PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 41, Issue 7, 2014, Pages 1440-1449

  Wang, Yu ^a,b   Yue, Xuyi ^b   Kiesewetter, Dale O ^b   Niu, Gang ^b,c   Teng, Gaojun ^a,c   Chen, Xiaoyuan ^b,c  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^c NONE   (United States)

Author keywords

Molecular imaging; PET; Translocator protein (TSPO); Traumatic brain injury (TBI)

Indexed keywords

CARRIER PROTEIN; DPA 714 F 18; FLUORINE 18; LIGAND; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; RADIOPHARMACEUTICAL AGENT; TRANSLOCATOR PROTEIN; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; BZRP PROTEIN, RAT; FLUORODEOXYGLUCOSE F 18; N,N-DIETHYL-2-(2-(4-(2-FLUOROETHOXY)PHENYL)-5,7-DIMETHYLPYRAZOLO(1,5-A)PYRIMIDIN-3-YL)ACETAMIDE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN METABOLISM; BRAIN REGION; BRAIN TISSUE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; DRUG UPTAKE; EX VIVO STUDY; IMMUNOFLUORESCENCE; IN VIVO STUDY; ISOTOPE LABELING; MALE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; SHAM PROCEDURE; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN; BRAIN INJURY; DIAGNOSTIC USE; DISEASE MODEL; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; SCINTISCANNING; TIME;

ANIMALS; BRAIN; BRAIN INJURIES; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; FLUORODEOXYGLUCOSE F18; GENE EXPRESSION REGULATION; INFLAMMATION; LIGANDS; MAGNETIC RESONANCE IMAGING; MALE; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; PYRIMIDINES; RATS; RECEPTORS, GABA-A; TIME FACTORS;

EID: 84903737591     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-014-2727-5     Document Type: Article

References (34)

1. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375-8. (Pubitemid 44413110)
2. Kumar A, Loane DJ. Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. Brain Behav Immun. 2012;26:1191-201.
3. Ceulemans AG, Zgavc T, Kooijman R, Hachimi-Idrissi S, Sarre S, Michotte Y. The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia. J Neuroinflammation. 2010;7:74.
4. Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007;8:57-69. (Pubitemid 46011999)
5. Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 2005;8:752-8. (Pubitemid 43085841)
6. Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol. 2011;11:775-87.
7. Gonzalez-Scarano F, Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci. 1999;22:219-40. (Pubitemid 29144887)
8. Winkeler A, Boisgard R, Awde AR, Dubois A, Theze B, Zheng J, et al. The translocator protein ligand [18F]DPA-714 images glioma and activated microglia in vivo. Eur J Nucl Med Mol Imaging. 2012;39:811-23.
9. Martin A, Boisgard R, Theze B, Van Camp N, Kuhnast B, Damont A, et al. Evaluation of the PBR/TSPO radioligand [18F]DPA-714 in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab. 2010;30:230-41.
10. Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, et al. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. J Neurosci. 2008;28:12255-67.
11. Scarf AM, Kassiou M. The translocator protein. J Nucl Med. 2011;52:677-80.
12. Folkersma H, Foster Dingley JC, van Berckel BN, Rozemuller A, Boellaard R, Huisman MC, et al. Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study. J Neuroinflammation. 2011;8:67.
13. Yu I, InajiM, Maeda J, Okauchi T, Nariai T, Ohno K, et al. Glial cell-mediated deterioration and repair of the nervous system after traumatic brain injury in a rat model as assessed by positron emission tomography. J Neurotrauma. 2010;27:1463-75.
14. Venneti S, Lopresti BJ, Wang G, Slagel SL, Mason NS, Mathis CA, et al. A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation. J Neurochem. 2007;102:2118-31. (Pubitemid 47329281)
15. Raghavendra Rao VL, Dogan A, Bowen KK, Dempsey RJ. Traumatic brain injury leads to increased expression of peripheraltype benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp Neurol. 2000;161:102-14. (Pubitemid 30136533)
16. Chauveau F, Van Camp N, Dolle F, Kuhnast B, Hinnen F, Damont A, et al. Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. J Nucl Med. 2009;50:468-76.
17. Doorduin J, Klein HC, Dierckx RA, James M, Kassiou M, de Vries EF. [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Mol Imaging Biol. 2009;11:386-98.
18. Arlicot N, Vercouillie J, Ribeiro MJ, Tauber C, Venel Y, Baulieu JL, et al. Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation. Nucl Med Biol. 2012;39:570-8.
19. Guide for the Care and Use of Laboratory Animals.Washington, DC: National Academy Press; 2010.
20. Baskaya MK, Dogan A, Temiz C, Dempsey RJ. Application of 2,3,5-triphenyltetrazolium chloride staining to evaluate injury volume after controlled cortical impact brain injury: role of brain edema in evolution of injury volume. J Neurotrauma. 2000;17:93-9. (Pubitemid 30075619)
21. Boutin H, Prenant C, Maroy R, Galea J, Greenhalgh AD, Smigova A, et al. [18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats. PLoS One. 2013;8:e56441.
22. Cai W, Guzman R, Hsu AR, Wang H, Chen K, Sun G, et al. Positron emission tomography imaging of poststroke angiogenesis. Stroke. 2009;40:270-7.
23. Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2007;104:1937-42. (Pubitemid 46239882)
24. Chen DL, Schuster DP. Positron emission tomography with [18F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004;286:L834-40. (Pubitemid 38365070)
25. Tardy M, Fages C, Le Prince G, Rolland B, Nunez J. Regulation of the glial fibrillary acidic protein (GFAP) and of its encoding mRNA in the developing brain and in cultured astrocytes. Adv Exp Med Biol. 1990;265:41-52. (Pubitemid 20189913)
26. Galan X, Llobera M, Ramirez I. Lipoprotein lipase in developing rat tissues: differences between Wistar and Sprague-Dawley rats. Biol Neonate. 1993;64:295-303. (Pubitemid 23346323)
27. James ML, Fulton RR, Vercoullie J, Henderson DJ, Garreau L, Chalon S, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008;49:814-22. (Pubitemid 351717548)
28. Kuhnast B, Damont A, Hinnen F, Catarina T, Demphel S, Le Helleix S, et al. [18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106-selective radioligands for imaging TSPO 18 kDa with PET: automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls. Appl Radiat Isot. 2012;70:489-97.
29. James ML, Selleri S, Kassiou M. Development of ligands for the peripheral benzodiazepine receptor. CurrMed Chem. 2006;13:1991-2001.
30. Shlosberg D, Benifla M, Kaufer D, Friedman A. Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat Rev Neurol. 2010;6:393-403.
31. Chen MK, Baidoo K, Verina T, Guilarte TR. Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain. 2004;127:1379-92. (Pubitemid 38745516)
32. Schilling M, Besselmann M, Muller M, Strecker JK, Ringelstein EB, Kiefer R. Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol. 2005;196:290-7. (Pubitemid 41607817)
33. Venneti S, Lopresti BJ, Wang G, Hamilton RL, Mathis CA, Klunk WE, et al. PK11195 labels activated microglia in Alzheimer 's disease and in vivo in a mouse model using PET. Neurobiol Aging. 2009;30:1217-26.
34. Maeda J, Higuchi M, Inaji M, Ji B, Haneda E, Okauchi T, et al. Phase-dependent roles of reactivemicroglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res. 2007;1157:100-11. (Pubitemid 46935074)