Repeatable, inducible micro-RNA-based technology tightly controls liver transgene expression

Molecular Therapy Nucleic Acids

Volumn 3, Issue , 2014, Pages

  Oprea, Iulian I ^a,b   Viola, Joana R ^a   Moreno, Pedro M D ^a   Simonson, Oscar E ^a   Rodin, Sergey ^c   Teller, Nathalie ^d   Tryggvason, Karl ^c   Lundin, Karin E ^a   Girnita, Leonard ^a   Edvard Smith, Carl Inge ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c KAROLINSKA INSTITUTE   (Sweden)

^d EUROGENTEC S A   (Belgium)

Author keywords

cell type specific; liver expression; long term gene expression; reporter system

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTAGOMIR; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; LENTIVIRUS VECTOR; MICRORNA; MICRORNA 122; OLIGONUCLEOTIDE; PLASMID VECTOR; UBIQUITIN C;

3' UNTRANSLATED REGION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DOWN REGULATION; GENE EXPRESSION; GENE TECHNOLOGY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VIVO STUDY; LIVER; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE; UNTRANSLATED REGION; UPREGULATION; ANIMAL MODEL; DNA MODIFICATION; ENHANCER REGION; GENE CONTROL; GENE INDUCTION; LIMIT OF QUANTITATION; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84903771744     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2014.25     Document Type: Article

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