE; RETROSPECTIVE STUDY; SUPERIOR FRONTAL GYRUS; SURVIVOR; TEMPORAL LOBE; THALAMUS; TISSUE STRUCTURE; VOXEL BASED MORPHOMETRY;

ADULT; AGED; ATROPHY; EPILEPSY, TEMPORAL LOBE; FEMALE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; MALE; MENINGITIS, BACTERIAL; MIDDLE AGED; RETROSPECTIVE STUDIES; TEMPORAL LOBE; THALAMUS; YOUNG ADULT;

EID: 84880780145     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A3351     Document Type: Article

References (23)

1. Edmond K, Clark A, Korczak VS, et al. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis 2010;10:317-28.
2. Nau R, Soto A, Bruck W. Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J Neuropathol Exp Neurol 1999;58:265-74.
3. Free SL, Li LM, Fish DR, et al. Bilateral hippocampal volume loss in patients with a history of encephalitis or meningitis. Epilepsia 1996;37:400-05.
4. Østergaard C, Leib S, Rowland I, et al. Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis. BMC Infect Dis 2010;10:1.
5. Gerber J, Seitz RC, Bunkowski S, et al. Evidence for frequent focal and diffuse acute axonal injury in human bacterial meningitis. Clin Neuropathol 2009;28:33-39.
6. Stringaris AK, Geisenhainer J, Bergmann F, et al. Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol Dis 2002;11:355-68.
7. Zysk G, Brück W, Gerber J, et al. Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis. J Neuropathol Exp Neurol 1996;55:722-28.
8. Grandgirard D, Steiner O, Täuber MG, et al. An infant mouse model of brain damage in pneumococcal meningitis. Acta Neuropathol 2007;114:609-17.
9. Leib SL, Kim YS, Chow LL, et al. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest 1996;98:2632-39.
10. Hammers A, Allom R, Koepp MJ, et al. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 2003;19:224-47.
11. Schmidt H, Heimann B, Djukic M, et al. Neuropsychological sequelae of bacterial and viral meningitis. Brain 2006;129:333-45.
12. Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage 2007;38:95-113.
13. Sury MD, Agarinis C, Widmer HR, et al. JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiol Dis 2008;32:142-50.
14. Blaser C, Wittwer M, Grandgirard D, et al. Adjunctive dexamethasone affects the expression of genes related to inflammation, neurogenesis and apoptosis in infant rat pneumococcal meningitis. PLoS One 2011;6:e17840.
15. Weisfelt M, van de Beek D, Hoogman M, et al. Cognitive outcome in adults with moderate disability after pneumococcal meningitis. J Infect 2006;52:433-39.
16. Merkelbach S, Sittinger H, Schweizer I, et al. Cognitive outcome after bacterial meningitis. Acta Neurol Scand 2000;102:118-23.
17. Focke NK, Yogarajah M, Bonelli SB, et al. Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Neuroimage 2008;40:728-37.
18. Keller SS, Roberts N. Voxel-based morphometry of temporal lobe epilepsy: an introduction and review of the literature. Epilepsia 2008;49:741-57.
19. Mathern GW, Babb TL, Vickrey BG, et al. The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy. Brain 1995;118:105-18.
20. Marks DA, Kim J, Spencer DD, et al. Characteristics of intractable seizures following meningitis and encephalitis. Neurology 1992;42: 1513-18.
21. O'Brien TJ, Moses H, Cambier D, et al. Age of meningitis or encephalitis is independently predictive of outcome from anterior temporal lobectomy. Neurology 2002;58:104-09.
22. Friedman A, Dingledine R. Molecular cascades that mediate the influence of inflammation on epilepsy. Epilepsia 2011;52:33-39.
23. Focke NK, Helms G, Kaspar S, et al. Multi-site voxel-based morphometry-not quite there yet. Neuroimage 2011;56:1164-70.