-
1
-
-
48449087282
-
The contributions of Paul Ehrlich to pharmacology: A tribute on the occasion of the centenary of his Nobel Prize
-
Bosch F, Rosich L. The contributions of Paul Ehrlich to pharmacology: a tribute on the occasion of the centenary of his Nobel Prize. Pharmacology 2008;82(3):171-179
-
(2008)
Pharmacology
, vol.82
, Issue.3
, pp. 171-179
-
-
Bosch, F.1
Rosich, L.2
-
2
-
-
36849060584
-
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
-
Brown BD, Gentner B, Cantore A, et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nat Biotechnol 2007;25(12):1457-1467
-
(2007)
Nat Biotechnol
, vol.25
, Issue.12
, pp. 1457-1467
-
-
Brown, B.D.1
Gentner, B.2
Cantore, A.3
-
3
-
-
67651087321
-
Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications
-
Brown BD, Naldini L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat Rev Genet 2009;10(8):578-585
-
(2009)
Nat Rev Genet
, vol.10
, Issue.8
, pp. 578-585
-
-
Brown, B.D.1
Naldini, L.2
-
4
-
-
44449145951
-
Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery
-
Wooddell CI, Reppen T, Wolff JA, Herweijer H. Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery. J Gene Med 2008;10(5):551-563
-
(2008)
J Gene Med
, vol.10
, Issue.5
, pp. 551-563
-
-
Wooddell, C.I.1
Reppen, T.2
Wolff, J.A.3
Herweijer, H.4
-
5
-
-
8944253295
-
Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
-
Sato Y, Roman M, Tighe H, et al. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996;273(5273):352-354
-
(1996)
Science
, vol.273
, Issue.5273
, pp. 352-354
-
-
Sato, Y.1
Roman, M.2
Tighe, H.3
-
6
-
-
67651102609
-
Gene transfer to mouse heart and skeletal muscles using a minicircle expressing human vascular endothelial growth factor
-
Stenler S, Andersson A, Simonson OE, et al. Gene transfer to mouse heart and skeletal muscles using a minicircle expressing human vascular endothelial growth factor. J Cardiovasc Pharmacol 2009;53(1):18-23
-
(2009)
J Cardiovasc Pharmacol
, vol.53
, Issue.1
, pp. 18-23
-
-
Stenler, S.1
Andersson, A.2
Simonson, O.E.3
-
7
-
-
77249156215
-
Functional efficacy of dystrophin expression from plasmids delivered to mdx mice by hydrodynamic limb vein injection
-
Zhang G, Wooddell CI, Hegge JO, et al. Functional efficacy of dystrophin expression from plasmids delivered to mdx mice by hydrodynamic limb vein injection. Hum Gene Ther 2010;21(2):221-237
-
(2010)
Hum Gene Ther
, vol.21
, Issue.2
, pp. 221-237
-
-
Zhang, G.1
Wooddell, C.I.2
Hegge, J.O.3
-
8
-
-
70249090327
-
Characterization and performance of nucleic acid nanoparticles combined with protamine and gold
-
DeLong RK, Akhtar U, Sallee M, et al. Characterization and performance of nucleic acid nanoparticles combined with protamine and gold. Biomaterials 2009;30(32):6451-6459
-
(2009)
Biomaterials
, vol.30
, Issue.32
, pp. 6451-6459
-
-
De Long, R.K.1
Akhtar, U.2
Sallee, M.3
-
9
-
-
70349783020
-
Tailoring the surface potential of gold nanoparticles with self-assembled monolayers with mixed functional groups
-
Lin YC, Yu BY, Lin WC, et al. Tailoring the surface potential of gold nanoparticles with self-assembled monolayers with mixed functional groups. J Colloid Interface Sci 2009;340(1):126-130
-
(2009)
J Colloid Interface Sci
, vol.340
, Issue.1
, pp. 126-130
-
-
Lin, Y.C.1
Yu, B.Y.2
Lin, W.C.3
-
10
-
-
70350780521
-
Nanoparticle-mediated gene delivery
-
Jin S, Leach JC, Ye K. Nanoparticle-mediated gene delivery. Methods Mol Biol 2009;544:547-557
-
(2009)
Methods Mol Biol
, vol.544
, pp. 547-557
-
-
Jin, S.1
Leach, J.C.2
Ye, K.3
-
11
-
-
33847353779
-
Non-ionic amphiphilic biodegradable PEG-PLGA-PEG copolymer enhances gene delivery efficiency in rat skeletal muscle
-
Chang CW, Choi D, Kim WJ, et al. Non-ionic amphiphilic biodegradable PEG-PLGA-PEG copolymer enhances gene delivery efficiency in rat skeletal muscle. J Control Release 2007;118(2):245-253
-
(2007)
J Control Release
, vol.118
, Issue.2
, pp. 245-253
-
-
Chang, C.W.1
Choi, D.2
Kim, W.J.3
-
12
-
-
73849083445
-
Fatty acid-spermine conjugates as DNA carriers for nonviral in vivo gene delivery
-
Viola JR, Leijonmarck H, Simonson OE, et al. Fatty acid-spermine conjugates as DNA carriers for nonviral in vivo gene delivery. Gene Ther 2009;16(12):1429-1440
-
(2009)
Gene Ther
, vol.16
, Issue.12
, pp. 1429-1440
-
-
Viola, J.R.1
Leijonmarck, H.2
Simonson, O.E.3
-
13
-
-
75349114584
-
Chemically modified cell-penetrating peptides for the delivery of nucleic acids
-
Mae M, Andaloussi SE, Lehto T, Langel U. Chemically modified cell-penetrating peptides for the delivery of nucleic acids. Expert Opin Drug Deliv 2009;6(11):1195-1205
-
(2009)
Expert Opin Drug Deliv
, vol.6
, Issue.11
, pp. 1195-1205
-
-
Mae, M.1
Andaloussi, S.E.2
Lehto, T.3
Langel, U.4
-
14
-
-
68549130637
-
Chemical vectors for gene delivery: A current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
-
Midoux P, Pichon C, Yaouanc JJ, Jaffres PA. Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. Br J Pharmacol 2009;157(2):166-178
-
(2009)
Br J Pharmacol
, vol.157
, Issue.2
, pp. 166-178
-
-
Midoux, P.1
Pichon, C.2
Yaouanc, J.J.3
Jaffres, P.A.4
-
15
-
-
14044252938
-
Toward synthetic viruses: Endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo
-
Walker GF, Fella C, Pelisek J, et al. Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. Mol Ther 2005;11(3):418-425
-
(2005)
Mol Ther
, vol.11
, Issue.3
, pp. 418-425
-
-
Walker, G.F.1
Fella, C.2
Pelisek, J.3
-
16
-
-
65749110643
-
Tissue-specific and transcription factor-mediated nuclear entry of DNA
-
Miller AM, Dean DA. Tissue-specific and transcription factor-mediated nuclear entry of DNA. Adv Drug Deliv Rev 2009;61(7-8):603-613
-
(2009)
Adv Drug Deliv Rev
, vol.61
, Issue.7-8
, pp. 603-613
-
-
Miller, A.M.1
Dean, D.A.2
-
17
-
-
64549148800
-
A synthetic snRNA m3G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids
-
Moreno PM, Wenska M, Lundin KE, et al. A synthetic snRNA m3G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids. Nucleic Acids Res 2009;37(6):1925-1935
-
(2009)
Nucleic Acids Res
, vol.37
, Issue.6
, pp. 1925-1935
-
-
Moreno, P.M.1
Wenska, M.2
Lundin, K.E.3
-
18
-
-
0032859928
-
A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA
-
Branden LJ, Mohamed AJ, Smith CI. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA. Nat Biotechnol 1999;17(8):784-787
-
(1999)
Nat Biotechnol
, vol.17
, Issue.8
, pp. 784-787
-
-
Branden, L.J.1
Mohamed, A.J.2
Smith, C.I.3
-
19
-
-
68949208465
-
Nanocarriers' entry into the cell: Relevance to drug delivery
-
Hillaireau H, Couvreur P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell Mol Life Sci 2009;66(17):2873-2896
-
(2009)
Cell Mol Life Sci
, vol.66
, Issue.17
, pp. 2873-2896
-
-
Hillaireau, H.1
Couvreur, P.2
-
20
-
-
52049110535
-
Advances in non-viral gene delivery: Using multifunctional envelope-type nano-device
-
Akita H, Harashima H. Advances in non-viral gene delivery: using multifunctional envelope-type nano-device. Expert Opin Drug Deliv 2008;5(8):847-859
-
(2008)
Expert Opin Drug Deliv
, vol.5
, Issue.8
, pp. 847-859
-
-
Akita, H.1
Harashima, H.2
-
22
-
-
0031447208
-
DNA condensation by multivalent cations
-
Bloomfield VA. DNA condensation by multivalent cations. Biopolymers 1997;44(3):269-282
-
(1997)
Biopolymers
, vol.44
, Issue.3
, pp. 269-282
-
-
Bloomfield, V.A.1
-
23
-
-
0034647016
-
Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes
-
Geall AJ, Blagbrough IS. Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes. Tetrahedron 2000;56(16):2449-2460
-
(2000)
Tetrahedron
, vol.56
, Issue.16
, pp. 2449-2460
-
-
Geall, A.J.1
Blagbrough, I.S.2
-
24
-
-
21244438799
-
Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse
-
Patel MM, Anchordoquy TJ. Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse. Biophys J 2005;88(3):2089-2103
-
(2005)
Biophys J
, vol.88
, Issue.3
, pp. 2089-2103
-
-
Patel, M.M.1
Anchordoquy, T.J.2
-
25
-
-
70849111210
-
Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy
-
Lehto T, Abes R, Oskolkov N, et al. Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy. J Control Release 2009;141(1):42-51
-
(2009)
J Control Release
, vol.141
, Issue.1
, pp. 42-51
-
-
Lehto, T.1
Abes, R.2
Oskolkov, N.3
-
26
-
-
61349197462
-
A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy
-
Mäe M, El Andaloussi S, Lundin P, et al. A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy. J Control Release 2009;134(3):221-227
-
(2009)
J Control Release
, vol.134
, Issue.3
, pp. 221-227
-
-
Mäe, M.1
El Andaloussi, S.2
Lundin, P.3
-
27
-
-
34547778409
-
Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing
-
Marshall NB, Oda SK, London CA, et al. Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing. J Immunol Methods 2007;325(1-2):114-126
-
(2007)
J Immunol Methods
, vol.325
, Issue.1-2
, pp. 114-126
-
-
Marshall, N.B.1
Oda, S.K.2
London, C.A.3
-
28
-
-
33645242923
-
Pluronic block copolymers for gene delivery
-
Kabanov A, Zhu J, Alakhov V. Pluronic block copolymers for gene delivery. Adv Genet 2005;53:231-261
-
(2005)
Adv Genet
, vol.53
, pp. 231-261
-
-
Kabanov, A.1
Zhu, J.2
Alakhov, V.3
-
29
-
-
33748451104
-
Colloidal stability of pluronic F68-coated PLGA nanoparticles: A variety of stabilisation mechanisms
-
Santander-Ortega MJ, Jodar-Reyes AB, Csaba N, et al. Colloidal stability of pluronic F68-coated PLGA nanoparticles: a variety of stabilisation mechanisms. J Colloid Interface Sci 2006;302(2):522-529
-
(2006)
J Colloid Interface Sci
, vol.302
, Issue.2
, pp. 522-529
-
-
Santander-Ortega, M.J.1
Jodar-Reyes, A.B.2
Csaba, N.3
-
30
-
-
77951673784
-
SANS from P85/Water-d under pressure
-
[Epub ahead of print]
-
Clover B, Hammouda B. SANS from P85/Water-d under pressure. Langmuir 2010 [Epub ahead of print]
-
(2010)
Langmuir
-
-
Clover, B.1
Hammouda, B.2
-
31
-
-
68249095090
-
DNA/amphiphilic block copolymer nanospheres promote low-dose DNA vaccination
-
McIlroy D, Barteau B, Cany J, et al. DNA/amphiphilic block copolymer nanospheres promote low-dose DNA vaccination. Mol Ther 2009;17(8):1473-1481
-
(2009)
Mol Ther
, vol.17
, Issue.8
, pp. 1473-1481
-
-
McIlroy, D.1
Barteau, B.2
Cany, J.3
-
32
-
-
49749101644
-
Pluronic block copolymers: Evolution of drug delivery concept from inert nanocarriers to biological response modifiers
-
Batrakova EV, Kabanov AV. Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers. J Control Release 2008;130(2):98-106
-
(2008)
J Control Release
, vol.130
, Issue.2
, pp. 98-106
-
-
Batrakova, E.V.1
Kabanov, A.V.2
-
33
-
-
67650553288
-
Parameters affecting organization and transfection efficiency of amphiphilic copolymers/DNA carriers
-
Roques C, Bouchemal K, Ponchel G, et al. Parameters affecting organization and transfection efficiency of amphiphilic copolymers/DNA carriers. J Control Release 2009;138(1):71-77
-
(2009)
J Control Release
, vol.138
, Issue.1
, pp. 71-77
-
-
Roques, C.1
Bouchemal, K.2
Ponchel, G.3
-
34
-
-
33847694963
-
Contribution of high-resolution correlative imaging techniques in the study of the liver sieve in three-dimensions
-
Braet F, Wisse E, Bomans P, et al. Contribution of high-resolution correlative imaging techniques in the study of the liver sieve in three-dimensions. Microsc Res Tech 2007;70(3):230-242
-
(2007)
Microsc Res Tech
, vol.70
, Issue.3
, pp. 230-242
-
-
Braet, F.1
Wisse, E.2
Bomans, P.3
-
35
-
-
33646900167
-
Linear topology confers in vivo gene transfer activity to polyethylenimines
-
Brissault B, Leborgne C, Guis C, et al. Linear topology confers in vivo gene transfer activity to polyethylenimines. Bioconjug Chem 2006;17(3):759-765
-
(2006)
Bioconjug Chem
, vol.17
, Issue.3
, pp. 759-765
-
-
Brissault, B.1
Leborgne, C.2
Guis, C.3
-
36
-
-
70449096070
-
Drug nanocarriers labeled with near-infrared-emitting quantum dots (quantoplexes): Imaging fast dynamics of distribution in living animals
-
Zintchenko A, Susha AS, Concia M, et al. Drug nanocarriers labeled with near-infrared-emitting quantum dots (quantoplexes): imaging fast dynamics of distribution in living animals. Mol Ther 2009;17(11):1849-1856
-
(2009)
Mol Ther
, vol.17
, Issue.11
, pp. 1849-1856
-
-
Zintchenko, A.1
Susha, A.S.2
Concia, M.3
-
37
-
-
70649098228
-
Tissue-specific gene delivery via nanoparticle coating
-
Harris TJ, Green JJ, Fung PW, et al. Tissue-specific gene delivery via nanoparticle coating. Biomaterials 2009;31(5):998-1006
-
(2009)
Biomaterials
, vol.31
, Issue.5
, pp. 998-1006
-
-
Harris, T.J.1
Green, J.J.2
Fung, P.W.3
-
38
-
-
61849103493
-
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes
-
Malek A, Merkel O, Fink L, et al. In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes. Toxicol Appl Pharmacol 2009;236(1):97-108
-
(2009)
Toxicol Appl Pharmacol
, vol.236
, Issue.1
, pp. 97-108
-
-
Malek, A.1
Merkel, O.2
Fink, L.3
-
39
-
-
77249179341
-
Gene expression in lung and liver after intravenous infusion of polyethyleneimine complexes and hydrodynamic delivery of sleeping beauty transposons
-
Hackett PB, Podetz-Petersen KM, Bell JB, et al. Gene expression in lung and liver after intravenous infusion of polyethyleneimine complexes and hydrodynamic delivery of sleeping beauty transposons. Hum Gene Ther 2010;21(2):210-220
-
(2010)
Hum Gene Ther
, vol.21
, Issue.2
, pp. 210-220
-
-
Hackett, P.B.1
Podetz-Petersen, K.M.2
Bell, J.B.3
-
40
-
-
59249088227
-
Physicochemical parameters of non-viral vectors that govern transfection efficiency
-
Barteau B, Chevre R, Letrou-Bonneval E, et al. Physicochemical parameters of non-viral vectors that govern transfection efficiency. Curr Gene Ther 2008;8(5):313-323
-
(2008)
Curr Gene Ther
, vol.8
, Issue.5
, pp. 313-323
-
-
Barteau, B.1
Chevre, R.2
Letrou-Bonneval, E.3
-
41
-
-
75349114023
-
Recent trends in stabilising peptides and proteins in pharmaceutical formulation--considerations in the choice of excipients
-
Jorgensen L, Hostrup S, Moeller EH, Grohganz H. Recent trends in stabilising peptides and proteins in pharmaceutical formulation--considerations in the choice of excipients. Expert Opin Drug Deliv 2009;6(11):1219-1230
-
(2009)
Expert Opin Drug Deliv
, vol.6
, Issue.11
, pp. 1219-1230
-
-
Jorgensen, L.1
Hostrup, S.2
Moeller, E.H.3
Grohganz, H.4
-
42
-
-
22644444670
-
PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice
-
Merdan T, Kunath K, Petersen H, et al. PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconjug Chem 2005;16(4):785-792
-
(2005)
Bioconjug Chem
, vol.16
, Issue.4
, pp. 785-792
-
-
Merdan, T.1
Kunath, K.2
Petersen, H.3
-
43
-
-
68249122805
-
Nonviral siRNA delivery to the lung: Investigation of PEG-PEI polyplexes and their in vivo performance
-
Merkel OM, Beyerle A, Librizzi D, et al. Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Mol Pharm 2009;6(4):1246-1260
-
(2009)
Mol Pharm
, vol.6
, Issue.4
, pp. 1246-1260
-
-
Merkel, O.M.1
Beyerle, A.2
Librizzi, D.3
-
44
-
-
0037320758
-
Recharging cationic DNA complexes with highly charged polyanions for in vitro and in vivo gene delivery
-
Trubetskoy VS, Wong SC, Subbotin V, et al. Recharging cationic DNA complexes with highly charged polyanions for in vitro and in vivo gene delivery. Gene Ther 2003;10(3):261-271
-
(2003)
Gene Ther
, vol.10
, Issue.3
, pp. 261-271
-
-
Trubetskoy, V.S.1
Wong, S.C.2
Subbotin, V.3
-
45
-
-
33847127824
-
Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically
-
Eliyahu H, Joseph A, Schillemans JP, et al. Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically. Biomaterials 2007;28(14):2339-2349
-
(2007)
Biomaterials
, vol.28
, Issue.14
, pp. 2339-2349
-
-
Eliyahu, H.1
Joseph, A.2
Schillemans, J.P.3
-
46
-
-
57349086242
-
RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response
-
Zhang W, Tripp RA. RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response. J Virol 2008;82(24):12221-12231
-
(2008)
J Virol
, vol.82
, Issue.24
, pp. 12221-12231
-
-
Zhang, W.1
Tripp, R.A.2
-
47
-
-
77952729474
-
Formulation and delivery of splice-correction antisense oligonucleotides by amino acid-modified polyethylenimine
-
[Epub ahead of print]
-
Zaghloul EM, Viola JR, Zuber G, et al. Formulation and delivery of splice-correction antisense oligonucleotides by amino acid-modified polyethylenimine. Mol Pharm 2010. [Epub ahead of print]
-
(2010)
Mol Pharm
-
-
Zaghloul, E.M.1
Viola, J.R.2
Zuber, G.3
-
48
-
-
58149400636
-
Self-assembling polyethylenimine derivatives mediate efficient siRNA delivery in mammalian cells
-
Creusat G, Zuber G. Self-assembling polyethylenimine derivatives mediate efficient siRNA delivery in mammalian cells. Chembiochem 2008;9(17):2787-2789
-
(2008)
Chembiochem
, vol.9
, Issue.17
, pp. 2787-2789
-
-
Creusat, G.1
Zuber, G.2
-
49
-
-
51049092308
-
Factors affecting the clearance and biodistribution of polymeric nanoparticles
-
Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 2008;5(4):505-515
-
(2008)
Mol Pharm
, vol.5
, Issue.4
, pp. 505-515
-
-
Alexis, F.1
Pridgen, E.2
Molnar, L.K.3
Farokhzad, O.C.4
-
50
-
-
0037270571
-
Poly(cationic lipid)-mediated in vivo gene delivery to mouse liver
-
Liu L, Zern MA, Lizarzaburu ME, et al. Poly(cationic lipid)-mediated in vivo gene delivery to mouse liver. Gene Ther 2003;10(2):180-751.
-
(2003)
Gene Ther
, vol.10
, Issue.2
, pp. 180-751
-
-
Liu, L.1
Zern, M.A.2
Lizarzaburu, M.E.3
-
51
-
-
71249126138
-
Physico-chemical characterization of polylipid nanoparticles for gene delivery to the liver
-
Nyunt MT, Dicus CW, Cui YY, et al. Physico-chemical characterization of polylipid nanoparticles for gene delivery to the liver. Bioconjug Chem 2009;20(11):2047-2054
-
(2009)
Bioconjug Chem
, vol.20
, Issue.11
, pp. 2047-2054
-
-
Nyunt, M.T.1
Dicus, C.W.2
Cui, Y.Y.3
-
52
-
-
0035081658
-
Cationic lipid polymerization as a novel approach for constructing new DNA delivery agents
-
Wu J, Lizarzaburu ME, Kurth MJ, et al. Cationic lipid polymerization as a novel approach for constructing new DNA delivery agents. Bioconjug Chem 2001;12(2):251-257
-
(2001)
Bioconjug Chem
, vol.12
, Issue.2
, pp. 251-257
-
-
Wu, J.1
Lizarzaburu, M.E.2
Kurth, M.J.3
-
53
-
-
0025341615
-
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
-
Klibanov AL, Maruyama K, Torchilin VP, Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett 1990;268(1):235-237
-
(1990)
FEBS Lett
, vol.268
, Issue.1
, pp. 235-237
-
-
Klibanov, A.L.1
Maruyama, K.2
Torchilin, V.P.3
Huang, L.4
-
54
-
-
71049193822
-
PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: Structure-function relationships
-
Beyerle A, Merkel O, Stoeger T, Kissel T. PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: structure-function relationships. Toxicol Appl Pharmacol 2009;242(2):146-154
-
(2009)
Toxicol Appl Pharmacol
, vol.242
, Issue.2
, pp. 146-154
-
-
Beyerle, A.1
Merkel, O.2
Stoeger, T.3
Kissel, T.4
-
55
-
-
0036293628
-
The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice
-
Kunath K, von Harpe A, Petersen H, et al. The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice. Pharm Res 2002;19(6):810-817
-
(2002)
Pharm Res
, vol.19
, Issue.6
, pp. 810-817
-
-
Kunath, K.1
Von Harpe, A.2
Petersen, H.3
-
56
-
-
73349127843
-
Control of the in vivo biodistribution of hybrid nanoparticles with different poly (ethylene glycol) coatings
-
Faure AC, Dufort S, Josserand V, et al. Control of the in vivo biodistribution of hybrid nanoparticles with different poly (ethylene glycol) coatings. Small 2009;5(22):2565-2575
-
(2009)
Small
, vol.5
, Issue.22
, pp. 2565-2575
-
-
Faure, A.C.1
Dufort, S.2
Josserand, V.3
-
57
-
-
70449526181
-
Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers
-
Kojima C, Regino C, Umeda Y, et al. Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers. Int J Pharm 2010;383(1-2):293-296
-
(2010)
Int J Pharm
, vol.383
, Issue.1-2
, pp. 293-296
-
-
Kojima, C.1
Regino, C.2
Umeda, Y.3
-
58
-
-
33845625261
-
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
-
DOI 10.1038/sj.gt.3302843, PII 3302843
-
Hatakeyama H, Akita H, Kogure K, et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther 2007;14(1):68-77 (Pubitemid 44942867)
-
(2007)
Gene Therapy
, vol.14
, Issue.1
, pp. 68-77
-
-
Hatakeyama, H.1
Akita, H.2
Kogure, K.3
Oishi, M.4
Nagasaki, Y.5
Kihira, Y.6
Ueno, M.7
Kobayashi, H.8
Kikuchi, H.9
Harashima, H.10
-
59
-
-
70350728656
-
Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting
-
Morille M, Montier T, Legras P, et al. Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. Biomaterials 2010;31(2):321-329
-
(2010)
Biomaterials
, vol.31
, Issue.2
, pp. 321-329
-
-
Morille, M.1
Montier, T.2
Legras, P.3
-
60
-
-
64749104933
-
Nanoparticles for human liver-specific drug and gene delivery systems: In vitro and in vivo advances
-
Kasuya T, Kuroda S. Nanoparticles for human liver-specific drug and gene delivery systems: in vitro and in vivo advances. Expert Opin Drug Deliv 2009;6(1):39-52
-
(2009)
Expert Opin Drug Deliv
, vol.6
, Issue.1
, pp. 39-52
-
-
Kasuya, T.1
Kuroda, S.2
-
61
-
-
0036225362
-
Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
-
Oupicky D, Ogris M, Howard KA, et al. Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol Ther 2002;5(4):463-472
-
(2002)
Mol Ther
, vol.5
, Issue.4
, pp. 463-472
-
-
Oupicky, D.1
Ogris, M.2
Howard, K.A.3
-
62
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek J, Akinc A, Bramlage B, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004;432(7014):173-178
-
(2004)
Nature
, vol.432
, Issue.7014
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
-
63
-
-
67349183756
-
Development of lipidoid-siRNA formulations for systemic delivery to the liver
-
Akinc A, Goldberg M, Qin J, et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol Ther 2009;17(5):872-879
-
(2009)
Mol Ther
, vol.17
, Issue.5
, pp. 872-879
-
-
Akinc, A.1
Goldberg, M.2
Qin, J.3
-
65
-
-
0035830624
-
Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: Formation of novel small multilamellar vesicle structures
-
Semple SC, Klimuk SK, Harasym TO, et al. Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochim Biophys Acta 2001;1510(1-2):152-166
-
(2001)
Biochim Biophys Acta
, vol.1510
, Issue.1-2
, pp. 152-166
-
-
Semple, S.C.1
Klimuk, S.K.2
Harasym, T.O.3
-
66
-
-
28444469246
-
Silencing of microRNAs in vivo with 'antagomirs'
-
Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;438(7068):685-689
-
(2005)
Nature
, vol.438
, Issue.7068
, pp. 685-689
-
-
Krutzfeldt, J.1
Rajewsky, N.2
Braich, R.3
-
67
-
-
57749168828
-
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
-
Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;456(7224):980-984
-
(2008)
Nature
, vol.456
, Issue.7224
, pp. 980-984
-
-
Thum, T.1
Gross, C.2
Fiedler, J.3
-
68
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
Akinc A, Zumbuehl A, Goldberg M, et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol 2008;26(5):561-569
-
(2008)
Nat Biotechnol
, vol.26
, Issue.5
, pp. 561-569
-
-
Akinc, A.1
Zumbuehl, A.2
Goldberg, M.3
-
69
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci USA 2008;105(33):11915-11920
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.33
, pp. 11915-11920
-
-
Frank-Kamenetsky, M.1
Grefhorst, A.2
Anderson, N.N.3
-
70
-
-
39549101284
-
Delivering silence: Advancements in developing siRNA therapeutics
-
Novobrantseva TI, Akinc A, Borodovsky A, de Fougerolles A. Delivering silence: advancements in developing siRNA therapeutics. Curr Opin Drug Discov Devel 2008;11(2):217-224
-
(2008)
Curr Opin Drug Discov Devel
, vol.11
, Issue.2
, pp. 217-224
-
-
Novobrantseva, T.I.1
Akinc, A.2
Borodovsky, A.3
De Fougerolles, A.4
-
71
-
-
58149091387
-
Distinct uptake routes of cell-penetrating peptide conjugates
-
Lundin P, Johansson H, Guterstam P, et al. Distinct uptake routes of cell-penetrating peptide conjugates. Bioconjug Chem 2008;19(12):2535-2542
-
(2008)
Bioconjug Chem
, vol.19
, Issue.12
, pp. 2535-2542
-
-
Lundin, P.1
Johansson, H.2
Guterstam, P.3
-
72
-
-
76649098887
-
Lipid-like materials for low-dose, in vivo gene silencing
-
Love K, Mahon KP, Levins CG, et al. Lipid-like materials for low-dose, in vivo gene silencing. PNAS 2010;107(5):1864-1869
-
(2010)
PNAS
, vol.107
, Issue.5
, pp. 1864-1869
-
-
Love, K.1
Mahon, K.P.2
Levins, C.G.3
-
73
-
-
4444379133
-
Nanoparticle and targeted systems for cancer therapy
-
Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 2004;56(11):1649-1659
-
(2004)
Adv Drug Deliv Rev
, vol.56
, Issue.11
, pp. 1649-1659
-
-
Brannon-Peppas, L.1
Blanchette, J.O.2
-
74
-
-
65549105188
-
Cancer-specific transgene expression mediated by systemic injection of nanoparticles
-
Chisholm EJ, Vassaux G, Martin-Duque P, et al. Cancer-specific transgene expression mediated by systemic injection of nanoparticles. Cancer Res 2009;69(6):2655-2662
-
(2009)
Cancer Res
, vol.69
, Issue.6
, pp. 2655-2662
-
-
Chisholm, E.J.1
Vassaux, G.2
Martin-Duque, P.3
-
75
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46(12 Pt 1):6387-6392
-
(1986)
Cancer Res
, vol.46
, Issue.12 PART 1
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
76
-
-
0038064402
-
Tumor-targeted gene transfer with DNA polyplexes
-
Ogris M, Wagner E. Tumor-targeted gene transfer with DNA polyplexes. Somat Cell Mol Genet 2002;27(1-6):85-95
-
(2002)
Somat Cell Mol Genet
, vol.27
, Issue.1-6
, pp. 85-95
-
-
Ogris, M.1
Wagner, E.2
-
77
-
-
76049111642
-
Improved in vivo gene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes
-
Russ V, Frohlich T, Li Y, et al. Improved in vivo gene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes. J Gene Med 2010;12(2):180-193
-
(2010)
J Gene Med
, vol.12
, Issue.2
, pp. 180-193
-
-
Russ, V.1
Frohlich, T.2
Li, Y.3
-
78
-
-
75749098035
-
HPMA copolymer-cyclic RGD conjugates for tumor targeting
-
Pike DB, Ghandehari H. HPMA copolymer-cyclic RGD conjugates for tumor targeting. Adv Drug Deliv Rev 2010;62(2):167-183
-
(2010)
Adv Drug Deliv Rev
, vol.62
, Issue.2
, pp. 167-183
-
-
Pike, D.B.1
Ghandehari, H.2
-
79
-
-
76249096258
-
RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy
-
Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010;7(1):94-104
-
(2010)
Mol Pharm
, vol.7
, Issue.1
, pp. 94-104
-
-
Li, Z.1
Huang, P.2
Zhang, X.3
-
80
-
-
77953503310
-
RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe
-
[Epub ahead of print]
-
Chen W, Jarzyna PA, van Tilborg GA, et al. RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe. FASEB J 2010. [Epub ahead of print]
-
(2010)
FASEB J
-
-
Chen, W.1
Jarzyna, P.A.2
Van Tilborg, G.A.3
-
81
-
-
56249097260
-
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt (IV) prodrug-PLGA-PEG nanoparticles
-
Dhar S, Gu FX, Langer R, et al. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt (IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci USA 2008;105(45):17356-17361
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.45
, pp. 17356-17361
-
-
Dhar, S.1
Gu, F.X.2
Langer, R.3
-
82
-
-
70249110439
-
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
-
Dassie JP, Liu XY, Thomas GS, et al. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol 2009;27(9):839-849
-
(2009)
Nat Biotechnol
, vol.27
, Issue.9
, pp. 839-849
-
-
Dassie, J.P.1
Liu, X.Y.2
Thomas, G.S.3
-
83
-
-
70349501374
-
Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles
-
Huang R, Han L, Li J, et al. Neuroprotection in a 6-hydroxydopamine- lesioned Parkinson model using lactoferrin-modified nanoparticles. J Gene Med 2009;11(9):754-763
-
(2009)
J Gene Med
, vol.11
, Issue.9
, pp. 754-763
-
-
Huang, R.1
Han, L.2
Li, J.3
-
84
-
-
72049105345
-
Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles
-
Huang R, Ke W, Han L, et al. Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles. J Cereb Blood Flow Metab 2009;29(12):1914-1923
-
(2009)
J Cereb Blood Flow Metab
, vol.29
, Issue.12
, pp. 1914-1923
-
-
Huang, R.1
Ke, W.2
Han, L.3
-
85
-
-
74849115546
-
Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model
-
Huang R, Ke W, Liu Y, et al. Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model. J Neurol Sci 2010;290(1-2):123-130
-
(2010)
J Neurol Sci
, vol.290
, Issue.1-2
, pp. 123-130
-
-
Huang, R.1
Ke, W.2
Liu, Y.3
-
86
-
-
33947625559
-
Efficient gene delivery targeted to the brain using a transferrin-conjugated polyehtyleneglycol-modified polyamidoamine dendrimer
-
Huang R-Q, Qu Y-H, Ke W-L, et al. Efficient gene delivery targeted to the brain using a transferrin-conjugated polyehtyleneglycol-modified polyamidoamine dendrimer. FASEB J 2007;21:1117-1125
-
(2007)
FASEB J
, vol.21
, pp. 1117-1125
-
-
Huang, R.-Q.1
Qu, Y.-H.2
Ke, W.-L.3
-
87
-
-
70350200866
-
Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer
-
Ke W, Shao K, Huang R, et al. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials 2009;30(36):6976-6985
-
(2009)
Biomaterials
, vol.30
, Issue.36
, pp. 6976-6985
-
-
Ke, W.1
Shao, K.2
Huang, R.3
-
88
-
-
34547637590
-
Drug targeting to the brain
-
Pardridge WM. Drug targeting to the brain. Pharm Res 2007;24(9):1733-1744
-
(2007)
Pharm Res
, vol.24
, Issue.9
, pp. 1733-1744
-
-
Pardridge, W.M.1
-
89
-
-
66149130750
-
Differential receptor-mediated drug targeting to the diseased brain
-
Rip J, Schenk GJ, de Boer AG. Differential receptor-mediated drug targeting to the diseased brain. Expert Opin Drug Deliv 2009;6(3):227-237
-
(2009)
Expert Opin Drug Deliv
, vol.6
, Issue.3
, pp. 227-237
-
-
Rip, J.1
Schenk, G.J.2
De Boer, A.G.3
-
90
-
-
61549096099
-
Selective or targeted gene/drug delivery for liver tumors: Advantages and current status of local delivery
-
Kim YI, Chung JW. Selective or targeted gene/drug delivery for liver tumors: advantages and current status of local delivery. Expert Rev Gastroenterol Hepatol 2008;2(6):791-802
-
(2008)
Expert Rev Gastroenterol Hepatol
, vol.2
, Issue.6
, pp. 791-802
-
-
Kim, Y.I.1
Chung, J.W.2
-
91
-
-
66449094611
-
Nano-vectors for efficient liver specific gene transfer
-
Pathak A, Vyas SP, Gupta KC. Nano-vectors for efficient liver specific gene transfer. Int J Nanomedicine 2008;3(1):31-49
-
(2008)
Int J Nanomedicine
, vol.3
, Issue.1
, pp. 31-49
-
-
Pathak, A.1
Vyas, S.P.2
Gupta, K.C.3
-
92
-
-
0023811723
-
Receptor-mediated gene delivery and expression in vivo
-
Wu GY, Wu CH. Receptor-mediated gene delivery and expression in vivo. J Biol Chem 1988;263(29):14621-14624
-
(1988)
J Biol Chem
, vol.263
, Issue.29
, pp. 14621-14624
-
-
Wu, G.Y.1
Wu, C.H.2
-
93
-
-
0037268894
-
Increased receptor-mediated gene delivery to the liver by protamineenhanced- asialofetuin-lipoplexes
-
Arangoa MA, Duzgunes N, Tros de Ilarduya C. Increased receptor-mediated gene delivery to the liver by protamineenhanced- asialofetuin-lipoplexes. Gene Ther 2003;10(1):5-14
-
(2003)
Gene Ther
, vol.10
, Issue.1
, pp. 5-14
-
-
Arangoa, M.A.1
Duzgunes, N.2
De Ilarduya, T.C.3
-
94
-
-
58149182882
-
Galactosylated multimodular lipoplexes for specific gene transfer into primary hepatocytes
-
Letrou-Bonneval E, Chevre R, Lambert O, et al. Galactosylated multimodular lipoplexes for specific gene transfer into primary hepatocytes. J Gene Med 2008;10(11):1198-1209
-
(2008)
J Gene Med
, vol.10
, Issue.11
, pp. 1198-1209
-
-
Letrou-Bonneval, E.1
Chevre, R.2
Lambert, O.3
-
95
-
-
59449091692
-
In vivo targeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma
-
Diez S, Navarro G, de ICT. In vivo targeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma. J Gene Med 2009;11(1):38-45
-
(2009)
J Gene Med
, vol.11
, Issue.1
, pp. 38-45
-
-
Diez, S.1
De Ict Navarro, G.2
-
96
-
-
0347917178
-
A new peptide ligand that targets particles and heterologous proteins to hepatocytes in vivo
-
Sokoloff AV, Wong SC, Ludtke JJ, et al. A new peptide ligand that targets particles and heterologous proteins to hepatocytes in vivo. Mol Ther 2003;8(6):867-872
-
(2003)
Mol Ther
, vol.8
, Issue.6
, pp. 867-872
-
-
Sokoloff, A.V.1
Wong, S.C.2
Ludtke, J.J.3
-
97
-
-
70349308251
-
Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)
-
Ludtke JJ, Sokoloff AV, Wong S, et al. Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP). Drug Deliv 2009;16(5):268-273
-
(2009)
Drug Deliv
, vol.16
, Issue.5
, pp. 268-273
-
-
Ludtke, J.J.1
Sokoloff, A.V.2
Wong, S.3
-
98
-
-
60549086933
-
Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver
-
Mukthavaram R, Marepally S, Venkata MY, et al. Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver. Biomaterials 2009;30(12):2369-2384
-
(2009)
Biomaterials
, vol.30
, Issue.12
, pp. 2369-2384
-
-
Mukthavaram, R.1
Marepally, S.2
Venkata, M.Y.3
-
99
-
-
67650477343
-
Aptamers and aptamer targeted delivery
-
Yan AC, Levy M. Aptamers and aptamer targeted delivery. RNA Biol 2009;6(3):316-320
-
(2009)
RNA Biol
, vol.6
, Issue.3
, pp. 316-320
-
-
Yan, A.C.1
Levy, M.2
-
100
-
-
0037880734
-
Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: Phase II study results
-
The Eyetech Study Group
-
The Eyetech Study Group. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results. Ophthalmology 2003;110(5):979-986
-
(2003)
Ophthalmology
, vol.110
, Issue.5
, pp. 979-986
-
-
-
101
-
-
27744431927
-
Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: A randomized controlled trial
-
Alexander JH, Hafley G, Harrington RA, et al. Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial. JAMA 2005;294(19):2446-2454
-
(2005)
JAMA
, vol.294
, Issue.19
, pp. 2446-2454
-
-
Alexander, J.H.1
Hafley, G.2
Harrington, R.A.3
-
102
-
-
34548262708
-
Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration
-
Apte RS, Modi M, Masonson H, et al. Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration. Ophthalmology 2007;114(9):1702-1712
-
(2007)
Ophthalmology
, vol.114
, Issue.9
, pp. 1702-1712
-
-
Apte, R.S.1
Modi, M.2
Masonson, H.3
-
103
-
-
44649163943
-
Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease
-
Chan MY, Cohen MG, Dyke CK, et al. Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease. Circulation 2008;117(22):2865-2874
-
(2008)
Circulation
, vol.117
, Issue.22
, pp. 2865-2874
-
-
Chan, M.Y.1
Cohen, M.G.2
Dyke, C.K.3
-
104
-
-
37349040378
-
First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers
-
Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, et al. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation 2007;116(23):2678-2686
-
(2007)
Circulation
, vol.116
, Issue.23
, pp. 2678-2686
-
-
Gilbert, J.C.1
De Feo-Fraulini, T.2
Hutabarat, R.M.3
-
106
-
-
33747031960
-
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
-
McNamara JO II, Andrechek ER, Wang Y, et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol 2006;24(8):1005-1015
-
(2006)
Nat Biotechnol
, vol.24
, Issue.8
, pp. 1005-1015
-
-
McNamara II, J.O.1
Andrechek, E.R.2
Wang, Y.3
-
107
-
-
67650657743
-
Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators
-
Shaw BR, Moussa L, Sharaf M, et al. Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators. Nucleic Acids Symp Ser (Oxf) 2008;52(1):655-656
-
(2008)
Nucleic Acids Symp ser (Oxf)
, vol.52
, Issue.1
, pp. 655-656
-
-
Shaw, B.R.1
Moussa, L.2
Sharaf, M.3
-
108
-
-
48349105059
-
Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy
-
Zhou J, Li H, Li S, et al. Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol Ther 2008;16(8):1481-1489
-
(2008)
Mol Ther
, vol.16
, Issue.8
, pp. 1481-1489
-
-
Zhou, J.1
Li, H.2
Li, S.3
-
109
-
-
44949092569
-
Nuclear-targeted chimeric vector enhancing nonviral gene transfer into skeletal muscle of Fabry mice in vivo
-
Lavigne MD, Yates L, Coxhead P, Gorecki DC. Nuclear-targeted chimeric vector enhancing nonviral gene transfer into skeletal muscle of Fabry mice in vivo. FASEB J 2008;22(6):2097-2107
-
(2008)
FASEB J
, vol.22
, Issue.6
, pp. 2097-2107
-
-
Lavigne, M.D.1
Yates, L.2
Coxhead, P.3
Gorecki, D.C.4
-
110
-
-
12744261398
-
Inducible production of erythropoietin using intramuscular injection of block copolymer/DNA formulation
-
Richard P, Pollard H, Lanctin C, et al. Inducible production of erythropoietin using intramuscular injection of block copolymer/DNA formulation. J Gene Med 2005;7(1):80-86
-
(2005)
J Gene Med
, vol.7
, Issue.1
, pp. 80-86
-
-
Richard, P.1
Pollard, H.2
Lanctin, C.3
-
111
-
-
70349451258
-
Development of antisense-mediated exon skipping as a treatment for duchenne muscular dystrophy
-
Heemskerk H, de Winter CL, van Ommen GJ, et al. Development of antisense-mediated exon skipping as a treatment for duchenne muscular dystrophy. Ann NY Acad Sci 2009;1175:71-79
-
(2009)
Ann NY Acad Sci
, vol.1175
, pp. 71-79
-
-
Heemskerk, H.1
De Winter, C.L.2
Van Ommen, G.J.3
-
112
-
-
74149085535
-
Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery
-
Rodino-Klapac LR, Montgomery CL, Bremer WG, et al. Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery. Mol Ther 2010;18(1):109-117
-
(2010)
Mol Ther
, vol.18
, Issue.1
, pp. 109-117
-
-
Rodino-Klapac, L.R.1
Montgomery, C.L.2
Bremer, W.G.3
-
113
-
-
27744513403
-
Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles
-
Richard P, Bossard F, Desigaux L, et al. Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles. Hum Gene Ther 2005;16(11):1318-1324
-
(2005)
Hum Gene Ther
, vol.16
, Issue.11
, pp. 1318-1324
-
-
Richard, P.1
Bossard, F.2
Desigaux, L.3
-
114
-
-
33847368155
-
Relationships between the physicochemical properties of an amphiphilic triblock copolymers/DNA complexes and their intramuscular transfection efficiency
-
Bello-Roufai M, Lambert O, Pitard B. Relationships between the physicochemical properties of an amphiphilic triblock copolymers/DNA complexes and their intramuscular transfection efficiency. Nucleic Acids Res 2007;35(3):728-739
-
(2007)
Nucleic Acids Res
, vol.35
, Issue.3
, pp. 728-739
-
-
Bello-Roufai, M.1
Lambert, O.2
Pitard, B.3
-
115
-
-
16544377151
-
Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer
-
Pitard B, Bello-Roufai M, Lambert O, et al. Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer. Nucleic Acids Res 2004;32(20):e159
-
(2004)
Nucleic Acids Res
, vol.32
, Issue.20
-
-
Pitard, B.1
Bello-Roufai, M.2
Lambert, O.3
-
116
-
-
0036401268
-
A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles
-
Pitard B, Pollard H, Agbulut O, et al. A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles. Hum Gene Ther 2002;13(14):1767-1775
-
(2002)
Hum Gene Ther
, vol.13
, Issue.14
, pp. 1767-1775
-
-
Pitard, B.1
Pollard, H.2
Agbulut, O.3
-
117
-
-
67849124159
-
An acid-labile temperature-responsive sol-gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells
-
Namgung R, Nam S, Kim SK, et al. An acid-labile temperature-responsive sol-gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells. Biomaterials 2009;30(28):5225-5233
-
(2009)
Biomaterials
, vol.30
, Issue.28
, pp. 5225-5233
-
-
Namgung, R.1
Nam, S.2
Kim, S.K.3
-
118
-
-
0030111359
-
Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer
-
Alakhov V, Moskaleva E, Batrakova EV, Kabanov AV. Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer. Bioconjug Chem 1996;7(2):209-216
-
(1996)
Bioconjug Chem
, vol.7
, Issue.2
, pp. 209-216
-
-
Alakhov, V.1
Moskaleva, E.2
Batrakova, E.V.3
Kabanov, A.V.4
-
119
-
-
55249114136
-
Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA
-
Yang Z, Sahay G, Sriadibhatla S, Kabanov AV. Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. Bioconjug Chem 2008;19(10):1987-1994
-
(2008)
Bioconjug Chem
, vol.19
, Issue.10
, pp. 1987-1994
-
-
Yang, Z.1
Sahay, G.2
Sriadibhatla, S.3
Kabanov, A.V.4
-
120
-
-
0346124164
-
Pluronic-grafted poly-L)-lysine as a new synthetic gene carrier
-
Jeon E, Kim HD, Kim JS. Pluronic-grafted poly-(L)-lysine as a new synthetic gene carrier. J Biomed Mater Res A 2003;66(4):854-859
-
(2003)
J Biomed Mater Res A
, vol.66
, Issue.4
, pp. 854-859
-
-
Jeon, E.1
Kim, H.D.2
Kim, J.S.3
-
121
-
-
0036319690
-
Inducing neutrophil recruitment in the liver of ICAM-1-deficient mice using polyethyleneimine grafted with Pluronic P123 as an organ-specific carrier for transgenic ICAM-1
-
Ochietti B, Lemieux P, Kabanov AV, et al. Inducing neutrophil recruitment in the liver of ICAM-1-deficient mice using polyethyleneimine grafted with Pluronic P123 as an organ-specific carrier for transgenic ICAM-1. Gene Ther 2002;9(14):939-945
-
(2002)
Gene Ther
, vol.9
, Issue.14
, pp. 939-945
-
-
Ochietti, B.1
Lemieux, P.2
Kabanov, A.V.3
-
122
-
-
20444459212
-
Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: Preparation, properties and possible applications in drug delivery
-
Avgoustakis K. Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery. Curr Drug Deliv 2004;1(4):321-333
-
(2004)
Curr Drug Deliv
, vol.1
, Issue.4
, pp. 321-333
-
-
Avgoustakis, K.1
-
123
-
-
75149147998
-
Targeted delivery of low molecular drugs using chitosan and its derivatives
-
Park JH, Saravanakumar G, Kim K, Kwon IC. Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv Drug Deliv Rev 2010;62(1):28-41
-
(2010)
Adv Drug Deliv Rev
, vol.62
, Issue.1
, pp. 28-41
-
-
Park, J.H.1
Saravanakumar, G.2
Kim, K.3
Kwon, I.C.4
-
124
-
-
70249127578
-
Chitosan-plasmid nanoparticle formulations for im and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies
-
Jean M, Smaoui F, Lavertu M, et al. Chitosan-plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies. Gene Ther 2009;16(9):1097-1110
-
(2009)
Gene Ther
, vol.16
, Issue.9
, pp. 1097-1110
-
-
Jean, M.1
Smaoui, F.2
Lavertu, M.3
-
125
-
-
67650679365
-
Non-viral vectors in cystic fibrosis gene therapy: Recent developments and future prospects
-
Pringle IA, Hyde SC, Gill DR. Non-viral vectors in cystic fibrosis gene therapy: recent developments and future prospects. Expert Opin Biol Ther 2009;9(8):991-1003
-
(2009)
Expert Opin Biol Ther
, vol.9
, Issue.8
, pp. 991-1003
-
-
Pringle, I.A.1
Hyde, S.C.2
Gill, D.R.3
-
126
-
-
45749158576
-
Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes
-
Davies LA, McLachlan G, Sumner-Jones SG, et al. Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes. Mol Ther 2008;16(7):1283-1290
-
(2008)
Mol Ther
, vol.16
, Issue.7
, pp. 1283-1290
-
-
Davies, L.A.1
McLachlan, G.2
Sumner-Jones, S.G.3
-
127
-
-
0025342635
-
Two-photon laser scanning fluorescence microscopy
-
Denk W, Strickler JH, Webb WW. Two-photon laser scanning fluorescence microscopy. Science 1990;248(4951):73-76
-
(1990)
Science
, vol.248
, Issue.4951
, pp. 73-76
-
-
Denk, W.1
Strickler, J.H.2
Webb, W.W.3
-
128
-
-
33845497677
-
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
-
Holtkamp S, Kreiter S, Selmi A, et al. Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells. Blood 2006;108(13):4009-4017
-
(2006)
Blood
, vol.108
, Issue.13
, pp. 4009-4017
-
-
Holtkamp, S.1
Kreiter, S.2
Selmi, A.3
-
129
-
-
77952702735
-
Pulmonary messenger RNA application prevents fatal respiratory distress in surfactant protein B deficient mice [abstract]
-
Kormann MHG, Aneja M, Nica G, et al. Pulmonary messenger RNA application prevents fatal respiratory distress in surfactant protein B deficient mice [abstract]. Hum Gene Ther 2009;20(11):1409-1410
-
(2009)
Hum Gene Ther
, vol.20
, Issue.11
, pp. 1409-1410
-
-
Kormann, M.H.G.1
Aneja, M.2
Nica, G.3
-
130
-
-
35649003344
-
Targeting of stabilized plasmid lipid particles to hepatocytes in vivo by means of coupled lactoferrin
-
Weeke-Klimp AH, Bartsch M, Morselt HW, et al. Targeting of stabilized plasmid lipid particles to hepatocytes in vivo by means of coupled lactoferrin. J Drug Target 2007;15(9):585-594
-
(2007)
J Drug Target
, vol.15
, Issue.9
, pp. 585-594
-
-
Weeke-Klimp, A.H.1
Bartsch, M.2
Morselt, H.W.3
-
131
-
-
34250806035
-
Genomewide identification of nuclear matrix attachment regions: An analysis of methods
-
Linnemann AK, Platts AE, Doggett N, et al. Genomewide identification of nuclear matrix attachment regions: an analysis of methods. Biochem Soc Trans 2007;35(Pt 3):612-617
-
(2007)
Biochem Soc Trans
, vol.35
, Issue.PART 3
, pp. 612-617
-
-
Linnemann, A.K.1
Platts, A.E.2
Doggett, N.3
-
132
-
-
33845322322
-
Genetically modified pigs produced with a nonviral episomal vector
-
Manzini S, Vargiolu A, Stehle IM, et al. Genetically modified pigs produced with a nonviral episomal vector. Proc Natl Acad Sci USA 2006;103(47):17672-17677
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.47
, pp. 17672-17677
-
-
Manzini, S.1
Vargiolu, A.2
Stehle, I.M.3
-
133
-
-
43449111490
-
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
-
Hyde SC, Pringle IA, Abdullah S, et al. CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression. Nat Biotechnol 2008;26(5):549-551
-
(2008)
Nat Biotechnol
, vol.26
, Issue.5
, pp. 549-551
-
-
Hyde, S.C.1
Pringle, I.A.2
Abdullah, S.3
-
134
-
-
65449120034
-
Virus entry by macropinocytosis
-
Mercer J, Helenius A. Virus entry by macropinocytosis. Nat Cell Biol 2009;11(5):510-520
-
(2009)
Nat Cell Biol
, vol.11
, Issue.5
, pp. 510-520
-
-
Mercer, J.1
Helenius, A.2
|