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Volumn 128, Issue 1, 2014, Pages 123-136

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts

Author keywords

Gene expression profile; Medulloblastoma; Mouse model; Mutations; SHH; WNT

Indexed keywords

NESTIN; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; WNT PROTEIN; CELL SURFACE RECEPTOR; PATCHED RECEPTORS; SHH PROTEIN, HUMAN; TRANSCRIPTOME;

EID: 84903815075     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1297-8     Document Type: Article
Times cited : (54)

References (54)
  • 1
    • 47949094459 scopus 로고    scopus 로고
    • Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells
    • doi:10.1634/stemcells.2007-0497
    • Atkinson SP, Koch CM, Clelland GK et al (2008) Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells. Stem Cells 26:1174-1185. doi:10.1634/stemcells.2007-0497
    • (2008) Stem Cells , vol.26 , pp. 1174-1185
    • Atkinson, S.P.1    Koch, C.M.2    Clelland, G.K.3
  • 2
    • 84864311315 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
    • doi:10.1038/ncomms1826
    • Bocker MT, Tuorto F, Raddatz G et al (2012) Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster. Nat Commun 3:818. doi:10.1038/ncomms1826
    • (2012) Nat Commun , vol.3 , pp. 818
    • Bocker, M.T.1    Tuorto, F.2    Raddatz, G.3
  • 3
    • 84863979877 scopus 로고    scopus 로고
    • High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age
    • doi:10.1200/JCO.2011.38.7258
    • Brugieres L, Remenieras A, Pierron G et al (2012) High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age. J Clin Oncol 30:2087-2093. doi:10.1200/JCO.2011.38. 7258
    • (2012) J Clin Oncol , vol.30 , pp. 2087-2093
    • Brugieres, L.1    Remenieras, A.2    Pierron, G.3
  • 4
    • 84867566934 scopus 로고    scopus 로고
    • HOXA7, 9, and 10 are methylation targets associated with aggressive behavior in meningiomas
    • doi:10.1016/j.trsl.2012.05.007
    • Di Vinci A, Brigati C, Casciano I et al (2012) HOXA7, 9, and 10 are methylation targets associated with aggressive behavior in meningiomas. Transl Res 160:355-362. doi:10.1016/j.trsl.2012.05.007
    • (2012) Transl Res , vol.160 , pp. 355-362
    • Di Vinci, A.1    Brigati, C.2    Casciano, I.3
  • 5
    • 84857036712 scopus 로고    scopus 로고
    • Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: Association with tumor WHO grade and clinical outcome
    • doi:10.1007/s00432-011-1070-5
    • Di Vinci A, Casciano I, Marasco E et al (2012) Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: association with tumor WHO grade and clinical outcome. J Cancer Res Clin Oncol 138:35-47. doi:10.1007/s00432-011-1070-5
    • (2012) J Cancer Res Clin Oncol , vol.138 , pp. 35-47
    • Di Vinci, A.1    Casciano, I.2    Marasco, E.3
  • 6
    • 65849356587 scopus 로고    scopus 로고
    • Beta-catenin status in paediatric medulloblastomas: Correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
    • doi:10.1002/path.2514
    • Fattet S, Haberler C, Legoix P et al (2009) Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics. J Pathol 218:86-94. doi:10.1002/path.2514
    • (2009) J Pathol , vol.218 , pp. 86-94
    • Fattet, S.1    Haberler, C.2    Legoix, P.3
  • 7
    • 0031062972 scopus 로고    scopus 로고
    • Developmental functions of mammalian Hox genes
    • Favier B, Dolle P (1997) Developmental functions of mammalian Hox genes. Mol Hum Reprod 3:115-131 (Pubitemid 127509441)
    • (1997) Molecular Human Reproduction , vol.3 , Issue.2 , pp. 115-131
    • Favier, B.1    Dolle, P.2
  • 8
    • 78650811198 scopus 로고    scopus 로고
    • Subtypes of medulloblastoma have distinct developmental origins
    • doi:10.1038/nature09587
    • Gibson P, Tong Y, Robinson G et al (2010) Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095-1099. doi:10.1038/ nature09587
    • (2010) Nature , vol.468 , pp. 1095-1099
    • Gibson, P.1    Tong, Y.2    Robinson, G.3
  • 9
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • DOI 10.1126/science.277.5329.1109
    • Goodrich LV, Milenkovic L, Higgins KM, Scott MP (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277:1109-1113 (Pubitemid 27371635)
    • (1997) Science , vol.277 , Issue.5329 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 10
    • 84862646026 scopus 로고    scopus 로고
    • Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem
    • doi:10.1007/s00401-012-0961-0
    • Grammel D, Warmuth-Metz M, von Bueren AO et al (2012) Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathol 123:601-614. doi:10.1007/s00401-012-0961-0
    • (2012) Acta Neuropathol , vol.123 , pp. 601-614
    • Grammel, D.1    Warmuth-Metz, M.2    Von Bueren, A.O.3
  • 11
    • 0037413703 scopus 로고    scopus 로고
    • Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development
    • DOI 10.1016/S0378111902010910
    • Hershko AY, Kafri T, Fainsod A, Razin A (2003) Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development. Gene 302:65-72 (Pubitemid 36078398)
    • (2003) Gene , vol.302 , Issue.1-2 , pp. 65-72
    • Hershko, A.Y.1    Kafri, T.2    Fainsod, A.3    Razin, A.4
  • 12
    • 77955175049 scopus 로고    scopus 로고
    • Cross-species genomics matches driver mutations and cell compartments to model ependymoma
    • doi:10.1038/nature09173
    • Johnson RA, Wright KD, Poppleton H et al (2010) Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466:632-636. doi:10.1038/nature09173
    • (2010) Nature , vol.466 , pp. 632-636
    • Johnson, R.A.1    Wright, K.D.2    Poppleton, H.3
  • 13
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • DOI 10.1093/biostatistics/kxj037
    • Johnson WE, Li C, Rabinovic A (2007) Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8:118-127. doi:10.1093/biostatistics/kxj037 (Pubitemid 44906106)
    • (2007) Biostatistics , vol.8 , Issue.1 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 14
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • doi:10.1038/nature11284
    • Jones DT, Jäger N, Kool M et al (2012) Dissecting the genomic complexity underlying medulloblastoma. Nature 488:100-105. doi:10.1038/ nature11284
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1    Jäger, N.2    Kool, M.3
  • 15
    • 84857013044 scopus 로고    scopus 로고
    • A mouse model of the most aggressive subgroup of human medulloblastoma
    • doi:10.1016/j.ccr.2011.12.023
    • Kawauchi D, Robinson G, Uziel T et al (2012) A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21:168-180. doi:10.1016/j.ccr.2011.12.023
    • (2012) Cancer Cell , vol.21 , pp. 168-180
    • Kawauchi, D.1    Robinson, G.2    Uziel, T.3
  • 16
    • 79551506231 scopus 로고    scopus 로고
    • Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor
    • doi:10.1523/JNEUROSCI.2166-10.201131/5/1825
    • Kim JJ, Gill PS, Rotin L et al (2011) Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor. J Neurosci 31:1825-1836. doi:10.1523/JNEUROSCI.2166-10.201131/5/1825
    • (2011) J Neurosci , vol.31 , pp. 1825-1836
    • Kim, J.J.1    Gill, P.S.2    Rotin, L.3
  • 17
    • 84863393028 scopus 로고    scopus 로고
    • Molecular subgroups of medulloblastoma: An international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
    • doi:10.1007/s00401-012-0958-8
    • Kool M, Korshunov A, Remke M et al (2012) Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol 123:473-484. doi:10.1007/s00401-012-0958-8
    • (2012) Acta Neuropathol , vol.123 , pp. 473-484
    • Kool, M.1    Korshunov, A.2    Remke, M.3
  • 18
    • 52449119078 scopus 로고    scopus 로고
    • Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    • doi:10.1371/journal.pone.0003088
    • Kool M, Koster J, Bunt J et al (2008) Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE 3:e3088. doi:10.1371/journal.pone. 0003088
    • (2008) PLoS ONE , vol.3
    • Kool, M.1    Koster, J.2    Bunt, J.3
  • 19
    • 84896096387 scopus 로고    scopus 로고
    • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened-inhibition
    • doi:10.1016/j.ccr.2014.02.004
    • Kool M, Jäger N, Northcott P et al (2014) Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened-inhibition. Cancer Cell 25(3):393-405. doi:10.1016/j.ccr.2014.02.004
    • (2014) Cancer Cell , vol.25 , Issue.3 , pp. 393-405
    • Kool, M.1    Jäger, N.2    Northcott, P.3
  • 20
    • 54549083228 scopus 로고    scopus 로고
    • H3K79 methylation profiles define murine and human ML-AF4 leukemias
    • doi:10.1016/j.ccr.2008.10.001
    • Krivtsov AV, Feng Z, Lemieux ME et al (2008) H3K79 methylation profiles define murine and human ML-AF4 leukemias. Cancer Cell 14:355-368. doi:10.1016/j.ccr.2008.10.001
    • (2008) Cancer Cell , vol.14 , pp. 355-368
    • Krivtsov, A.V.1    Feng, Z.2    Lemieux, M.E.3
  • 21
    • 44249093277 scopus 로고    scopus 로고
    • Expression analysis of G Protein-Coupled Receptors in mouse macrophages
    • doi:10.1186/1745-7580-4-5
    • Lattin JE, Schroder K, Su AI et al (2008) Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res 4:5. doi:10.1186/1745-7580-4-5
    • (2008) Immunome Res , vol.4 , pp. 5
    • Lattin, J.E.1    Schroder, K.2    Su, A.I.3
  • 22
    • 84859877199 scopus 로고    scopus 로고
    • Matching mice to malignancy: Molecular subgroups and models of medulloblastoma
    • doi:10.1007/s00381-012-1704-1
    • Lau J, Schmidt C, Markant SL, Taylor MD, Wechsler-Reya RJ, Weiss WA (2012) Matching mice to malignancy: molecular subgroups and models of medulloblastoma. Childs Nerv Syst 28:521-532. doi:10.1007/s00381-012-1704-1
    • (2012) Childs Nerv Syst , vol.28 , pp. 521-532
    • Lau, J.1    Schmidt, C.2    Markant, S.L.3    Taylor, M.D.4    Wechsler-Reya, R.J.5    Weiss, W.A.6
  • 23
    • 77649267695 scopus 로고    scopus 로고
    • Dynamic changes in the human methylome during differentiation
    • doi:10.1101/gr.101907.109
    • Laurent L, Wong E, Li G et al (2010) Dynamic changes in the human methylome during differentiation. Genome Res 20:320-331. doi:10.1101/gr.101907. 109
    • (2010) Genome Res , vol.20 , pp. 320-331
    • Laurent, L.1    Wong, E.2    Li, G.3
  • 24
    • 34848893044 scopus 로고    scopus 로고
    • Loss of suppressor-of-fused function promotes tumorigenesis
    • DOI 10.1038/sj.onc.1210467, PII 1210467
    • Lee Y, Kawagoe R, Sasai K et al (2007) Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 26:6442-6447. doi:10.1038/sj.onc. 1210467 (Pubitemid 47494220)
    • (2007) Oncogene , vol.26 , Issue.44 , pp. 6442-6447
    • Lee, Y.1    Kawagoe, R.2    Sasai, K.3    Li, Y.4    Russell, H.R.5    Curran, T.6    McKinnon, P.J.7
  • 25
    • 84859098571 scopus 로고    scopus 로고
    • The sva package for removing batch effects and other unwanted variation in high-throughput experiments
    • doi:10.1093/bioinformatics/bts034
    • Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD (2012) The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28:882-883. doi:10.1093/ bioinformatics/bts034
    • (2012) Bioinformatics , vol.28 , pp. 882-883
    • Leek, J.T.1    Johnson, W.E.2    Parker, H.S.3    Jaffe, A.E.4    Storey, J.D.5
  • 27
    • 79954553212 scopus 로고    scopus 로고
    • Improving SNP discovery by base alignment quality
    • doi:10.1093/bioinformatics/btr076
    • Li H (2011) Improving SNP discovery by base alignment quality. Bioinformatics 27:1157-1158. doi:10.1093/bioinformatics/btr076
    • (2011) Bioinformatics , vol.27 , pp. 1157-1158
    • Li, H.1
  • 28
    • 68549104404 scopus 로고    scopus 로고
    • The sequence alignment/map format and SAMtools
    • doi:10.1093/bioinformatics/btp352
    • Li H, Handsaker B, Wysoker A et al (2009) The sequence alignment/map format and SAMtools. Bioinformatics 25:2078-2079. doi:10.1093/bioinformatics/ btp352
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1    Handsaker, B.2    Wysoker, A.3
  • 29
    • 84888330535 scopus 로고    scopus 로고
    • A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity
    • doi:10.1038/nn.3553
    • Li P, Du F, Yuelling LW et al (2013) A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nat Neurosci 16:1737-1744. doi:10.1038/nn.3553
    • (2013) Nat Neurosci , vol.16 , pp. 1737-1744
    • Li, P.1    Du, F.2    Yuelling, L.W.3
  • 31
    • 79960842253 scopus 로고    scopus 로고
    • Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
    • Northcott PA, Hielscher T, Dubuc A et al (2011) Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol (Berl) 122:231-240
    • (2011) Acta Neuropathol (Berl) , vol.122 , pp. 231-240
    • Northcott, P.A.1    Hielscher, T.2    Dubuc, A.3
  • 32
    • 84870215426 scopus 로고    scopus 로고
    • Medulloblastomics: The end of the beginning
    • doi:10.1038/nrc3410nrc3410
    • Northcott PA, Jones DT, Kool M et al (2012) Medulloblastomics: the end of the beginning. Nat Rev Cancer 12:818-834. doi:10.1038/nrc3410nrc3410
    • (2012) Nat Rev Cancer , vol.12 , pp. 818-834
    • Northcott, P.A.1    Jones, D.T.2    Kool, M.3
  • 33
    • 79955034739 scopus 로고    scopus 로고
    • Medulloblastoma comprises four distinct molecular variants
    • Northcott PA, Korshunov A, Witt H et al (2011) Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 29:1408-1414
    • (2011) J Clin Oncol , vol.29 , pp. 1408-1414
    • Northcott, P.A.1    Korshunov, A.2    Witt, H.3
  • 34
    • 84864425646 scopus 로고    scopus 로고
    • Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    • doi:10.1038/nature11327
    • Northcott PA, Shih DJ, Peacock J et al (2012) Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 488:49-56. doi:10.1038/nature11327
    • (2012) Nature , vol.488 , pp. 49-56
    • Northcott, P.A.1    Shih, D.J.2    Peacock, J.3
  • 37
    • 84863012675 scopus 로고    scopus 로고
    • An animal model of MYC-driven medulloblastoma
    • doi:10.1016/j.ccr.2011.12.021
    • Pei Y, Moore CE, Wang J et al (2012) An animal model of MYC-driven medulloblastoma. Cancer Cell 21:155-167. doi:10.1016/j.ccr.2011.12.021
    • (2012) Cancer Cell , vol.21 , pp. 155-167
    • Pei, Y.1    Moore, C.E.2    Wang, J.3
  • 38
    • 79960410568 scopus 로고    scopus 로고
    • A procedure to statistically evaluate agreement of differential expression for cross-species genomics
    • doi:10.1093/bioinformatics/btr362
    • Pounds S, Gao CL, Johnson RA et al (2011) A procedure to statistically evaluate agreement of differential expression for cross-species genomics. Bioinformatics 27:2098-2103. doi:10.1093/bioinformatics/btr362
    • (2011) Bioinformatics , vol.27 , pp. 2098-2103
    • Pounds, S.1    Gao, C.L.2    Johnson, R.A.3
  • 39
    • 84864444165 scopus 로고    scopus 로고
    • Novel mutations target distinct subgroups of medulloblastoma
    • doi:10.1038/nature11213
    • Robinson G, Parker M, Kranenburg TA et al (2012) Novel mutations target distinct subgroups of medulloblastoma. Nature 488:43-48. doi:10.1038/nature11213
    • (2012) Nature , vol.488 , pp. 43-48
    • Robinson, G.1    Parker, M.2    Kranenburg, T.A.3
  • 40
    • 79951910309 scopus 로고    scopus 로고
    • Survival and prognostic factors of early childhood medulloblastoma: An international meta-analysis
    • Rutkowski S, von Hoff K, Emser A et al (2010) Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J Clin Oncol 28:4961-4968
    • (2010) J Clin Oncol , vol.28 , pp. 4961-4968
    • Rutkowski, S.1    Von Hoff, K.2    Emser, A.3
  • 41
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    • doi:10.1016/j.ccr.2008.07.005
    • Schüller U, Heine VM, Mao J et al (2008) Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14:123-134. doi:10.1016/j.ccr.2008.07.005
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schüller, U.1    Heine, V.M.2    Mao, J.3
  • 42
    • 0037118586 scopus 로고    scopus 로고
    • HOX gene clusters are hotspots of de novo methylation in CpG islands of human lung adenocarcinomas
    • DOI 10.1038/sj.onc.1205453
    • Shiraishi M, Sekiguchi A, Oates AJ, Terry MJ, Miyamoto Y (2002) HOX gene clusters are hotspots of de novo methylation in CpG islands of human lung adenocarcinomas. Oncogene 21:3659-3662. doi:10.1038/sj.onc.1205453 (Pubitemid 34587698)
    • (2002) Oncogene , vol.21 , Issue.22 , pp. 3659-3662
    • Shiraishi, M.1    Sekiguchi, A.2    Oates, A.J.3    Terry, M.J.4    Miyamoto, Y.5
  • 45
    • 77952375097 scopus 로고    scopus 로고
    • Pleiotropic role for MYCN in medulloblastoma
    • doi:10.1101/gad.190751024/10/1059
    • Swartling FJ, Grimmer MR, Hackett CS et al (2010) Pleiotropic role for MYCN in medulloblastoma. Genes Dev 24:1059-1072. doi:10.1101/gad.190751024/10/ 1059
    • (2010) Genes Dev , vol.24 , pp. 1059-1072
    • Swartling, F.J.1    Grimmer, M.R.2    Hackett, C.S.3
  • 46
    • 84861399134 scopus 로고    scopus 로고
    • Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    • doi:10.1016/j.ccr.2012.04.012
    • Swartling FJ, Savov V, Persson AI et al (2012) Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 21:601-613. doi:10.1016/j.ccr.2012.04.012
    • (2012) Cancer Cell , vol.21 , pp. 601-613
    • Swartling, F.J.1    Savov, V.2    Persson, A.I.3
  • 47
    • 84860821444 scopus 로고    scopus 로고
    • Molecular subgroups of medulloblastoma: The current consensus
    • doi:10.1007/s00401-011-0922-z
    • Taylor MD, Northcott PA, Korshunov A et al (2012) Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 123:465-472. doi:10.1007/s00401-011-0922-z
    • (2012) Acta Neuropathol , vol.123 , pp. 465-472
    • Taylor, M.D.1    Northcott, P.A.2    Korshunov, A.3
  • 49
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
    • doi:10.1093/nar/gkq603gkq603
    • Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38:e164. doi:10.1093/nar/gkq603gkq603
    • (2010) Nucleic Acids Res , vol.38
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 50
    • 84901647519 scopus 로고    scopus 로고
    • Subgroup-specific localization of human medulloblastoma based on preoperative MRI
    • doi:10.1007/s00401-014-1271-5
    • Wefers AK, Warmuth-Metz M, Pöschl J et al (2014) Subgroup-specific localization of human medulloblastoma based on preoperative MRI. Acta Neuropathol 127:931-933. doi:10.1007/s00401-014-1271-5
    • (2014) Acta Neuropathol , vol.127 , pp. 931-933
    • Wefers, A.K.1    Warmuth-Metz, M.2    Pöschl, J.3
  • 51
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T (2001) Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 61:513-516 (Pubitemid 32128609)
    • (2001) Cancer Research , vol.61 , Issue.2 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 52
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • doi:10.1016/j.ccr.2008.07.003
    • Yang ZJ, Ellis T, Markant SL et al (2008) Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14:135-145. doi:10.1016/j.ccr.2008.07.003
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1    Ellis, T.2    Markant, S.L.3
  • 53
    • 84885423998 scopus 로고    scopus 로고
    • Sub-group-specific prognostic implications of TP53 mutation in medulloblastoma
    • doi:10.1200/JCO.2012.48.5052
    • Zhukova N, Ramaswamy V, Remke M et al (2013) Sub-group-specific prognostic implications of TP53 mutation in medulloblastoma. J Clin Oncol 31:2927-2935. doi:10.1200/JCO.2012.48.5052
    • (2013) J Clin Oncol , vol.31 , pp. 2927-2935
    • Zhukova, N.1    Ramaswamy, V.2    Remke, M.3
  • 54
    • 34047263220 scopus 로고    scopus 로고
    • Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors
    • DOI 10.1158/0008-5472.CAN-06-3418
    • Zindy F, Uziel T, Ayrault O et al (2007) Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors. Cancer Res 67:2676-2684. doi:10.1158/0008-5472.CAN- 06-3418 (Pubitemid 46548955)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2676-2684
    • Zindy, F.1    Uziel, T.2    Ayrault, O.3    Calabrese, C.4    Valentine, M.5    Rehg, J.E.6    Gilbertson, R.J.7    Sherr, C.J.8    Roussel, M.F.9


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