Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability

Journal of Biological Chemistry

Volumn 286, Issue 29, 2011, Pages 25748-25755

  Wakabayashi, Hironao ^a   Griffiths, Amy E ^a   Fay, Philip J ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; COFACTORS; COVALENT MODIFICATIONS; DISULFIDE BONDING; DISULFIDE BONDS; FACTOR VIII; FACTOR XA; GUANIDINIUM; HYDROPHOBIC GROUPS; LIGHT CHAIN; WESTERN BLOTS; X-RAY STRUCTURE;

BINDING ENERGY; COVALENT BONDS; HYDROPHOBICITY; THERMODYNAMIC STABILITY;

CHEMICAL STABILITY;

ARGININE; BLOOD CLOTTING FACTOR 8; CYSTEINE; GUANIDINE; LEUCINE; THROMBIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CHEMICAL PARAMETERS; CHEMICAL STABILITY; CONTROLLED STUDY; DISULFIDE BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN VARIANT; THERMOSTABILITY;

AMINO ACID SUBSTITUTION; ANIMALS; CRICETINAE; DISULFIDES; FACTOR VIIIA; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MUTATION; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS;

EID: 79960397088     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.241109     Document Type: Article

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