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Volumn 74, Issue 13, 2014, Pages 3501-3511

Nadph oxidase nox4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of hif2a

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MANGANESE SUPEROXIDE DISMUTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TEMPOL; VON HIPPEL LINDAU PROTEIN;

EID: 84903977831     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-2979     Document Type: Article
Times cited : (59)

References (44)
  • 2
    • 65949102289 scopus 로고    scopus 로고
    • Immunotherapy of metastatic renal cell carcinoma
    • McDermott DF. Immunotherapy of metastatic renal cell carcinoma. Cancer 2009;115:2298-305.
    • (2009) Cancer , vol.115 , pp. 2298-2305
    • McDermott, D.F.1
  • 4
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
    • Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002;1:247-55.
    • (2002) Cancer Cell , vol.1 , pp. 247-255
    • Maranchie, J.K.1    Vasselli, J.R.2    Riss, J.3    Bonifacino, J.S.4    Linehan, W.M.5    Klausner, R.D.6
  • 5
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K, Klco J, Nakamura E, Lechpammer M, KaelinWGJr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002;1:237-46.
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr., W.G.5
  • 6
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
    • Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003;1:E83.
    • (2003) PLoS Biol , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Wg, R.J.4
  • 7
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 2005;25:5675-86.
    • (2005) Mol Cell Biol , vol.25 , pp. 5675-5686
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3    Sowter, H.M.4    Mandriota, S.J.5    Li, J.L.6
  • 9
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003;23:9361-74.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 10
    • 27144444002 scopus 로고    scopus 로고
    • Nox4 is critical for hypoxia-inducible factor 2- alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma
    • Maranchie JK, Zhan Y. Nox4 is critical for hypoxia-inducible factor 2- alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. Cancer Res 2005;65:9190-3.
    • (2005) Cancer Res , vol.65 , pp. 9190-9193
    • Maranchie, J.K.1    Zhan, Y.2
  • 12
    • 26244444476 scopus 로고    scopus 로고
    • Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases
    • Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 2006;18:69-82.
    • (2006) Cell Signal , vol.18 , pp. 69-82
    • Martyn, K.D.1    Frederick, L.M.2    Von Loehneysen, K.3    Dinauer, M.C.4    Knaus, U.G.5
  • 13
  • 16
    • 0029090338 scopus 로고
    • Tumour suppression by the human von Hippel-Lindau gene product
    • Iliopoulos O, Kibel A, Gray S, KaelinWGJr. Tumour suppression by the human von Hippel-Lindau gene product. Nat Med 1995;1:822-6.
    • (1995) Nat Med , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin Jr., W.G.4
  • 17
    • 4544250814 scopus 로고    scopus 로고
    • Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells
    • Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem 2004;279: 34643-54.
    • (2004) J Biol Chem , vol.279 , pp. 34643-34654
    • Vaquero, E.C.1    Edderkaoui, M.2    Pandol, S.J.3    Gukovsky, I.4    Gukovskaya, A.S.5
  • 18
    • 0141529733 scopus 로고    scopus 로고
    • Catalase, but not MnSOD, inhibits glucose deprivation- activated ASK1-MEK-MAPK signal transduction pathway and prevents relocalization of Daxx: Hydrogen peroxide as a major second messenger of metabolic oxidative stress
    • Song JJ, Lee YJ. Catalase, but not MnSOD, inhibits glucose deprivation- activated ASK1-MEK-MAPK signal transduction pathway and prevents relocalization of Daxx: hydrogen peroxide as a major second messenger of metabolic oxidative stress. J Cell Biochem 2003;90: 304-14.
    • (2003) J Cell Biochem , vol.90 , pp. 304-314
    • Song, J.J.1    Lee, Y.J.2
  • 19
    • 0034662620 scopus 로고    scopus 로고
    • Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde
    • Steiner MS, Zhang X, Wang Y, Lu Y. Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde. Cancer Res 2000;60:4419-25.
    • (2000) Cancer Res , vol.60 , pp. 4419-4425
    • Steiner, M.S.1    Zhang, X.2    Wang, Y.3    Lu, Y.4
  • 20
    • 0028596392 scopus 로고
    • Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle
    • Mohazzab KM, Wolin MS. Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle. Am J Physiol 1994;267:L815-22.
    • (1994) Am J Physiol , vol.267
    • Mohazzab, K.M.1    Wolin, M.S.2
  • 21
    • 11144356447 scopus 로고    scopus 로고
    • Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species
    • Goyal P, Weissmann N, Grimminger F, Hegel C, Bader L, Rose F, et al. Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species. Free Radic Biol Med 2004;36:1279-88.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1279-1288
    • Goyal, P.1    Weissmann, N.2    Grimminger, F.3    Hegel, C.4    Bader, L.5    Rose, F.6
  • 22
    • 0032795938 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells
    • Koochekpour S, Jeffers M,Wang PH, Gong C, Taylor GA, Roessler LM, et al. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol Cell Biol 1999;19: 5902-12.
    • (1999) Mol Cell Biol , vol.19 , pp. 5902-5912
    • Koochekpour, S.1    Jeffers Mwang, P.H.2    Gong, C.3    Taylor, G.A.4    Roessler, L.M.5
  • 23
    • 35348966260 scopus 로고    scopus 로고
    • Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress
    • Chen Y, Pearlman A, Luo Z, Wilcox CS. Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress. Am J Physiol Heart Circ Physiol 2007;293:H2085-92.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Chen, Y.1    Pearlman, A.2    Luo, Z.3    Wilcox, C.S.4
  • 25
    • 14044272777 scopus 로고    scopus 로고
    • Production of intracellular superoxide mediates dithiothreitol-dependent inhibition of apoptotic cell death
    • Clement MV, Sivarajah S, Pervaiz S. Production of intracellular superoxide mediates dithiothreitol-dependent inhibition of apoptotic cell death. Antioxid Redox Signal 2005;7:456-64.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 456-464
    • Clement, M.V.1    Sivarajah, S.2    Pervaiz, S.3
  • 26
    • 33747366672 scopus 로고    scopus 로고
    • Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment
    • Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J Biol Chem 2006;281:22575-85.
    • (2006) J Biol Chem , vol.281 , pp. 22575-22585
    • Bracken, C.P.1    Fedele, A.O.2    Linke, S.3    Balrak, W.4    Lisy, K.5    Whitelaw, M.L.6
  • 27
    • 84866172766 scopus 로고    scopus 로고
    • HIF-1 versus HIF-2-is one more important than the other
    • Loboda A, Jozkowicz A, Dulak J. HIF-1 versus HIF-2-is one more important than the other. Vascul Pharmacol 2012;56:245-51.
    • (2012) Vascul Pharmacol , vol.56 , pp. 245-251
    • Loboda, A.1    Jozkowicz, A.2    Dulak, J.3
  • 28
    • 0037093238 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factors in human renal cancer: Relationship to angiogenesis and to the von Hippel-Lindau gene mutation
    • Turner KJ, Moore JW, Jones A, Taylor CF, Cuthbert-Heavens D, Han C, et al. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res 2002;62:2957-61.
    • (2002) Cancer Res , vol.62 , pp. 2957-2961
    • Turner, K.J.1    Moore, J.W.2    Jones, A.3    Taylor, C.F.4    Cuthbert-Heavens, D.5    Han, C.6
  • 29
    • 84866390484 scopus 로고    scopus 로고
    • Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial- to-mesenchymal transition and migration of breast epithelial cells
    • Boudreau HE, Casterline BW, Rada B, Korzeniowska A, Leto TL. Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial- to-mesenchymal transition and migration of breast epithelial cells. Free Radic Biol Med 2012;53:1489-99.
    • (2012) Free Radic Biol Med , vol.53 , pp. 1489-1499
    • Boudreau, H.E.1    Casterline, B.W.2    Rada, B.3    Korzeniowska, A.4    Leto, T.L.5
  • 30
    • 65549114660 scopus 로고    scopus 로고
    • NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression
    • Yamaura M, Mitsushita J, Furuta S, Kiniwa Y, Ashida A, Goto Y, et al. NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression. Cancer Res 2009;69:2647-54.
    • (2009) Cancer Res , vol.69 , pp. 2647-2654
    • Yamaura, M.1    Mitsushita, J.2    Furuta, S.3    Kiniwa, Y.4    Ashida, A.5    Goto, Y.6
  • 31
    • 77951950611 scopus 로고    scopus 로고
    • Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation
    • Nam HJ, Park YY, Yoon G, Cho H, Lee JH. Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation. Exp Mol Med 2010;42:270-9.
    • (2010) Exp Mol Med , vol.42 , pp. 270-279
    • Nam, H.J.1    Park, Y.Y.2    Yoon, G.3    Cho, H.4    Lee, J.H.5
  • 32
    • 46449129179 scopus 로고    scopus 로고
    • Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration
    • Haurani MJ, Cifuentes ME, Shepard AD, Pagano PJ. Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration. Hypertension 2008;52:143-9.
    • (2008) Hypertension , vol.52 , pp. 143-149
    • Haurani, M.J.1    Cifuentes, M.E.2    Shepard, A.D.3    Pagano, P.J.4
  • 33
    • 60749098324 scopus 로고    scopus 로고
    • Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells
    • Pendyala S, Gorshkova IA, Usatyuk PV, He D, Pennathur A, Lambeth JD, et al. Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells. Antioxid Redox Signal 2009;11:747-64.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 747-764
    • Pendyala, S.1    Gorshkova, I.A.2    Usatyuk, P.V.3    He, D.4    Pennathur, A.5    Lambeth, J.D.6
  • 34
    • 54149115156 scopus 로고    scopus 로고
    • Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells
    • Meng D, Lv DD, Fang J. Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells. Cardiovasc Res 2008;80: 299-308.
    • (2008) Cardiovasc Res , vol.80 , pp. 299-308
    • Meng, D.1    Lv, D.D.2    Fang, J.3
  • 36
    • 73949101383 scopus 로고    scopus 로고
    • Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation
    • Diaz B, Shani G, Pass I, Anderson D, Quintavalle M, Courtneidge SA. Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal 2009;2:ra53.
    • (2009) Sci Signal , vol.2
    • Diaz, B.1    Shani, G.2    Pass, I.3    Anderson, D.4    Quintavalle, M.5    Courtneidge, S.A.6
  • 38
    • 65549142759 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism
    • Pelicano H, Lu W, Zhou Y, Zhang W, Chen Z, Hu Y, et al. Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism. Cancer Res 2009;69:2375-83.
    • (2009) Cancer Res , vol.69 , pp. 2375-2383
    • Pelicano, H.1    Lu, W.2    Zhou, Y.3    Zhang, W.4    Chen, Z.5    Hu, Y.6
  • 39
    • 70449519966 scopus 로고    scopus 로고
    • Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation
    • Chiu WT, Shen SC, Chow JM, Lin CW, Shia LT, Chen YC. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. Neurobiol Dis 2010;37:118-29.
    • (2010) Neurobiol Dis , vol.37 , pp. 118-129
    • Chiu, W.T.1    Shen, S.C.2    Chow, J.M.3    Lin, C.W.4    Shia, L.T.5    Chen, Y.C.6
  • 40
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
    • Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 2000; 275:25130-8.
    • (2000) J Biol Chem , vol.275 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3    Wood, T.M.4    Melendez, J.A.5    Rodriguez, A.M.6
  • 41
    • 28744439265 scopus 로고    scopus 로고
    • Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor
    • WangM, Kirk JS, Venkataraman S,Domann FE, Zhang HJ, Schafer FQ, et al. Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene 2005;24:8154-66.
    • (2005) Oncogene , vol.24 , pp. 8154-8166
    • Wang, M.1    Kirk, J.S.2    Venkataraman, S.3    Domann, F.E.4    Zhang, H.J.5    Schafer, F.Q.6
  • 42
    • 42349117302 scopus 로고    scopus 로고
    • Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide
    • Kaewpila S, Venkataraman S, Buettner GR, Oberley LW. Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide. Cancer Res 2008;68:2781-8.
    • (2008) Cancer Res , vol.68 , pp. 2781-2788
    • Kaewpila, S.1    Venkataraman, S.2    Buettner, G.R.3    Oberley, L.W.4
  • 43
    • 41849117298 scopus 로고    scopus 로고
    • Flavonoids-induced accumulation of hypoxiainducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron
    • Park SS, Bae I, Lee YJ. Flavonoids-induced accumulation of hypoxiainducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. J Cell Biochem 2008;103:1989-98.
    • (2008) J Cell Biochem , vol.103 , pp. 1989-1998
    • Park, S.S.1    Bae, I.2    Lee, Y.J.3
  • 44
    • 77952079054 scopus 로고    scopus 로고
    • The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin
    • Block K, Gorin Y, New DD, Eid A, Chelmicki T, Reed A, et al. The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin. Am J Pathol 2010;176: 2447-55.
    • (2010) Am J Pathol , vol.176 , pp. 2447-2455
    • Block, K.1    Gorin, Y.2    New, D.D.3    Eid, A.4    Chelmicki, T.5    Reed, A.6


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