Identification of nephrotoxic compounds with embryonic stem-cell-derived human renal proximal tubular-like cells

Molecular Pharmaceutics

Volumn 11, Issue 7, 2014, Pages 1982-1990

  Li, Yao ^a   Kandasamy, Karthikeyan ^a   Chuah, Jacqueline Kai Chin ^a   Lam, Yue Ning ^a   Toh, Wei Seong ^a,b   Oo, Zay Yar ^a   Zink, Daniele ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

drug induced kidney injury; embryonic stem cell derived human renal cell; interleukins; nephrotoxicity; predictive in vitro model; renal proximal tubular cell; stem cell

Indexed keywords

CEPHALOSPORIN C; CIPROFLOXACIN; CISPLATIN; CITRININ; CUPRIC ION; CYCLOSPORIN A; DICHROMATE POTASSIUM; FUROSEMIDE; GENTAMICIN; GOLD CHLORIDE; IBUPROFEN; IFOSFAMIDE; INTERLEUKIN 6; INTERLEUKIN 8; LEAD ACETATE; LINCOMYCIN; LITHIUM CHLORIDE; PARACETAMOL; PARAQUAT; PHENACETIN; PUROMYCIN; RIBAVIRIN; RIFAMPICIN; TACROLIMUS; TENOFOVIR; TETRACYCLINE; TOBRAMYCIN; UNINDEXED DRUG; VALACICLOVIR; VANCOMYCIN; BIOLOGICAL MARKER; DRUG;

ARTICLE; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; NEPHROTOXICITY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; ACUTE KIDNEY FAILURE; ADVERSE DRUG REACTION; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; KIDNEY; METABOLISM;

ACUTE KIDNEY INJURY; BIOMARKERS; CELL LINE; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; EMBRYONIC STEM CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; KIDNEY; KIDNEY TUBULES, PROXIMAL; PHARMACEUTICAL PREPARATIONS;

EID: 84904011024     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400637s     Document Type: Article

References (37)

1. Nash, K.; Hafeez, A.; Hou, S. Hospital-acquired renal insufficiency Am. J. Kidney Dis. 2002, 39 (5) 930-936
2. Guo, X.; Nzerue, C. How to prevent, recognize, and treat drug-induced nephrotoxicity Cleve. Clin. J. Med. 2002, 69 (4) 289-290
3. Choudhury, D.; Ahmed, Z. Drug-associated renal dysfunction and injury Nat. Clin. Pract. Nephrol. 2006, 2 (2) 80-91
4. Szeto, C. C.; Chow, K. M. Nephrotoxicity related to new therapeutic compounds Renal Failure 2005, 27 (3) 329-333
5. Redfern, W. S.; Ewart, L.; Hammond, T. G.; Bialecki, R.; Kinter, L.; Lindgren, S.; Pollard, C. E.; Roberts, R.; Rolf, M. G.; Valentin, J. P. Impact and frequency of different toxicities throughout the pharmaceutical life cycle The Toxicologist 2010, 114 (S1) 231
6. Lohr, J. W.; Willsky, G. R.; Acara, M. A. Renal drug metabolism Pharmacol. Rev. 1998, 50 (1) 107-141
7. Wu, Y.; Connors, D.; Barber, L.; Jayachandra, S.; Hanumegowda, U. M.; Adams, S. P. Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds Toxicol. in Vitro 2009, 23 (6) 1170-1178
8. Bach, P. H.; Obatomi, D. K.; Brant, S. In Vitro Methods for Nephrotoxicity Screening and Risk Assessment. In In Vitro Methods in Pharmaceutical Research; Castell, J. V.; Gomez-Lechon, M. J., Eds.; Academic Press Ltd: San Diego, CA, 1997; p 55-101.
9. Bens, M.; Vandewalle, A. Cell models for studying renal physiology Pflugers Arch. 2008, 457 (1) 1-15
10. Jenkinson, S. E.; Chung, G. W.; van Loon, E.; Bakar, N. S.; Dalzell, A. M.; Brown, C. D. The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule Pflugers Arch. 2012, 464 (6) 601-611
11. Li, Y.; Oo, Z. Y.; Chang, S. Y.; Huang, P.; Eng, K. G.; Zeng, J. L.; Kaestli, A. J.; Gopalan, B.; Kandasamy, K.; Tasnim, F.; Zink, D. An in vitro method for the prediction of renal proximal tubular toxicity in humans Toxicol. Res. 2013, 2 (5) 352-362
12. Wieser, M.; Stadler, G.; Jennings, P.; Streubel, B.; Pfaller, W.; Ambros, P.; Riedl, C.; Katinger, H.; Grillari, J.; Grillari-Voglauer, R. hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics Am. J. Physiol. Renal Physiol. 2008, 295 (5) F1365-F1375
13. Cummings, B. S.; Lasker, J. M.; Lash, L. H. Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney J. Pharmacol. Exp. Ther. 2000, 293 (2) 677-685
14. Brown, C. D.; Sayer, R.; Windass, A. S.; Haslam, I. S.; De Broe, M. E.; DHaese, P. C.; Verhulst, A. Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling Toxicol. Appl. Pharmacol. 2008, 233 (3) 428-38
15. Elberg, G.; Guruswamy, S.; Logan, C. J.; Chen, L.; Turman, M. A. Plasticity of epithelial cells derived from human normal and ADPKD kidneys in primary cultures Cell Tissue Res. 2008, 331 (2) 495-508
16. Zhang, H.; Lau, S. F.; Heng, B. F.; Teo, P. Y.; Alahakoon, P. K.; Ni, M.; Tasnim, F.; Ying, J. Y.; Zink, D. Generation of easily accessible human kidney tubules on two-dimensional surfaces in vitro J. Cell Mol. Med. 2011, 15 (6) 1287-1298
17. Narayanan, K.; Schumacher, K. M.; Tasnim, F.; Kandasamy, K.; Schumacher, A.; Ni, M.; Gao, S.; Gopalan, B.; Zink, D.; Ying, J. Y. Human embryonic stem cells differentiate into functional renal proximal tubular-like cells Kidney Int. 2013, 83 (4) 593-603
18. Lin, Z.; Will, Y. Evaluation of drugs with specific organ toxicities in organ-specific cell lines Toxicol. Sci. 2012, 126 (1) 114-127
19. DesRochers, T. M.; Suter, L.; Roth, A.; Kaplan, D. L. Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity PLoS One 2013, 8 (3) e59219
20. Weiland, C.; Ahr, H. J.; Vohr, H. W.; Ellinger-Ziegelbauer, H. Characterization of primary rat proximal tubular cells by gene expression analysis Toxicol. in Vitro 2007, 21 (3) 466-491
21. Araki, M.; Fahmy, N.; Zhou, L.; Kumon, H.; Krishnamurthi, V.; Goldfarb, D.; Modlin, C.; Flechner, S.; Novick, A. C.; Fairchild, R. L. Expression of IL-8 during reperfusion of renal allografts is dependent on ischemic time Transplantation 2006, 81 (5) 783-788
22. Grigoryev, D. N.; Liu, M.; Hassoun, H. T.; Cheadle, C.; Barnes, K. C.; Rabb, H. The local and systemic inflammatory transcriptome after acute kidney injury J. Am. Soc. Nephrol. 2008, 19 (3) 547-558
23. Tramma, D.; Hatzistylianou, M.; Gerasimou, G.; Lafazanis, V. Interleukin-6 and interleukin-8 levels in the urine of children with renal scarring Pediatr. Nephrol. 2012, 27 (9) 1525-1530
24. Akcay, A.; Nguyen, Q.; Edelstein, C. L. Mediators of inflammation in acute kidney injury Mediators Inflammation 2009, 2009, 137072
25. Faubel, S.; Lewis, E. C.; Reznikov, L.; Ljubanovic, D.; Hoke, T. S.; Somerset, H.; Oh, D. J.; Lu, L.; Klein, C. L.; Dinarello, C. A.; Edelstein, C. L. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney J. Pharmacol. Exp. Ther. 2007, 322 (1) 8-15
26. Astashkina, A. I.; Mann, B. K.; Prestwich, G. D.; Grainger, D. W. A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays Biomaterials 2012, 33 (18) 4700-4711
27. Zhang, J. H.; Chung, T. D.; Oldenburg, K. R. A simple statistical parameter for use in evaluation and validation of high throughput screening assays J. Biomol. Screening 1999, 4 (2) 67-73
28. Sekine, T.; Miyazaki, H.; Endou, H. Molecular physiology of renal organic anion transporters Am. J. Physiol. Renal Physiol. 2006, 290 (2) F251-F261
29. Nishimura, M.; Naito, S. Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies Drug Metab. Pharmacokinet. 2005, 20 (6) 452-477
30. Randhawa, P. S.; Starzl, T. E.; Demetris, A. J. Tacrolimus (FK506)-associated renal pathology Adv. Anat. Pathol. 1997, 4 (4) 265-276
31. Liptak, P.; Ivanyi, B. Primer: histopathology of calcineurin-inhibitor toxicity in renal allografts Nat. Clin. Pract. Nephrol. 2006, 2 (7) 398-404 quiz following 404
32. Tune, B. M.; Fravert, D. Mechanisms of cephalosporin nephrotoxicity: a comparison of cephaloridine and cephaloglycin Kidney Int. 1980, 18 (5) 591-600
33. Atkinson, R. M.; Currie, J. P.; Davis, B.; Pratt, D. A.; Sharpe, H. M.; Tomich, E. G. Acute toxicity of cephaloridine, an antibiotic derived from cephalosporin C Toxicol. Appl. Pharmacol. 1966, 8 (3) 398-406
34. Quiros, Y.; Vicente-Vicente, L.; Morales, A. I.; Lopez-Novoa, J. M.; Lopez-Hernandez, F. J. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin Toxicol. Sci. 2011, 119 (2) 245-256
35. Ozbek, E.; Cekmen, M.; Ilbey, Y. O.; Simsek, A.; Polat, E. C.; Somay, A. Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways Renal Failure 2009, 31 (5) 382-392
36. Ramesh, G.; Reeves, W. B. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity J. Clin. Invest. 2002, 110 (6) 835-842
37. Simon, N.; Morin, C.; Urien, S.; Tillement, J. P.; Bruguerolle, B. Tacrolimus and sirolimus decrease oxidative phosphorylation of isolated rat kidney mitochondria Br. J. Pharmacol. 2003, 138 (2) 369-376