Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures

Neurotoxicity Research

Volumn 26, Issue 2, 2014, Pages 190-206

  Smaga, Irena ^a   Bystrowska, Beata ^a   Gawliński, Dawid ^a   Pomierny, Bartosz ^a   Stankowicz, Piotr ^a   Filip, Małgorzata ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Antidepressant; Depression; Endocannabinoid; N Acylethanolamine

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACETYLCYSTEINE; ANANDAMIDE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; ESCITALOPRAM; IMIPRAMINE; N OLEOYLETHANOLAMINE; PALMIDROL; TIANEPTINE; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; AMIDASE; AMIDE; ANTIDEPRESSANT AGENT; ARACHIDONIC ACID DERIVATIVE; BENZAMIDE DERIVATIVE; CARBAMIC ACID DERIVATIVE; CITALOPRAM; CYCLOHEXYL CARBAMIC ACID 3'-CARBAMOYLBIPHENYL-3-YL ESTER; ENDOCANNABINOID; ENZYME INHIBITOR; ETHANOLAMINE DERIVATIVE; EXPECTORANT AGENT; FATTY-ACID AMIDE HYDROLASE; OLEIC ACID; PALMITIC ACID DERIVATIVE; THIAZEPINE DERIVATIVE;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CEREBELLUM; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FRONTAL CORTEX; HIPPOCAMPUS; LIMBIC SYSTEM; MALE; NEUROANATOMY; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; DRUG EFFECTS; METABOLISM; WISTAR RAT;

RATTUS;

ACETYLCYSTEINE; AMIDOHYDROLASES; ANIMALS; ANTIDEPRESSIVE AGENTS; ARACHIDONIC ACIDS; BENZAMIDES; BRAIN; CARBAMATES; CITALOPRAM; ENDOCANNABINOIDS; ENZYME INHIBITORS; ETHANOLAMINES; EXPECTORANTS; GLYCERIDES; IMIPRAMINE; MALE; OLEIC ACIDS; PALMITIC ACIDS; POLYUNSATURATED ALKAMIDES; RATS, WISTAR; THIAZEPINES;

EID: 84903819476     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-014-9465-0     Document Type: Article

References (70)

1. Adamczyk P, Gołda A, McCreary AC, Filip M, Przegaliński E (2008) Activation of endocannabinoid transmission induces antidepressant-like effects in rats. J Physiol Pharmacol 59:217-228 (Pubitemid 351955748)
2. Aso E, Ozaita A, Valdizán EM, Ledent C, Pazos A, Maldonado R, Valverde O (2008) BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. J Neurochem 105:565-572 (Pubitemid 351490016)
3. Bambico FR, Katz N, Debonnel G, Gobbi G (2007) Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex. J Neurosci 27:11700-11711 (Pubitemid 350006914)
4. Bortolato M, Mangieri RA, Fu J, Kim JH, Arguello O, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D (2007) Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry 62:1103-1110 (Pubitemid 350029716)
5. Bourdeau ML, Morin F, Laurent CE, Azzi M, Lacaille JC (2007) Kv4.3-mediated A-type K+ currents underlie rhythmic activity in hippocampal interneurons. J Neurosci 27:1942-1953
6. Burkhalter A, Gonchar Y, Mellor RL, Nerbonne JM (2006) Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses. J Neurosci 26:12274-12282 (Pubitemid 44808395)
7. Cao X, Liu Z, Xu C, Li J, Gao Q, Sun N, Xu Y, Ren Y, Yang C, Zhang K (2012) Disrupted resting-state functional connectivity of the hippocampus in medication-naive patients with major depressive disorder. J Affect Disord 141:194-203
8. Carey MR, Myoga MH, McDaniels KR, Marsicano G, Lutz B, Mackie K, Regehr WG (2011) Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses. J Neurophysiol 105:958-963
9. Choi K, Le T, McGuire J, Xing G, Zhang L, Li H, Parker CC, Johnson LR, Ursano RJ (2012) Expression pattern of the cannabinoid receptor genes in the frontal cortex of mood disorder patients and mice selectively bred for high and low fear. J Psychiatr Res 46:882-889
10. Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A (2007) Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet 370:1706-1713 (Pubitemid 350100788)
11. De Petrocellis L, Davis JB, Di Marzo V (2001) Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. FEBS Lett 506:253-256 (Pubitemid 32964824)
12. Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D (2005) Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 30 -carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther 313:352-358 (Pubitemid 40411361)
13. Ferreira FR, Biojone C, Joca SR, Guimarães FS (2008) Antidepressant-like effects of N-acetyl-L-cysteine in rats. Behav Pharmacol 19:747-750
14. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
15. Galve-Roperh I, Rueda D, Gomez del Pulgar T, Velasco G, Guzman M (2002) Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Mol Pharmacol 62:1385-1392 (Pubitemid 35403833)
16. Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T, Morgese MG, Debonnel G, Duranti A, Tontini A, Tarzia G, Mor M, Trezza V, Goldberg SR, Cuomo V, Piomelli D (2005) Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci USA 102:18620-18625 (Pubitemid 43011275)
17. Hill MN, Gorzalka BB (2005) Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. Eur Neuropsychopharmacol 15:593-599 (Pubitemid 41587409)
18. Hill MN, Patel S, Carrier EJ, Rademacher DJ, Ormerod BK, Hillard CJ, Gorzalka BB (2005) Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. Neuropsychopharmacology 30:508-515 (Pubitemid 40271153)
19. Hill MN, Ho WS, Sinopoli KJ, Viau V, Hillard CJ, Gorzalka BB (2006) Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis. Neuropsychopharmacology 31:2591-2599 (Pubitemid 44764156)
20. Hill MN, Carrier EJ, Ho WS, Shi L, Patel S, Gorzalka BB, Hillard CJ (2008a) Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. Hippocampus 18:221-226 (Pubitemid 351413487)
21. Hill MN, Carrier EJ, McLaughlin RJ, Morrish AC, Meier SE, Hillard CJ, Gorzalka BB (2008b) Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. J Neurochem 106:2322-2336
22. Hill MN, Ho WS, Hillard CJ, Gorzalka BB (2008c) Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. J Neural Transm 115:1673-1679
23. Hill MN, Hunter RG, McEwen BS (2009) Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields. Eur J Pharmacol 614:66-69
24. Holmes A (2008) Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neurosci Biobehav Rev 32:1293-1314
25. Hu W, Zhang M, Czeh B, Zhang W, Flugge G (2011) Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats. Brain Res Bull 85:374-379
26. Hungund BL, Vinod KY, Kassir SA, Basavarajappa BS, Yalamanchili R, Cooper TB, Mann JJ, Arango V (2004) Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims. Mol Psychiatry 9:184-190 (Pubitemid 38299532)
27. Invernizzi R, Pozzi L, Garattini S, Samanin R (1992) Tianeptine increases the extracellular concentrations of dopamine in the nucleus accumbens by a serotonin-independent mechanism. Neuropharmacology 31:221-227
28. Jiang W, Zhang Y, Xiao L, Van Cleemput J, Ji SP, Bai G, Zhang X (2005) Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. J Clin Invest 115:3104-3116 (Pubitemid 41567575)
29. Kathuria S, Gaetani S, Fegley D, Valino F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, Piomelli D (2003) Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81 (Pubitemid 36098263)
30. Koethe D, Llenos IC, Dulay JR, Hoyer C, Torrey EF, Leweke FM, Weis S (2007) Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression. J Neural Transm 114:1055-1063 (Pubitemid 47106441)
31. Kreitzer AC, Carter AG, Regehr WG (2002) Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum. Neuron 34:787-796 (Pubitemid 34628740)
32. Lafourcade M, Elezgarai I, Mato S, Bakiri Y, Grandes P, Manzoni OJ (2007) Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. PLoS One 2:e709
33. Lovinger DM (2008) Presynaptic modulation by endocannabinoids. Handb Exp Pharmacol 184:435-477
34. Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutierrez SO, van der Stelt M, Lopez-Rodriguez ML, Casanova E, Schutz G, Zieglgansberger W, Di Marzo V, Behl C, Lutz B (2003) CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302:84-88 (Pubitemid 37210691)
35. Mato S, Vidal R, Castro E, Diaz A, Pazos A, Valdizan EM (2010) Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms. Mol Pharmacol 77:424-434
36. McLaughlin RJ, Gobbi G (2012) Cannabinoids and emotionality: a neuroanatomical perspective. Neuroscience 204:134-144
37. McLaughlin RJ, Hill MN, Morrish AC, Gorzalka BB (2007) Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behav Pharmacol 18:431-438 (Pubitemid 47356369)
38. McLaughlin RJ, Hill MN, Bambico FR, Stuhr KL, Gobbi G, Hillard CJ, Gorzalka BB (2012) Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. Eur Neuropsychopharmacol 22:664-671
39. Micale V, Di Marzo V, Sulcova A, Wotjak CT, Drago F (2013) Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacol Ther 138:18-37
40. Mikics E, Vas J, Aliczki M, Halasz J, Haller J (2009) Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission. Behav Pharmacol 20:265-272
41. Nagayama T, Sinor AD, Simon RP, Chen J, Graham SH, Jin K, Greenberg DA (1999) Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J Neurosci 19:2987-2995 (Pubitemid 29173995)
42. Naidu PS, Varvel SA, Ahn K, Cravatt BF, Martin BR, Lichtman AH (2007) Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology 192:61-70 (Pubitemid 46673891)
43. Ozaita A, Puighermanal E, Maldonado R (2007) Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 102:1105-1114 (Pubitemid 47174245)
44. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates, 4th edn. Academic Press, San Diego
45. Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman D (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev 12:21-38 (Pubitemid 44133578)
46. Realini N, Vigano D, Guidali C, Zamberletti E, Rubino T, Parolaro D (2011) Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats. Neuropharmacology 60:235-243
47. Reed AL, Anderson JC, Bylund DB, Petty F, El Refaey H, Happe HK (2009) Treatment with escitalopram but not desipramine decreases escape latency times in a learned helplessness model using juvenile rats. Psychopharmacology 205:249-259
48. Reich CG, Iskander AN, Weiss MS (2013a) Cannabinoid modulation of chronic mild stress-induced selective enhancement of trace fear conditioning in adolescent rats. J Psychopharmacol 27:947-955
49. Reich CG, Mihalik GR, Iskander AN, Seckler JC, Weiss MS (2013b) Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity. Neuroscience 253:444-454
50. Robinson OJ, Cools R, Carlisi CO, Sahakian BJ, Drevets WC (2012) Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder. Am J Psychiatry 169:152-159
51. Rodriguez-Gaztelumendi A, Rojo ML, Pazos A, Diaz A (2009) Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine. J Neurochem 108:1423-1433
52. Rutkowska M, Jachimczuk O (2004) Antidepressant-like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors. Acta Pol Pharm 61:165-167 (Pubitemid 40515126)
53. Safo PK, Cravatt BF, Regehr WG (2006) Retrograde endocannabinoid signaling in the cerebellar cortex. Cerebellum 5:134-145
54. Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R (2004) Reduced sensitivity to reward in CB1 knockout mice. Psychopharmacology 176:223-232 (Pubitemid 39517952)
55. Segev A, Rubin AS, Abush H, Richter-Levin G, Akirav I (2013) Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression. Neuropsychopharmacology
56. Skaper SD, Buriani A, Dal Toso R, Petrelli L, Romanello S, Facci L, Leon A (1996) The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Natl Acad Sci USA 93:3984-3989 (Pubitemid 26146721)
57. Smaga I, Pomierny B, Krzyżanowska W, Pomierny-Chamioło L, Miszkiel J, Niedzielska E, Ogórka A, Filip M (2012) N-Acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: behavioral and biochemical analyses in rats. Prog Neuropsychopharmacol Biol Psychiatry 39:280-287
58. Smart D, Jonsson KO, Vandevoorde S, Lambert DM, Fowler CJ (2002) 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. Br J Pharmacol 136:452-458 (Pubitemid 34620526)
59. Steiner MA, Wanisch K, Monory K, Marsicano G, Borroni E, Bächli H, Holsboer F, Lutz B, Wotjak CT (2008) Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice. Pharmacogenomics J 8:196-208 (Pubitemid 351712644)
60. Suarez J, Bermudez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravatt BF, de Fonseca FR (2008) Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. J Comp Neurol 509:400-421
61. Tokita K, Fujita Y, Yamaji T, Hashimoto K (2012) Depressive-like behavior in adrenocorticotropic hormone-treated rats blocked by memantine. Pharmacol Biochem Behav 102:329-334
62. Vadachkoria D, Gabunia L, Gambashidze K, Pkhaladze N, Kuridze N (2009) Addictive potential of Tianeptine: the threatening reality. Georgian Med News 92-94
63. Vinod KY, Arango V, Xie S, Kassir SA, Mann JJ, Cooper TB, Hungund BL (2005) Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims. Biol Psychiatry 57:480-486 (Pubitemid 40311982)
64. Vinod KY, Kassir SA, Hungund BL, Cooper TB, Mann JJ, Arango V (2010) Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides. J Psychiatr Res 44:591-597
65. Whitton PS, Sarna GS, Datla KP, Curzon G (1991) Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour. Psychopharmacology 104:81-85
66. You IJ, Jung YH, Kim MJ, Kwon SH, Hong SI, Lee SY, Jang CG (2012) Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT(1)A, GABA(A), and NMDA receptors. Neuropharmacology 62:1034-1043
67. Yu HL, Deng XQ, Li YJ, Li YC, Quan ZS, Sun XY (2011) N- Palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice. Pharmacol Rep 63:834-839
68. Zarate J, Churruca I, Echevarria E, Casis L, Lopez de Jesus M, Saenz del Burgo L, Salles J (2008) Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: effects of chronic fluoxetine treatment. Brain Res 1236:57-72
69. Zhong P, Pan B, Gao XP, Blankman JL, Cravatt BF, Liu QS (2011) Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol 589:4847-4855
70. Zhong P, Wang W, Pan B, Liu X, Zhang Z, Long JZ, Zhang HT, Cravatt BF, Liu QS (2014) Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology