Changes in the factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS

Biochemical Journal

Volumn 461, Issue 3, 2014, Pages 443-451

  Pantazatos, Dionysios ^a,c   Gessner, Christopher R ^b   Woods Jr , Virgil L ^b   Gilbert, Gary E ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

C2 domain; Factor IX; Factor VIII; Hydrogen deuterium exchange; Phospholipid vesicle; Protein dynamics

Indexed keywords

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 C2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; MASS SPECTROMETRY; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM EXCHANGE MEASUREMENT; FACTOR VIII; HUMANS; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; PEPSIN A; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PHOSPHOLIPIDS; PLIABILITY; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; PROTEOLYSIS; RECOMBINANT PROTEINS; SOLUBILITY; SURFACE PROPERTIES; UNILAMELLAR LIPOSOMES;

EID: 84904098769     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140121     Document Type: Article

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