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Volumn 37, Issue 8, 2009, Pages 947-955

Patients with myelodysplastic syndromes display several T-cell expansions, which are mostly polyclonal in the CD4+ subset and oligoclonal in the CD8+ subset

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA ANTIGEN; T LYMPHOCYTE RECEPTOR;

EID: 67650065350     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2009.04.009     Document Type: Article
Times cited : (71)

References (34)
  • 1
    • 34347236177 scopus 로고    scopus 로고
    • A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia
    • Bacher U., Haferlach T., Kern W., Haferlach C., and Schnittger S. A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia. Haematologica 92 (2007) 744-752
    • (2007) Haematologica , vol.92 , pp. 744-752
    • Bacher, U.1    Haferlach, T.2    Kern, W.3    Haferlach, C.4    Schnittger, S.5
  • 2
    • 0029071829 scopus 로고
    • Immune-mediated complications in patients with myelodysplastic syndromes-clinical and cytogenetic features
    • Billstrom R., Johansson H., Johansson B., and Mitelman F. Immune-mediated complications in patients with myelodysplastic syndromes-clinical and cytogenetic features. Eur J Haematol 55 (1995) 42-48
    • (1995) Eur J Haematol , vol.55 , pp. 42-48
    • Billstrom, R.1    Johansson, H.2    Johansson, B.3    Mitelman, F.4
  • 3
    • 0345701967 scopus 로고    scopus 로고
    • A pilot study of antithymocyte globulin (ATG) in the treatment of patients with 'low-risk' myelodysplasia
    • Killick S.B., Mufti G., Cavenagh J.D., et al. A pilot study of antithymocyte globulin (ATG) in the treatment of patients with 'low-risk' myelodysplasia. Br J Haematol 120 (2003) 679-684
    • (2003) Br J Haematol , vol.120 , pp. 679-684
    • Killick, S.B.1    Mufti, G.2    Cavenagh, J.D.3
  • 5
    • 0031257730 scopus 로고    scopus 로고
    • Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients
    • Okamoto T., Okada M., Mori A., et al. Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients. Int J Hematol 66 (1997) 345-351
    • (1997) Int J Hematol , vol.66 , pp. 345-351
    • Okamoto, T.1    Okada, M.2    Mori, A.3
  • 6
    • 7044237599 scopus 로고    scopus 로고
    • Myelodysplasia-associated autoimmunity: clinical and pathophysiologic concepts
    • Voulgarelis M., Giannouli S., Ritis K., and Tzioufas A.G. Myelodysplasia-associated autoimmunity: clinical and pathophysiologic concepts. Eur J Clin Invest 34 (2004) 690-700
    • (2004) Eur J Clin Invest , vol.34 , pp. 690-700
    • Voulgarelis, M.1    Giannouli, S.2    Ritis, K.3    Tzioufas, A.G.4
  • 7
    • 0025784748 scopus 로고
    • Rheumatic manifestations in myelodysplastic syndromes
    • Castro M., Conn D.L., Su W.P., and Garton J.P. Rheumatic manifestations in myelodysplastic syndromes. J Rheumatol 18 (1991) 721-727
    • (1991) J Rheumatol , vol.18 , pp. 721-727
    • Castro, M.1    Conn, D.L.2    Su, W.P.3    Garton, J.P.4
  • 9
    • 34547957665 scopus 로고    scopus 로고
    • CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS)
    • Kordasti S.Y., Ingram W., Hayden J., et al. CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS). Blood 110 (2007) 847-850
    • (2007) Blood , vol.110 , pp. 847-850
    • Kordasti, S.Y.1    Ingram, W.2    Hayden, J.3
  • 10
    • 7344223859 scopus 로고    scopus 로고
    • Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles
    • Molldrem J.J., Jiang Y.Z., Stetler-Stevenson M., Mavroudis D., Hensel N., and Barrett A.J. Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles. Br J Haematol 102 (1998) 1314-1322
    • (1998) Br J Haematol , vol.102 , pp. 1314-1322
    • Molldrem, J.J.1    Jiang, Y.Z.2    Stetler-Stevenson, M.3    Mavroudis, D.4    Hensel, N.5    Barrett, A.J.6
  • 11
    • 0025868236 scopus 로고
    • The occurrence subtype and significance of haemopoietic inhibitory T cells (HIT cells) in myelodysplasia: an in vitro study
    • Smith M.A., and Smith J.G. The occurrence subtype and significance of haemopoietic inhibitory T cells (HIT cells) in myelodysplasia: an in vitro study. Leuk Res 15 (1991) 597-601
    • (1991) Leuk Res , vol.15 , pp. 597-601
    • Smith, M.A.1    Smith, J.G.2
  • 12
    • 0035412374 scopus 로고    scopus 로고
    • Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalphabeta T-cell proliferations
    • Langerak A.W., van Den Beemd R., Wolvers-Tettero I.L., Boor P.P., van Lochem E.G., Hooijkaas H., and van Dongen J.J. Molecular and flow cytometric analysis of the Vbeta repertoire for clonality assessment in mature TCRalphabeta T-cell proliferations. Blood 98 (2001) 165-173
    • (2001) Blood , vol.98 , pp. 165-173
    • Langerak, A.W.1    van Den Beemd, R.2    Wolvers-Tettero, I.L.3    Boor, P.P.4    van Lochem, E.G.5    Hooijkaas, H.6    van Dongen, J.J.7
  • 13
    • 0028220953 scopus 로고
    • Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status
    • Gorski J., Yassai M., Zhu X., Kissela B., Kissella B., Keever C., and Flomenberg N. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J Immunol 152 (1994) 5109-5119
    • (1994) J Immunol , vol.152 , pp. 5109-5119
    • Gorski, J.1    Yassai, M.2    Zhu, X.3    Kissela, B.4    Kissella, B.5    Keever, C.6    Flomenberg, N.7
  • 14
    • 0036400123 scopus 로고    scopus 로고
    • Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome
    • Melenhorst J.J., Eniafe R., Follmann D., Nakamura R., Kirby M., and Barrett A.J. Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome. Br J Haematol 119 (2002) 97-105
    • (2002) Br J Haematol , vol.119 , pp. 97-105
    • Melenhorst, J.J.1    Eniafe, R.2    Follmann, D.3    Nakamura, R.4    Kirby, M.5    Barrett, A.J.6
  • 15
    • 0034782479 scopus 로고    scopus 로고
    • Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process
    • Epperson D.E., Nakamura R., Saunthararajah Y., Melenhorst J., and Barrett A.J. Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process. Leuk Res 25 (2001) 1075-1083
    • (2001) Leuk Res , vol.25 , pp. 1075-1083
    • Epperson, D.E.1    Nakamura, R.2    Saunthararajah, Y.3    Melenhorst, J.4    Barrett, A.J.5
  • 16
    • 0037376257 scopus 로고    scopus 로고
    • Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypoplasia
    • Matsutani T., Yoshioka T., Tsuruta Y., et al. Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypoplasia. Leuk Res 27 (2003) 305-312
    • (2003) Leuk Res , vol.27 , pp. 305-312
    • Matsutani, T.1    Yoshioka, T.2    Tsuruta, Y.3
  • 17
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman J.W., Harris N.L., and Brunning R.D. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 100 (2002) 2292-2302
    • (2002) Blood , vol.100 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunning, R.D.3
  • 18
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg P., Cox C., LeBeau M.M., et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89 (1997) 2079-2088
    • (1997) Blood , vol.89 , pp. 2079-2088
    • Greenberg, P.1    Cox, C.2    LeBeau, M.M.3
  • 19
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 20
    • 19944428980 scopus 로고    scopus 로고
    • Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients
    • Chen X., Barfield R., Benaim E., et al. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood 105 (2005) 886-893
    • (2005) Blood , vol.105 , pp. 886-893
    • Chen, X.1    Barfield, R.2    Benaim, E.3
  • 21
    • 2942535837 scopus 로고    scopus 로고
    • Analysis of T-cell repertoire in hepatitis-associated aplastic anemia
    • Lu J., Basu A., Melenhorst J.J., Young N.S., and Brown K.E. Analysis of T-cell repertoire in hepatitis-associated aplastic anemia. Blood 103 (2004) 4588-4593
    • (2004) Blood , vol.103 , pp. 4588-4593
    • Lu, J.1    Basu, A.2    Melenhorst, J.J.3    Young, N.S.4    Brown, K.E.5
  • 24
    • 33748433889 scopus 로고    scopus 로고
    • Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome
    • Wlodarski M.W., Gondek L.P., Nearman Z.P., et al. Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome. Blood 108 (2006) 2632-2641
    • (2006) Blood , vol.108 , pp. 2632-2641
    • Wlodarski, M.W.1    Gondek, L.P.2    Nearman, Z.P.3
  • 25
    • 33947388858 scopus 로고    scopus 로고
    • Prevalence and clinical association of clonal T-cell expansions in Myelodysplastic Syndrome
    • Epling-Burnette P.K., Painter J.S., Rollison D.E., et al. Prevalence and clinical association of clonal T-cell expansions in Myelodysplastic Syndrome. Leukemia 21 (2007) 659-667
    • (2007) Leukemia , vol.21 , pp. 659-667
    • Epling-Burnette, P.K.1    Painter, J.S.2    Rollison, D.E.3
  • 26
    • 0036660175 scopus 로고    scopus 로고
    • Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry
    • Risitano A.M., Kook H., Zeng W., Chen G., Young N.S., and Maciejewski J.P. Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry. Blood 100 (2002) 178-183
    • (2002) Blood , vol.100 , pp. 178-183
    • Risitano, A.M.1    Kook, H.2    Zeng, W.3    Chen, G.4    Young, N.S.5    Maciejewski, J.P.6
  • 27
    • 0034307521 scopus 로고    scopus 로고
    • Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria
    • Karadimitris A., Manavalan J.S., Thaler H.T., et al. Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood 96 (2000) 2613-2620
    • (2000) Blood , vol.96 , pp. 2613-2620
    • Karadimitris, A.1    Manavalan, J.S.2    Thaler, H.T.3
  • 28
    • 27144530279 scopus 로고    scopus 로고
    • Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia
    • Wlodarski M.W., O'Keefe C., Howe E.C., et al. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood 106 (2005) 2769-2780
    • (2005) Blood , vol.106 , pp. 2769-2780
    • Wlodarski, M.W.1    O'Keefe, C.2    Howe, E.C.3
  • 29
    • 0031782686 scopus 로고    scopus 로고
    • Hypothesis: myelodysplastic syndromes may have a viral etiology
    • Raza A. Hypothesis: myelodysplastic syndromes may have a viral etiology. Int J Hematol 68 (1998) 245-256
    • (1998) Int J Hematol , vol.68 , pp. 245-256
    • Raza, A.1
  • 30
    • 33947232277 scopus 로고    scopus 로고
    • Immune-mediated bone marrow failure syndromes of progenitor and stem cells: molecular analysis of cytotoxic T cell clones
    • Maciejewski J.P., O'Keefe C., Gondek L., and Tiu R. Immune-mediated bone marrow failure syndromes of progenitor and stem cells: molecular analysis of cytotoxic T cell clones. Folia Histochem Cytobiol 45 (2007) 5-14
    • (2007) Folia Histochem Cytobiol , vol.45 , pp. 5-14
    • Maciejewski, J.P.1    O'Keefe, C.2    Gondek, L.3    Tiu, R.4
  • 31
    • 66349100779 scopus 로고    scopus 로고
    • Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome
    • Chamuleau M.E.D., Westers T.M., van Dreunen L., et al. Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome. Haematologica 94 (2009) 496-506
    • (2009) Haematologica , vol.94 , pp. 496-506
    • Chamuleau, M.E.D.1    Westers, T.M.2    van Dreunen, L.3
  • 32
    • 0028264338 scopus 로고
    • Neutrophils from patients with myelodysplastic syndromes: relationship between impairment of granular contents, complement receptors, functional activities and disease status
    • Moretti S., Lanza F., Spisani S., et al. Neutrophils from patients with myelodysplastic syndromes: relationship between impairment of granular contents, complement receptors, functional activities and disease status. Leuk Lymphoma 13 (1994) 471-477
    • (1994) Leuk Lymphoma , vol.13 , pp. 471-477
    • Moretti, S.1    Lanza, F.2    Spisani, S.3
  • 33
    • 34249740754 scopus 로고    scopus 로고
    • Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
    • Epling-Burnette P.K., Bai F., Painter J.S., et al. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 109 (2007) 4816-4824
    • (2007) Blood , vol.109 , pp. 4816-4824
    • Epling-Burnette, P.K.1    Bai, F.2    Painter, J.S.3
  • 34
    • 40849127239 scopus 로고    scopus 로고
    • Activation of cytotoxic T-cell receptor gammadelta T lymphocytes in response to specific stimulation in myelodysplastic syndromes
    • Kiladjian J.J., Visentin G., Viey E., et al. Activation of cytotoxic T-cell receptor gammadelta T lymphocytes in response to specific stimulation in myelodysplastic syndromes. Haematologica 93 (2008) 381-389
    • (2008) Haematologica , vol.93 , pp. 381-389
    • Kiladjian, J.J.1    Visentin, G.2    Viey, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.