Prediction of cytochrome P450 mediated metabolism of designer drugs

Current Topics in Medicinal Chemistry

Volumn 14, Issue 11, 2014, Pages 1365-1373

  Nielsen, Line Marie ^a   Linnet, Kristian ^a   Olsen, Lars ^a   Rydberg, Patrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cytochromes P450; Designer drugs; Drug metabolism; Site of metabolism

Indexed keywords

1 PHENYLPIPERAZINE DERIVATIVE; AMPHETAMINE DERIVATIVE; CATHINONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DESIGNER DRUG; PHENCYCLIDINE DERIVATIVE; PHENETHYLAMINE DERIVATIVE; TRYPTAMINE DERIVATIVE; LIGAND;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; COMPUTER MODEL; DEALKYLATION; DENSITY FUNCTIONAL THEORY; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HYDROXYLATION; LIGAND BASED MODEL; MEASUREMENT ACCURACY; METHODOLOGY; METHYLATION; PREDICTION; PREDICTOR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; CHEMISTRY; METABOLISM;

CYTOCHROME P-450 ENZYME SYSTEM; DESIGNER DRUGS; HUMANS; LIGANDS; MOLECULAR STRUCTURE;

EID: 84903744376     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026614666140506122202     Document Type: Article

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