Inhibition of small-conductance ca2+-activated k+ channels terminates and protects against atrial fibrillation

Circulation: Arrhythmia and Electrophysiology

Volumn 3, Issue 4, 2010, Pages 380-390

  Diness, Jonas Goldin ^a,b   Sørensen, Ulrik S ^a   Nissen, Jakob Dahl ^b   Al Shahib, Baha ^a,c   Jespersen, Thomas ^b   Grunnet, Morten ^a,b   Hansen, Rie Schultz ^a  

^a NEUROSEARCH A S   (Denmark)

^b DANISH NATIONAL RESEARCH FOUNDATION   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Amiodarone; Antiarrhythmia agents; Atrial fibrillation; Drugs; Ion channels; NS8593; SK channels

Indexed keywords

ACETYLCHOLINE; AMIODARONE; ANTIARRHYTHMIC AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; N(PYRIDIN 2 YL) 4 (PYRIDIN 2 YL)THIAZOL 2 AMINE; NS 8593; POTASSIUM CHANNEL BLOCKING AGENT; UCL 1684; UNCLASSIFIED DRUG; (R) N (BENZIMIDAZOL 2 YL) 1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINE; (R)-N-(BENZIMIDAZOL-2-YL)-1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE; 1 NAPHTHYLAMINE; ALKANE; DRUG DERIVATIVE; PYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE DURATION; ELECTROSTIMULATION; EX VIVO STUDY; EXPERIMENTAL RABBIT; FEMALE; GUINEA PIG; HEART ATRIUM FIBRILLATION; HEART PACING; HEART PROTECTION; HEART STIMULATION; IN VIVO STUDY; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; RAT; ACTION POTENTIAL; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; ELECTROCARDIOGRAPHY; HEART MUSCLE; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; PERFUSION; RABBIT; SPRAGUE DAWLEY RAT; TIME;

1-NAPHTHYLAMINE; ACETYLCHOLINE; ACTION POTENTIALS; ALKANES; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; CARDIAC PACING, ARTIFICIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; GUINEA PIGS; MALE; MYOCARDIUM; PERFUSION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PYRIDINES; QUINOLINIUM COMPOUNDS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLES; TIME FACTORS;

EID: 77956662777     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.110.957407     Document Type: Article

References (5)

1. Hansen RS, Diness TG, Christ T, Wettwer E, Ravens U, Olesen SP, Grunnet M. Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'- trifluoromethylphenyl)urea]. Mol.Pharmacol. 2006; 70:1319-29.
2. Diness JG, Hansen RS, Nissen JD, Jespersen T, Grunnet M. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm. 2009; 6:100-6.
3. Strobaek D, Hougaard C, Johansen TH, Sorensen US, Nielsen EO, Nielsen KS, Taylor RD, Pedarzani P, Christophersen P. Inhibitory gating modulation of small conductance Ca2+- activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4- tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Mol.Pharmacol. 2006; 70:1771-82.
4. Diness TG, Hansen RS, Olesen SP, Grunnet M. Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels. Biochem.Biophys.Res.Commun. 2006; 343:1224-33.
5. Jespersen T, Grunnet M, Angelo K, Klaerke DA, Olesen SP. Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes. Biotechniques. 2002; 32:536-40.