A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: Application to [ 11 C]PBR28 and [ 18 F]PBR111 for TSPO imaging

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 7, 2014, Pages 1162-1168

  Guo, Qi ^a,b,c   Owen, David R ^c   Rabiner, Eugenii A ^a,b   Turkheimer, Federico E ^a   Gunn, Roger N ^b,c,d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Imanova Ltd   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

graphical analysis; PET; radioligand comparison; specific binding; TSPO

Indexed keywords

ADAM C 11; AFM C 11; CARBON 11; CARRIER PROTEIN; DAPA C 11; DASB C 11; MCN 5652 C 11; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PBR 111 F 18; PBR 28 C 11; RADIOLIGAND; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BINDING AFFINITY; CEREBELLUM; CORPUS STRIATUM; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; LIGAND BINDING; MESENCEPHALON; NEUROIMAGING; NORMAL HUMAN; OCCIPITAL CORTEX; PET-CT SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SIGNAL NOISE RATIO; TEMPORAL CORTEX; THALAMUS;

ALGORITHMS; BRAIN; FEMALE; HUMANS; LIGANDS; LINEAR MODELS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 84903770918     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.65     Document Type: Article

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