Caudatin inhibits carcinomic human alveolar basal epithelial cell growth and angiogenesis through modulating GSK3β/β-catenin pathway

Journal of Cellular Biochemistry

Volumn 113, Issue 11, 2012, Pages 3403-3410

  Fei, Hong Rong ^a   Cui, Li Yuan ^a   Zhang, Zhao Rui ^a   Zhao, Ying ^a   Wang, Feng Ze ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

Author keywords

CATENIN; ANGIOGENESIS; CAUDATIN; CELL GROWTH; GSK3 ; VEGF

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CASPASE 3; CASPASE 9; CAUDATIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL LINE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BETA CATENIN; CARCINOMA; CASPASE 3; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; GLYCOSIDES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LUNG NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; ORGAN SPECIFICITY; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; STEROIDS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866505616     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24216     Document Type: Article

References (24)

1. Baryawno N, Sveinbjörnsson B, Eksborg S, Chen CS, Kogner P, Johnsen JI,. 2010. Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res 70: 266-276.
2. Behari J,. 2010. The Wnt/β-catenin signaling pathway in liver biology and disease. Expert Rev Gastroenterol Hepatol 4: 745-756.
3. Crawford ED, Wells JA,. 2011. Caspase substrates and cellular remodeling. Annu Rev Biochem 80: 1055-1087.
4. Dodge ME, Lum L,. 2011. Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol 51: 289-310.
5. El Wakil A, Lalli E,. 2011. The Wnt/beta-catenin pathway in adrenocortical development and cancer. Mol Cell Endocrinol 332: 32-37.
6. Eom TY, Jope RS,. 2009. Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation. Biol Psychiatry 66: 494-502.
7. Fei HR, Chen HL, Xiao T, Chen G, Wang FZ,. 2012. Caudatin induces cell cycle arrest and caspase-dependent apoptosis in HepG2 cell. Mol Biol Rep 39: 131-138.
8. Florentin A, Arama E,. 2012. Caspase levels and execution efficiencies determine the apoptotic potential of the cell. J Cell Biol 196: 513-527.
9. Folkman J, Shing Y,. 1992. Angiogenesis J Biol Chem 267: 10931-10934.
10. Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D,. 2011. Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol 13: 1244-1251.
11. Li J, Xing M, Zhu M, Wang X, Wang M, Zhou S, Li N, Wu R, Zhou M,. 2008. Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization. Cancer Lett 272: 91-101.
12. Liang MH, Chuang DM,. 2007. Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J Biol Chem 282: 3904-3917.
13. Liu Z, Tanabe K, Bernal-Mizrachi E, Permutt MA,. 2008. Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation. Diabetologia 51: 623-631.
14. MacDonald BT, Tamai K, He X,. 2009. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26.
15. Monga SP,. 2011. Role of Wnt/β-catenin signaling in liver metabolism and cancer. Int J Biochem Cell Biol 43: 1021-1029.
16. Naito AT, Shiojima I, Komuro I,. 2010. Wnt signaling and aging-related heart disorders. Circ Res 107: 1295-1303.
17. Peng YR, Li YB, Liu XD, Zhang JF, Duan JA,. 2008. Apoptosis Induced by Caudatin in Human Hepatoma Cell Line SMMC7721. Chin J Nat Med 6: 210-213.
18. Prosperi JR, Goss KH,. 2010. A Wnt-ow of opportunity: targeting the Wnt/beta-catenin pathway in breast cancer. Curr Drug Targets 11: 1074-1088.
19. Tsai AC, Pan SL, Liao CH, Guh JH, Wang SW, Sun HL, Liu YN, Chen CC, Shen CC, Chang YL, Teng CM,. 2010. Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo. Cancer Lett 292: 163-170.
20. Tung JN, Chiang CC, Tsai YY, Chou YY, Yeh KT, Lee H, Cheng YW,. 2010. CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization. Mol Vis 16: 2733-2738.
21. Xiong F, Leonov S, Howard AC, Xiong S, Zhang B, Mei L, McNeil P, Simon S, Xiong WC,. 2011. Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a {beta}-catenin-dependent manner. J Biol Chem 286: 35061-35070.
22. Zhang JF, Li YB, Li CL, Jiang JQ,. 2006. Studies on chemical constituents in root tuber of Cynanchum auriculatum. Zhongguo Zhong Yao Za Zhi 31: 814-816.
23. Zhang R, Liu Y, Wang Y, Ye Y, Li X,. 2007. Cytotoxic and apoptosis-inducing properties of auriculoside A in tumor cells. Chem Biodivers 4: 887-892.
24. Zhang JY, Tao LY, Liang YJ, Yan YY, Dai CL, Xia XK, She ZG, Lin YC, Fu LW,. 2009. Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G(1) with involvement of GSK-3beta/beta-catenin/c-Myc pathway. Cell Cycle 8: 2444-2450.