Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca 2+-activated K+ (SK2) channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 27, 2014, Pages 9989-9994

  Rafizadeh, Sassan ^a   Zhang, Zheng ^a   Woltz, Ryan L ^a   Kim, Hyo Jeong ^b   Myers, Richard E ^a   Lu, Ling ^a,c   Tuteja, Dipika ^a   Singapuri, Anil ^a   Bigdeli, Amir Ali Ziaei ^a   Harchache, Sana Ben ^a   Knowlton, Anne A ^a,d   Yarov Yarovoy, Vladimir ^a   Yamoah, Ebenezer N ^b   Chiamvimonvat, Nipavan ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NANJING NORMAL UNIVERSITY   (China)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Atrial fibrillation; Atrial myocytes; Ion channel trafficking

Indexed keywords

ALPHA ACTININ 2; CALCIUM ION; CYTOSKELETON PROTEIN; FILAMIN A; SK2 CHANNEL; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HEART ATRIUM; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

ATRIAL FIBRILLATION; ATRIAL MYOCYTES; ION CHANNEL TRAFFICKING;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; CALCIUM; FILAMINS; HEART ATRIA; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MYOCYTES, CARDIAC; PROTEIN BINDING; RNA, SMALL INTERFERING; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 84904016043     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323541111     Document Type: Article

References (38)

1. Köhler M, et al. (1996) Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273(5282):1709-1714. (Pubitemid 26317786)
2. Vergara C, Latorre R, Marrion NV, Adelman JP (1998) Calcium-activated potassium channels. Curr Opin Neurobiol 8(3):321-329. (Pubitemid 28288566)
3. + channels: Molecular determinants and function of the SK family. Nat Rev Neurosci 5(10):758-770.
4. Pennefather P, Lancaster B, Adams PR, Nicoll RA (1985) Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells. Proc Natl Acad Sci USA 82(9):3040-3044. (Pubitemid 15097788)
5. Pedarzani P, et al. (2005) Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons. J Biol Chem 280(50):41404-41411. (Pubitemid 41832199)
6. + channel in human and mouse hearts. J Biol Chem 278(49):49085-49094.
7. + channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol 289(6):H2714-H2723.
8. + channel (SK2 channel) results in action potential prolongation in atrialmyocytes and atrial fibrillation. J Physiol 587(Pt 5):1087-1100.
9. + channels terminates and protects against atrial fibrillation. Circ Arrhythm Electrophysiol 3(4):380-390.
10. Schumacher SM, Martens JR (2010) Ion channel trafficking: A new therapeutic horizon for atrial fibrillation. Heart Rhythm 7(9):1309-1315.
11. +) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. Circ Res 86(4):441-447.
12. Le Scouarnec S, et al. (2008) Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci USA 105(40):15617-15622.
13. 2+ channels via alpha-actinin2. Circ Res 100(1):112-120.
14. + channel (SK2 channel). Proc Natl Acad Sci USA 106(43):18402-18407.
15. Minsaas L, et al. (2010) Filamin A binds to CCR2B and regulates its internalization. PLoS ONE 5(8):e12212.
16. Gravante B, et al. (2004) Interaction of the pacemaker channel HCN1 with filamin A. J Biol Chem 279(42):43847-43853. (Pubitemid 39390691)
17. v4.2 potassium channel by interaction with the actin-binding protein filamin. J Neurosci 20(23):8736-8744.
18. Sampson LJ, Leyland ML, Dart C (2003) Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1. J Biol Chem 278(43):41988-41997. (Pubitemid 37310462)
19. Thelin WR, et al. (2007) Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J Clin Invest 117(2):364-374. (Pubitemid 46203965)
20. + channels and calmodulin. J Physiol 554(Pt 2):255-261.
21. Pettersen EF, et al. (2004) UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 25(13):1605-1612.
22. 2+/calmodulin. Nature 410(6832):1120-1124.
23. Chagot B, Chazin WJ (2011) Solution NMR structure of apo-calmodulin in complex with the IQ motif of human cardiac sodium channel Nav1.5. J Mol Biol 406(1):106-119.
24. Raman S, et al. (2009) Structure prediction for CASP8 with all-atom refinement using Rosetta. Proteins 77(Suppl 9):89-99.
25. Chivian D, Baker D (2006) Homology modeling using parametric alignment ensemble generation with consensus and energy-based model selection. Nucleic Acids Res 34(17):e112.
26. Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10(8):513-525.
27. Zhang SS, Shaw RM (2013) Multilayered regulation of cardiac ion channels. Biochim Biophys Acta 1833(4):876-885.
28. Calaghan SC, Le Guennec JY, White E (2004) Cytoskeletal modulation of electrical and mechanical activity in cardiac myocytes. Prog Biophys Mol Biol 84(1):29-59. (Pubitemid 37457744)
29. Ozgen N, et al. (2007) Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites. Cardiovasc Res 75(4):758-769. (Pubitemid 47238736)
30. + channel inhibition. Hypertension 57(6):1129-1135.
31. +) channels. J Cardiovasc Pharmacol 57(6):672-681.
32. Chua SK, et al. (2011) Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles. Circ Res 108(8):971-979.
33. Chang PC, et al. (2013) Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles. J Am Heart Assoc 2(1):e004713.
34. + channel in atrioventricular nodes. Circ Res 102(4):465-471.
35. + channels in the absence of direct actin binding. Mol Pharmacol 72(3):622- 630.
36. O'Connell MP, et al. (2009) Wnt5A activates the calpain-mediated cleavage of filamin A. J Invest Dermatol 129(7):1782-1789.
37. Ohta Y, Hartwig JH, Stossel TP (2006) FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol 8(8):803-814. (Pubitemid 44151583)
38. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391(2):85-100. (Pubitemid 11012976) Disorders Disorders Disorders