메뉴 건너뛰기




Volumn 5, Issue 7, 2010, Pages 1-14

Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC

Author keywords

[No Author keywords available]

Indexed keywords

CALYCOSIN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ISOFLAVONOID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RALOXIFENE; TAMOXIFEN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; 7,3' DIHYDROXY 4' METHOXYISOFLAVONE; 7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE; ISOFLAVONE DERIVATIVE;

EID: 77955591123     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011822     Document Type: Article
Times cited : (121)

References (63)
  • 2
    • 1542314421 scopus 로고    scopus 로고
    • Molecular mechanisms, physiological consequences and pharmacological implications of estrogen receptor action
    • Barkhem T, Nilsson S, Gustafsson JA (2004) Molecular mechanisms, physiological consequences and pharmacological implications of estrogen receptor action. Am J Pharmacogenomics 4: 19-28.
    • (2004) Am J Pharmacogenomics , vol.4 , pp. 19-28
    • Barkhem, T.1    Nilsson, S.2    Gustafsson, J.A.3
  • 4
    • 44549084372 scopus 로고    scopus 로고
    • Vascular cell signaling by membrane estrogen receptors
    • Kim KH, Moriarty K, Bender JR (2008) Vascular cell signaling by membrane estrogen receptors. Steroids 73: 864-869.
    • (2008) Steroids , vol.73 , pp. 864-869
    • Kim, K.H.1    Moriarty, K.2    Bender, J.R.3
  • 5
    • 0029822927 scopus 로고    scopus 로고
    • Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells
    • Kim-Schulze S, McGowan KA, Hubchak SC, Cid MC, Martin MB, et al. (1996) Expression of an estrogen receptor by human coronary artery and umbilical vein endothelial cells. Circulation 94: 1402-1407.
    • (1996) Circulation , vol.94 , pp. 1402-1407
    • Kim-Schulze, S.1    McGowan, K.A.2    Hubchak, S.C.3    Cid, M.C.4    Martin, M.B.5
  • 6
    • 0028815410 scopus 로고
    • Estrogen promotes angiogenic activity in human umbilical vein endothelial cells in vitro and in a murine model
    • Morales DE, McGowan KA, Grant DS, Maheshwari S, Bhartiya D, et al. (1995) Estrogen promotes angiogenic activity in human umbilical vein endothelial cells in vitro and in a murine model. Circulation 91: 755-763.
    • (1995) Circulation , vol.91 , pp. 755-763
    • Morales, D.E.1    McGowan, K.A.2    Grant, D.S.3    Maheshwari, S.4    Bhartiya, D.5
  • 7
    • 33747722742 scopus 로고    scopus 로고
    • Raloxifene increases proliferation and up-regulates telomerase activity in human umbilical vein endothelial cells
    • Doshida M, Ohmichi M, Tsutsumi S, Kawagoe J, Takahashi T, et al. (2006) Raloxifene increases proliferation and up-regulates telomerase activity in human umbilical vein endothelial cells. J Biol Chem 281: 24270-24278.
    • (2006) J Biol Chem , vol.281 , pp. 24270-24278
    • Doshida, M.1    Ohmichi, M.2    Tsutsumi, S.3    Kawagoe, J.4    Takahashi, T.5
  • 8
    • 4444331727 scopus 로고    scopus 로고
    • Cellular and physiological effects of soy flavonoids
    • Valachovicova T, Slivova V, Sliva D (2004) Cellular and physiological effects of soy flavonoids. Mini Rev Med Chem 4: 881-887.
    • (2004) Mini Rev Med Chem , vol.4 , pp. 881-887
    • Valachovicova, T.1    Slivova, V.2    Sliva, D.3
  • 9
    • 0346849610 scopus 로고    scopus 로고
    • Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element
    • Kostelac D, Rechkemmer G, Briviba K (2003) Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element. J Agric Food Chem 51: 7632-7635.
    • (2003) J Agric Food Chem , vol.51 , pp. 7632-7635
    • Kostelac, D.1    Rechkemmer, G.2    Briviba, K.3
  • 10
    • 12444341888 scopus 로고    scopus 로고
    • Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment
    • Seng WL, Eng K, Lee J, McGrath P (2004) Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment. Angiogenesis 7: 243-253.
    • (2004) Angiogenesis , vol.7 , pp. 243-253
    • Seng, W.L.1    Eng, K.2    Lee, J.3    McGrath, P.4
  • 11
    • 33646709613 scopus 로고    scopus 로고
    • Cardiac protective effect of Astragalus on viral myocarditis mice: Comparison with Perindopril
    • Chen XJ, Bian ZP, Lu S, Xu JD, Gu CR, et al. (2006) Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. Am J Chin Med 34: 493-502.
    • (2006) Am J Chin Med , vol.34 , pp. 493-502
    • Chen, X.J.1    Bian, Z.P.2    Lu, S.3    Xu, J.D.4    Gu, C.R.5
  • 12
    • 65149099113 scopus 로고    scopus 로고
    • Effects of Astragaloside IV on heart failure in rats
    • Zhao Z, Wang W, Wang F, Zhao K, Han Y, et al. (2009) Effects of Astragaloside IV on heart failure in rats. Chin Med 4: 6.
    • (2009) Chin Med , vol.4 , pp. 6
    • Zhao, Z.1    Wang, W.2    Wang, F.3    Zhao, K.4    Han, Y.5
  • 13
    • 40849104906 scopus 로고    scopus 로고
    • Cardioprotective effects of Astragali Radix against isoproterenol-induced myocardial injury in rats and its possible mechanism
    • Xu XL, Ji H, Gu SY, Shao Q, Huang QJ, et al. (2008) Cardioprotective effects of Astragali Radix against isoproterenol-induced myocardial injury in rats and its possible mechanism. Phytother Res 22: 389-394.
    • (2008) Phytother Res , vol.22 , pp. 389-394
    • Xu, X.L.1    Ji, H.2    Gu, S.Y.3    Shao, Q.4    Huang, Q.J.5
  • 14
    • 0033188290 scopus 로고    scopus 로고
    • Collagen expression of intra-acinar pulmonary arteries and right ventricle and intervention of Radix Astragali in rats with hypoxic pulmonary hypertension
    • He J, Jing Z, Gu Q (1999) Collagen expression of intra-acinar pulmonary arteries and right ventricle and intervention of Radix Astragali in rats with hypoxic pulmonary hypertension. Zhonghua Yi Xue Za Zhi 79: 654-656.
    • (1999) Zhonghua Yi Xue Za Zhi , vol.79 , pp. 654-656
    • He, J.1    Jing, Z.2    Gu, Q.3
  • 15
    • 0032056790 scopus 로고    scopus 로고
    • Morphometric investigation on hypoxic structural remodeling of intraacinar pulmonary arteries
    • Xi S, Ruan Y, Liu Y (1998) Morphometric investigation on hypoxic structural remodeling of intraacinar pulmonary arteries. Zhonghua Jie He He Hu Xi Za Zhi 21: 303-305.
    • Zhonghua Jie He He Hu Xi Za Zhi , vol.21 , pp. 303-305
    • Xi, S.1    Ruan, Y.2    Liu, Y.3
  • 16
    • 0031173249 scopus 로고    scopus 로고
    • Therapeutic effect of radix Astragali on hypoxia pulmonary hypertension in rats
    • Inside back cover
    • Chen X, Ruan Y, Xi S, Si W, Zhang L (1997) Therapeutic effect of radix Astragali on hypoxia pulmonary hypertension in rats. Zhongguo Zhong Yao Za Zhi 22: 432-434, inside back cover.
    • (1997) Zhongguo Zhong Yao Za Zhi , vol.22 , pp. 432-434
    • Chen, X.1    Ruan, Y.2    Xi, S.3    Si, W.4    Zhang, L.5
  • 17
    • 77952453159 scopus 로고    scopus 로고
    • Influence of Radix Astragali on nitric oxide and endothelin-1 in pulmonary tissue in hypoxemic pulmonary hypertension in rats
    • Liu JC, An CS, Wang JF, Li FY, Li JH (2006) Influence of Radix Astragali on nitric oxide and endothelin-1 in pulmonary tissue in hypoxemic pulmonary hypertension in rats. Zhonghua Er Ke Za Zhi 44: 46-48.
    • (2006) Zhonghua Er Ke Za Zhi , vol.44 , pp. 46-48
    • Liu, J.C.1    An, C.S.2    Wang, J.F.3    Li, F.Y.4    Li, J.H.5
  • 18
    • 20244384405 scopus 로고
    • Preliminary report on various symptoms of chronic hepatitis treated with radix Astragali and its regulative effect on levels of serum hormone
    • Liu K (1990) Preliminary report on various symptoms of chronic hepatitis treated with radix Astragali and its regulative effect on levels of serum hormone. Zhong Xi Yi Jie He Za Zhi 10: 330-333, 323.
    • (1990) Zhong Xi Yi Jie He Za Zhi , vol.10
    • Liu, K.1
  • 19
    • 33751418681 scopus 로고    scopus 로고
    • Influence of an anti-diabetic foot ulcer formula and its component herbs on tissue and systemic glucose homeostasis
    • Chan CM, Chan YW, Lau CH, Lau TW, Lau KM, et al. (2007) Influence of an anti-diabetic foot ulcer formula and its component herbs on tissue and systemic glucose homeostasis. J Ethnopharmacol 109: 10-20.
    • (2007) J Ethnopharmacol , vol.109 , pp. 10-20
    • Chan, C.M.1    Chan, Y.W.2    Lau, C.H.3    Lau, T.W.4    Lau, K.M.5
  • 20
    • 59649117072 scopus 로고    scopus 로고
    • Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice
    • Xu A, Wang H, Hoo RL, Sweeney G, Vanhoutte PM, et al. (2009) Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology 150: 625-633.
    • (2009) Endocrinology , vol.150 , pp. 625-633
    • Xu, A.1    Wang, H.2    Hoo, R.L.3    Sweeney, G.4    Vanhoutte, P.M.5
  • 21
    • 38049063983 scopus 로고    scopus 로고
    • Effects of radix Astragali injection on apoptosis of lymphocytes and immune function in patients with systemic lupus erythematosus
    • Cai XY, Xu YL, Lin XJ (2006) Effects of radix Astragali injection on apoptosis of lymphocytes and immune function in patients with systemic lupus erythematosus. Zhongguo Zhong Xi Yi Jie He Za Zhi 26: 443-445.
    • (2006) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.26 , pp. 443-445
    • Cai, X.Y.1    Xu, Y.L.2    Lin, X.J.3
  • 22
    • 77955408038 scopus 로고    scopus 로고
    • A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells: Genomic Approach to Reveal Specific Gene Activation
    • Choi RC, Gao QT, Cheung AW, Zhu JT, Lau FT, et al. (2009) A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells: Genomic Approach to Reveal Specific Gene Activation. Evid Based Complement Alternat Med.
    • (2009) Evid Based Complement Alternat Med
    • Choi, R.C.1    Gao, Q.T.2    Cheung, A.W.3    Zhu, J.T.4    Lau, F.T.5
  • 23
    • 11944260596 scopus 로고    scopus 로고
    • Chemical and biological assessment of a traditional chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis: Orthogonal array design to optimize the extraction of chemical constituents
    • Song ZH, Ji ZN, Lo CK, Dong TT, Zhao KJ, et al. (2004) Chemical and biological assessment of a traditional chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis: orthogonal array design to optimize the extraction of chemical constituents. Planta Med 70: 1222-1227.
    • (2004) Planta Med , vol.70 , pp. 1222-1227
    • Song, Z.H.1    Ji, Z.N.2    Lo, C.K.3    Dong, T.T.4    Zhao, K.J.5
  • 24
    • 33645960959 scopus 로고    scopus 로고
    • Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties
    • Dong TT, Zhao KJ, Gao QT, Ji ZN, Zhu TT, et al. (2006) Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. J Agric Food Chem 54: 2767-2774.
    • (2006) J Agric Food Chem , vol.54 , pp. 2767-2774
    • Dong, T.T.1    Zhao, K.J.2    Gao, Q.T.3    Ji, Z.N.4    Zhu, T.T.5
  • 25
    • 33846251985 scopus 로고    scopus 로고
    • Danggui buxue tang-a Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor alpha in cultured MCF-7 cells
    • Gao QT, Choi RC, Cheung AW, Zhu JT, Li J, et al. (2007) Danggui buxue tang-a Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor alpha in cultured MCF-7 cells. FEBS Lett 581: 233-240.
    • (2007) FEBS Lett , vol.581 , pp. 233-240
    • Gao, Q.T.1    Choi, R.C.2    Cheung, A.W.3    Zhu, J.T.4    Li, J.5
  • 27
    • 34547369758 scopus 로고    scopus 로고
    • Quantitative analysis of calycosin glycoside and formononetin in Radix astragali from different sources
    • Shi ZY, Bao Z, Jiang Y, Tu PF (2007) Quantitative analysis of calycosin glycoside and formononetin in Radix astragali from different sources. Zhongguo Zhong Yao Za Zhi 32: 779-783.
    • (2007) Zhongguo Zhong Yao Za Zhi , vol.32 , pp. 779-783
    • Shi, Z.Y.1    Bao, Z.2    Jiang, Y.3    Tu, P.F.4
  • 28
    • 42749097819 scopus 로고    scopus 로고
    • Chemical comparison and classification of Radix Astragali by determination of isoflavonoids and astragalosides
    • Song JZ, Yiu HH, Qiao CF, Han QB, Xu HX (2008) Chemical comparison and classification of Radix Astragali by determination of isoflavonoids and astragalosides. J Pharm Biomed Anal 47: 399-406.
    • (2008) J Pharm Biomed Anal , vol.47 , pp. 399-406
    • Song, J.Z.1    Yiu, H.H.2    Qiao, C.F.3    Han, Q.B.4    Xu, H.X.5
  • 29
    • 0344585455 scopus 로고    scopus 로고
    • Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells
    • Fan Y, Wu DZ, Gong YQ, Zhou JY, Hu ZB (2003) Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells. Eur J Pharmacol 481: 33-40.
    • (2003) Eur J Pharmacol , vol.481 , pp. 33-40
    • Fan, Y.1    Wu, D.Z.2    Gong, Y.Q.3    Zhou, J.Y.4    Hu, Z.B.5
  • 30
    • 69749109625 scopus 로고    scopus 로고
    • Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor-related phosphatidylinositol 3-kinase/Akt-dependent pathway in human endothelial cells
    • Zhang Y, Hu G, Lin HC, Hong SJ, Deng YH, et al. (2009) Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor-related phosphatidylinositol 3-kinase/Akt-dependent pathway in human endothelial cells. Phytother Res 23: 1205-1213.
    • (2009) Phytother Res , vol.23 , pp. 1205-1213
    • Zhang, Y.1    Hu, G.2    Lin, H.C.3    Hong, S.J.4    Deng, Y.H.5
  • 31
    • 33847039645 scopus 로고    scopus 로고
    • Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    • Siekmann AF, Lawson ND (2007) Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 445: 781-784.
    • (2007) Nature , vol.445 , pp. 781-784
    • Siekmann, A.F.1    Lawson, N.D.2
  • 32
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, et al. (1991) The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266: 11947-11954.
    • (1991) J Biol Chem , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5
  • 33
    • 0030265393 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptors
    • Klagsbrun M, D'Amore PA (1996) Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev 7: 259-270.
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 259-270
    • Klagsbrun, M.1    D'amore, P.A.2
  • 34
    • 0034979275 scopus 로고    scopus 로고
    • Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
    • Zachary I (2001) Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am J Physiol Cell Physiol 280: C1375-1386.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Zachary, I.1
  • 35
    • 0042510626 scopus 로고    scopus 로고
    • Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching
    • Furet P, Bold G, Hofmann F, Manley P, Meyer T, et al. (2003) Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett 13: 2967-2971.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 2967-2971
    • Furet, P.1    Bold, G.2    Hofmann, F.3    Manley, P.4    Meyer, T.5
  • 36
    • 0036240126 scopus 로고    scopus 로고
    • Mechanism of raloxifene-induced relaxation in femoral veins depends on ovarian hormonal status
    • Bracamonte MP, Rud KS, Miller VM (2002) Mechanism of raloxifene-induced relaxation in femoral veins depends on ovarian hormonal status. J Cardiovasc Pharmacol 39: 704-713.
    • (2002) J Cardiovasc Pharmacol , vol.39 , pp. 704-713
    • Bracamonte, M.P.1    Rud, K.S.2    Miller, V.M.3
  • 37
    • 30444434216 scopus 로고    scopus 로고
    • Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer
    • Jordan VC (2006) Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. Br J Pharmacol 147 Suppl 1: S269-276.
    • (2006) Br J Pharmacol , vol.147 , Issue.SUPPL 1
    • Jordan, V.C.1
  • 39
    • 0037462671 scopus 로고    scopus 로고
    • Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitricoxide synthase activation by estrogen
    • Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, et al. (2003) Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitricoxide synthase activation by estrogen. J Biol Chem 278: 2118-2123.
    • (2003) J Biol Chem , vol.278 , pp. 2118-2123
    • Haynes, M.P.1    Li, L.2    Sinha, D.3    Russell, K.S.4    Hisamoto, K.5
  • 40
    • 0029742473 scopus 로고    scopus 로고
    • Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice
    • Johns A, Freay AD, Fraser W, Korach KS, Rubanyi GM (1996) Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice. Endocrinology 137: 4511-4513.
    • (1996) Endocrinology , vol.137 , pp. 4511-4513
    • Johns, A.1    Freay, A.D.2    Fraser, W.3    Korach, K.S.4    Rubanyi, G.M.5
  • 41
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W (1997) Mechanisms of angiogenesis. Nature 386: 671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 43
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash J, Wiegand SJ, Yancopoulos GD (1999) New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18: 5356-5362.
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 44
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara N (1999) Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77: 527-543.
    • (1999) J Mol Med , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 45
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, et al. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439.
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3    Pollefeyt, S.4    Kieckens, L.5
  • 46
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, et al. (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439-442.
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1    Carver-Moore, K.2    Chen, H.3    Dowd, M.4    Lu, L.5
  • 47
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, Tang C, App H, et al. (1999) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 59: 99-106.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5
  • 48
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, et al. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66.
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3    Gertsenstein, M.4    Wu, X.F.5
  • 49
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park JE, Chen HH, Winer J, Houck KA, Ferrara N (1994) Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 269: 25646-25654.
    • (1994) J Biol Chem , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 50
    • 63249106052 scopus 로고    scopus 로고
    • The benefits of oestrogen following menopause: Why hormone replacement therapy should be offered to postmenopausal women
    • Wren BG (2009) The benefits of oestrogen following menopause: why hormone replacement therapy should be offered to postmenopausal women. Med J Aust 190: 321-325.
    • (2009) Med J Aust , vol.190 , pp. 321-325
    • Wren, B.G.1
  • 52
    • 34948886074 scopus 로고    scopus 로고
    • Therapeuti concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro
    • Leung FP, Yung LM, Leung HS, Au CL, Yao X, et al. (2007) Therapeuti concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro. Br J Pharmacol 152: 223-229.
    • (2007) Br J Pharmacol , vol.152 , pp. 223-229
    • Leung, F.P.1    Yung, L.M.2    Leung, H.S.3    Au, C.L.4    Yao, X.5
  • 53
    • 33750988195 scopus 로고    scopus 로고
    • Tamoxifen dilates porcine coronary arteries: Roles for nitric oxide and ouabain-sensitive mechanisms
    • Leung HS, Yung LM, Leung FP, Yao X, Chen ZY, et al. (2006) Tamoxifen dilates porcine coronary arteries: roles for nitric oxide and ouabain-sensitive mechanisms. Br J Pharmacol 149: 703-711.
    • (2006) Br J Pharmacol , vol.149 , pp. 703-711
    • Leung, H.S.1    Yung, L.M.2    Leung, F.P.3    Yao, X.4    Chen, Z.Y.5
  • 54
    • 33751178013 scopus 로고    scopus 로고
    • Raloxifene elicits combined rapid vasorelaxation and long-term anti-inflammatory actions in rat aorta
    • Pinna C, Bolego C, Sanvito P, Pelosi V, Baetta R, et al. (2006) Raloxifene elicits combined rapid vasorelaxation and long-term anti-inflammatory actions in rat aorta. J Pharmacol Exp Ther 319: 1444-1451.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1444-1451
    • Pinna, C.1    Bolego, C.2    Sanvito, P.3    Pelosi, V.4    Baetta, R.5
  • 55
    • 52949136618 scopus 로고    scopus 로고
    • Raloxifene protects endothelial cell function against oxidative stress
    • Wong CM, Yung LM, Leung FP, Tsang SY, Au CL, et al. (2008) Raloxifene protects endothelial cell function against oxidative stress. Br J Pharmacol 155: 326-334.
    • (2008) Br J Pharmacol , vol.155 , pp. 326-334
    • Wong, C.M.1    Yung, L.M.2    Leung, F.P.3    Tsang, S.Y.4    Au, C.L.5
  • 56
    • 33751032262 scopus 로고    scopus 로고
    • A chemical genetic screen for cell cycle inhibitors in zebrafish embryos
    • Murphey RD, Stern HM, Straub CT, Zon LI (2006) A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des 68: 213-219.
    • (2006) Chem Biol Drug Des , vol.68 , pp. 213-219
    • Murphey, R.D.1    Stern, H.M.2    Straub, C.T.3    Zon, L.I.4
  • 57
    • 3142517825 scopus 로고    scopus 로고
    • Functions of MAP kinases: Insights from genetargeting studies
    • Kuida K, Boucher DM (2004) Functions of MAP kinases: insights from genetargeting studies. J Biochem 135: 653-656.
    • (2004) J Biochem , vol.135 , pp. 653-656
    • Kuida, K.1    Boucher, D.M.2
  • 58
    • 3142680906 scopus 로고    scopus 로고
    • Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo
    • Uchiba M, Okajima K, Oike Y, Ito Y, Fukudome K, et al. (2004) Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res 95: 34-41.
    • (2004) Circ Res , vol.95 , pp. 34-41
    • Uchiba, M.1    Okajima, K.2    Oike, Y.3    Ito, Y.4    Fukudome, K.5
  • 59
    • 0032873957 scopus 로고    scopus 로고
    • 17 Betaestradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells
    • Suzuma I, Mandai M, Takagi H, Suzuma K, Otani A, et al. (1999) 17 Betaestradiol increases VEGF receptor-2 and promotes DNA synthesis in retinal microvascular endothelial cells. Invest Ophthalmol Vis Sci 40: 2122-2129.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2122-2129
    • Suzuma, I.1    Mandai, M.2    Takagi, H.3    Suzuma, K.4    Otani, A.5
  • 60
    • 0042416621 scopus 로고    scopus 로고
    • Specific contribution of estrogen receptors on mitogen-activated protein kinase pathways and vascular cell activation
    • Geraldes P, Sirois MG, Tanguay JF (2003) Specific contribution of estrogen receptors on mitogen-activated protein kinase pathways and vascular cell activation. Circ Res 93: 399-405.
    • (2003) Circ Res , vol.93 , pp. 399-405
    • Geraldes, P.1    Sirois, M.G.2    Tanguay, J.F.3
  • 62
    • 51249106641 scopus 로고    scopus 로고
    • Compound profiling using a panel of steroid hormone receptor cell-based assays
    • Wilkinson JM, Hayes S, Thompson D, Whitney P, Bi K (2008) Compound profiling using a panel of steroid hormone receptor cell-based assays. J Biomol Screen 13: 755-765.
    • (2008) J Biomol Screen , vol.13 , pp. 755-765
    • Wilkinson, J.M.1    Hayes, S.2    Thompson, D.3    Whitney, P.4    Bi, K.5
  • 63
    • 0037420209 scopus 로고    scopus 로고
    • In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril
    • Merchan JR, Chan B, Kale S, Schnipper LE, Sukhatme VP (2003) In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril. J Natl Cancer Inst 95: 388-399.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 388-399
    • Merchan, J.R.1    Chan, B.2    Kale, S.3    Schnipper, L.E.4    Sukhatme, V.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.