-
1
-
-
0037416141
-
The small-molecule approach to biology
-
Schreiber S.L. The small-molecule approach to biology. Chem Eng News 2003, 81:51-61.
-
(2003)
Chem Eng News
, vol.81
, pp. 51-61
-
-
Schreiber, S.L.1
-
2
-
-
11144298973
-
Exploring biology with small organic molecules
-
Stockwell B.R. Exploring biology with small organic molecules. Nature 2004, 432:846-854.
-
(2004)
Nature
, vol.432
, pp. 846-854
-
-
Stockwell, B.R.1
-
3
-
-
78049296965
-
A small molecule accelerates neuronal differentiation in the adult rat
-
Wurdak H., Zhu S., Min K.H., Aimone L., Lairson L.L., Watson J., Chopiuk G., Demas J., Charette B., Weerapana E., Cravatt B.F., et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A 2010, 107:16542-16547.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 16542-16547
-
-
Wurdak, H.1
Zhu, S.2
Min, K.H.3
Aimone, L.4
Lairson, L.L.5
Watson, J.6
Chopiuk, G.7
Demas, J.8
Charette, B.9
Weerapana, E.10
Cravatt, B.F.11
-
4
-
-
77955463320
-
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease
-
Bradner J.E., Mak R., Tanguturi S.K., Mazitschek R., Haggarty S.J., Ross K., Chang C.Y., Bosco J., West N., Morse E., Lin K., et al. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci U S A 2010, 107:12617-12622.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 12617-12622
-
-
Bradner, J.E.1
Mak, R.2
Tanguturi, S.K.3
Mazitschek, R.4
Haggarty, S.J.5
Ross, K.6
Chang, C.Y.7
Bosco, J.8
West, N.9
Morse, E.10
Lin, K.11
-
5
-
-
11144311139
-
Lessons from natural molecules
-
Clardy J., Walsh C. Lessons from natural molecules. Nature 2004, 432:829-837.
-
(2004)
Nature
, vol.432
, pp. 829-837
-
-
Clardy, J.1
Walsh, C.2
-
6
-
-
0037208308
-
Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
-
Feher M., Schmidt J.M. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J Chem Inf Comput Sci 2003, 43:218-227.
-
(2003)
J Chem Inf Comput Sci
, vol.43
, pp. 218-227
-
-
Feher, M.1
Schmidt, J.M.2
-
7
-
-
64549160613
-
Novel chemical space exploration via natural products
-
Rosén J., Gottfries J., Muresan S., Backlund A., Oprea T.I. Novel chemical space exploration via natural products. J Med Chem 2009, 52:1953-1962.
-
(2009)
J Med Chem
, vol.52
, pp. 1953-1962
-
-
Rosén, J.1
Gottfries, J.2
Muresan, S.3
Backlund, A.4
Oprea, T.I.5
-
8
-
-
0042975166
-
Natural products-a simple model to explain chemical diversity
-
Firn R.D., Jones C.G. Natural products-a simple model to explain chemical diversity. Nat Prod Rep 2003, 20:382-391.
-
(2003)
Nat Prod Rep
, vol.20
, pp. 382-391
-
-
Firn, R.D.1
Jones, C.G.2
-
9
-
-
77955705492
-
Bioactivity-guided navigation of chemical space
-
Bon R.S., Waldmann H. Bioactivity-guided navigation of chemical space. Acc Chem Res 2010, 43:1103-1114.
-
(2010)
Acc Chem Res
, vol.43
, pp. 1103-1114
-
-
Bon, R.S.1
Waldmann, H.2
-
10
-
-
36448991184
-
Cellular targets of natural products
-
Dixon N., Wong L.S., Geerlings T.H., Micklefield J. Cellular targets of natural products. Nat Prod Rep 2007, 24:1288-1310.
-
(2007)
Nat Prod Rep
, vol.24
, pp. 1288-1310
-
-
Dixon, N.1
Wong, L.S.2
Geerlings, T.H.3
Micklefield, J.4
-
11
-
-
0001404141
-
Fumagillin (H-3), a new antibiotic with amebicidal properties
-
McCowen M.C., Callender M.E., Lawlis J.F. Fumagillin (H-3), a new antibiotic with amebicidal properties. Science 1951, 113:202-203.
-
(1951)
Science
, vol.113
, pp. 202-203
-
-
McCowen, M.C.1
Callender, M.E.2
Lawlis, J.F.3
-
12
-
-
0025204095
-
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
-
Ingber D., Fujita T., Kishimoto S., Sudo K., Kanamaru T., Brem H., Folkman J. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990, 348:555-557.
-
(1990)
Nature
, vol.348
, pp. 555-557
-
-
Ingber, D.1
Fujita, T.2
Kishimoto, S.3
Sudo, K.4
Kanamaru, T.5
Brem, H.6
Folkman, J.7
-
13
-
-
0031171961
-
Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin
-
Griffith E.C., Su Z., Turk B.E., Chen S., Chang Y.H., Wu Z., Biemann K., Liu J.O. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol 1997, 4:461-471.
-
(1997)
Chem Biol
, vol.4
, pp. 461-471
-
-
Griffith, E.C.1
Su, Z.2
Turk, B.E.3
Chen, S.4
Chang, Y.H.5
Wu, Z.6
Biemann, K.7
Liu, J.O.8
-
14
-
-
0030924753
-
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2
-
Sin N., Meng L., Wang M.Q.W., Wen J.J., Bornmann W.G., Crews C.M. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci U S A 1997, 94:6099-6103.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 6099-6103
-
-
Sin, N.1
Meng, L.2
Wang, M.Q.W.3
Wen, J.J.4
Bornmann, W.G.5
Crews, C.M.6
-
15
-
-
0034612236
-
Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
-
Zhang Y., Griffith E.C., Sage J., Jacks T., Liu J.O. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proc Natl Acad Sci U S A 2000, 97:6427-6432.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6427-6432
-
-
Zhang, Y.1
Griffith, E.C.2
Sage, J.3
Jacks, T.4
Liu, J.O.5
-
16
-
-
0033749398
-
The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest
-
Yeh J.J., Mohan R., Crews C.M. The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest. Proc Natl Acad Sci U S A 2000, 97:12782-12787.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12782-12787
-
-
Yeh, J.J.1
Mohan, R.2
Crews, C.M.3
-
17
-
-
0028943870
-
Design, synthesis and structure-activity relationships of 2-substituted 2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720
-
Adachi K., Kohara T., Nakao N., Arita M., Chiba K., Mishina T., Sasaki S., Fujita T. Design, synthesis and structure-activity relationships of 2-substituted 2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720. Bioorg Med Chem Lett 1995, 5:853-856.
-
(1995)
Bioorg Med Chem Lett
, vol.5
, pp. 853-856
-
-
Adachi, K.1
Kohara, T.2
Nakao, N.3
Arita, M.4
Chiba, K.5
Mishina, T.6
Sasaki, S.7
Fujita, T.8
-
18
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C., Rosenbach M., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002, 296:346-349.
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
Thornton, R.7
Shei, G.J.8
Card, D.9
Keohane, C.10
Rosenbach, M.11
-
19
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann V., Davis M.D., Heise C.E., Albert R., Cottens S., Hof R., Bruns C., Prieschl E., Baumruker T., Hiestand P., Foster C.A., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002, 277:21453-21457.
-
(2002)
J Biol Chem
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
-
20
-
-
3042743990
-
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
-
Brinkmann V., Cyster J.G., Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 2004, 4:1019-1025.
-
(2004)
Am J Transplant
, vol.4
, pp. 1019-1025
-
-
Brinkmann, V.1
Cyster, J.G.2
Hla, T.3
-
21
-
-
0025904512
-
Isolation and structure determination of diazonamides A and B, unusual cytotoxic metabolites from the marine ascidian Diazona chinensis
-
Lindquist N., Fenical W., Van Duyne G.D., Clardy J. Isolation and structure determination of diazonamides A and B, unusual cytotoxic metabolites from the marine ascidian Diazona chinensis. J Am Chem Soc 1991, 113:2303-2304.
-
(1991)
J Am Chem Soc
, vol.113
, pp. 2303-2304
-
-
Lindquist, N.1
Fenical, W.2
Van Duyne, G.D.3
Clardy, J.4
-
22
-
-
41749110005
-
The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product
-
Lachia M., Moody C.J. The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product. Nat Prod Rep 2008, 25:227-253.
-
(2008)
Nat Prod Rep
, vol.25
, pp. 227-253
-
-
Lachia, M.1
Moody, C.J.2
-
23
-
-
33847788820
-
Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division
-
Wang G., Shang L., Burgett A.W., Harran P.G., Wang X. Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proc Natl Acad Sci U S A 2007, 104:2068-2073.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 2068-2073
-
-
Wang, G.1
Shang, L.2
Burgett, A.W.3
Harran, P.G.4
Wang, X.5
-
24
-
-
52049109838
-
Natural products in drug discovery
-
Harvey A.L. Natural products in drug discovery. Drug Discov Today 2008, 13:894-901.
-
(2008)
Drug Discov Today
, vol.13
, pp. 894-901
-
-
Harvey, A.L.1
-
25
-
-
44949134801
-
The impact of natural products upon modern drug discovery
-
Ganesan A. The impact of natural products upon modern drug discovery. Curr Opin Chem Biol 2008, 12:306-317.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 306-317
-
-
Ganesan, A.1
-
26
-
-
44249098800
-
Natural products to drugs: natural product-derived compounds in clinical trials
-
Butler M.S. Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep 2008, 25:475-516.
-
(2008)
Nat Prod Rep
, vol.25
, pp. 475-516
-
-
Butler, M.S.1
-
27
-
-
77952545822
-
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective
-
Bauer R.A., Wurst J.M., Tan D.S. Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective. Curr Opin Chem Biol 2010, 14:308-314.
-
(2010)
Curr Opin Chem Biol
, vol.14
, pp. 308-314
-
-
Bauer, R.A.1
Wurst, J.M.2
Tan, D.S.3
-
28
-
-
37549071045
-
Drug discovery beyond the 'rule-of-five'
-
Zhang M.Q., Wilkinson B. Drug discovery beyond the 'rule-of-five'. Curr Opin Biotechnol 2007, 18:478-488.
-
(2007)
Curr Opin Biotechnol
, vol.18
, pp. 478-488
-
-
Zhang, M.Q.1
Wilkinson, B.2
-
29
-
-
20444420189
-
Natural product-like chemical space: search for chemical dissectors of macromolecular interactions
-
Reayi A., Arya P. Natural product-like chemical space: search for chemical dissectors of macromolecular interactions. Curr Opin Chem Biol 2005, 9:240-247.
-
(2005)
Curr Opin Chem Biol
, vol.9
, pp. 240-247
-
-
Reayi, A.1
Arya, P.2
-
30
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
Wells J.A., McClendon C.L. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007, 450:1001-1009.
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
31
-
-
33646567148
-
Between a rock and a hard place?
-
Whitty A., Kumaravel G. Between a rock and a hard place?. Nat Chem Biol 2006, 2:112-118.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 112-118
-
-
Whitty, A.1
Kumaravel, G.2
-
32
-
-
50249186849
-
Inhibition of transcription factors with small organic molecules
-
Berg T. Inhibition of transcription factors with small organic molecules. Curr Opin Chem Biol 2008, 12:464-471.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 464-471
-
-
Berg, T.1
-
33
-
-
33746288394
-
Small molecule modulators of transcription
-
Arndt H.D. Small molecule modulators of transcription. Angew Chem Int Ed 2006, 45:4552-4560.
-
(2006)
Angew Chem Int Ed
, vol.45
, pp. 4552-4560
-
-
Arndt, H.D.1
-
34
-
-
33845903833
-
Drugs for bad bugs: confronting the challenges of antibacterial discovery
-
Payne D.J., Gwynn M.N., Holmes D.J., Pompilano D.L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 2007, 6:29-40.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompilano, D.L.4
-
35
-
-
46449115901
-
The exploration of macrocycles for drug discovery-an underexploited structural class
-
Driggers E.M., Hale S.P., Lee J., Terrett N.K. The exploration of macrocycles for drug discovery-an underexploited structural class. Nat Rev Drug Discov 2008, 7:608-624.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 608-624
-
-
Driggers, E.M.1
Hale, S.P.2
Lee, J.3
Terrett, N.K.4
-
36
-
-
0026575932
-
The mechanism of action of cyclosporin A and FK506
-
Schreiber S.L., Crabtree G.R. The mechanism of action of cyclosporin A and FK506. Immunol Today 1992, 13:136-142.
-
(1992)
Immunol Today
, vol.13
, pp. 136-142
-
-
Schreiber, S.L.1
Crabtree, G.R.2
-
37
-
-
0032105481
-
Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
-
Sehgal S.N. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998, 31:335-340.
-
(1998)
Clin Biochem
, vol.31
, pp. 335-340
-
-
Sehgal, S.N.1
-
38
-
-
3042701597
-
Epothilones: mechanism of action and biologic activity
-
Goodin S., Kane M.P., Rubin E.H. Epothilones: mechanism of action and biologic activity. J Clin Oncol 2004, 22:2015-2025.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2015-2025
-
-
Goodin, S.1
Kane, M.P.2
Rubin, E.H.3
-
39
-
-
0035950132
-
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
-
Schlünzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 2001, 413:814-821.
-
(2001)
Nature
, vol.413
, pp. 814-821
-
-
Schlünzen, F.1
Zarivach, R.2
Harms, J.3
Bashan, A.4
Tocilj, A.5
Albrecht, R.6
Yonath, A.7
Franceschi, F.8
-
40
-
-
70349784870
-
Synthesis of natural product inspired compound collections
-
Kumar K., Waldmann H. Synthesis of natural product inspired compound collections. Angew Chem Int Ed Engl 2009, 48:3224-3242.
-
(2009)
Angew Chem Int Ed Engl
, vol.48
, pp. 3224-3242
-
-
Kumar, K.1
Waldmann, H.2
-
41
-
-
67049134276
-
Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries
-
Nandy J.P., Prakesch M., Khadem S., Reddy P.T., Sharma U., Arya P. Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries. Chem Rev 2009, 109:1999-2060.
-
(2009)
Chem Rev
, vol.109
, pp. 1999-2060
-
-
Nandy, J.P.1
Prakesch, M.2
Khadem, S.3
Reddy, P.T.4
Sharma, U.5
Arya, P.6
-
42
-
-
3042799070
-
A planning strategy for diversity-oriented synthesis
-
Burke M.D., Schreiber S.L. A planning strategy for diversity-oriented synthesis. Angew Chem Int Ed 2004, 43:46-58.
-
(2004)
Angew Chem Int Ed
, vol.43
, pp. 46-58
-
-
Burke, M.D.1
Schreiber, S.L.2
-
43
-
-
33644839988
-
Diversity-oriented synthesis: exploring the intersections between chemistry and biology
-
Tan D.S. Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol 2005, 1:74-84.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 74-84
-
-
Tan, D.S.1
-
44
-
-
84880296641
-
Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules
-
Galloway W.R., Isidro-Llobet A., Spring D.R. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules. Nat Commun 2010, 1:1-13.
-
(2010)
Nat Commun
, vol.1
, pp. 1-13
-
-
Galloway, W.R.1
Isidro-Llobet, A.2
Spring, D.R.3
-
45
-
-
0037061492
-
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
-
Kuruvilla F.G., Shamji A.F., Sternson S.M., Hergenrother P.J., Schreiber S.L. Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature 2002, 416:653-657.
-
(2002)
Nature
, vol.416
, pp. 653-657
-
-
Kuruvilla, F.G.1
Shamji, A.F.2
Sternson, S.M.3
Hergenrother, P.J.4
Schreiber, S.L.5
-
46
-
-
0038713943
-
Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis
-
Koehler A.N., Shamji A.F., Schreiber S.L. Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis. J Am Chem Soc 2003, 125:8420-8421.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 8420-8421
-
-
Koehler, A.N.1
Shamji, A.F.2
Schreiber, S.L.3
|