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Volumn 64, Issue 6, 1998, Pages 713-723

ISCOMs: An adjuvant with multiple functions

Author keywords

Antibody and T cell response; Immunostimulating complex; Quillaia saponaria; Saponin; Triterpene glycosides; Vaccine

Indexed keywords

ANTIGEN; CHOLESTEROL; CYTOKINE; GANGLIOSIDE GM2; IMMUNOLOGICAL ADJUVANT; ISCOM; ISCOMATRIX; ISCOPREP 703; KEYHOLE LIMPET HEMOCYANIN; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROSPHERE; OVALBUMIN; PHOSPHOLIPID; QUIL A; SAPONIN; TUMOR VACCINE; UNCLASSIFIED DRUG; VACCINE; VIRUS ANTIGEN; VIRUS GLYCOPROTEIN; VIRUS VACCINE;

EID: 0031730080     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.64.6.713     Document Type: Review
Times cited : (146)

References (152)
  • 1
    • 0021255985 scopus 로고
    • Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses
    • Morein, B., Sundquist, B., Höglund, S., Dalsgaard, K., Osterhaus, A. (1984) Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 308, 457-460.
    • (1984) Nature , vol.308 , pp. 457-460
    • Morein, B.1    Sundquist, B.2    Höglund, S.3    Dalsgaard, K.4    Osterhaus, A.5
  • 2
    • 0029879995 scopus 로고    scopus 로고
    • ISCOMs (immunostimulating complexes): The first decade
    • Barr, I. G., Mitchell, G. F. (1996) ISCOMs (immunostimulating complexes): The first decade. Immunol. Cell Biol. 74, 8-25.
    • (1996) Immunol. Cell Biol. , vol.74 , pp. 8-25
    • Barr, I.G.1    Mitchell, G.F.2
  • 3
    • 0026703434 scopus 로고
    • The iscom structure as an immune-enhancing moiety: Experience with viral systems
    • Claassen, I., Osterhaus, A. (1992) The iscom structure as an immune-enhancing moiety: experience with viral systems. Res. Immunol. 143, 531-541
    • (1992) Res. Immunol. , vol.143 , pp. 531-541
    • Claassen, I.1    Osterhaus, A.2
  • 5
    • 0029188935 scopus 로고
    • A novel generation of viral vaccines based on ISCOM matrix
    • M. F. Powell and M. J. Newman, eds., New York: Plenum
    • Rimmelzwaan, G. F., Osterhaus, A. D. M. E. (1995) A novel generation of viral vaccines based on ISCOM matrix. In Vaccine Design, the Subunit and Adjuvant Approach (M. F. Powell and M. J. Newman, eds.), New York: Plenum, 543-558.
    • (1995) Vaccine Design, the Subunit and Adjuvant Approach , pp. 543-558
    • Rimmelzwaan, G.F.1    Osterhaus, A.D.M.E.2
  • 6
    • 0344913456 scopus 로고    scopus 로고
    • ISCOMs, liposomes, and oil based vaccine delivery systems
    • H. Kiyono, P. L. Ogra, and J. R. McGhee eds., San Diego: Academic
    • Tomasi, M., Hearn, T. L. (1996) ISCOMs, liposomes, and oil based vaccine delivery systems. In Mucosal Vaccines (H. Kiyono, P. L. Ogra, and J. R. McGhee eds.), San Diego: Academic, 175-186.
    • (1996) Mucosal Vaccines , pp. 175-186
    • Tomasi, M.1    Hearn, T.L.2
  • 7
    • 0023840989 scopus 로고
    • Incorporation of the major outer membrane protein of Neisseria gonorrhoeae in saponinlipid complexes (Iscoms): Chemical analysis, some structural features, and comparison of their immunogenicity with three other antigen delivery systems
    • Kersten, G. F. A., Teerlink, T., Derks, H. J. G. M., Verkleij, A. J., van Wezel, T. L., Crommelin, D. J. A., Beuvery, E. C. (1988) Incorporation of the major outer membrane protein of Neisseria gonorrhoeae in saponinlipid complexes (Iscoms): Chemical analysis, some structural features, and comparison of their immunogenicity with three other antigen delivery systems. Infect. Immun. 56, 432-438.
    • (1988) Infect. Immun. , vol.56 , pp. 432-438
    • Kersten, G.F.A.1    Teerlink, T.2    Derks, H.J.G.M.3    Verkleij, A.J.4    Van Wezel, T.L.5    Crommelin, D.J.A.6    Beuvery, E.C.7
  • 11
    • 0027218839 scopus 로고
    • Induction of feline leukaemia virus-neutralizing antibodies by immunization with synthetic peptides derived from the FeLV env gene
    • Weijer, K., Pfauth, A., van Herwijnen, R., Jarrett, O., Meloen, R. H., Tomee, C., Osterhaus, A. D. M. E. (1993) Induction of feline leukaemia virus-neutralizing antibodies by immunization with synthetic peptides derived from the FeLV env gene. Vaccine 11, 946-956.
    • (1993) Vaccine , vol.11 , pp. 946-956
    • Weijer, K.1    Pfauth, A.2    Van Herwijnen, R.3    Jarrett, O.4    Meloen, R.H.5    Tomee, C.6    Osterhaus, A.D.M.E.7
  • 12
    • 0023812182 scopus 로고
    • Humoral immune response elicited in rats by measles viral membrane antigens presented in liposomes and ISCOMs
    • Mougin, B., Bakouche, O., Gerlier, D. (1988) Humoral immune response elicited in rats by measles viral membrane antigens presented in liposomes and ISCOMs. Vaccine 6, 445-448.
    • (1988) Vaccine , vol.6 , pp. 445-448
    • Mougin, B.1    Bakouche, O.2    Gerlier, D.3
  • 13
    • 0022260674 scopus 로고
    • Subunit vaccines against enveloped viruses: Virosomes, micelles and other protein complexes
    • Morein, B., Simons, K. (1985) Subunit vaccines against enveloped viruses: virosomes, micelles and other protein complexes. Vaccine 3, 83-93
    • (1985) Vaccine , vol.3 , pp. 83-93
    • Morein, B.1    Simons, K.2
  • 16
    • 0023882657 scopus 로고
    • The requirement of lipids for the formation of immunostimulating complexes (iscoms)
    • Lövgren, K., Morein, B. (1988) The requirement of lipids for the formation of immunostimulating complexes (iscoms). Biotechnol. Appl. Biochem. 10, 161-172.
    • (1988) Biotechnol. Appl. Biochem. , vol.10 , pp. 161-172
    • Lövgren, K.1    Morein, B.2
  • 17
    • 0002647599 scopus 로고
    • A study of the isolation and characterization of the saponin Quil A
    • Dalsgaard, K. (1978) A study of the isolation and characterization of the saponin Quil A. Acta Vet. Scand. (Suppl.) 69, 1-40.
    • (1978) Acta Vet. Scand. (Suppl.) , vol.69 , pp. 1-40
    • Dalsgaard, K.1
  • 18
    • 0025619633 scopus 로고
    • Classical and new approaches to adjuvant use in domestic food animals
    • Dalsgaard, K., Hilgers, L., Trouvé, G. (1990) Classical and new approaches to adjuvant use in domestic food animals. Adv. Vet. Sci. Comp. Med. 35 121-160.
    • (1990) Adv. Vet. Sci. Comp. Med. , vol.35 , pp. 121-160
    • Dalsgaard, K.1    Hilgers, L.2    Trouvé, G.3
  • 20
    • 0015620452 scopus 로고
    • Dünnschichtchromatographische untersuchungen an den saponinen aus cortex Quillajae
    • von Kartnig, T., Ri, C. Y. (1973) Dünnschichtchromatographische untersuchungen an den saponinen aus cortex Quillajae. Planta Med. 23, 269-271.
    • (1973) Planta Med. , vol.23 , pp. 269-271
    • Von Kartnig, T.1    Ri, C.Y.2
  • 22
    • 0022634034 scopus 로고
    • Immune responses of mice to inactivated rabies vaccine administered orally: Potentiation by Quillaja saponin
    • Maharaj, I., Froh, K. J., Campbell, J. B. (1986) Immune responses of mice to inactivated rabies vaccine administered orally: potentiation by Quillaja saponin. Can. J. Microbiol. 32, 414-420.
    • (1986) Can. J. Microbiol. , vol.32 , pp. 414-420
    • Maharaj, I.1    Froh, K.J.2    Campbell, J.B.3
  • 23
    • 0026033441 scopus 로고
    • Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
    • Kensil, C. R., Patel, U., Lennick, M., Marciani, D. (1991) Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J. Immunol. 146, 431-437.
    • (1991) J. Immunol. , vol.146 , pp. 431-437
    • Kensil, C.R.1    Patel, U.2    Lennick, M.3    Marciani, D.4
  • 26
    • 0028856624 scopus 로고
    • Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM matrix
    • Rönnberg, B., Fekadu, M., Morein, B. (1995) Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM matrix. Vaccine 13, 1375-1382.
    • (1995) Vaccine , vol.13 , pp. 1375-1382
    • Rönnberg, B.1    Fekadu, M.2    Morein, B.3
  • 28
    • 0344482144 scopus 로고    scopus 로고
    • Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response is required for generation of immunity to Leshmaniasis
    • Sjölander, A., Baldwin, T. M., Curtis, J. M., Handman, E. (1998) Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response is required for generation of immunity to Leshmaniasis. J. Immunol. 160, 3949-3957.
    • (1998) J. Immunol. , vol.160 , pp. 3949-3957
    • Sjölander, A.1    Baldwin, T.M.2    Curtis, J.M.3    Handman, E.4
  • 29
    • 0023854025 scopus 로고
    • Influenza virus ISCOMs: Biochemical characterization
    • Sundquist, B., Lövgren, K., Höglund, S., Morein, B. (1988) Influenza virus ISCOMs: biochemical characterization. Vaccine 6, 44-58.
    • (1988) Vaccine , vol.6 , pp. 44-58
    • Sundquist, B.1    Lövgren, K.2    Höglund, S.3    Morein, B.4
  • 30
    • 0023236130 scopus 로고
    • Vaccination of rabbits with a bovine herpes virus type 1 subunit vaccine: Adjuvant effect of ISCOMs
    • Trudel, M., Nadon, F., Seguin, C., Boulay, G., Lussier, G. (1987) Vaccination of rabbits with a bovine herpes virus type 1 subunit vaccine: adjuvant effect of ISCOMs. Vaccine 5, 239-243.
    • (1987) Vaccine , vol.5 , pp. 239-243
    • Trudel, M.1    Nadon, F.2    Seguin, C.3    Boulay, G.4    Lussier, G.5
  • 32
    • 0023872566 scopus 로고
    • Measles virus fusion protein presented in an immune-stimulating complex (iscom) induces haemolysis-inhibiting and fusion-inhibiting antibodies, virus-specific T cells and protection in mice
    • de Vries, P., van Binnendijk, R. S., van der Marel, P., van Wezel, A. L., Voorma, H. O., Sundquist, B., Uytdehaag, F. G. C. M., Osterhaus, A. D. M. E. (1988) Measles virus fusion protein presented in an immune-stimulating complex (iscom) induces haemolysis-inhibiting and fusion-inhibiting antibodies, virus-specific T cells and protection in mice. J. Gen. Virol. 69, 549-559.
    • (1988) J. Gen. Virol. , vol.69 , pp. 549-559
    • De Vries, P.1    Van Binnendijk, R.S.2    Van Der Marel, P.3    Van Wezel, A.L.4    Voorma, H.O.5    Sundquist, B.6    Uytdehaag, F.G.C.M.7    Osterhaus, A.D.M.E.8
  • 33
    • 0027487487 scopus 로고
    • HIV experimental vaccines based on the iscom technology using envelope and gag gene products
    • Akerblom, L., Nara, P., Dunlop, N., Putney, S., Morein, B. (1993) HIV experimental vaccines based on the iscom technology using envelope and gag gene products. Biotechnol. Therapeut. 4, 145-161.
    • (1993) Biotechnol. Therapeut. , vol.4 , pp. 145-161
    • Akerblom, L.1    Nara, P.2    Dunlop, N.3    Putney, S.4    Morein, B.5
  • 34
    • 0024454657 scopus 로고
    • Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein gp120
    • Pyle, S. W., Morein, B., Bess, J. W., Åkerblom, L., Nara, P. L., Nigida, S. M., Lerche, N. W., Robey, W. G., Fishinger, P. J., Arthur, L. O. (1989) Immune response to immunostimulatory complexes (ISCOMs) prepared from human immunodeficiency virus type 1 (HIV-1) or the HIV-1 external envelope glycoprotein gp120. Vaccine 7, 465-473.
    • (1989) Vaccine , vol.7 , pp. 465-473
    • Pyle, S.W.1    Morein, B.2    Bess, J.W.3    Åkerblom, L.4    Nara, P.L.5    Nigida, S.M.6    Lerche, N.W.7    Robey, W.G.8    Fishinger, P.J.9    Arthur, L.O.10
  • 35
    • 0025373282 scopus 로고
    • Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into iscoms
    • Morein, B., Ekström, J., Lövgren, K. (1990) Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into iscoms. J. Immunol. Meth. 128, 177-181.
    • (1990) J. Immunol. Meth. , vol.128 , pp. 177-181
    • Morein, B.1    Ekström, J.2    Lövgren, K.3
  • 36
    • 0025762026 scopus 로고
    • + cytotoxic T lymphocytes towards soluble antigens: Immunostimulating-ovalbumin complexes enter the class I MHC-restricted antigen pathway and allow sensitization against the immunodominant peptide
    • + cytotoxic T lymphocytes towards soluble antigens: immunostimulating-ovalbumin complexes enter the class I MHC-restricted antigen pathway and allow sensitization against the immunodominant peptide. Eur. J. Immunol. 21, 1523-1527.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1523-1527
    • Heeg, K.1    Kuon, W.2    Wagner, H.3
  • 37
    • 0025806703 scopus 로고
    • Immune-stimulating complexes containing Quil a and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route
    • Mowat, A. M. CI., Donachie, A. M., Reid, G., Jarrett, O. (1991) Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route. Immunol. 72, 317-322.
    • (1991) Immunol. , vol.72 , pp. 317-322
    • Mowat, A.M.C.I.1    Donachie, A.M.2    Reid, G.3    Jarrett, O.4
  • 38
    • 0026697004 scopus 로고
    • Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid
    • Reid, G. (1992) Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid. Vaccine 10, 597-602.
    • (1992) Vaccine , vol.10 , pp. 597-602
    • Reid, G.1
  • 39
    • 0026689113 scopus 로고
    • Incorporation of soluble antigens into ISCOMs: HIV gp120 ISCOMs induce virus neutralizing antibodies
    • Browning, M., Reid, G., Osborne, R., Jarrett, O. (1992) Incorporation of soluble antigens into ISCOMs: HIV gp120 ISCOMs induce virus neutralizing antibodies. Vaccine 10, 585-590.
    • (1992) Vaccine , vol.10 , pp. 585-590
    • Browning, M.1    Reid, G.2    Osborne, R.3    Jarrett, O.4
  • 40
    • 0028243439 scopus 로고
    • Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeira falciformis in ISCOMs
    • Kazanji, M., Laurent, F., Péry. P. (1994) Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeira falciformis in ISCOMs. Vaccine 12, 798-804.
    • (1994) Vaccine , vol.12 , pp. 798-804
    • Kazanji, M.1    Laurent, F.2    Péry, P.3
  • 41
    • 0026721872 scopus 로고
    • Iscom immunization with synthetic peptides representing measles virus hemagglutinin
    • Pedersen, I. R., Bøg-Hansen, T. C., Dalsgaard, K., Heegaard, P. M. H. (1992) Iscom immunization with synthetic peptides representing measles virus hemagglutinin. Virus Res. 24, 145-169.
    • (1992) Virus Res. , vol.24 , pp. 145-169
    • Pedersen, I.R.1    Bøg-Hansen, T.C.2    Dalsgaard, K.3    Heegaard, P.M.H.4
  • 42
    • 0023245697 scopus 로고
    • Antigenic presentation of small molecules and peptides conjugated to a preformed iscom as carrier
    • Lövgren, K., Lindmark, J., Pipkorn, R., Morein, B. (1987) Antigenic presentation of small molecules and peptides conjugated to a preformed iscom as carrier. J. Immunol. Meth. 98, 137-143.
    • (1987) J. Immunol. Meth. , vol.98 , pp. 137-143
    • Lövgren, K.1    Lindmark, J.2    Pipkorn, R.3    Morein, B.4
  • 44
    • 0027299139 scopus 로고
    • Immunopotentiation of synthetic oligopeptides by chemical conjugation to iscoms
    • Larsson, M., Lövgren, K., Morein, B. (1993) Immunopotentiation of synthetic oligopeptides by chemical conjugation to iscoms. J. Immunol. Meth. 162, 257-260.
    • (1993) J. Immunol. Meth. , vol.162 , pp. 257-260
    • Larsson, M.1    Lövgren, K.2    Morein, B.3
  • 45
    • 0028111918 scopus 로고
    • Conjugation of synthetic peptides to carrier ISCOMs: Factors affecting the immunogenicity of the conjugate
    • Lövgren, K., Larsson, M. (1994) Conjugation of synthetic peptides to carrier ISCOMs: factors affecting the immunogenicity of the conjugate. J. Immunol. Meth. 173, 237-243.
    • (1994) J. Immunol. Meth. , vol.173 , pp. 237-243
    • Lövgren, K.1    Larsson, M.2
  • 46
    • 0025162786 scopus 로고
    • Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
    • Weiss, H. P., Stitz, L., Becht, H. (1990) Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein. Arch. Virol. 114, 109-120.
    • (1990) Arch. Virol. , vol.114 , pp. 109-120
    • Weiss, H.P.1    Stitz, L.2    Becht, H.3
  • 47
    • 0028141888 scopus 로고
    • Removal of the cleavage site of recombinant feline immunodeficiency virus envelope protein facilitates incorporation of the surface glycoprotein in immune-stimulating complexes
    • Rimmelzwaan, G. F., Siebelink, K. H. J., Huisman, R. C., Moss, B., Francis, M. J., Osterhaus, A. D. M. E. (1994) Removal of the cleavage site of recombinant feline immunodeficiency virus envelope protein facilitates incorporation of the surface glycoprotein in immune-stimulating complexes. J. Gen. Virol. 75, 2097-2102.
    • (1994) J. Gen. Virol. , vol.75 , pp. 2097-2102
    • Rimmelzwaan, G.F.1    Siebelink, K.H.J.2    Huisman, R.C.3    Moss, B.4    Francis, M.J.5    Osterhaus, A.D.M.E.6
  • 50
    • 0029198471 scopus 로고
    • Design and production of single-immunization vaccines using polylactide polyglycolide microsphere systems
    • M. F. Powell and M. J. Newman, eds., New York: Plenum
    • Cleland, J. L. (1995) Design and production of single-immunization vaccines using polylactide polyglycolide microsphere systems. In Vaccine Design: The Subunit and Adjuvant Approach (M. F. Powell and M. J. Newman, eds.), New York: Plenum, 439-462.
    • (1995) Vaccine Design: the Subunit and Adjuvant Approach , pp. 439-462
    • Cleland, J.L.1
  • 53
    • 0042715130 scopus 로고
    • Legal status and toxicity of saponins
    • George, A. J. (1965) Legal status and toxicity of saponins. Fd. Cosmet. Toxicol. 3, 85-91.
    • (1965) Fd. Cosmet. Toxicol. , vol.3 , pp. 85-91
    • George, A.J.1
  • 54
    • 0039111844 scopus 로고
    • The effect of saponins, sterols and linoleic acid on weight increase of growing rats
    • Coulson, C., Evans, R. (1960) The effect of saponins, sterols and linoleic acid on weight increase of growing rats. Br. J. Nutr. 14, 121-134.
    • (1960) Br. J. Nutr. , vol.14 , pp. 121-134
    • Coulson, C.1    Evans, R.2
  • 55
    • 0015703206 scopus 로고
    • Chemie und biologie der saponinen
    • W. Herz, H. Grisebach, and G. Kirby, eds., New York: Springer-Verlag
    • Tschesche, R., Wulff, G. (1973) Chemie und biologie der saponinen. In Fortschiritte der Chemie Organischer Naturstoffe Vol. 30 (W. Herz, H. Grisebach, and G. Kirby, eds.), New York: Springer-Verlag, 461-496.
    • (1973) Fortschiritte der Chemie Organischer Naturstoffe , vol.30 , pp. 461-496
    • Tschesche, R.1    Wulff, G.2
  • 56
    • 0022635290 scopus 로고
    • Immunopotentiating effects of the adjuvants SGP and Quil A. I. Antibody responses to T-dependent and T-independent antigens
    • Flebbe, L. M., Braley-Mullen, H. (1986) Immunopotentiating effects of the adjuvants SGP and Quil A. I. Antibody responses to T-dependent and T-independent antigens. Cell. Immunol. 99, 119-127.
    • (1986) Cell. Immunol. , vol.99 , pp. 119-127
    • Flebbe, L.M.1    Braley-Mullen, H.2
  • 57
    • 0028837225 scopus 로고
    • Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations
    • Stieneker, F., Kersten, G., van Bloois, L. Crommelin, D. J. A., Hem, S. L., Lower, J., Kreuter, J. (1995) Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations. Vaccine 13, 45-53.
    • (1995) Vaccine , vol.13 , pp. 45-53
    • Stieneker, F.1    Kersten, G.2    Van Bloois, L.3    Crommelin, D.J.A.4    Hem, S.L.5    Lower, J.6    Kreuter, J.7
  • 58
    • 0024515734 scopus 로고
    • Serological responses in cats vaccinated with FeLV ISCOM and an inactivated FeLV vaccine
    • Osterhaus, A., Weijer, K., Uytdehaag, F., Knell, P., Jarrett, O., Åkerblom, L., Morein, B. (1989) Serological responses in cats vaccinated with FeLV ISCOM and an inactivated FeLV vaccine. Vaccine 7, 137-141.
    • (1989) Vaccine , vol.7 , pp. 137-141
    • Osterhaus, A.1    Weijer, K.2    Uytdehaag, F.3    Knell, P.4    Jarrett, O.5    Åkerblom, L.6    Morein, B.7
  • 59
    • 0030174297 scopus 로고    scopus 로고
    • Protective immunity induced in chicken by a single immunization with Mycoplasma gallisepticum immunostimulating complexes (ISCOMS)
    • Sundquist, B. G., Czifra, G., Stipkovits, L. (1996) Protective immunity induced in chicken by a single immunization with Mycoplasma gallisepticum immunostimulating complexes (ISCOMS). Vaccine 14, 892-897.
    • (1996) Vaccine , vol.14 , pp. 892-897
    • Sundquist, B.G.1    Czifra, G.2    Stipkovits, L.3
  • 60
    • 0026323273 scopus 로고
    • Efficacy and safety field trials of a recombinant DNA vaccine against feline leukemia virus infection
    • Clark, N., Kushner, N. N., Barrett, C. B., Kensil, C. R., Salsbury, D., Cotter, S. (1991) Efficacy and safety field trials of a recombinant DNA vaccine against feline leukemia virus infection. J. Am. Vet. Med. Assoc. 199, 1433-1443.
    • (1991) J. Am. Vet. Med. Assoc. , vol.199 , pp. 1433-1443
    • Clark, N.1    Kushner, N.N.2    Barrett, C.B.3    Kensil, C.R.4    Salsbury, D.5    Cotter, S.6
  • 61
    • 0028943532 scopus 로고
    • Characterization of canine humoral immune responses to outer surface protein subunit vaccines and to natural infection by Lyme disease spirochetes
    • Ma, J., Bulger, P. A., Dante, S., van Riet Davis, D., Perilli-Palmer, B., Coughlin, R. T. (1995) Characterization of canine humoral immune responses to outer surface protein subunit vaccines and to natural infection by Lyme disease spirochetes. J. Infect. Dis. 171, 909-915.
    • (1995) J. Infect. Dis. , vol.171 , pp. 909-915
    • Ma, J.1    Bulger, P.A.2    Dante, S.3    Van Riet Davis, D.4    Perilli-Palmer, B.5    Coughlin, R.T.6
  • 63
    • 0025041447 scopus 로고
    • Influence of antigen and adjuvants on the production of gamma-interferon and antibody by ovine lymphocytes
    • Emery, D. L., Rothel, J. S., Wood, P. R. (1990) Influence of antigen and adjuvants on the production of gamma-interferon and antibody by ovine lymphocytes. Immunol. Cell Biol. 68, 127-136.
    • (1990) Immunol. Cell Biol. , vol.68 , pp. 127-136
    • Emery, D.L.1    Rothel, J.S.2    Wood, P.R.3
  • 64
    • 0021827710 scopus 로고
    • A bovine ephemeral fever vaccine incorporating adjuvant Quil A: A comparative study using adjuvants Quil A, aluminium hydroxide gel and dextran sulphate
    • Vanselow, B. A., Abetz, I., Trenfield, K. (1985) A bovine ephemeral fever vaccine incorporating adjuvant Quil A: A comparative study using adjuvants Quil A, aluminium hydroxide gel and dextran sulphate. Vet. Rec. 117, 37-43.
    • (1985) Vet. Rec. , vol.117 , pp. 37-43
    • Vanselow, B.A.1    Abetz, I.2    Trenfield, K.3
  • 65
    • 77957184814 scopus 로고
    • Local reactions of the saponin Quil A and a Quil A containing ISCOM measles vaccine after intramuscular injection of rats: A comparison with the effect of DPT-Polio vaccine
    • Speijers, G. J. A., Danse, L. H. J. C., Beuvery, E. C., Strik, J. J. T. W. A., Vos, J. G. (1988) Local reactions of the saponin Quil A and a Quil A containing ISCOM measles vaccine after intramuscular injection of rats: A comparison with the effect of DPT-Polio vaccine. Fund. Appl. Toxicol. 10, 425-430.
    • (1988) Fund. Appl. Toxicol. , vol.10 , pp. 425-430
    • Speijers, G.J.A.1    Danse, L.H.J.C.2    Beuvery, E.C.3    Strik, J.J.T.W.A.4    Vos, J.G.5
  • 66
    • 0022854034 scopus 로고
    • An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity
    • Allison, A. C., Byars, N. E. (1986) An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity. J. Immunol. Meth. 95, 157-168.
    • (1986) J. Immunol. Meth. , vol.95 , pp. 157-168
    • Allison, A.C.1    Byars, N.E.2
  • 67
    • 0030059927 scopus 로고    scopus 로고
    • Brown Norway rat model of food allergy: Effect of plant components on the development of oral sensitization
    • Atkinson, H. A. C., Johnson, I. T., Gee, J. M., Grigoriadou, F., Miller, K. (1996) Brown Norway rat model of food allergy: effect of plant components on the development of oral sensitization. Food Chem. Toxicol. 34, 27-32.
    • (1996) Food Chem. Toxicol. , vol.34 , pp. 27-32
    • Atkinson, H.A.C.1    Johnson, I.T.2    Gee, J.M.3    Grigoriadou, F.4    Miller, K.5
  • 68
    • 0017576458 scopus 로고
    • The adjuvant activity of saponin and aluminium hydroxide for promoting reagins
    • Black, L. (1977) The adjuvant activity of saponin and aluminium hydroxide for promoting reagins. J. Immunol. Meth. 15, 193-195.
    • (1977) J. Immunol. Meth. , vol.15 , pp. 193-195
    • Black, L.1
  • 69
    • 0019434769 scopus 로고
    • Antigenic, adjuvant and permeability enhancing properties of melittin in mice
    • Kind, L. S., Ramaika, C., Allaway, E. (1981) Antigenic, adjuvant and permeability enhancing properties of melittin in mice. Allergy 36, 155-160.
    • (1981) Allergy , vol.36 , pp. 155-160
    • Kind, L.S.1    Ramaika, C.2    Allaway, E.3
  • 70
    • 0029176755 scopus 로고
    • Structural and immunological characterization of the vaccine adjuvant QS-21
    • M. F. Powell and M. J. Newman, eds., New York: Plenum
    • Kensil, C. R., Wu, J.-Y., Soltysik, S. (1995) Structural and immunological characterization of the vaccine adjuvant QS-21. In Vaccine Design: The Subunit and Adjuvant Approach (M. F. Powell and M. J. Newman, eds.), New York: Plenum, 525-541.
    • (1995) Vaccine Design: The Subunit and Adjuvant Approach , pp. 525-541
    • Kensil, C.R.1    Wu, J.-Y.2    Soltysik, S.3
  • 71
    • 0026546526 scopus 로고
    • Interactions between immune-stimulating complexes (ISCOMs) and peritoneal mononuclear leukocytes
    • Watson, D. L. Watson, N. A., Fossum, C., Lövgren, K., Morein, B. (1992) Interactions between immune-stimulating complexes (ISCOMs) and peritoneal mononuclear leukocytes. Microbiol. Immunol. 36, 199-203.
    • (1992) Microbiol. Immunol. , vol.36 , pp. 199-203
    • Watson, D.L.1    Watson, N.A.2    Fossum, C.3    Lövgren, K.4    Morein, B.5
  • 72
    • 0026744423 scopus 로고
    • Antigen-specific increases in the number of splenocytes expressing MHC Class II molecules following restimulation with antigen in various physical forms
    • Bergström-Mollaoglu, M., Lövgren, K., Åkerblom, L., Fossum, C., Morein, B. (1992) Antigen-specific increases in the number of splenocytes expressing MHC Class II molecules following restimulation with antigen in various physical forms. Scand. J. Immunol. 36, 565-574.
    • (1992) Scand. J. Immunol. , vol.36 , pp. 565-574
    • Bergström-Mollaoglu, M.1    Lövgren, K.2    Åkerblom, L.3    Fossum, C.4    Morein, B.5
  • 73
    • 0027214826 scopus 로고
    • The induction of cell-associated and secreted interleukin-1 by iscoms, matrix or micelles in murine splenic cells
    • Villacres-Eriksson, M., Bergström-Mollaoglu, M., Kåberg, H., Lövgren, K., Morein, B. (1993) The induction of cell-associated and secreted interleukin-1 by iscoms, matrix or micelles in murine splenic cells. Clin. Exp. Immunol. 93, 120-125.
    • (1993) Clin. Exp. Immunol. , vol.93 , pp. 120-125
    • Villacres-Eriksson, M.1    Bergström-Mollaoglu, M.2    Kåberg, H.3    Lövgren, K.4    Morein, B.5
  • 74
    • 0030016032 scopus 로고    scopus 로고
    • In vitro activation of antigen-presenting cells (APC) by defined composition of Quillaja saponaria Molina triterpenoids
    • Behboudi, S., Morein. B., Villacres-Eriksson, M. (1996) In vitro activation of antigen-presenting cells (APC) by defined composition of Quillaja saponaria Molina triterpenoids. Clin. Exp. Immunol. 105, 26-30.
    • (1996) Clin. Exp. Immunol. , vol.105 , pp. 26-30
    • Behboudi, S.1    Morein, B.2    Villacres-Eriksson, M.3
  • 75
    • 0031239111 scopus 로고    scopus 로고
    • In vivo and in vitro induction of IL-6 by Quillaja saponaria Molina triterpenoid formulations
    • Behboudi, S., Morein, B., Villacres-Eriksson, M. (1997) In vivo and in vitro induction of IL-6 by Quillaja saponaria Molina triterpenoid formulations. Cytokine 9, 682-687.
    • (1997) Cytokine , vol.9 , pp. 682-687
    • Behboudi, S.1    Morein, B.2    Villacres-Eriksson, M.3
  • 76
    • 0031081461 scopus 로고    scopus 로고
    • Immunomodulation by Quillaja saponaria adjuvant formulations: In vivo stimulation of interleukin 12 and its effects on the antibody response
    • Villacres-Eriksson, M., Behboudi, S., Morgan, A. J. Trinchieri, G., Morein, B. (1997) Immunomodulation by Quillaja saponaria adjuvant formulations: in vivo stimulation of interleukin 12 and its effects on the antibody response. Cytokine 9, 73-82.
    • (1997) Cytokine , vol.9 , pp. 73-82
    • Villacres-Eriksson, M.1    Behboudi, S.2    Morgan, A.J.3    Trinchieri, G.4    Morein, B.5
  • 77
    • 0028867560 scopus 로고
    • Antigen presentation by naive macrophages, dendritic cells and B cells to primed T lymphocytes and their cytokine production following exposure to immunostimulating complexes
    • Villacres-Eriksson, M. (1995) Antigen presentation by naive macrophages, dendritic cells and B cells to primed T lymphocytes and their cytokine production following exposure to immunostimulating complexes. Clin. Exp. Immunol. 102, 46-52.
    • (1995) Clin. Exp. Immunol. , vol.102 , pp. 46-52
    • Villacres-Eriksson, M.1
  • 78
    • 0029002567 scopus 로고
    • Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: Involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes
    • Claassen, I. J. T. M., Osterhaus, A. D. M. E., Claassen, E. (1995) Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes. Eur. J. Immunol. 25, 1446-1452.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1446-1452
    • Claassen, I.J.T.M.1    Osterhaus, A.D.M.E.2    Claassen, E.3
  • 79
    • 0024447780 scopus 로고
    • Inflammatory response and antigen localization following immunization with influenza virus ISCOMs
    • Watson, D. L., Lövgren, K., Watson, N. A., Fossum, C., Morein, B., Höglund, S. (1989) Inflammatory response and antigen localization following immunization with influenza virus ISCOMs. Inflammation 13, 641-649.
    • (1989) Inflammation , vol.13 , pp. 641-649
    • Watson, D.L.1    Lövgren, K.2    Watson, N.A.3    Fossum, C.4    Morein, B.5    Höglund, S.6
  • 80
    • 0030175481 scopus 로고    scopus 로고
    • Adjuvant activity of iscoms; effect of ratio and co-incorporation of antigen and adjuvant
    • Lövgren Bengtsson, K., Sjölander, A. (1996) Adjuvant activity of iscoms; effect of ratio and co-incorporation of antigen and adjuvant. Vaccine 14, 753-760.
    • (1996) Vaccine , vol.14 , pp. 753-760
    • Lövgren Bengtsson, K.1    Sjölander, A.2
  • 81
    • 9044251204 scopus 로고    scopus 로고
    • Kinetics, localization and isotype profile of antibody responses to immune stimulating complexes (Iscoms) containing human influenza virus envelope glycoproteins
    • Sjölander, A., Lövgren Bengtsson, K., Johansson, M., Morein, B. (1996) Kinetics, localization and isotype profile of antibody responses to immune stimulating complexes (Iscoms) containing human influenza virus envelope glycoproteins. Scand. J. Immunol. 43, 164-172.
    • (1996) Scand. J. Immunol. , vol.43 , pp. 164-172
    • Sjölander, A.1    Lövgren Bengtsson, K.2    Johansson, M.3    Morein, B.4
  • 82
    • 0031171954 scopus 로고    scopus 로고
    • Kinetics, localization and cytokine profile of T cell responses to immune stimulating complexes (iscoms) containing human influenza virus envelope glycoproteins
    • Sjölander, A., Lövgren Bengtsson, K., Morein, B. (1997) Kinetics, localization and cytokine profile of T cell responses to immune stimulating complexes (iscoms) containing human influenza virus envelope glycoproteins. Vaccine 15, 1030-1038.
    • (1997) Vaccine , vol.15 , pp. 1030-1038
    • Sjölander, A.1    Lövgren Bengtsson, K.2    Morein, B.3
  • 86
    • 0025106451 scopus 로고
    • Effect of Iscoms and their adjuvant moiety (matrix) on the initial proliferation and IL-2 responses: Comparison of spleen cells from mice inoculated with Iscoms and/or matrix
    • Fossum, C., Bergström, M., Lövgren, K., Watson, D. L., Morein, B. (1990) Effect of Iscoms and their adjuvant moiety (matrix) on the initial proliferation and IL-2 responses: comparison of spleen cells from mice inoculated with Iscoms and/or matrix. Cell. Immunol. 129, 414-125.
    • (1990) Cell. Immunol. , vol.129 , pp. 414-1125
    • Fossum, C.1    Bergström, M.2    Lövgren, K.3    Watson, D.L.4    Morein, B.5
  • 88
  • 89
    • 0031562670 scopus 로고    scopus 로고
    • Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-tike immune responses
    • Sjölander, A., van't Land, B., Lövgren Bengtsson, K. (1997) Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-tike immune responses. Cell. Immunol. 177, 69-76.
    • (1997) Cell. Immunol. , vol.177 , pp. 69-76
    • Sjölander, A.1    Van't Land, B.2    Lövgren Bengtsson, K.3
  • 90
    • 0030467147 scopus 로고    scopus 로고
    • Immune responses in mice induced by HSV-1 glycoproteins presented with ISCOMs or NISV delivery systems
    • Hassan, Y., Brewer, J. M., Alexander, J., Jennings, R. (1996) Immune responses in mice induced by HSV-1 glycoproteins presented with ISCOMs or NISV delivery systems. Vaccine 14, 1581-1589.
    • (1996) Vaccine , vol.14 , pp. 1581-1589
    • Hassan, Y.1    Brewer, J.M.2    Alexander, J.3    Jennings, R.4
  • 91
    • 0031052744 scopus 로고    scopus 로고
    • Influence of Quillaja saponaria triterpenoid content on the immunomodulatory capacity of Epstein-Barr virus Iscoms
    • Dotsika, E., Karagouni, E., Sundquist, B., Morein, B., Morgan, A., Villacres-Eriksson, M. (1997) Influence of Quillaja saponaria triterpenoid content on the immunomodulatory capacity of Epstein-Barr virus Iscoms. Scand. J. Immunol. 45, 261-268.
    • (1997) Scand. J. Immunol. , vol.45 , pp. 261-268
    • Dotsika, E.1    Karagouni, E.2    Sundquist, B.3    Morein, B.4    Morgan, A.5    Villacres-Eriksson, M.6
  • 92
    • 0032078696 scopus 로고    scopus 로고
    • ISCOMs vaccine against experimental leishmaniasis
    • Papadopoulou, G., Karagouni, E., Dotsika, E. (1998) ISCOMs vaccine against experimental leishmaniasis. Vaccine 16, 885-892.
    • (1998) Vaccine , vol.16 , pp. 885-892
    • Papadopoulou, G.1    Karagouni, E.2    Dotsika, E.3
  • 93
    • 0032388140 scopus 로고    scopus 로고
    • Vaccination with recombinant Parasite Surface Antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection
    • In press
    • Sjölander A., Baldwin, T. M., Curtis, J. M., Lövgren Bengtsson, K., Handman, E. Vaccination with recombinant Parasite Surface Antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection. Vaccine, In press.
    • Vaccine
    • Sjölander, A.1    Baldwin, T.M.2    Curtis, J.M.3    Lövgren Bengtsson, K.4    Handman, E.5
  • 94
    • 0029076809 scopus 로고
    • Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice
    • Heinzel, F. P., Rerko, R. M., Ahmed, F., Pearlman, E. (1995) Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice. J. Immunol. 155, 730-739.
    • (1995) J. Immunol. , vol.155 , pp. 730-739
    • Heinzel, F.P.1    Rerko, R.M.2    Ahmed, F.3    Pearlman, E.4
  • 95
    • 0030298147 scopus 로고    scopus 로고
    • Early IL-4 production does not predict suseptibility to Leishmania major
    • Scott, P. A., Eaton, W. C., Gause, X.-D., Hondowiczk, B. (1996) Early IL-4 production does not predict suseptibility to Leishmania major. Exp. Parasitol. 84, 178-187.
    • (1996) Exp. Parasitol. , vol.84 , pp. 178-187
    • Scott, P.A.1    Eaton, W.C.2    Gause, X.-D.3    Hondowiczk, B.4
  • 96
    • 0031946347 scopus 로고    scopus 로고
    • Preservation of mucosal and systemic adjuvant properties of ISCOMS in the absence of functional interleukin-4 or interferon-γ
    • Smith, R. E., Donachie, A. M., McLaren, F. H., Mowat McI. (1998) Preservation of mucosal and systemic adjuvant properties of ISCOMS in the absence of functional interleukin-4 or interferon-γ. Immunol. 93,
    • (1998) Immunol. , vol.93
    • Smith, R.E.1    Donachie, A.M.2    McLaren, F.H.3    Mowat, McI.4
  • 97
    • 0027984259 scopus 로고
    • Systemic cytokine profiles in BALB/c mice immunised with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants
    • Valensi, J.-P. M., Carlson, J. R., Van Nest, G. A. (1994) Systemic cytokine profiles in BALB/c mice immunised with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants. J. Immunol. 153, 4029-4039.
    • (1994) J. Immunol. , vol.153 , pp. 4029-4039
    • Valensi, J.-P.M.1    Carlson, J.R.2    Van Nest, G.A.3
  • 100
    • 0027183555 scopus 로고
    • Monophosphoryl lipid a enhances specific CTL induction by a soluble protein antigen entrapped in liposomes
    • Zhou, F., Huang, L. (1993) Monophosphoryl lipid A enhances specific CTL induction by a soluble protein antigen entrapped in liposomes. Vaccine 11, 1139-1144.
    • (1993) Vaccine , vol.11 , pp. 1139-1144
    • Zhou, F.1    Huang, L.2
  • 101
    • 0024389666 scopus 로고
    • In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine
    • Deres, K., Schild, H., Wiesmuller, K. H., Jung, G., Rammensee, H. G. (1989) In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature 342, 561-564.
    • (1989) Nature , vol.342 , pp. 561-564
    • Deres, K.1    Schild, H.2    Wiesmuller, K.H.3    Jung, G.4    Rammensee, H.G.5
  • 103
    • 0028049676 scopus 로고
    • Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles
    • Maloy, K. J., Donachie, A. M., O'Hagan, D. T., Mowat, McI. (1994) Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. Immunol. 81, 661-667.
    • (1994) Immunol. , vol.81 , pp. 661-667
    • Maloy, K.J.1    Donachie, A.M.2    O'Hagan, D.T.3    Mowat, McI.4
  • 104
    • 0026762981 scopus 로고
    • Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- And class II-restricted cytotoxic T cell recognition
    • van Binnendijk, R. S., van Baalen, C. A., Poelen, M. C. M., de Vries, P., Boes, J., Cerundolo, V., Osterhaus, A. D. M. E., UytdeHaag, F. G. C. M. (1992) Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I-and class II-restricted cytotoxic T cell recognition. J. Exp. Med. 176, 119-128.
    • (1992) J. Exp. Med. , vol.176 , pp. 119-128
    • Van Binnendijk, R.S.1    Van Baalen, C.A.2    Poelen, M.C.M.3    De Vries, P.4    Boes, J.5    Cerundolo, V.6    Osterhaus, A.D.M.E.7    Uytdehaag, F.G.C.M.8
  • 105
    • 0026530511 scopus 로고
    • Initiation of cytotoxic T-cell response and protection of Balb/c mice by vaccination with an experimental ISCOMs respiratory syncytial virus subunit vaccine
    • Trudel, M., Nadon, F. Séguin, C., Brault, S., Lusignan, Y., Lemieux, S. (1992) Initiation of cytotoxic T-cell response and protection of Balb/c mice by vaccination with an experimental ISCOMs respiratory syncytial virus subunit vaccine. Vaccine 10, 107-112.
    • (1992) Vaccine , vol.10 , pp. 107-112
    • Trudel, M.1    Nadon, F.2    Séguin, C.3    Brault, S.4    Lusignan, Y.5    Lemieux, S.6
  • 106
    • 0028946369 scopus 로고
    • Cross-recognition by CD8 T cell receptor alpha beta cytotoxic T lymphocytes of peptides in the self and the mycobacterial hsp60 which share intermediate sequence homology
    • Zugel, U., Schoel, B., Yamamoto, S., Hengel, H., Morein, B., Kaufmann, S. H. (1995) Cross-recognition by CD8 T cell receptor alpha beta cytotoxic T lymphocytes of peptides in the self and the mycobacterial hsp60 which share intermediate sequence homology. Eur. J. Immunol. 25, 451-458.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 451-458
    • Zugel, U.1    Schoel, B.2    Yamamoto, S.3    Hengel, H.4    Morein, B.5    Kaufmann, S.H.6
  • 107
    • 0028809674 scopus 로고
    • Antigenicity and immunogenicity of recombinant enveloped glycoproteins of SIVmac32H with different in vivo passage histories
    • Hulskotte, E. G., Rimmelzwaan, G. F., Boes, J., Bosch, M. L., Heeney, J. L., Norley, S. G., de Vries, P., Osterhaus, A. D. (1995) Antigenicity and immunogenicity of recombinant enveloped glycoproteins of SIVmac32H with different in vivo passage histories. Vaccine 13, 1187-1197.
    • (1995) Vaccine , vol.13 , pp. 1187-1197
    • Hulskotte, E.G.1    Rimmelzwaan, G.F.2    Boes, J.3    Bosch, M.L.4    Heeney, J.L.5    Norley, S.G.6    De Vries, P.7    Osterhaus, A.D.8
  • 108
    • 0029996188 scopus 로고    scopus 로고
    • Priming in vivo and quantification in vitro of class I MHC-restricted cytotoxic T cells to human papilloma virus type 11 early proteins (E6 and E7) using immunostimulating complexes (ISCOMs)
    • Tarpey, I., Stacey, S. N., McIndoe, A., Davies, D. H. (1996) Priming in vivo and quantification in vitro of class I MHC-restricted cytotoxic T cells to human papilloma virus type 11 early proteins (E6 and E7) using immunostimulating complexes (ISCOMs). Vaccine 14, 230-236.
    • (1996) Vaccine , vol.14 , pp. 230-236
    • Tarpey, I.1    Stacey, S.N.2    McIndoe, A.3    Davies, D.H.4
  • 109
    • 0023677230 scopus 로고
    • Cellular immune responses in the murine lung to local immunization with influenza a virus glycoproteins in micelles and immunostimulatory complexes (Iscoms)
    • Jones, P. D., Tha Hla, R., Morein, B. Lövgren, K., Ada, G. L. (1988) Cellular immune responses in the murine lung to local immunization with influenza A virus glycoproteins in micelles and immunostimulatory complexes (Iscoms). Scand. J. Immunol. 27, 645-652.
    • (1988) Scand. J. Immunol. , vol.27 , pp. 645-652
    • Jones, P.D.1    Tha Hla, R.2    Morein, B.3    Lövgren, K.4    Ada, G.L.5
  • 110
    • 0030581353 scopus 로고    scopus 로고
    • Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMs and induction of CTL responses following intranasal immunization
    • Hsu, S.-C., Schadeck, E. B., Delmas, A., Shaw, M., Steward, M. W. (1996) Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMs and induction of CTL responses following intranasal immunization. Vaccine 14, 1159-1166.
    • (1996) Vaccine , vol.14 , pp. 1159-1166
    • Hsu, S.-C.1    Schadeck, E.B.2    Delmas, A.3    Shaw, M.4    Steward, M.W.5
  • 111
    • 0027137598 scopus 로고
    • Immune-stimulating complexes as adjuvants for inducing local and systemic immunity after oral immunization with protein antigens
    • Mowat, A. McI., Maloy, K. J., Donachie, A. M. (1993) Immune-stimulating complexes as adjuvants for inducing local and systemic immunity after oral immunization with protein antigens. Immunol. 80, 527-534.
    • (1993) Immunol. , vol.80 , pp. 527-534
    • Mowat, A.McI.1    Maloy, K.J.2    Donachie, A.M.3
  • 115
    • 0028858810 scopus 로고
    • Formulation of an immunogenic human cytomegalovirus vaccine: Responses in mice
    • Britt, W., Fay, J., Seals, J., Kensil C. (1995) Formulation of an immunogenic human cytomegalovirus vaccine: responses in mice. J. Infect. Dis. 171, 18-25.
    • (1995) J. Infect. Dis. , vol.171 , pp. 18-25
    • Britt, W.1    Fay, J.2    Seals, J.3    Kensil, C.4
  • 116
    • 0028902386 scopus 로고
    • Formulation of the purified fusion protein of respiratory syncitial virus with the saponin QS-21 induces protective immune responses in Balb/c mice that are similar to those generated by experimental infection
    • Hancock, G. E. Speelman, D. J., Frenchick, P. J., Mineo-Kuhn, M. M., Baggs, R. B., Hahn, D. J. (1995) Formulation of the purified fusion protein of respiratory syncitial virus with the saponin QS-21 induces protective immune responses in Balb/c mice that are similar to those generated by experimental infection. Vaccine 13, 391-400.
    • (1995) Vaccine , vol.13 , pp. 391-400
    • Hancock, G.E.1    Speelman, D.J.2    Frenchick, P.J.3    Mineo-Kuhn, M.M.4    Baggs, R.B.5    Hahn, D.J.6
  • 117
    • 0028863172 scopus 로고
    • Induction of T-cell immunity against Ras oncoproteins by soluble protein or Ras expressing Escherichia coli
    • Fenton, R. G., Keller, C. J., Hanna, N., Taub, D. D. (1995) Induction of T-cell immunity against Ras oncoproteins by soluble protein or Ras expressing Escherichia coli. J. Natl. Cancer Inst. 87, 1853-1861.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1853-1861
    • Fenton, R.G.1    Keller, C.J.2    Hanna, N.3    Taub, D.D.4
  • 118
    • 0029151884 scopus 로고
    • Vaccine-induced virus-neutralizing antibodies and cytotoxic T cells do not protect macaques from experimental infection with simian immunodeficiency virus SIVmac32H (J5)
    • Hulskotte, E. G. J., Geretti, A.-M., Siebelink, K. H. J., van Amerongen, G., Cranage, M. P., Rud, E. W., Norley, S. G., de Vries, P., Osterhaus, A. D. M. E. (1995) Vaccine-induced virus-neutralizing antibodies and cytotoxic T cells do not protect macaques from experimental infection with simian immunodeficiency virus SIVmac32H (J5). J. Virol. 69, 6289-6296.
    • (1995) J. Virol. , vol.69 , pp. 6289-6296
    • Hulskotte, E.G.J.1    Geretti, A.-M.2    Siebelink, K.H.J.3    Van Amerongen, G.4    Cranage, M.P.5    Rud, E.W.6    Norley, S.G.7    De Vries, P.8    Osterhaus, A.D.M.E.9
  • 120
    • 0024582107 scopus 로고
    • Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro
    • Macatonia, S. E., Taylor, P. M., Knight, S. C., Askonas, B. A. (1989) Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J. Exp. Med. 169, 1255-1264.
    • (1989) J. Exp. Med. , vol.169 , pp. 1255-1264
    • Macatonia, S.E.1    Taylor, P.M.2    Knight, S.C.3    Askonas, B.A.4
  • 122
    • 0024357678 scopus 로고
    • Antibody responses and protection in mice immunized with Herpes Simplex Virus type 1 antigen immune-stimulating complex preparations
    • Ertürk, M., Jennings, R., Hockley, D., Potter, W. (1989) Antibody responses and protection in mice immunized with Herpes Simplex Virus type 1 antigen immune-stimulating complex preparations. J. Gen. Virol. 70, 2149-2155.
    • (1989) J. Gen. Virol. , vol.70 , pp. 2149-2155
    • Ertürk, M.1    Jennings, R.2    Hockley, D.3    Potter, W.4
  • 124
    • 0018612959 scopus 로고
    • Activation of mouse complement by different classes of mouse antibody
    • Klaus, G. G., Pepys, M. B., Kitajima, K., Askonas, B. A. (1979) Activation of mouse complement by different classes of mouse antibody. Immunol. 38, 687-695.
    • (1979) Immunol. , vol.38 , pp. 687-695
    • Klaus, G.G.1    Pepys, M.B.2    Kitajima, K.3    Askonas, B.A.4
  • 125
  • 126
    • 0017735263 scopus 로고
    • Receptors for IgG: Subclass specificity of receptors on different mouse cell types and the definition of two distinct receptors on a macrophage cell line
    • Heusser, C. H., Anderson, C. L., Grey, H. M. (1977) Receptors for IgG: subclass specificity of receptors on different mouse cell types and the definition of two distinct receptors on a macrophage cell line. J. Exp. Med. 145, 1316-1327.
    • (1977) J. Exp. Med. , vol.145 , pp. 1316-1327
    • Heusser, C.H.1    Anderson, C.L.2    Grey, H.M.3
  • 128
    • 0024498009 scopus 로고
    • Experimental polyvalent ISCOMs subunit vaccine induces antibodies that neutralize human and bovine respiratory syncytial virus
    • Trudel, M., Nadon, F., Seguin, C., Simard, C., Lussier, G. (1989) Experimental polyvalent ISCOMs subunit vaccine induces antibodies that neutralize human and bovine respiratory syncytial virus. Vaccine 7, 12-16.
    • (1989) Vaccine , vol.7 , pp. 12-16
    • Trudel, M.1    Nadon, F.2    Seguin, C.3    Simard, C.4    Lussier, G.5
  • 129
    • 0028172934 scopus 로고
    • A type-specific avian influenza virus subunit vaccine for turkeys: Induction of protective immunity to challenge infection
    • Kodihalli, S., Sivanadan, V., Nagaraja, K. V., Shaw, D., Halvorson, D. A. (1994) A type-specific avian influenza virus subunit vaccine for turkeys: induction of protective immunity to challenge infection. Vaccine 12, 1467-1472.
    • (1994) Vaccine , vol.12 , pp. 1467-1472
    • Kodihalli, S.1    Sivanadan, V.2    Nagaraja, K.V.3    Shaw, D.4    Halvorson, D.A.5
  • 130
    • 0027587525 scopus 로고
    • A lipid-conjugated immunostimulating complex subunit vaccine against Salmonella infection in turkeys
    • Charles, S. D., Nagaraja, K. V., Sivanadan, V. (1993) A lipid-conjugated immunostimulating complex subunit vaccine against Salmonella infection in turkeys. Avian Dis. 37, 477-484.
    • (1993) Avian Dis. , vol.37 , pp. 477-484
    • Charles, S.D.1    Nagaraja, K.V.2    Sivanadan, V.3
  • 131
    • 0027177022 scopus 로고
    • Immunogenicity in rabbits and monkeys of influenza ISCOMs conjugated with repeated sequences of the Plasmodium falciparum antigen Pf155/RESA
    • Sjölander, A, Hansson, M., Lövgren, K., Wåhlin, B., Berzins, K., Perlmann, P. (1993) Immunogenicity in rabbits and monkeys of influenza ISCOMs conjugated with repeated sequences of the Plasmodium falciparum antigen Pf155/RESA. Parasite Immunol. 15, 355-359.
    • (1993) Parasite Immunol. , vol.15 , pp. 355-359
    • Sjölander, A.1    Hansson, M.2    Lövgren, K.3    Wåhlin, B.4    Berzins, K.5    Perlmann, P.6
  • 132
    • 0023748549 scopus 로고
    • Canine distemper virus (CDV) immune-stimulating complexes (Iscoms), but not measles virus iscoms, protect dogs against CDV infection
    • de Vries, P., Uytdehaag, F. G., Osterhaus, A. D. (1988) Canine distemper virus (CDV) immune-stimulating complexes (Iscoms), but not measles virus iscoms, protect dogs against CDV infection. J. Gen. Virol. 69, 2071-2083.
    • (1988) J. Gen. Virol. , vol.69 , pp. 2071-2083
    • De Vries, P.1    Uytdehaag, F.G.2    Osterhaus, A.D.3
  • 133
    • 0026596414 scopus 로고
    • Canine distemper virus Iscoms induce protection in harbour seals (Phoca vitulina) against phocid distemper but still allow subsequent infection with phocid distemper virus-1
    • Visser, I. K. G., Vedder, E. J., van de Bildt, M. W. G., Örvell, C., Barrett, T., Osterhaus, A. D. M. E. (1992) Canine distemper virus Iscoms induce protection in harbour seals (Phoca vitulina) against phocid distemper but still allow subsequent infection with phocid distemper virus-1. Vaccine 10, 435-438.
    • (1992) Vaccine , vol.10 , pp. 435-438
    • Visser, I.K.G.1    Vedder, E.J.2    Van De Bildt, M.W.G.3    Örvell, C.4    Barrett, T.5    Osterhaus, A.D.M.E.6
  • 134
    • 0025912902 scopus 로고
    • Protective effect of an ISCOM bovine virus diarrhoea virus (BVDV) vaccine against an experimental BVDV infection in vaccinated and non-vaccinated pregnant ewes
    • Carlsson, U., Alenius, S., Sundquist, B. (1991) Protective effect of an ISCOM bovine virus diarrhoea virus (BVDV) vaccine against an experimental BVDV infection in vaccinated and non-vaccinated pregnant ewes. Vaccine 9, 577-580.
    • (1991) Vaccine , vol.9 , pp. 577-580
    • Carlsson, U.1    Alenius, S.2    Sundquist, B.3
  • 135
    • 0028814052 scopus 로고
    • Immune responses in sheep after immunization with Toxoplasma gondii antigens incorporated into iscoms
    • Lundén, A. (1995) Immune responses in sheep after immunization with Toxoplasma gondii antigens incorporated into iscoms. Vet. Parasitol. 56, 23-25.
    • (1995) Vet. Parasitol. , vol.56 , pp. 23-25
    • Lundén, A.1
  • 137
    • 0027996210 scopus 로고
    • Delivery of pseudorabies virus envelope antigens in immunostimulating complexes (ISCOMs): Elicitation of neutralizing antibody responses in swine and protection in mice
    • Tulman, E. R., Garmendia, A. E. (1994) Delivery of pseudorabies virus envelope antigens in immunostimulating complexes (ISCOMs): Elicitation of neutralizing antibody responses in swine and protection in mice. Vaccine 12, 1349-1354.
    • (1994) Vaccine , vol.12 , pp. 1349-1354
    • Tulman, E.R.1    Garmendia, A.E.2
  • 138
    • 0026811964 scopus 로고
    • Evaluation of a subunit vaccine for bovine adenovirus type 3
    • York, I. A., Thorsen, J. (1992) Evaluation of a subunit vaccine for bovine adenovirus type 3. Am. J. Vet. Res. 53, 180-183.
    • (1992) Am. J. Vet. Res. , vol.53 , pp. 180-183
    • York, I.A.1    Thorsen, J.2
  • 139
    • 0028453952 scopus 로고
    • Quil A and ISCOM as adjuvants for midgut membrane antigens of Boophilus microplus
    • Jackson, L. A., Opdebeeck, J. P. (1994) Quil A and ISCOM as adjuvants for midgut membrane antigens of Boophilus microplus. Appl. Parasitol. 35, 87-98.
    • (1994) Appl. Parasitol. , vol.35 , pp. 87-98
    • Jackson, L.A.1    Opdebeeck, J.P.2
  • 141
    • 0027247369 scopus 로고
    • Responses of ponies to equid herpesvirus-1 ISCOM vaccination and challenge with virus of the homologous strain
    • Hannant, D., Jessett, D. M., O'Neill, T., Dolby, C. A., Cook, R. F., Mumford, J. A. (1993) Responses of ponies to equid herpesvirus-1 ISCOM vaccination and challenge with virus of the homologous strain. Res. Vet. Sci. 54, 299-305.
    • (1993) Res. Vet. Sci. , vol.54 , pp. 299-305
    • Hannant, D.1    Jessett, D.M.2    O'Neill, T.3    Dolby, C.A.4    Cook, R.F.5    Mumford, J.A.6
  • 143
    • 0030426068 scopus 로고    scopus 로고
    • Immunogenicity of immunostimulating complexes of Japanese encephalitis virus in experimental animals
    • Yeolekar, L. R., Banerjee, K. (1996) Immunogenicity of immunostimulating complexes of Japanese encephalitis virus in experimental animals. Acta Virol. 40, 245-250.
    • (1996) Acta Virol. , vol.40 , pp. 245-250
    • Yeolekar, L.R.1    Banerjee, K.2
  • 144
    • 0026784317 scopus 로고
    • Comparison of protection afforded by whole virus ISCOM versus MDP adjuvanted formalin-inactivated SIV vaccines from IV cell-free or cell-associated homologous challenge
    • Osterhaus, A., de Vries, P., Morein, B., Åkerblom, L., Heeney, J. (1992) Comparison of protection afforded by whole virus ISCOM versus MDP adjuvanted formalin-inactivated SIV vaccines from IV cell-free or cell-associated homologous challenge. AIDS Res. Hum. Retroviruses 8, 1507-1510.
    • (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 1507-1510
    • Osterhaus, A.1    De Vries, P.2    Morein, B.3    Åkerblom, L.4    Heeney, J.5
  • 146
    • 0028963136 scopus 로고
    • Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination
    • Snodgrass, D. R., Campbell, I., Mwenda, J. M., Chege, G., Suleman, M. A., Morein, B., Hart, C. A. (1995) Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination. Vaccine 13, 408-413.
    • (1995) Vaccine , vol.13 , pp. 408-413
    • Snodgrass, D.R.1    Campbell, I.2    Mwenda, J.M.3    Chege, G.4    Suleman, M.A.5    Morein, B.6    Hart, C.A.7
  • 147
    • 0031027893 scopus 로고    scopus 로고
    • Protective immunity in Macaques vaccinated with live attenuated recombinant and subunit vaccines in the presence of passively aquired antibodies
    • van Binnendijk, R. S., Pooler, C. M., van Amerongen, G., de Vries, P., Osterhaus, A. D. M. E. (1997) Protective immunity in Macaques vaccinated with live attenuated recombinant and subunit vaccines in the presence of passively aquired antibodies. J. Infect. Dis. 175, 524-532.
    • (1997) J. Infect. Dis. , vol.175 , pp. 524-532
    • Van Binnendijk, R.S.1    Pooler, C.M.2    Van Amerongen, G.3    De Vries, P.4    Osterhaus, A.D.M.E.5
  • 151
    • 0023772681 scopus 로고
    • Prevention of Epstein-Barr (EB) virus-induced lymphoma in cottontop tamarins by vaccination with the EB virus envelope glycoprotein gp340 incorporated into immune-stimulating complexes
    • Morgan, A. J., Finerty, S., Lövgren, K., Scullion, F. T., Morein, B. (1988) Prevention of Epstein-Barr (EB) virus-induced lymphoma in cottontop tamarins by vaccination with the EB virus envelope glycoprotein gp340 incorporated into immune-stimulating complexes. J. Gen. Virol. 69, 2093-2096.
    • (1988) J. Gen. Virol. , vol.69 , pp. 2093-2096
    • Morgan, A.J.1    Finerty, S.2    Lövgren, K.3    Scullion, F.T.4    Morein, B.5
  • 152
    • 0028171987 scopus 로고
    • Phase 1 trial of immunological adjuvant QS-21 with GM2 ganglioside-keyhole limpet haemocynanin conjugate vaccine in patients with malignant melanoma
    • Livingston, P. O., Adluri, S. Helling, F., Yao, T. J., Kensil, C. R., Newman, M. J., Marciani, D. (1994) Phase 1 trial of immunological adjuvant QS-21 with GM2 ganglioside-keyhole limpet haemocynanin conjugate vaccine in patients with malignant melanoma. Vaccine 12, 1275-1280.
    • (1994) Vaccine , vol.12 , pp. 1275-1280
    • Livingston, P.O.1    Adluri, S.2    Helling, F.3    Yao, T.J.4    Kensil, C.R.5    Newman, M.J.6    Marciani, D.7


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