Lacto-N-fucopentaose III found on Schitosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response1

Journal of Immunology

Volumn 167, Issue 1, 2001, Pages 442-450

  Okano, M ^a   Satoskar, A R ^a   Nishizaki, K ^a   Harn D A , Jr ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; LACTO N FUCOPENTAOSE III; NEOGLYCOPROTEIN; PARASITE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; CARBOHYDRATE ANALYSIS; CONJUGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHISTOSOMA MANSONI; TH2 CELL;

EID: 0035399579     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.1.442     Document Type: Article

References (28)

1. The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum
2. Carbohydrate-dependent, HLA class II-restricted human T cell response to the bee venom allergen phospholipase A2 in allergic patients
3. Selectin ligands
4. Heparinase inhibits neovascularization
5. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase
6. Biology, biochemistry and immunology of carcinoma-associated mucins
7. Strain-dependent induction of allergic rhinitis without adjuvant in mice
8. Induction of Th2 responses and IgE is largely due to carbohydrates functioning as adjuvants on Schistosoma mansoni egg antigens
9. + T-cell subsets
10. +) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polylactosamine sugars
11. A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free otigosaccharide is ineffective
12. Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma
13. Milk oligosaccharide profiles by reversed-phase HPLC of their perbenzoylated derivatives
14. Characterization of mouse nasal lymphocytes isolated by enzymatic extraction with collagenase
15. Involvement of carbohydrate on phospholipase A2, a bee venom, in in vivo antigen-specific IgE synthesis in mice
16. T cell costimulation
17. In interleukin-4-deficient mice, alum not only genarates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production
18. Egg deposition is the major stimulus for the production of Th2 cytokines in murine shistosomiasis mansoni
19. Schistosomiasis
20. A Schistosoma mansoni epitope recognized by a protective monoclonal antibody is identical to the stage-specific embryonic antigen 1
21. Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor
22. The mannose receptor and other macrophage lectins
23. + T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis
24. The B7 and CD28 receptor families
25. B70 antigen is a second ligand for CTLA-4 and CD28
26. CD86 (B7-2) antigen on B cells from atopic patients shows selective, antigen-specific upregulation
27. Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression
28. IgE-selective and antigen-specific unresponsiveness in mice. I. Induction of the unresponsiveness by administration of ovalbumin-pullulan conjugate