Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25

Journal of Medicinal Chemistry

Volumn 44, Issue 24, 2001, Pages 4042-4049

  Lazo, J S ^a   Aslan, D C ^a   Southwick, E C ^a   Cooley, K A ^a   Ducruet, A P ^a   Joo, B ^b   Vogt, A ^a   Wipf, P ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 7 (2 MORPHOLIN 4 YLETHYLAMINO)QUINOLINE 5,8 DIONE; 7 CHLORO 6 (2 MORPHOLIN 4 YLETHYLAMINO)QUINOLINE 5,8 DIONE; NSC 663284; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN PHOSPHATASE CDC25; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CDC25 PHOSPHATASE; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; QUINOLINES; QUINOLONES; QUINONES; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035935711     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102046     Document Type: Article

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