Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: A longitudinal pilot study

Journal of Neuroinflammation

Volumn 8, Issue , 2011, Pages

  Folkersma, Hedy ^a   Foster Dingley, Jessica C ^a   van Berckel, Bart N M ^a   Rozemuller, Annemieke ^a   Boellaard, Ronald ^a   Huisman, Marc C ^a   Lammertsma, Adriaan A ^a   Vandertop, W Peter ^a   Molthoff, Carla F M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; CD74 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; PERL PROTEIN; PROTEIN ED 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARBON; FLUORESCENT DYE; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BRAIN NERVE CELL; BRAIN RADIOGRAPHY; CELL ACTIVATION; CONTROLLED STUDY; EXTRACELLULAR FLUID; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LONGITUDINAL STUDY; MALE; MICRODIALYSIS; MICROGLIA; NONHUMAN; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; RAT; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN; BRAIN INJURY; CHEMISTRY; METABOLISM; METHODOLOGY; PATHOLOGY; SCINTISCANNING; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; BRAIN INJURIES; CARBON RADIOISOTOPES; FLUORESCENT DYES; GLUTAMIC ACID; ISOQUINOLINES; MALE; MICRODIALYSIS; PILOT PROJECTS; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, WISTAR;

EID: 79958277386     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-67     Document Type: Article

References (32)

1. Farber K, Kettenmann H. Physiology of microglial cells. Brain Res Brain Res Rev 2005, 48:133-143.
2. Hardingham GE. Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochem Soc Trans 2009, 37:1147-1160. 10.1042/BST0371147, 2837198, 19909238.
3. Olney JW, Ho OL. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature 1970, 227:609-611.
4. Takeuchi H, Jin S, Suzuki H, Doi Y, Liang J, Kawanokuchi J, Mizuno T, Sawada M, Suzumura A. Blockade of microglial glutamate release protects against ischemic brain injury. Exp Neurol 2008, 214(1):144-6. 10.1016/j.expneurol.2008.08.001, 18775425.
5. Folkersma H, Boellaard R, Vandertop WP, Kloet RW, Lubberink M, Lammertsma AA, van Berckel BN. Reference tissue models and blood-brain barrier disruption: lessons from (R)-[11C]PK11195 in traumatic brain injury. J Nucl Med 2009, 50:1975-1979. 10.2967/jnumed.109.067512, 19910429.
6. Kropholler MA, Boellaard R, Schuitemaker A, Folkersma H, van Berckel BN, Lammertsma AA. Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies. J Cereb Blood Flow Metab 2006, 26:1431-1441. 10.1038/sj.jcbfm.9600289, 16511500.
7. Chen MK, Guilarte TR. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol Ther 2008, 118:1-17. 10.1016/j.pharmthera.2007.12.004, 2453598, 18374421.
8. Doorduin J, Klein HC, Dierckx RA, James M, Kassiou M, de Vries EF. [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Mol Imaging Biol 2009, 11:386-398. 10.1007/s11307-009-0211-6, 2763079, 19330384.
9. Folkersma H, Breve JJ, Tilders FJ, Cherian L, Robertson CS, Vandertop WP. Cerebral microdialysis of interleukin (IL)-1beta and IL-6: extraction efficiency and production in the acute phase after severe traumatic brain injury in rats. Acta Neurochir (Wien) 2008, 150:1277-1284.
10. Shah F, Hume SP, Pike VW, Ashworth S, McDermott J. Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol 1994, 21:573-581. 10.1016/0969-8051(94)90022-1, 9234314.
11. Boellaard R, Buijs F, de Jong HW, Lenox M, Gremillion T, Lammertsma AA. Characterization of a single LSO crystal layer high resolution research tomograph. Phys Med Biol 2003, 48:429-448. 10.1088/0031-9155/48/4/302, 12630740.
12. de Jong HW, van Velden FH, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA. Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol 2007, 52:1505-1526. 10.1088/0031-9155/52/5/019, 17301468.
13. Heiss WD, Habedank B, Klein JC, Herholz K, Wienhard K, Lenox M, Nutt R. Metabolic rates in small brain nuclei determined by high-resolution PET. J Nucl Med 2004, 45:1811-1815.
14. Sato M, Chang E, Igarashi T, Noble LJ. Neuronal injury and loss after traumatic brain injury: time course and regional variability. Brain Res 2001, 917:45-54. 10.1016/S0006-8993(01)02905-5, 11602228.
15. Schmued LC, Hopkins KJ. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 2000, 874:123-130. 10.1016/S0006-8993(00)02513-0, 10960596.
16. Hume SP, Gunn RN, Jones T. Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals. Eur J Nucl Med 1998, 25:173-176. 10.1007/s002590050211, 9473266.
17. Toyama H, Hatano K, Suzuki H, Ichise M, Momosaki S, Kudo G, Ito F, Kato T, Yamaguchi H, Katada K, Sawada M, Ito K. In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum. Ann Nucl Med 2008, 22:417-424. 10.1007/s12149-008-0136-1, 18600420.
18. Ito F, Toyama H, Kudo G, Suzuki H, Hatano K, Ichise M, Katada K, Ito K, Sawada M. Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [(11)C]PK11195 in rats. Ann Nucl Med 2010, 24:163-169. 10.1007/s12149-009-0339-0, 20101481.
19. Yu I, Inaji M, Maeda J, Okauchi T, Nariai T, Ohno K, Higuchi M, Suhara T. Glial cell-mediated deterioration and repair of the nervous system after traumatic brain injury in a rat model as assessed by positron emission tomography. J Neurotrauma 2010, 27(8):1463-75. 10.1089/neu.2009.1196, 20504160.
20. Woodroofe MN, Sarna GS, Wadhwa M, Hayes GM, Loughlin AJ, Tinker A, Cuzner ML. Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J Neuroimmunol 1991, 33:227-236. 10.1016/0165-5728(91)90110-S, 1874973.
21. Mattson MP. Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders. Neuromolecular Med 2003, 3:65-94. 10.1385/NMM:3:2:65, 12728191.
22. Fei Z, Zhang X, Bai HM, Jiang XF, Li X, Zhang W, Hu W. Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptors. BMC Neurosci 2007, 8:96. 10.1186/1471-2202-8-96, 2242800, 18021417.
23. Bullock R, Zauner A, Woodward JJ, Myseros J, Choi SC, Ward JD, Marmarou A, Young HF. Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg 1998, 89:507-518. 10.3171/jns.1998.89.4.0507, 9761042.
24. Sahuquillo J, Poca MA, Amoros S. Current aspects of pathophysiology and cell dysfunction after severe head injury. Curr Pharm Des 2001, 7:1475-1503. 10.2174/1381612013397311, 11562294.
25. Faden AI, Demediuk P, Panter SS, Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 1989, 244:798-800. 10.1126/science.2567056, 2567056.
26. Falo MC, Reeves TM, Phillips LL. Agrin expression during synaptogenesis induced by traumatic brain injury. J Neurotrauma 2008, 25:769-783. 10.1089/neu.2008.0511, 2946878, 18627255.
27. Katoh H, Sima K, Nawashiro H, Wada K, Chigasaki H. The effect of MK-801 on extracellular neuroactive amino acids in hippocampus after closed head injury followed by hypoxia in rats. Brain Res 1997, 758:153-162. 10.1016/S0006-8993(97)00213-8, 9203544.
28. Okiyama K, Smith DH, White WF, McIntosh TK. Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. Brain Res 1998, 792:291-298. 10.1016/S0006-8993(98)00158-9, 9593949.
29. Suma T, Koshinaga M, Fukushima M, Kano T, Katayama Y. Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury. Neurol Res 2008, 30:420-429. 10.1179/016164107X251745, 18248696.
30. Liu GJ, Nagarajah R, Banati RB, Bennett MR. Glutamate induces directed chemotaxis of microglia. Eur J Neurosci 2009, 29:1108-1118. 10.1111/j.1460-9568.2009.06659.x, 19302147.
31. Lemstra AW, Groen in't Woud JC, Hoozemans JJ, van Haastert ES, Rozemuller AJ, Eikelenboom P, van Gool WA. Microglia activation in sepsis: a case-control study. J Neuroinflammation 2007, 4:4. 10.1186/1742-2094-4-4, 1783646, 17224051.
32. Cho BP, Song DY, Sugama S, Shin DH, Shimizu Y, Kim SS, Kim YS, Joh TH. Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia 2006, 53:92-102. 10.1002/glia.20265, 16206155.