Writing and reading H2B monoubiquitylation

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1839, Issue 8, 2014, Pages 694-701

  Fuchs, Gilad ^a   Oren, Moshe ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

H2B monoubiquitylation; H2Bub1; Histone crosstalk; Transcription elongation

Indexed keywords

HISTONE H2A; HISTONE H2B; HISTONE H3;

ANCHORAGE INDEPENDENT GROWTH; BREAST METASTASIS; CARCINOGENESIS; CELL MIGRATION; CHROMATIN; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; GENE EXPRESSION; HISTONE METHYLATION; HISTONE UBIQUITINATION; HITONE MONOUBIQUITYLATION; HUMAN; MAMMAL CELL; METASTASIS; NONHUMAN; NUCLEOSOME; PARATHYROID TUMOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; RNA PROCESSING; SEMINOMA; T CELL LEUKEMIA; THERAPY RESISTANCE; TRANSCRIPTION ELONGATION; TRANSCRIPTION INITIATION;

H2B MONOUBIQUITYLATION; H2BUB1; HISTONE CROSSTALK; TRANSCRIPTION ELONGATION;

CHROMOSOMAL PROTEINS, NON-HISTONE; EPIGENESIS, GENETIC; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; METHYLATION; NUCLEOSOMES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN PROCESSING, POST-TRANSLATIONAL; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84904036680     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2014.01.002     Document Type: Review

References (103)

1. Kouzarides T. Chromatin modifications and their function. Cell 2007, 128:693-705.
2. Tan M., Luo H., Lee S., Jin F., Yang J.S., Montellier E., Buchou T., Cheng Z., Rousseaux S., Rajagopal N., Lu Z., Ye Z., Zhu Q., Wysocka J., Ye Y., Khochbin S., Ren B., Zhao Y. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146:1016-1028.
3. Taverna S.D., Li H., Ruthenburg A.J., Allis C.D., Patel D.J. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat. Struct. Mol. Biol. 2007, 14:1025-1040.
4. Plass C., Pfister S.M., Lindroth A.M., Bogatyrova O., Claus R., Lichter P. Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer - Nature Reviews. Genetics 2013, 14:765-780.
5. Shogren-Knaak M., Ishii H., Sun J.M., Pazin M.J., Davie J.R., Peterson C.L. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 2006, 311:844-847.
6. Lu X., Simon M.D., Chodaparambil J.V., Hansen J.C., Shokat K.M., Luger K. The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat. Struct. Mol. Biol. 2008, 15:1122-1124.
7. Dhalluin C., Carlson J.E., Zeng L., He C., Aggarwal A.K., Zhou M.M. Structure and ligand of a histone acetyltransferase bromodomain. Nature 1999, 399:491-496.
8. Bannister A.J., Zegerman P., Partridge J.F., Miska E.A., Thomas J.O., Allshire R.C., Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 2001, 410:120-124.
9. Wysocka J., Swigut T., Xiao H., Milne T.A., Kwon S.Y., Landry J., Kauer M., Tackett A.J., Chait B.T., Badenhorst P., Wu C., Allis C.D. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 2006, 442:86-90.
10. Yun M., Wu J., Workman J.L., Li B. Readers of histone modifications. Cell. Res. 2011, 21:564-578.
11. Sanchez R., Zhou M.M. The PHD finger: a versatile epigenome reader. Trends Biochem. Sci. 2011, 36:364-372.
12. Musselman C.A., Lalonde M.E., Cote J., Kutateladze T.G. Perceiving the epigenetic landscape through histone readers. Nat. Struct. Mol. Biol. 2012, 19:1218-1227.
13. Wu L., Zee B.M., Wang Y., Garcia B.A., Dou Y. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. Mol. Cell 2011, 43:132-144.
14. Wood A., Krogan N.J., Dover J., Schneider J., Heidt J., Boateng M.A., Dean K., Golshani A., Zhang Y., Greenblatt J.F., Johnston M., Shilatifard A. Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol. Cell 2003, 11:267-274.
15. Hwang W.W., Venkatasubrahmanyam S., Ianculescu A.G., Tong A., Boone C., Madhani H.D. A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol. Cell 2003, 11:261-266.
16. Kim J., Hake S.B., Roeder R.G. The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. Mol. Cell 2005, 20:759-770.
17. Ahn J.I., Lee K.H., Shin D.M., Shim J.W., Lee J.S., Chang S.Y., Lee Y.S., Brownstein M.J., Lee S.H., Lee Y.S. Comprehensive transcriptome analysis of differentiation of embryonic stem cells into midbrain and hindbrain neurons. Dev. Biol. 2004, 265:491-501.
18. Li X.S., Trojer P., Matsumura T., Treisman J.E., Tanese N. Mammalian SWI/SNF-a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. Mol. Cell. Biol. 2010, 30:1673-1688.
19. Minsky N., Oren M. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol. Cell 2004, 16:631-639.
20. Thakar A., Parvin J., Zlatanova J. BRCA1/BARD1 E3 ubiquitin ligase can modify histones H2A and H2B in the nucleosome particle. J. Biomol. Struct. Dyn. 2010, 27:399-406.
21. Kim J., Guermah M., McGinty R.K., Lee J.S., Tang Z., Milne T.A., Shilatifard A., Muir T.W., Roeder R.G. RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell 2009, 137:459-471.
22. Geng F., Tansey W.P. Polyubiquitylation of histone H2B. Mol. Biol. Cell 2008, 19:3616-3624.
23. Shabek N., Herman-Bachinsky Y., Buchsbaum S., Lewinson O., Haj-Yahya M., Hejjaoui M., Lashuel H.A., Sommer T., Brik A., Ciechanover A. The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Mol. Cell 2012, 48:87-97.
24. Nijman S.M., Luna-Vargas M.P., Velds A., Brummelkamp T.R., Dirac A.M., Sixma T.K., Bernards R. A genomic and functional inventory of deubiquitinating enzymes. Cell 2005, 123:773-786.
25. Henry K.W., Wyce A., Lo W.S., Duggan L.J., Emre N.C., Kao C.F., Pillus L., Shilatifard A., Osley M.A., Berger S.L. Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev. 2003, 17:2648-2663.
26. Emre N.C., Ingvarsdottir K., Wyce A., Wood A., Krogan N.J., Henry K.W., Li K., Marmorstein R., Greenblatt J.F., Shilatifard A., Berger S.L. Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Mol. Cell 2005, 17:585-594.
27. Zhang X.Y., Varthi M., Sykes S.M., Phillips C., Warzecha C., Zhu W., Wyce A., Thorne A.W., Berger S.L., McMahon S.B. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol. Cell 2008, 29:102-111.
28. Nicassio F., Corrado N., Vissers J.H., Areces L.B., Bergink S., Marteijn J.A., Geverts B., Houtsmuller A.B., Vermeulen W., Di Fiore P.P., Citterio E. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr. Biol. 2007, 17:1972-1977.
29. van der Knaap J.A., Kumar B.R., Moshkin Y.M., Langenberg K., Krijgsveld J., Heck A.J., Karch F., Verrijzer C.P. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Mol. Cell 2005, 17:695-707.
30. Joo H.Y., Jones A., Yang C., Zhai L., Smith A.D.t., Zhang Z., Chandrasekharan M.B., Sun Z.W., Renfrow M.B., Wang Y., Chang C., Wang H. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J. Biol. Chem. 2011, 286:7190-7201.
31. Fuchs G., Shema E., Vesterman R., Kotler E., Wolchinsky Z., Wilder S., Golomb L., Pribluda A., Zhang F., Haj-Yahya M., Feldmesser E., Brik A., Yu X., Hanna J., Aberdam D., Domany E., Oren M. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol. Cell 2012, 46:662-673.
32. Zhang Z., Jones A., Joo H.Y., Zhou D., Cao Y., Chen S., Erdjument-Bromage H., Renfrow M., He H., Tempst P., Townes T.M., Giles K.E., Ma L., Wang H. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. Genes Dev. 2013, 27:1581-1595.
33. Pavri R., Zhu B., Li G., Trojer P., Mandal S., Shilatifard A., Reinberg D. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA Polymerase II. Cell 2006, 125:703-717.
34. Weinberger L., Voichek Y., Tirosh I., Hornung G., Amit I., Barkai N. Expression noise and acetylation profiles distinguish HDAC functions. Mol. Cell 2012, 47:193-202.
35. Chernikova S.B., Dorth J.A., Razorenova O.V., Game J.C., Brown J.M. Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells. Radiat. Res. 2010, 174:558-565.
36. Moyal L., Lerenthal Y., Gana-Weisz M., Mass G., So S., Wang S.Y., Eppink B., Chung Y.M., Shalev G., Shema E., Shkedy D., Smorodinsky N.I., van Vliet N., Kuster B., Mann M., Ciechanover A., Dahm-Daphi J., Kanaar R., Hu M.C., Chen D.J., Oren M., Shiloh Y. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol. Cell 2011, 41:529-542.
37. Nakamura K., Kato A., Kobayashi J., Yanagihara H., Sakamoto S., Oliveira D.V., Shimada M., Tauchi H., Suzuki H., Tashiro S., Zou L., Komatsu K. Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. Mol. Cell 2011, 41:515-528.
38. Kari V., Shchebet A., Neumann H., Johnsen S.A. The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. Cell Cycle 2011, 10:3495-3504.
39. Trujillo K.M., Osley M.A. A role for H2B ubiquitylation in DNA replication. Mol. Cell 2012, 48:734-746.
40. Batta K., Zhang Z., Yen K., Goffman D.B., Pugh B.F. Genome-wide function of H2B ubiquitylation in promoter and genic regions. Genes Dev. 2011, 25:2254-2265.
41. Pirngruber J., Shchebet A., Schreiber L., Shema E., Minsky N., Chapman R.D., Eick D., Aylon Y., Oren M., Johnsen S.A. CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. EMBO Rep. 2009, 10:894-900.
42. Jung I., Kim S.K., Kim M., Han Y.M., Kim Y.S., Kim D., Lee D. H2B monoubiquitylation is a 5'-enriched active transcription mark and correlates with exon-intron structure in human cells. Genome Res. 2012, 22:1026-1035.
43. Vitaliano-Prunier A., Babour A., Herissant L., Apponi L., Margaritis T., Holstege F.C., Corbett A.H., Gwizdek C., Dargemont C. H2B ubiquitylation controls the formation of export-competent mRNP. Mol. Cell 2012, 45:132-139.
44. Latham J.A., Chosed R.J., Wang S., Dent S.Y. Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination. Cell 2011, 146:709-719.
45. Ma M.K., Heath C., Hair A., West A.G. Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity. PLoS Genet. 2011, 7:e1002175.
46. Hwang W.W., Madhani H.D. Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin. PLoS Genet. 2009, 5:e1000588.
47. Walter D., Matter A., Fahrenkrog B. Bre1p-mediated histone H2B ubiquitylation regulates apoptosis in Saccharomyces cerevisiae. J. Cell Sci. 2010, 123:1931-1939.
48. Buszczak M., Paterno S., Spradling A.C. Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny. Science 2009, 323:248-251.
49. Karpiuk O., Najafova Z., Kramer F., Hennion M., Galonska C., Konig A., Snaidero N., Vogel T., Shchebet A., Begus-Nahrmann Y., Kassem M., Simons M., Shcherbata H., Beissbarth T., Johnsen S.A. The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Mol. Cell 2012, 46:705-713.
50. Wright D.E., Wang C.Y., Kao C.F. Flickin' the ubiquitin switch: the role of H2B ubiquitylation in development. Epigenetics 2011, 6:1165-1175.
51. Sarkari F., Sanchez-Alcaraz T., Wang S., Holowaty M.N., Sheng Y., Frappier L. EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. PLoS Pathog. 2009, 5:e1000624.
52. Fonseca G.J., Thillainadesan G., Yousef A.F., Ablack J.N., Mossman K.L., Torchia J., Mymryk J.S. Adenovirus evasion of interferon-mediated innate immunity by direct antagonism of a cellular histone posttranslational modification. Cell Host Microbe 2012, 11:597-606.
53. Shema E., Tirosh I., Aylon Y., Huang J., Ye C., Moskovits N., Raver-Shapira N., Minsky N., Pirngruber J., Tarcic G., Hublarova P., Moyal L., Gana-Weisz M., Shiloh Y., Yarden Y., Johnsen S.A., Vojtesek B., Berger S.L., Oren M. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev. 2008, 22:2664-2676.
54. Johnsen S.A. The enigmatic role of H2Bub1 in cancer. FEBS Lett. 2012, 586:1592-1601.
55. Sen R., Bhaumik S.R. Transcriptional Stimulatory and Repressive Functions of Histone H2B Ubiquitin Ligase, Transcription, 4 2013.
56. Xiao T., Kao C.F., Krogan N.J., Sun Z.W., Greenblatt J.F., Osley M.A., Strahl B.D. Histone H2B ubiquitylation is associated with elongating RNA Polymerase II. Mol. Cell. Biol. 2005, 25:637-651.
57. Minsky N., Shema E., Field Y., Schuster M., Segal E., Oren M. Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat. Cell Biol. 2008, 10:483-488.
58. Weiner A., Chen H.V., Liu C.L., Rahat A., Klien A., Soares L., Gudipati M., Pfeffner J., Regev A., Buratowski S., Pleiss J.A., Friedman N., Rando O.J. Systematic dissection of roles for chromatin regulators in a yeast stress response. PLoS Biol. 2012, 10:e1001369.
59. Ehrensberger A.H., Kelly G.P., Svejstrup J.Q. Mechanistic interpretation of promoter-proximal peaks and RNAPII density maps. Cell 2013, 154:713-715.
60. Fleming A.B., Kao C.F., Hillyer C., Pikaart M., Osley M.A. H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. Mol. Cell 2008, 31:57-66.
61. Chandrasekharan M.B., Huang F., Sun Z.W. Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:16686-16691.
62. Fierz B., Kilic S., Hieb A.R., Luger K., Muir T.W. Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis. J. Am. Chem. Soc. 2012, 134:19548-19551.
63. Fierz B., Chatterjee C., McGinty R.K., Bar-Dagan M., Raleigh D.P., Muir T.W. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat. Chem. Biol. 2011, 7:113-119.
64. Briggs S.D., Xiao T., Sun Z.W., Caldwell J.A., Shabanowitz J., Hunt D.F., Allis C.D., Strahl B.D. Gene silencing: trans-histone regulatory pathway in chromatin. Nature 2002, 418:498.
65. Sun Z.W., Allis C.D. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 2002, 418:104-108.
66. Ng H.H., Xu R.M., Zhang Y., Struhl K. Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J. Biol. Chem. 2002, 277:34655-34657.
67. Johnson D.G., Dent S.Y. Chromatin: receiver and quarterback for cellular signals. Cell 2013, 152:685-689.
68. Prenzel T., Begus-Nahrmann Y., Kramer F., Hennion M., Hsu C., Gorsler T., Hintermair C., Eick D., Kremmer E., Simons M., Beissbarth T., Johnsen S.A. Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B. Cancer Res. 2011, 71:5739-5753.
69. Chernikova S.B., Razorenova O.V., Higgins J.P., Sishc B.J., Nicolau M., Dorth J.A., Chernikova D.A., Kwok S., Brooks J.D., Bailey S.M., Game J.C., Brown J.M. Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res. 2012, 72:2111-2119.
70. Hahn M.A., Dickson K.A., Jackson S., Clarkson A., Gill A.J., Marsh D.J. The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination. Hum. Mol. Genet. 2012, 21:559-568.
71. Mosbech A., Lukas C., Bekker-Jensen S., Mailand N. The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases. J. Biol. Chem. 2013, 288:16579-16587.
72. Zhang Y., van Deursen J., Galardy P.J. Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. PLoS One 2011, 6:e23389.
73. Chernikova S.B., Razorenova O.V., Higgins J.P., Sishc B.J., Nicolau M., Dorth J.A., Chernikova D.A., Kwok S., Brooks J.D., Bailey S.M., Game J.C., Brown J.M. Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res. 2012, 72:2111-2119.
74. Shema E., Kim J., Roeder R.G., Oren M. RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Mol. Cell 2011, 42:477-488.
75. Wang E., Kawaoka S., Yu M., Shi J., Ni T., Yang W., Zhu J., Roeder R.G., Vakoc C.R. Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:3901-3906.
76. Blank M., Tang Y., Yamashita M., Burkett S.S., Cheng S.Y., Zhang Y.E. A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat. Med. 2012, 18:227-234.
77. Shema-Yaacoby E., Nikolov M., Haj-Yahya M., Siman P., Allemand E., Yamaguchi Y., Muchardt C., Urlaub H., Brik A., Oren M., Fischle W. Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription. Cell Rep. 2013, 4:601-608.
78. Ezhkova E., Tansey W.P. Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. Mol. Cell 2004, 13:435-442.
79. Robzyk K., Recht J., Osley M.A. Rad6-dependent ubiquitination of histone H2B in yeast. Science 2000, 287:501-504.
80. Lee J.S., Shukla A., Schneider J., Swanson S.K., Washburn M.P., Florens L., Bhaumik S.R., Shilatifard A. Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS. Cell 2007, 131:1084-1096.
81. Wu M., Wang P.F., Lee J.S., Martin-Brown S., Florens L., Washburn M., Shilatifard A. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol. Cell. Biol. 2008, 28:7337-7344.
82. Vitaliano-Prunier A., Menant A., Hobeika M., Geli V., Gwizdek C., Dargemont C. Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation. Nat. Cell Biol. 2008, 10:1365-1371.
83. Kim J., Kim J.A., McGinty R.K., Nguyen U.T., Muir T.W., Allis C.D., Roeder R.G. The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol. Cell 2013, 49:1121-1133.
84. Wu L., Lee S.Y., Zhou B., Nguyen U.T., Muir T.W., Tan S., Dou Y. ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes. Mol. Cell 2013, 49:1108-1120.
85. Nguyen A.T., Zhang Y. The diverse functions of Dot1 and H3K79 methylation. Genes Dev. 2011, 25:1345-1358.
86. Oh S., Jeong K., Kim H., Kwon C.S., Lee D. A lysine-rich region in Dot1p is crucial for direct interaction with H2B ubiquitylation and high level methylation of H3K79. Biochem. Biophys. Res. Commun. 2010, 399:512-517.
87. Hwang J., Saffert R.T., Kalejta R.F. Elongin B-mediated epigenetic alteration of viral chromatin correlates with efficient human cytomegalovirus gene expression and replication. mBio 2011, 2:e00023-e.
88. Bres V., Yoshida T., Pickle L., Jones K.A. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. Mol. Cell 2009, 36:75-87.
89. Fonseca G.J., Cohen M.J., Nichols A.C., Barrett J.W., Mymryk J.S. Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation. PLoS Pathog. 2013, 9:e1003411.
90. Bres V., Yoh S.M., Jones K.A. The multi-tasking P-TEFb complex. Curr. Opin. Cell Biol. 2008, 20:334-340.
91. Bracken C.P., Wall S.J., Barre B., Panov K.I., Ajuh P.M., Perkins N.D. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res. 2008, 68:7621-7628.
92. Wu J., Chen Y., Lu L.Y., Wu Y., Paulsen M.T., Ljungman M., Ferguson D.O., Yu X. Chfr and RNF8 synergistically regulate ATM activation. Nat. Struct. Mol. Biol. 2011, 18:761-768.
93. Luco R.F., Pan Q., Tominaga K., Blencowe B.J., Pereira-Smith O.M., Misteli T. Regulation of alternative splicing by histone modifications. Science 2010, 327:996-1000.
94. Nikolov M., Fischle W. Systematic analysis of histone modification readout. Mol. Biosyst. 2013, 9:182-194.
95. Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S., Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G., Mann M. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 2010, 142:967-980.
96. Bartke T., Vermeulen M., Xhemalce B., Robson S.C., Mann M., Kouzarides T. Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 2010, 143:470-484.
97. Nikolov M., Stutzer A., Mosch K., Krasauskas A., Soeroes S., Stark H., Urlaub H., Fischle W. Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Molecular & cellular proteomics: MCP 2011, 10. (M110 005371).
98. Haj-Yahya M., Eltarteer N., Ohayon S., Shema E., Kotler E., Oren M., Brik A. N-methylation of isopeptide bond as a strategy to resist deubiquitinases. Angew. Chem. 2012, 51:11535-11539.
99. Tatum D., Li S. Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79. J. Biol. Chem. 2011, 286:17530-17535.
100. Wyce A., Xiao T., Whelan K.A., Kosman C., Walter W., Eick D., Hughes T.R., Krogan N.J., Strahl B.D., Berger S.L. H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol. Cell 2007, 27:275-288.
101. Sanso M., Lee K.M., Viladevall L., Jacques P.E., Page V., Nagy S., Racine A., St Amour C.V., Zhang C., Shokat K.M., Schwer B., Robert F., Fisher R.P., Tanny J.C. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS Genet. 2012, 8:e1002822.
102. Stegmeier F., Rape M., Draviam V.M., Nalepa G., Sowa M.E., Ang X.L., McDonald E.R., Li M.Z., Hannon G.J., Sorger P.K., Kirschner M.W., Harper J.W., Elledge S.J. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 2007, 446:876-881.
103. Belkina A.C., Denis G.V. BET domain co-regulators in obesity, inflammation and cancer, Nature Reviews. Cancer 2012, 12:465-477.