In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase

ChemBioChem

Volumn 15, Issue 10, 2014, Pages 1436-1445

  Korotchenko, Vasiliy N ^a,c   Saydmohammed, Manush ^b   Vollmer, Laura L ^a   Bakan, Ahmet ^b   Sheetz, Kyle ^b   Debiec, Karl T ^a   Greene, Kristina A ^a   Agliori, Christine S ^a   Bahar, Ivet ^b   Day, Billy W ^a   Vogt, Andreas ^a,b   Tsang, Michael ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

BCI; cognition network technology; FGF signaling; high content screening; zebrafish

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 6; ENZYME INHIBITOR; FIBROBLAST GROWTH FACTOR; INDENE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE;

ALLOSTERISM; ARTICLE; ENZYME INHIBITION ASSAY; GENETIC COMPLEMENTATION; IN VIVO STUDY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; EMBRYOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; ANIMALS; DRUG DESIGN; DUAL SPECIFICITY PHOSPHATASE 6; EMBRYO, NONMAMMALIAN; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTORS; INDENES; MODELS, MOLECULAR; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH;

EID: 84903730449     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402000     Document Type: Article

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