-
1
-
-
78349301194
-
Antibody therapy in neurodegenerative disease
-
A.L. Southwell, and P.H. Patterson Antibody therapy in neurodegenerative disease Rev. Neurosci. 21 2010 273 287
-
(2010)
Rev. Neurosci.
, vol.21
, pp. 273-287
-
-
Southwell, A.L.1
Patterson, P.H.2
-
2
-
-
0032698746
-
Alzheimer's disease: Perspectives for the new millennium
-
S.S. Sisodia Alzheimer's disease: perspectives for the new millennium J. Clin. Invest. 104 1999 1169 1170 (Pubitemid 29536286)
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.9
, pp. 1169-1170
-
-
Sisodia, S.S.1
-
3
-
-
77949884626
-
Amyloid-beta immunotherapy for Alzheimer's disease
-
H.J. Fu et al. Amyloid-beta immunotherapy for Alzheimer's disease CNS Neurol. Disord. Drug Targets 9 2010 197 206
-
(2010)
CNS Neurol. Disord. Drug Targets
, vol.9
, pp. 197-206
-
-
Fu, H.J.1
-
4
-
-
77953892400
-
Molecular mechanisms of neurodegeneration in Alzheimer's disease
-
L. Crews, and E. Masliah Molecular mechanisms of neurodegeneration in Alzheimer's disease Hum. Mol. Genet. 19 2010 12 20
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 12-20
-
-
Crews, L.1
Masliah, E.2
-
5
-
-
18244389436
-
The role of cerebral amyloid β accumulation in common forms of Alzheimer disease
-
DOI 10.1172/JCI200525100
-
S. Gandy The role of amyloid beta accumulation in common forms of Alzheimer's disease J. Clin. Invest. 115 2005 1121 1129 (Pubitemid 40629026)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1121-1129
-
-
Gandy, S.1
-
6
-
-
81155154302
-
Neural death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia
-
U. Neniskyte et al. Neural death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia J. Biol. Chem. 286 2011 39904 39913
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 39904-39913
-
-
Neniskyte, U.1
-
7
-
-
0034516988
-
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid β-protein
-
D.J. Selkoe Toward a comprehensive theory of Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid-beta protein Ann. N. Y. Acad. Sci. 924 2000 17 25 (Pubitemid 32050177)
-
(2000)
Annals of the New York Academy of Sciences
, vol.924
, pp. 17-25
-
-
Selkoe, D.J.1
-
8
-
-
0028106152
-
Relative abundance of Alzheimer Aβ amyloid peptide variants in Alzheimer disease and normal aging
-
J. Naslund et al. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging Proc. Natl. Acad. Sci. U. S. A. 91 1994 8378 8382 (Pubitemid 24273667)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.18
, pp. 8378-8382
-
-
Naslund, J.1
Schierhorn, A.2
Hellman, U.3
Lannfelt, L.4
Roses, A.D.5
Tjernberg, L.O.6
Silberring, J.7
Gandy, S.E.8
Winblad, B.9
Greengard, P.10
Nordstedt, C.11
Terenius, L.12
-
9
-
-
0028915895
-
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42 (43)
-
S.A. Gravina et al. Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42 (43) J. Biol. Chem. 1270 1995 7013 7016
-
(1995)
J. Biol. Chem.
, vol.1270
, pp. 7013-7016
-
-
Gravina, S.A.1
-
10
-
-
0028945660
-
Evidence that A beta 42 is the real culprit in Alzheimer's disease
-
S.G. Younkin Evidence that A beta 42 is the real culprit in Alzheimer's disease Ann. Neurol. 37 1995 287 288
-
(1995)
Ann. Neurol.
, vol.37
, pp. 287-288
-
-
Younkin, S.G.1
-
11
-
-
84862300056
-
Structure and pathology of tau protein in Alzheimer's disease
-
M. Kolarova et al. Structure and pathology of tau protein in Alzheimer's disease Int. J. Alzheimers Dis. 2012 2012 732526
-
(2012)
Int. J. Alzheimers Dis.
, vol.2012
, pp. 732526
-
-
Kolarova, M.1
-
12
-
-
58849143335
-
Accumulated amyloid-beta peptide and hyper-phosphorylated tau protein: Relationship and links in Alzheimer's disease
-
H.C. Huang, and Z.F. Jiang Accumulated amyloid-beta peptide and hyper-phosphorylated tau protein: relationship and links in Alzheimer's disease J. Alzheimers Dis. 16 2009 15 27
-
(2009)
J. Alzheimers Dis.
, vol.16
, pp. 15-27
-
-
Huang, H.C.1
Jiang, Z.F.2
-
13
-
-
79958714437
-
Recent advances in the development of immuno-therapies for tauopathies
-
K. Ubhi, and E. Masliah Recent advances in the development of immuno-therapies for tauopathies Exp. Neurol. 230 2011 157 161
-
(2011)
Exp. Neurol.
, vol.230
, pp. 157-161
-
-
Ubhi, K.1
Masliah, E.2
-
14
-
-
79751486524
-
Intracellular and extracellular tau
-
J. Avila Intracellular and extracellular tau Front. Neurosci. 4 2010 49
-
(2010)
Front. Neurosci.
, vol.4
, pp. 49
-
-
Avila, J.1
-
15
-
-
79955044494
-
Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
-
J. Ming et al. Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration Proc. Natl. Acad. Sci. U. S. A. 108 2011 5819 5824
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 5819-5824
-
-
Ming, J.1
-
16
-
-
84855761078
-
Truncated tau and Aβ cooperatively impair mitochondria in primary neurons
-
R.A. Quintanilla et al. Truncated tau and Aβ cooperatively impair mitochondria in primary neurons Neurobiol. Aging 33 2012 e25 e35
-
(2012)
Neurobiol. Aging
, vol.33
-
-
Quintanilla, R.A.1
-
17
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse
-
DOI 10.1038/22124
-
D. Schenk et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 400 1999 173 177 (Pubitemid 29327547)
-
(1999)
Nature
, vol.400
, Issue.6740
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guldo, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
18
-
-
4444362840
-
Current progress in beta-amyloid immunotherapy
-
DOI 10.1016/j.coi.2004.07.012, PII S0952791504001189
-
D. Schenk et al. Current progress in beta-amyloid immunotherapy Curr. Opin. Immunol. 16 2004 599 606 (Pubitemid 39165888)
-
(2004)
Current Opinion in Immunology
, vol.16
, Issue.5
, pp. 599-606
-
-
Schenk, D.1
Hagen, M.2
Seubert, P.3
-
19
-
-
84863032711
-
Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses
-
D.M. Wilcock et al. Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses ASN Neuro. 3 2011 249 258
-
(2011)
ASN Neuro.
, vol.3
, pp. 249-258
-
-
Wilcock, D.M.1
-
20
-
-
5144234938
-
Immunotherapy for Alheimer's disease
-
D.S. Gelinas et al. Immunotherapy for Alheimer's disease Proc. Natl. Acad. Sci. U. S. A. 101 2004 14657 14662
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 14657-14662
-
-
Gelinas, D.S.1
-
21
-
-
0031626756
-
QS-21 and QS-7: Purified saponin adjuvants
-
C.R. Kensil et al. QS-21 and QS-7: purified saponin adjuvants Dev. Biol. Stand. 92 1998 41 47
-
(1998)
Dev. Biol. Stand.
, vol.92
, pp. 41-47
-
-
Kensil, C.R.1
-
22
-
-
0038117796
-
Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
-
J. Naslund et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline JAMA 83 2000 1571 1577 (Pubitemid 30161512)
-
(2000)
Journal of the American Medical Association
, vol.283
, Issue.12
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
Davis, K.L.4
Davies, P.5
Greengard, P.6
Buxbaum, J.D.7
-
23
-
-
0141889064
-
Vaccine adjuvants: Role and mechanisms of action in vaccine immunogenicity
-
DOI 10.1016/S1359-6446(03)02864-2, PII S1359644603028642
-
D.J. Marciani Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity Drug Discov. Today 8 2003 934 943 (Pubitemid 37230013)
-
(2003)
Drug Discovery Today
, vol.8
, Issue.20
, pp. 934-943
-
-
Marciani, D.J.1
-
24
-
-
67749122581
-
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
-
M. Britschgi et al. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 106 2009 12145 12150
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 12145-12150
-
-
Britschgi, M.1
-
25
-
-
84860369530
-
Preventive immunization of aged and juvenile non-human primates to beta-amyloid
-
J. Kofler et al. Preventive immunization of aged and juvenile non-human primates to beta-amyloid J. Neuroinflammation 9 2012 84
-
(2012)
J. Neuroinflammation
, vol.9
, pp. 84
-
-
Kofler, J.1
-
26
-
-
0037452779
-
Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology
-
DOI 10.1073/pnas.0436286100
-
F. Bard et al. Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology Proc. Natl. Acad. Sci. U. S. A. 10 2003 2023 2028 (Pubitemid 36254567)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.4
, pp. 2023-2028
-
-
Bard, F.1
Barbour, R.2
Cannon, C.3
Carretto, R.4
Fox, M.5
Games, D.6
Guido, T.7
Hoenow, K.8
Hu, K.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, C.13
Lee, M.14
Motter, R.15
Nguyen, M.16
Reed, A.17
Schenk, D.18
Tang, P.19
Vasquez, N.20
Seubert, P.21
Yednock, T.22
more..
-
27
-
-
0041320819
-
Human anti-β-amyloid antibodies block β-amyloid fibril formation and prevent β-amyloid-induced neurotoxicity
-
DOI 10.1093/brain/awg191
-
Y. Du et al. Human anti-β-amyloid antibodies block β-amyloid fibril formation and prevent β-amyloid-induced neurotoxicity Brain 126 2003 1935 1939 (Pubitemid 37059433)
-
(2003)
Brain
, vol.126
, Issue.9
, pp. 1935-1939
-
-
Du, Y.1
Wei, X.2
Dodel, R.3
Sommer, N.4
Hampel, H.5
Gao, F.6
Ma, Z.7
Zhao, L.8
Oertel, W.H.9
Farlow, M.10
-
28
-
-
48949085739
-
Amyloid-β immunisation for Alzheimer's disease
-
T. Wisniewski, and U. Konietzko Amyloid-β immunisation for Alzheimer's disease Lancet Neurol. 7 2008 805 811
-
(2008)
Lancet Neurol.
, vol.7
, pp. 805-811
-
-
Wisniewski, T.1
Konietzko, U.2
-
29
-
-
58149375748
-
Anti-Aβ immunotherapy in Alzheimer's disease; Relevance of transgenic mice studies to clinical trials
-
D.M. Wilcock, and C.A. Colton Anti-Aβ immunotherapy in Alzheimer's disease; relevance of transgenic mice studies to clinical trials J. Alzheimers Dis. 15 2008 555 569
-
(2008)
J. Alzheimers Dis.
, vol.15
, pp. 555-569
-
-
Wilcock, D.M.1
Colton, C.A.2
-
30
-
-
77953351071
-
Factors that may impact on immunosenescence: An appraisal
-
J. Ongradi, and D. Kövesdi Factors that may impact on immunosenescence: an appraisal Immun. Ageing 7 2010 7
-
(2010)
Immun. Ageing
, vol.7
, pp. 7
-
-
Ongradi, J.1
Kövesdi, D.2
-
31
-
-
39049105161
-
Challenges for vaccination in the elderly
-
R. Aspinall et al. Challenges for vaccination in the elderly Immun. Ageing 4 2007 9
-
(2007)
Immun. Ageing
, vol.4
, pp. 9
-
-
Aspinall, R.1
-
33
-
-
0036774278
-
T-cell activation: A multidimensional signaling network
-
DOI 10.1016/S0955-0674(02)00370-8
-
T. Su-Yi, and M.L. Dustin T-cell activation: a multidimensional signaling network Curr. Opin. Cell Biol. 14 2002 575 580 (Pubitemid 35247740)
-
(2002)
Current Opinion in Cell Biology
, vol.14
, Issue.5
, pp. 575-580
-
-
Tseng, S.-Y.1
Dustin, M.L.2
-
34
-
-
79955964506
-
Age effects on B cells and humoral immunity in humans
-
D. Frasca et al. Age effects on B cells and humoral immunity in humans Ageing Res. Rev. 10 2011 330 335
-
(2011)
Ageing Res. Rev.
, vol.10
, pp. 330-335
-
-
Frasca, D.1
-
35
-
-
77950826971
-
Microglia in the aging brain: Relevance to neurodegeneration
-
X.-G. Luo et al. Microglia in the aging brain: relevance to neurodegeneration Mol. Neurodegener. 5 2010 12
-
(2010)
Mol. Neurodegener.
, vol.5
, pp. 12
-
-
Luo, X.-G.1
-
36
-
-
32944464648
-
Pathogen recognition and innate immunity
-
DOI 10.1016/j.cell.2006.02.015, PII S0092867406001905
-
S. Akira et al. Pathogen recognition and innate immunity Cell 124 2006 783 801 (Pubitemid 43261452)
-
(2006)
Cell
, vol.124
, Issue.4
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
37
-
-
84900767317
-
Nasal immunization with the 40-kDa outer membrane protein of Porphyromonas gingivalis plus cholera toxin induces protective immunity in aged mice
-
Y. Cai et al. Nasal immunization with the 40-kDa outer membrane protein of Porphyromonas gingivalis plus cholera toxin induces protective immunity in aged mice J. Oral. Sci. 55 2013 107 114
-
(2013)
J. Oral. Sci.
, vol.55
, pp. 107-114
-
-
Cai, Y.1
-
38
-
-
51149090409
-
Alum adjuvanticity: Unraveling a century old mystery
-
E. De Gregorio et al. Alum adjuvanticity: unraveling a century old mystery Eur. J. Immunol. 38 2008 2068 2071
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 2068-2071
-
-
De Gregorio, E.1
-
39
-
-
63149126030
-
Towards an understanding of the adjuvant action of aluminium
-
P. Marrack et al. Towards an understanding of the adjuvant action of aluminium Nat. Rev. Immunol. 9 2009 287 293
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 287-293
-
-
Marrack, P.1
-
40
-
-
33750905657
-
Vaccination of Alzheimer's model mice with Aβ derivative in alum adjuvant reduces Aβ burden without microhemorrhages
-
DOI 10.1111/j.1460-9568.2006.05149.x
-
A.A. Asuni et al. Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages Eur. J. Neurosci. 24 2006 2530 2542 (Pubitemid 44726765)
-
(2006)
European Journal of Neuroscience
, vol.24
, Issue.9
, pp. 2530-2542
-
-
Asuni, A.A.1
Boutajangout, A.2
Scholtzova, H.3
Knudsen, E.4
Li, Y.S.5
Quartermain, D.6
Frangione, B.7
Wisniewski, T.8
Sigurdsson, E.M.9
-
41
-
-
67650355471
-
Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity
-
J.P. Hewitson et al. Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity Mol. Biochem. Parasitol. 167 2009 1 11
-
(2009)
Mol. Biochem. Parasitol.
, vol.167
, pp. 1-11
-
-
Hewitson, J.P.1
-
42
-
-
1642554719
-
Immune biasing by helminth glycans
-
DOI 10.1046/j.1462-5822.2003.00337.x
-
P.G. Thomas, and D.A. Harn Immune biasing by helminth glycans Cell Microbiol. 6 2004 13 22 (Pubitemid 38111585)
-
(2004)
Cellular Microbiology
, vol.6
, Issue.1
, pp. 13-22
-
-
Thomas, P.G.1
Harn Jr., D.A.2
-
43
-
-
84871705521
-
Polarization of host immune responses by helminth-expressed glycans
-
S. Tundup et al. Polarization of host immune responses by helminth-expressed glycans Ann. N. Y. Acad. Sci. 1253 2012 E1 E13
-
(2012)
Ann. N. Y. Acad. Sci.
, vol.1253
-
-
Tundup, S.1
-
45
-
-
34249822792
-
Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in mice
-
DOI 10.1016/j.jaci.2007.01.034, PII S0091674907003442
-
S.-C. Hsu et al. Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in mice J. Allergy Clin. Immunol. 119 2007 1522 1528 (Pubitemid 46855835)
-
(2007)
Journal of Allergy and Clinical Immunology
, vol.119
, Issue.6
, pp. 1522-1528
-
-
Hsu, S.-C.1
Tsai, T.-H.2
Kawasaki, H.3
Chen, C.-H.4
Plunkett, B.5
Lee, R.T.6
Lee, Y.C.7
Huang, S.-K.8
-
46
-
-
70849122823
-
Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response?
-
I. Van Die, and R.D. Cummings Glycan gimmickry by parasitic helminths: a strategy for modulating the host immune response? Glycobiology 20 2010 2 12
-
(2010)
Glycobiology
, vol.20
, pp. 2-12
-
-
Van Die, I.1
Cummings, R.D.2
-
47
-
-
68149163162
-
The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is T2 ribonuclease (omega-1)
-
S. Steinfelder et al. The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is T2 ribonuclease (omega-1) J. Exp. Med. 206 2009 1681 1690
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1681-1690
-
-
Steinfelder, S.1
-
48
-
-
84870262436
-
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
-
B. Everts et al. Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor J. Exp. Med. 209 2012 1753 1767
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1753-1767
-
-
Everts, B.1
-
49
-
-
0001578834
-
Structure/function relationships of immunostimulating saponins
-
J.B. Press et al. Structure/function relationships of immunostimulating saponins Stud. Nat. Prod. Chem. 24 2000 131 174
-
(2000)
Stud. Nat. Prod. Chem.
, vol.24
, pp. 131-174
-
-
Press, J.B.1
-
50
-
-
0028800377
-
Structure/function studies of QS-21 adjuvant: Assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function
-
S. Soltysik et al. Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function Vaccine 13 1995 1403 1410
-
(1995)
Vaccine
, vol.13
, pp. 1403-1410
-
-
Soltysik, S.1
-
51
-
-
0026033441
-
Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
-
C.R. Kensil et al. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex J. Immunol. 146 1991 431 437
-
(1991)
J. Immunol.
, vol.146
, pp. 431-437
-
-
Kensil, C.R.1
-
53
-
-
0035106036
-
Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins
-
DOI 10.1016/S1567-5769(01)00016-9, PII S1567576901000169
-
D.J. Marciani et al. Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins Int. Immunopharmacol. 1 2001 813 818 (Pubitemid 32206543)
-
(2001)
International Immunopharmacology
, vol.1
, Issue.4
, pp. 813-818
-
-
Marciani, D.J.1
Pathak, A.K.2
Reynolds, R.C.3
Seitz, L.4
May, R.D.5
-
54
-
-
0036844380
-
Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccine
-
DOI 10.1016/S1567-5769(02)00192-3, PII S1567576902001923
-
D.J. Marciani et al. Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine Int. Immunopharmacol. 2 2002 1703 1711 (Pubitemid 35284608)
-
(2002)
International Immunopharmacology
, vol.2
, Issue.12
, pp. 1703-1711
-
-
Marciani, D.J.1
Ptak, R.G.2
Voss, T.G.3
Reynolds, R.C.4
Pathak, A.K.5
Chamblin, T.L.6
Scholl, D.R.7
May, R.D.8
-
56
-
-
33344460820
-
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Aβ antibody response with Alum to Quil A adjuvant switch
-
DOI 10.1016/j.vaccine.2005.11.039, PII S0264410X05011916
-
A. Ghochikyan et al. Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Aβ antibody response with Alum to Quil A adjuvant switch Vaccine 24 2006 2275 2282 (Pubitemid 43290409)
-
(2006)
Vaccine
, vol.24
, Issue.13
, pp. 2275-2282
-
-
Ghochikyan, A.1
Mkrtichyan, M.2
Petrushina, I.3
Movsesyan, N.4
Karapetyan, A.5
Cribbs, D.H.6
Agadjanyan, M.G.7
-
57
-
-
84874901987
-
Immunogenicity, efficacy, safety and mechanism of action of epitope vaccine (LuAF20513) for Alzheimer's disease: Prelude to a clinical trial
-
H. Davtyan et al. Immunogenicity, efficacy, safety and mechanism of action of epitope vaccine (LuAF20513) for Alzheimer's disease: prelude to a clinical trial J. Neurosci. 3 2013 4923 4934
-
(2013)
J. Neurosci.
, vol.3
, pp. 4923-4934
-
-
Davtyan, H.1
-
58
-
-
84655160770
-
'Clinical trials in Alzheimer's disease': Immunotherapy approaches
-
J. Delrieu et al. 'Clinical trials in Alzheimer's disease': immunotherapy approaches J. Neurochem. 120 Suppl. 1 2012 186 193
-
(2012)
J. Neurochem.
, vol.120
, Issue.SUPPL. 1
, pp. 186-193
-
-
Delrieu, J.1
-
59
-
-
0024230659
-
Immunopotentiation by orally-administered Quillaja saponins: Effects in mice vaccinated intraperitoneally against rabies
-
S.R. Chavali et al. Immunopotentiation by orally-administered Quillaja saponins: effects in mice vaccinated intraperitoneally against rabies Clin. Exp. Immunol. 74 1988 339 343 (Pubitemid 19039719)
-
(1988)
Clinical and Experimental Immunology
, vol.74
, Issue.3
, pp. 339-343
-
-
Chavali, S.R.1
Barton, L.D.2
Campbell, J.B.3
-
60
-
-
84879616587
-
Differential involvement of Th1 and Th17 in pathogenic autoimmune processes triggered by different TLR ligands
-
G. Shi et al. Differential involvement of Th1 and Th17 in pathogenic autoimmune processes triggered by different TLR ligands J. Immunol. 191 2013 1415 1423
-
(2013)
J. Immunol.
, vol.191
, pp. 1415-1423
-
-
Shi, G.1
-
61
-
-
0029083716
-
Therapeutic potentiation of the immune system by co-stimulatory Schiff-base forming drugs
-
J. Rhodes et al. Therapeutic potentiation of the immune system by co-stimulatory Schiff-base forming drugs Nature 377 1995 71 75
-
(1995)
Nature
, vol.377
, pp. 71-75
-
-
Rhodes, J.1
-
62
-
-
0034662482
-
Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity
-
D.J. Marciani et al. Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity Vaccine 18 2000 3145 3151
-
(2000)
Vaccine
, vol.18
, pp. 3145-3151
-
-
Marciani, D.J.1
-
63
-
-
0023197097
-
Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
-
C.M. Snapper, and W.E. Paul Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production Science 236 1987 944 947 (Pubitemid 17107942)
-
(1987)
Science
, vol.236
, Issue.4804
, pp. 944-947
-
-
Snapper, C.M.1
Paul, W.E.2
-
64
-
-
13444283725
-
Efficacy of anti-Aβ antibody isotypes used for intracerebroventricular immunization in TgCRND8
-
DOI 10.1016/j.neulet.2004.10.090
-
N.B. Chauhan, and G.J. Siegel Efficacy of anti-Beta antibodies isotypes used for intracerebroventricular immunization in TgCRND8 Neurosci. Lett. 375 2005 143 147 (Pubitemid 40202940)
-
(2005)
Neuroscience Letters
, vol.375
, Issue.3
, pp. 143-147
-
-
Chauhan, N.B.1
Siegel, G.J.2
-
65
-
-
70350548365
-
CD8+ T cells and neuronal damage: Direct and collateral mechanisms of cytotoxicity and impaired electrical excitability
-
N. Melzer et al. CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability FASEB J. 23 2009 3659 3673
-
(2009)
FASEB J.
, vol.23
, pp. 3659-3673
-
-
Melzer, N.1
-
66
-
-
57649229390
-
Evaluation of the efficacy of a recombinant subunit West Nile vaccine in Syrian golden hamsters
-
M.T. Siirin et al. Evaluation of the efficacy of a recombinant subunit West Nile vaccine in Syrian golden hamsters Am. J. Trop. Med. Hyg. 79 2008 955 962
-
(2008)
Am. J. Trop. Med. Hyg.
, vol.79
, pp. 955-962
-
-
Siirin, M.T.1
-
67
-
-
67650095592
-
Mannosylated saponins based on oleanoloic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems
-
A.M. Daines et al. Mannosylated saponins based on oleanoloic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems Bioorg. Med. Chem. 17 2009 5207 5218
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 5207-5218
-
-
Daines, A.M.1
-
68
-
-
77949431000
-
Immunization therapy for Alzheimer's disease: A comprehensive review of active immunization strategies
-
T. Tabira Immunization therapy for Alzheimer's disease: a comprehensive review of active immunization strategies Tohoku J. Exp. Med. 220 2010 95 106
-
(2010)
Tohoku J. Exp. Med.
, vol.220
, pp. 95-106
-
-
Tabira, T.1
-
69
-
-
79959670013
-
The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects
-
C. Wiessner et al. The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects J. Neurosci. 31 2009 9323 9331
-
(2009)
J. Neurosci.
, vol.31
, pp. 9323-9331
-
-
Wiessner, C.1
-
70
-
-
84862331908
-
Safety, tolerability and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: Randomized, double-blind, placebo-controlled, first-in-human study
-
B. Winblad et al. Safety, tolerability and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomized, double-blind, placebo-controlled, first-in-human study Lancet Neurol. 11 2012 597 604
-
(2012)
Lancet Neurol.
, vol.11
, pp. 597-604
-
-
Winblad, B.1
|