The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca2+-activated k+ channels

Journal of Cardiovascular Pharmacology

Volumn 57, Issue 6, 2011, Pages 672-681

  Skibsbye, Lasse ^a   Diness, Jonas Goldin ^a   Sørensen, Ulrik Svane ^a   Hansen, Rie Schultz ^b   Grunnet, Morten ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Zealand Pharma AS   (Denmark)

^c NEUROSEARCH A S   (Denmark)

Author keywords

antiarrhythmic drugs; apamin; NS8593; pacing induced atrial fibrillation; SK; UCL1684

Indexed keywords

APAMIN; DOFETILIDE; LIDOCAINE; NS 8593; POTASSIUM CHANNEL BLOCKING AGENT; RANOLAZINE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UCL 1684; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HEART ATRIUM FIBRILLATION; HEART PACING; IN VIVO STUDY; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REFRACTORY PERIOD;

1-NAPHTHYLAMINE; ALKANES; ANESTHESIA; ANIMALS; ANTI-ARRHYTHMIA AGENTS; APAMIN; ATRIAL FIBRILLATION; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INSECT PROTEINS; MALE; MOLECULAR TARGETED THERAPY; POTASSIUM CHANNEL BLOCKERS; QUINOLINIUM COMPOUNDS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; TIME FACTORS;

EID: 79958245621     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318217943d     Document Type: Article

References (27)

1. Nattel S. New ideas about atrial fibrillation 50 years on. Nature. 2002;415: 219-226. (Pubitemid 34059528)
2. Pedersen OD, Abildstrom SZ, Ottesen MM, et al. Increased risk of sudden and non-sudden cardiovascular death in patients with atrial fibrillation/ flutter following acute myocardial infarction. Eur Heart J. 2006;27: 290-295. (Pubitemid 43100023)
3. Benjamin EJ, Wolf PA, D'Agostino RB, et al. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation. 1998;98: 946-952. (Pubitemid 28446646)
4. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22: 983-988.
5. Waldo AL, Camm AJ, deRuyter H, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival with oral D-sotalol. Lancet. 1996;348:7-12. (Pubitemid 26237238)
6. Flaker GC, Blackshear JL, McBride R, et al. Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. The Stroke Prevention in Atrial Fibrillation Investigators. J Am Coll Cardiol. 1992;20: 527-532.
7. Kumar K, Zimetbaum PJ. New and emerging antiarrhythmic drugs for atrial fibrillation: what may become available to the clinician in the near future. Curr Treat Options Cardiovasc Med. 2009;11:373-380.
8. Li D, Sun H, Levesque P. Antiarrhythmic drug therapy for atrial fibrillation: focus on atrial selectivity and safety. Cardiovasc Hematol Agents Med Chem. 2009;7:64-75.
9. Bentzen BH, Nardi A, Calloe K, et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007;72:1033-1044. (Pubitemid 47481426)
10. Bentzen BH, Osadchii O, Jespersen T, et al. Activation of big conductance Ca(2+)- activated K (+) channels (BK) protects the heart against ischemiareperfusion injury. Pflugers Arch. 2009;457:979-988.
11. Xu Y, Tuteja D, Zhang Z, et al. Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. J Biol Chem. 2003;278:49085-49094.
12. Tuteja D, Xu D, Timofeyev V, et al. Differential expression of smallconductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol. 2005; 289:H2714-H2723. (Pubitemid 41698589)
13. Lu L, Zhang Q, Timofeyev V, et al. Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2. Circ Res. 2007; 100:112-120. (Pubitemid 46066779)
14. Ozgen N, Dun W, Sosunov EA, et al. Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites. Cardiovasc Res. 2007;75:758-769. (Pubitemid 47238736)
15. Li N, Timofeyev V, Tuteja D, et al. Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol. 2009;587(pt 5):1087-1100.
16. Ellinor PT, Lunetta KL, Glazer NL, et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet. 2010;42:240-244.
17. Nattel S. Calcium-activated potassium current: a novel ion channel candidate in atrial fibrillation. J Physiol. 2009;587(pt 7):1385-1386.
18. Diness JG, Sorensen US, Nissen JD, et al. Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. Circ Arrhythm Electrophysiol. 2010;3:380-390.
19. Haugan K, Lam HR, Knudsen CB, et al. Atrial fibrillation in rats induced by rapid transesophageal atrial pacing during brief episodes of asphyxia: a new in vivo model. J Cardiovasc Pharmacol. 2004;44: 125-135. (Pubitemid 38857138)
20. Sugiyama A, Takahara A, Honsho S, et al. A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing. J Pharmacol Sci. 2005;98:315-318. (Pubitemid 41296413)
21. Strobaek D, Hougaard C, Johansen TH, et al. Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1- naphtylamine (NS8593) reduces after hyperpolarizing current in hippocampal CA1 neurons. Mol Pharmacol. 2006;70:1771-1782.
22. Sorensen US, Strobaek D, Christophersen P, et al. Synthesis and structure- activity relationship studies of 2-(N-substituted)- aminobenzimidazoles as potent negative gating modulators of small conductance Ca2+-activated K+ channels. J Med Chem. 2008;51:7625-7634.
23. Grunnet M, Jensen BS, Olesen SP, et al. Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels. Pflugers Arch. 2001;441:544-550. (Pubitemid 32128151)
24. Weatherall KL, Goodchild SJ, Jane DE, et al. Small conductance calciumactivated potassium channels: from structure to function. Prog Neurobiol. 2010;91:242-255.
25. Nagy N, Szuts V, Horvath Z, et al. Does small-conductance calciumactivated potassium channel contribute to cardiac repolarization? J Mol Cell Cardiol. 2009;47:656-663.
26. Tuteja D, Rafizadeh S, Timofeyev V, et al. Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ Res. 2010; 107:851-859.
27. Antzelevitch C, Burashnikov A. Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation. Ann N Y Acad Sci. 2010;1188:78-86.