Characterization of antibodies induced by human factor VIII in a murine knockout model of hemophilia A

Thrombosis and Haemostasis

Volumn 84, Issue 5, 2000, Pages 826-832

  Reipert, B M ^a   Ahmad, R U ^a   Turecek, P L ^a   Schwarz, H P ^a  

^a BAXTER INNOVATIONS GMBH   (Austria)

Author keywords

Animal model; Antibodies; Factor VIII; Hemophilia A; Knockout mice

Indexed keywords

FREUND ADJUVANT; IMMUNOGLOBULIN G1; RECOMBINANT BLOOD CLOTTING FACTOR 8;

ADJUVANT THERAPY; ANIMAL DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; HEMOPHILIA A; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 0033693889     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614124     Document Type: Article

References (25)

1. The incidence of factor VIII inhibitors in patients with severe hemophilia A
2. Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs
3. A higher than expected incidence of factor VIII inhibitors in multitransfused haemophilia A patients treated with an intermediate purity pasteurized fector VIII concentrate
4. Factor VIII inhibitors in previously treated hemophilia A patients with a double virus-inactivated plasma derived factor VIII concentrate
5. Inhibitor development surveillance in hemophilia A patients shifted to recombinant factor VIII (rFVIII) preparations: A prospective multicenter Italian study
6. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A
7. Inhibitor development and T cell response to human factor VIII in murine haemophilia A
8. Prevention and treatment of factor VIII inhibitors in murine hemophilia A
9. Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies
10. Phenotypic expression of murine hemophilia
11. Toleranzinduktion gegen humanen Faktor VIII in Mausen - Untersuchungen zur Toleranzaufhebung durch denaturierten Faktor VIII
12. A more uniform measurement of factor VIII inhibitors
13. The mode of action of antibodies which destroy factor VIII. I. Antibodies which have second-order concentration graphs
14. The mode of action of antibodies which destroy factor VIII. II. Antibodies which give complex concentration graphs
15. Sequence of the murine factor VIII cDNA
16. Induction of human factor VIII inhibitors in rats by immunization with human recombinant factor VIII: A small animal model for humans with high responder inhibitor phenotype
17. Induction of human factor VIII inhibitors in rats 2: Fine mapping of rat anti-human rFVIII antibodies
18. Anti-factor VIII antibodies in hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restrictions
19. Localization of human factor VIII inhibitor epitopes to two polypeptide fragments
20. The presence of anti-A1 and B domain antibodies in factor VIII inhibitor patients
21. Inactivation of Factor VIII coagulant activity by two different types of human antibodies
22. FVIII inhibitor subclass and FVIII polypeptide specificity determined by immunoblotting
23. The immunological characterization of human antibodies to factor VIII isolated by affinity chromatography
24. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
25. Heterogeneity of cytokine secretion patterns and functions of helper T cells