In vivo angiogenesis screening and mechanism of action of novel tanshinone derivatives produced by one-pot combinatorial modification of natural tanshinone mixture from Salvia miltiorrhiza

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Zhang, Zhe Rui ^a   Li, Jin Hang ^b   Li, Shang ^a   Liu, Ai Lin ^a,c   Hoi, Pui Man ^a   Tian, Hai Yan ^b   Ye, Wen Cai ^b   Lee, Simon Ming Yuen ^a   Jiang, Ren Wang ^b  

^a China Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute   (Macao)

^b JINAN UNIVERSITY   (China)

^c INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANGIOGENIC FACTOR; ANTINEOPLASTIC AGENT; FIBROBLAST GROWTH FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; TANSHINONE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN; ABIETANE DERIVATIVE; EPIDERMAL GROWTH FACTOR; PLANT MEDICINAL PRODUCT; TANSHINONE;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BLOOD VESSEL INJURY; CANCER CELL LINE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; EMBRYO; GENE EXPRESSION; IC 50; NONHUMAN; ONE POT SYNTHESIS; PROPHYLAXIS; REAL TIME POLYMERASE CHAIN REACTION; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ZEBRA FISH; ANGIOGENESIS; ANIMAL; BIOLOGICAL MODEL; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; EMBRYOLOGY; HUMAN; ISOLATION AND PURIFICATION; MCF 7 CELL LINE; METABOLISM; NONMAMMALIAN EMBRYO;

ANIMALS; CELL PROLIFERATION; DITERPENES, ABIETANE; EMBRYO, NONMAMMALIAN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTORS; HUMANS; MCF-7 CELLS; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PHYSIOLOGIC; PLANT PREPARATIONS; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; ZEBRAFISH;

EID: 84903762461     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100416     Document Type: Article

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