Interactions between the anxiogenic effects of CB1 gene disruption and 5-HT3 neurotransmission

Behavioural Pharmacology

Volumn 20, Issue 3, 2009, Pages 265-272

  Mikics, Eva ^a   Vas, Judit ^a   Aliczki, Mano ^a   Halasz, Jozsef ^a   Haller, Jozsef ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

5 HT3; Anxiety; Cannabinoid; CB1; CB1 KO; Mouse; Plus maze; Serotonin

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 4 AMINOBUTYRIC ACID; CANNABINOID 1 RECEPTOR; SEROTONIN 3 RECEPTOR;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; GENE DISRUPTION; MALE; MAZE TEST; MOUSE; NONHUMAN; SEROTONINERGIC TRANSMISSION;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BIGUANIDES; ENDOCANNABINOIDS; GAMMA-AMINOBUTYRIC ACID; MALE; MAZE LEARNING; MICE; MICE, KNOCKOUT; RECEPTOR, CANNABINOID, CB1; RECEPTORS, SEROTONIN, 5-HT3; SPECIES SPECIFICITY; SYNAPTIC TRANSMISSION;

EID: 67649550681     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e32832c70b1     Document Type: Article

References (73)

1. 3 receptor Iigands following chronic diazepam treatment? Psychopharmacology 108:333-337.
2. 3 receptor-mediated effect in the raphe nuclei of the rat. Brain Res Bull 45:203-208.
3. Barnes NM, Sharp T (1999). A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152.
4. Beinfeld MC, Connolly K (2001). Activation of CB1 cannabinoid receptors in rat hippocampal slices Inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids. Neurosci Lett 301: 69-71.
5. 3 receptor differentially affects behavior of males and females in the Porsolt forced swim and defensive withdrawal tests. Behav Brain Res 153:527-535.
6. Bhatnagar S, Sun LM, Raber J, Maren S, Julius D, Dallman MF (2004b). Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity In mice lacking the 5-HT-3A receptor. Physiol Behav 81:545-555.
7. Blier P, Bouchard C (1993). Functional characterization of a 5-HT3 receptor which modulates the release of 5-HT In the guinea-pig brain. Br J Pharmacol 108:13-22.
8. Bloom FE, Morales M (1998). The central 5-HT3 receptor In CNS disorders. Neurochem Res 23:663-669.
9. Bodor AL, Katona I, Nylri G, Mackie K, Ledent C, Hajos N, Freund TF (2005). Endocannabinolds signaling in rat somatosensory cortex: laminar differences and Involvement of specific interneuron types. J Neurosci 25: 6845-6856.
10. Bourin M, Nic Dhonnchadha BA, Claude Colombel M, Dib M, Hascoët M (2001). Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice. Behav Brain Res 124:87-95.
11. 3 receptors In the central nervous system. Cell Tissue Res 326:573-581.
12. Chesnoy-Marchais D, Levi S, Acher F (2000). Glyclnergic potentiation by some 5-HT(3) receptor antagonists: Insight into selectivity. Eur J Pharmacol 402:206-213.
13. 3 receptors. Curr Drug Targets CNS Neurol Disord 3:27-37.
14. Costall B, Kelly ME, Naylor RJ, Onaivi ES (1988). Actions of busplrone in a putative model of anxiety in the mouse. J Pharm Pharmacol 40:494-500.
15. 3 receptor antagonists prevent cisplatininduced emesis in Cryptotis parva: a new experimental model of emesis. J Neural Transm 105:1143-1154.
16. Davidson RJ (2002). Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry 51:68-80.
17. Davis M, Rainnle D, Cassell M (1994). Neurotransmission In the rat amygdala related to fear and anxiety. Trends Neurosci 17:208-214.
18. 3 partial agonist, in mouse anxiety. Zhongguo Yao Li Xue Bao 20: 805-812.
19. 3 receptor antagonism. Pharmacol Biochem Behav 68:677-683.
20. Engin E, Treit D (2007). The role of hippocampus in anxiety: intracerebral infusion studies. Behav Pharmacol 18:365-374.
21. 3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. J Neurosci 22:7389-7397.
22. Freund TF (2003). Interneuron diversity series: rhythm and mood in perisomatic Inhibition. Trends Neurosci 26:489-495.
23. Gerald TM, Ward GR, Howlett AC, Franklin SO (2006). CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression. Brain Res 1093:20-24.
24. Gulyas Al, Acsady L, Freund TF (1999). Structural basis of the cholinergic and serotonergic modulation of GABAergic neurons in the hippocampus. Neurochem Int 34:359-372.
25. Hajos N, Katona I, Naiem SS, MacKie K, Ledent C, Mody I, Freund TF (2000). Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations. Eur J Neurosci 12:3239-3249.
26. Haller J, Bakos N, Szirmay M, Ledent C, Freund TF (2002). The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. Eur J Neurosci 16:1395-1398.
27. Haller J, Varga B, Ledent C, Barna I, Freund TF (2004a). Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice. Eur J Neurosci 19:1906-1912.
28. Haller J, Varga B, Ledent C, Freund TF (2004b). CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-speciflc agents. Behav Pharmacol 15:299-304.
29. Haller J, Mátyás F, Soproni K, Varga B, Barsy B, Németh B, et al. (2007). Correlated species differences in the effects of cannabinoid Uganda on anxiety and on GABAergic and glutamatergic synaptic transmission. Eur J Neurosci 25:2445-2456.
30. 3 receptor overexpressing mice. Learn Mem 10:410-419.
31. Hogg S (1996). A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol Biochem Behav 54:21 -30.
32. Jardinaud F, Crété D, Canestrelli C, Ledent C, Roques BP, Noble F (2005). CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited. Brain Res 1063:77-83.
33. Karson MA, Whittington KC, Alger BE (2008). Cholecystokinin inhibits endocannabinold-sensitive hippocampal IPSPs and stimulates others. Neuropharmacology 54:117-128.
34. Katona I, Sperlagh B, Sik A, Kafalvi A, Vizi ES, Mackie K, Freund TF (1999). Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J Neurosci 19:4544-4558.
35. Katona I, Rancz EA, Acsady L, Ledent C., Mackie K, Hajos N, Freund TF (2001). Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission. Neurosci 21:9506-9518.
36. 3 receptor agonist Eur J Pharmacol 182:193-197.
37. Kreitzer AC, Regehr WG (2001). Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 29:717-727.
38. Lecci A, Borsini F, Volterra G, Meli A (1990). Pharmacological validation of a novel animal model of anticipatory anxiety in mice. Psychopharmacology 101:255-261.
39. Ledent C, Valverde O, Cossu G, Petitet F, Aubert JF, Beslot F (1999). Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283:401-404.
40. Leveleki C, Sziray N, Levay G, Barsvàri B, Soprani K, Mikics E, Haller J (2006). Pharmacological evaluation of the stress-induced social avoidance model of anxiety. Brain Res Bull 69:153-160.
41. Maccarrone M, Valverde O, Barbaccia ML, Castaña A, Maldonado R, Ledent C, et al. (2002). Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. Eur J Neurosci 15:1178-1186.
42. 3 agonists and antagonists to displace [3H]granisetron binding. J Neurochem 67:407-412.
43. Marsicano G, Lutz B (1999). Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. Eur J Neurosci 11:4213-4225.
44. Martin M, Ledent C, Parmentier M, Maldonado R, Valverde O (2002). Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology 159:379-387.
45. Mascagni F, McDonald AJ (2007). A novel subpopulation of 5-HT type 3A receptor subunit immunoreactive interneurons in the rat basolateral amygdala. Neuroscience 144:1015-1024.
46. Mato S, Aso E, Castro E, Martin M, Valverde O, Maldonado R, Pazos A (2007). CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors. J Neurochem 103:2111-2120.
47. 3 and 5-HT4 receptors or 5-HT uptake inhibition: short- and long-term memory. Behav Brain Res 184:81-90.
48. Merali Z, Levac C, Anisman H (2003). Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice. Biol Psychiatry 54:552-565.
49. A receptors in cultured myenteric neurons. Synapse 61:732-740.
50. 3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structures. Eur J Pharmacol 256:269-279.
51. 3 receptor is present in different subpopulations of GABAergic neurons in the rat telencephalon. J Neurosci 17:3157-3167.
52. Morales M, Battenberg E, de Lecea L , Bloom FE (1996). The type 3 serotonin receptor is expressed In a subpopulatlon of GABAergic neurons in the rat neocortex and hippocampus. Brain Res 731:199-202.
53. Naderi N, Haghparast A, Saber-Tehrani A, Rezaii N, Alizadeh AM, Khani A, Motamedi F (2008). Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice. Pharmacol Biochem Behav 89:64-75.
54. Ohno-Shosaku T, Maejima T, Kano M (2001). Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic presynaptic terminals. Neuron 29:729-738.
55. Ohno-Shosaku T, Tsubokawa H, Mlzushima I, Yoneda N, Zimmer A, Kano M (2002). Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses. J Neurosci 22:3864-3872.
56. Olivier B, Molewijk HE, van der Heyden JA, van Oorsohot R, Ronken E, Mos J, Miczek KA (1998). Ultrasonic vocalizations in rat pups: effects of serotonergic ligands. Neurosci Biobehav Rev 23:215-227.
57. Olivier B, van Wijngaarden I, Soudijn W (2000). 5-HT(3) receptor antagonists and anxiety; a preclinical and clinical review. Eur Neuropsychopharmacol 10:77-95.
58. 3 receptors In rat cerebral cortex and nucleus accumbens. Br J Pharmacol 103:1790-1794.
59. Pellow S, Chopin P, File SE, Briley M (1986). Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149-167.
60. 3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. J Med Chem 40: 1808-1819.
61. 3 receptors. Cereo Cortex 14:1365-1375.
62. Ricci LA, Grimes JM, Melloni RH Jr (2004). Serotonin type 3 receptors modulate the aggression-stimulating effects of adolescent cocaine exposure in Syrian hamsters (Mesocricetus auratus). Behav Neurosci 118: 1097-1110.
63. Rubio M, Fernández-Ruiz J, de Miguel R, Maestro B, Michael Walker J, Ramos JA (2008). CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. Neuropharmacology 54:976-988.
64. Sethi BB, Trivedi JK, Kumar P, Gulati A, Agarwal AK, Sethi N (1986). Antianxiety effect of cannabis: involvement of central benzodiazepine receptors. Biol Psychiatry 21:3-10.
65. Shah AA, Treit D (2004). Infusions of midazolam into the medial prefrontal cortex produce anxiolytic effects in the elevated plus-maze and shock-probe burying tests. Brain Res 996:31-40.
66. Simon P, Dupuis R, Costentin J (1994). Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behav Brain Res 61:59-64.
67. Smiley JF, Goldman-Rakic PS (1996). Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy. J Comp Neurol 367:431-443.
68. Steiner H, Bonner Tl, Zimmer AM, Kitai ST, Zimmer A (1999). Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice. Proc Natl Acad Sci U S A 96:5786-5790.
69. Tourino C, Ledent C, Maldonado R, Valverde O (2008). CB1 cannabinoid receptor modulates 3,4-methylenedioxymethamphetamine acute responses and reinforcement. Biol Psychiatry 63:1030-1038.
70. Uriguen L, Pèrez-Rial S, Ledent C, Palomo T, Manzanares J (2004). Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. Neuropharmacology 46:966-973.
71. Varty GB, Morgan CA, Cohen-Williams ME, Coffin VL, Carey GJ (2002). The gerbil elevated plus-maze I: behavioral characterization and pharmacological validation. Neuropsychopharmacology 27:357-370.
72. Wilson Rl, Nicoll RA (2001). Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses. Nature 410:588-592.
73. Zupanc GK (1996). Peptidergic transmission: from morphological correlates to functional implications. Micron 27:35-91.