-
1
-
-
77952002277
-
Gastric cancer: A primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease
-
Shah MA, Kelsen DP: Gastric cancer: a primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease. J. Natl Compr. Canc. Netw. 8(4), 437-447 (2010).
-
(2010)
J. Natl Compr. Canc. Netw.
, vol.8
, Issue.4
, pp. 437-447
-
-
Shah, M.A.1
Kelsen, D.P.2
-
2
-
-
33646568784
-
Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
-
Kamangar F, Dores GM, Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol. 24(14), 2137-2150 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.14
, pp. 2137-2150
-
-
Kamangar, F.1
Dores, G.M.2
Anderson, W.F.3
-
3
-
-
20944437877
-
Survival after gastric adenocarcinoma resection: Eighteen-year experience at a single institution
-
Cunningham SC, Kamangar F, Kim MP et al.: Survival after gastric adenocarcinoma resection: eighteen-year experience at a single institution. J. Gastrointest. Surg. 9(5), 718-725 (2005).
-
(2005)
J. Gastrointest. Surg.
, vol.9
, Issue.5
, pp. 718-725
-
-
Cunningham, S.C.1
Kamangar, F.2
Kim, M.P.3
-
4
-
-
38049047178
-
Capecitabine and oxaliplatin for advanced esophagogastric cancer
-
Cunningham D, Starling N, Rao S et al.: Capecitabine and oxaliplatin for advanced esophagogastric cancer. N. Engl. J. Med. 358(1), 36-46 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, Issue.1
, pp. 36-46
-
-
Cunningham, D.1
Starling, N.2
Rao, S.3
-
5
-
-
63749118193
-
Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: A randomised Phase III noninferiority trial
-
Kang YK, Kang WK, Shin DB et al.: Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised Phase III noninferiority trial. Ann. Oncol. 20(4), 666-673 (2009).
-
(2009)
Ann. Oncol.
, vol.20
, Issue.4
, pp. 666-673
-
-
Kang, Y.K.1
Kang, W.K.2
Shin, D.B.3
-
6
-
-
33745547767
-
Chemotherapy in advanced gastric cancer: A systematic review and meta-analysis based on aggregate data
-
Wagner AD, Grothe W, Haerting J, Kleber G, Grothey A, Fleig WE: Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J. Clin. Oncol. 24(18), 2903-2909 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.18
, pp. 2903-2909
-
-
Wagner, A.D.1
Grothe, W.2
Haerting, J.3
Kleber, G.4
Grothey, A.5
Fleig, W.E.6
-
7
-
-
33750949065
-
Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A report of the V325 Study Group
-
Van Cutsem E, Moiseyenko VM, Tjulandin S et al.: Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J. Clin. Oncol. 24(31), 4991-4997 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.31
, pp. 4991-4997
-
-
Van Cutsem, E.1
Moiseyenko, V.M.2
Tjulandin, S.3
-
8
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235(4785), 177-182 (1987).
-
(1987)
Science
, vol.235
, Issue.4785
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
9
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al.: Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1659-1672 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, Issue.16
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
10
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J et al.: Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1673-1684 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, Issue.16
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
11
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S et al.: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344(11), 783-792 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
12
-
-
33845914783
-
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
-
Smith I, Procter M, Gelber RD et al.: 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 369(9555), 29-36 (2007).
-
(2007)
Lancet
, vol.369
, Issue.9555
, pp. 29-36
-
-
Smith, I.1
Procter, M.2
Gelber, R.D.3
-
13
-
-
0035115441
-
Overexpression of HER2/neu in solid tumours: An immunohistochemical survey
-
Koeppen HK, Wright BD, Burt AD et al.: Overexpression of HER2/neu in solid tumours: an immunohistochemical survey. Histopathology 38(2), 96-104 (2001).
-
(2001)
Histopathology
, vol.38
, Issue.2
, pp. 96-104
-
-
Koeppen, H.K.1
Wright, B.D.2
Burt, A.D.3
-
14
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA et al.: Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244(4905), 707-712 (1989).
-
(1989)
Science
, vol.244
, Issue.4905
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
15
-
-
50849123421
-
HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target
-
Gravalos C, Jimeno A: HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann. Oncol. 19(9), 1523-1529 (2008). •• Review of the role of HER2 in gastric cancer.
-
(2008)
Ann. Oncol.
, vol.19
, Issue.9
, pp. 1523-1529
-
-
Gravalos, C.1
Jimeno, A.2
-
16
-
-
33748154637
-
HER-2/neu amplification is an independent prognostic factor in gastric cancer
-
Park DI, Yun JW, Park JH et al.: HER-2/neu amplification is an independent prognostic factor in gastric cancer. Dig. Dis. Sci. 51(8), 1371-1379 (2006).
-
(2006)
Dig. Dis. Sci.
, vol.51
, Issue.8
, pp. 1371-1379
-
-
Park, D.I.1
Yun, J.W.2
Park, J.H.3
-
17
-
-
44249092320
-
Assessment of a HER2 scoring system for gastric cancer: Results from a validation study
-
Hofmann M, Stoss O, Shi D et al.: Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology 52(7), 797-805 (2008). • Initial guidance on scoring considerations for HER2 testing in gastric cancer.
-
(2008)
Histopathology
, vol.52
, Issue.7
, pp. 797-805
-
-
Hofmann, M.1
Stoss, O.2
Shi, D.3
-
18
-
-
20044372721
-
Amplification of HER-2 in gastric carcinoma: Association with topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
-
Tanner M, Hollmen M, Junttila TT et al.: Amplification of HER-2 in gastric carcinoma: association with topoisomerase IIα gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann. Oncol. 16(2), 273-278 (2005).
-
(2005)
Ann. Oncol.
, vol.16
, Issue.2
, pp. 273-278
-
-
Tanner, M.1
Hollmen, M.2
Junttila, T.T.3
-
19
-
-
77749273477
-
HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - Conclusions from 924 cases of two independent series
-
Grabsch H, Sivakumar S, Gray S, Gabbert HE, Muller W: HER2 expression in gastric cancer: rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series. Cell. Oncol. 32(1-2), 57-65 (2010).
-
(2010)
Cell. Oncol.
, vol.32
, Issue.1-2
, pp. 57-65
-
-
Grabsch, H.1
Sivakumar, S.2
Gray, S.3
Gabbert, H.E.4
Muller, W.5
-
20
-
-
79952149837
-
Human epidermal growth factor receptor 2 (HER2) in gastric cancer (GC): Results of the ToGA trial screening programme and recommendations for HER2 testing
-
Presented at: Berlin, Germany, 20-24 September
-
Chung HC, Bang YJ, Xu JM et al.: Human epidermal growth factor receptor 2 (HER2) in gastric cancer (GC): results of the ToGA trial screening programme and recommendations for HER2 testing. Presented at: European Cancer Organisation 15/European Society for Medical Oncology 34. Berlin, Germany, 20-24 September 2009.
-
(2009)
European Cancer Organisation 15/European Society for Medical Oncology 34
-
-
Chung, H.C.1
Bang, Y.J.2
Xu, J.M.3
-
21
-
-
0025318271
-
Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product
-
Fendly BM, Winget M, Hudziak RM, Lipari MT, Napier MA, Ullrich A: Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. Cancer Res. 50(5), 1550-1558 (1990).
-
(1990)
Cancer Res.
, vol.50
, Issue.5
, pp. 1550-1558
-
-
Fendly, B.M.1
Winget, M.2
Hudziak, R.M.3
Lipari, M.T.4
Napier, M.A.5
Ullrich, A.6
-
22
-
-
0027375130
-
Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies
-
Lewis GD, Figari I, Fendly B et al.: Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies. Cancer Immunol. Immunother. 37(4), 255-263 (1993).
-
(1993)
Cancer Immunol. Immunother.
, vol.37
, Issue.4
, pp. 255-263
-
-
Lewis, G.D.1
Figari, I.2
Fendly, B.3
-
23
-
-
0026610881
-
Humanization of an anti-p185HER2 antibody for human cancer therapy
-
Carter P, Presta L, Gorman CM et al.: Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc. Natl Acad. Sci. USA 89(10), 4285-4289 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, Issue.10
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
-
24
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the herceptin Fab
-
Cho HS, Mason K, Ramyar KX et al.: Structure of the extracellular region of HER2 alone and in complex with the herceptin Fab. Nature 421(6924), 756-760 (2003).
-
(2003)
Nature
, vol.421
, Issue.6924
, pp. 756-760
-
-
Cho, H.S.1
Mason, K.2
Ramyar, K.X.3
-
25
-
-
34347395733
-
Trastuzumab - Mechanism of action and use in clinical practice
-
Hudis CA: Trastuzumab - mechanism of action and use in clinical practice. N. Engl. J. Med. 357(1), 39-51 (2007). • Overview of trastuzumab activity and clinical potential.
-
(2007)
N. Engl. J. Med.
, vol.357
, Issue.1
, pp. 39-51
-
-
Hudis, C.A.1
-
26
-
-
0037099532
-
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
-
Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL: Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res. 62(14), 4132-4141 (2002).
-
(2002)
Cancer Res.
, vol.62
, Issue.14
, pp. 4132-4141
-
-
Yakes, F.M.1
Chinratanalab, W.2
Ritter, C.A.3
King, W.4
Seelig, S.5
Arteaga, C.L.6
-
27
-
-
0035874981
-
Trastuzumab (herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J: Trastuzumab (herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells. Cancer Res. 61(12), 4744-4749 (2001).
-
(2001)
Cancer Res.
, vol.61
, Issue.12
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
28
-
-
34447298092
-
Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance
-
Barok M, Isola J, Palyi-Krekk Z et al.: Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance. Mol. Cancer Ther. 6(7), 2065-2072 (2007).
-
(2007)
Mol. Cancer Ther.
, vol.6
, Issue.7
, pp. 2065-2072
-
-
Barok, M.1
Isola, J.2
Palyi-Krekk, Z.3
-
29
-
-
42949157368
-
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
-
Musolino A, Naldi N, Bortesi B et al.: Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J. Clin. Oncol. 26(11), 1789-1796 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.11
, pp. 1789-1796
-
-
Musolino, A.1
Naldi, N.2
Bortesi, B.3
-
30
-
-
38749149510
-
Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin
-
Kim SY, Kim HP, Kim YJ et al.: Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. Int. J. Oncol. 32(1), 89-95 (2008).
-
(2008)
Int. J. Oncol.
, vol.32
, Issue.1
, pp. 89-95
-
-
Kim, S.Y.1
Kim, H.P.2
Kim, Y.J.3
-
31
-
-
0036225446
-
Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
-
Normanno N, Campiglio M, De LA et al.: Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Ann. Oncol. 13(1), 65-72 (2002).
-
(2002)
Ann. Oncol.
, vol.13
, Issue.1
, pp. 65-72
-
-
Normanno, N.1
Campiglio, M.2
De, L.A.3
-
32
-
-
0033118889
-
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
-
Pegram M, Hsu S, Lewis G et al.: Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 18(13), 2241-2251 (1999).
-
(1999)
Oncogene
, vol.18
, Issue.13
, pp. 2241-2251
-
-
Pegram, M.1
Hsu, S.2
Lewis, G.3
-
33
-
-
0030870295
-
The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells
-
Pegram MD, Finn RS, Arzoo K, Beryt M, Pietras RJ, Slamon DJ: The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells. Oncogene 15(5), 537-547 (1997).
-
(1997)
Oncogene
, vol.15
, Issue.5
, pp. 537-547
-
-
Pegram, M.D.1
Finn, R.S.2
Arzoo, K.3
Beryt, M.4
Pietras, R.J.5
Slamon, D.J.6
-
34
-
-
33947320114
-
Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models
-
Fujimoto-Ouchi K, Sekiguchi F, Yasuno H, Moriya Y, Mori K, Tanaka Y: Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models. Cancer Chemother. Pharmacol. 59(6), 795-805 (2007). • Preclinical findings indicating potential for chemotherapy plus trastuzumab in gastric cancer.
-
(2007)
Cancer Chemother. Pharmacol.
, vol.59
, Issue.6
, pp. 795-805
-
-
Fujimoto-Ouchi, K.1
Sekiguchi, F.2
Yasuno, H.3
Moriya, Y.4
Mori, K.5
Tanaka, Y.6
-
35
-
-
0029886350
-
In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product
-
Tokuda Y, Ohnishi Y, Shimamura K et al.: In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product. Br. J. Cancer 73(11), 1362-1365 (1996).
-
(1996)
Br. J. Cancer
, vol.73
, Issue.11
, pp. 1362-1365
-
-
Tokuda, Y.1
Ohnishi, Y.2
Shimamura, K.3
-
36
-
-
24344489058
-
Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model
-
Matsui Y, Inomata M, Tojigamori M, Sonoda K, Shiraishi N, Kitano S: Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model. Int. J. Oncol. 27(3), 681-685 (2005).
-
(2005)
Int. J. Oncol.
, vol.27
, Issue.3
, pp. 681-685
-
-
Matsui, Y.1
Inomata, M.2
Tojigamori, M.3
Sonoda, K.4
Shiraishi, N.5
Kitano, S.6
-
37
-
-
23244455101
-
+ metastatic breast cancer
-
+ metastatic breast cancer. Cancer Chemother. Pharmacol. 56(4), 361-369 (2005).
-
(2005)
Cancer Chemother. Pharmacol.
, vol.56
, Issue.4
, pp. 361-369
-
-
Bruno, R.1
Washington, C.B.2
Lu, J.F.3
Lieberman, G.4
Banken, L.5
Klein, P.6
-
38
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A Phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A et al.: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a Phase 3, open-label, randomised controlled trial. Lancet 376(9742), 687-697 (2010). •• Key Phase III results from the Trastuzumab for Gastric Cancer (ToGA) study.
-
(2010)
Lancet
, vol.376
, Issue.9742
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
39
-
-
79952136325
-
Phase II of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/ amplification. Presented at
-
Cortes-Funes H, Rivera F, Ales I et al. Phase II of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/ amplification. Presented at: 43rd American Society of Clinical Oncology (ASCO) Annual Meeting. Chicago, IL, USA, 1-5 June 2007.
-
43rd American Society of Clinical Oncology (ASCO) Annual Meeting. Chicago, IL, USA, 1-5 June 2007
-
-
Cortes-Funes, H.1
Rivera, F.2
Ales, I.3
-
40
-
-
79952121124
-
Early results of a trial of trastuzumab, cisplatin, and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER-2
-
Presented at
-
Nicholas G, Cripps C, Au H et al.: Early results of a trial of trastuzumab, cisplatin, and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER-2. Presented at: 31st European Society for Medical Oncology Congress. Istanbul, Turkey, 29 September-3 October 2006.
-
31st European Society for Medical Oncology Congress. Istanbul, Turkey, 29 September-3 October 2006
-
-
Nicholas, G.1
Cripps, C.2
Au, H.3
-
41
-
-
79952159424
-
Quality of life results from a Phase III trial of trastuzumab plus chemotherapy in first-line HER2-positive advanced gastric and GE junction cancer
-
Presented at
-
Satoh T, Leon J, Lopez RI et al.: Quality of life results from a Phase III trial of trastuzumab plus chemotherapy in first-line HER2-positive advanced gastric and GE junction cancer. Presented at: 2010 Gastrointestinal Cancers Symposium. Orlando, FL, USA, 22-24 January 2010.
-
2010 Gastrointestinal Cancers Symposium. Orlando, FL, USA, 22-24 January 2010
-
-
Satoh, T.1
Leon, J.2
Lopez, R.I.3
-
42
-
-
79952169493
-
(Q)-TWIST analysis of trastuzumab plus fluoropyrimidine/cisplatin (T-XP/FP) versus XP/FP alone as first-line therapy for advanced HER2-positive gastric cancer
-
Presented at
-
Chung HC, Bang Y, Van Cutsem E et al.: (Q)-TWIST analysis of trastuzumab plus fluoropyrimidine/cisplatin (T-XP/FP) versus XP/FP alone as first-line therapy for advanced HER2-positive gastric cancer. Presented at: 2010 American Society of Clinical Oncology (ASCO) Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
-
2010 American Society of Clinical Oncology (ASCO) Annual Meeting. Chicago, IL, USA, 4-8 June 2010
-
-
Chung, H.C.1
Bang, Y.2
Van Cutsem, E.3
-
43
-
-
33745547767
-
Chemotherapy in advanced gastric cancer: A systematic review and meta-analysis based on aggregate data
-
Wagner AD, Grothe W, Haerting J, Kleber G, Grothey A, Fleig WE: Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J. Clin. Oncol. 24(18), 2903-2909 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.18
, pp. 2903-2909
-
-
Wagner, A.D.1
Grothe, W.2
Haerting, J.3
Kleber, G.4
Grothey, A.5
Fleig, W.E.6
-
44
-
-
41149154862
-
Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: A study of the Arbeitsgemeinschaft Internistische Onkologie
-
Al Batran SE, Hartmann JT, Probst S et al.: Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. J. Clin. Oncol. 26(9), 1435-1442 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, Issue.9
, pp. 1435-1442
-
-
Al Batran, S.E.1
Hartmann, J.T.2
Probst, S.3
-
45
-
-
77955296163
-
Trastuzumab-related cardiotoxicity following anthracycline-based adjuvant chemotherapy: How worried should we be?
-
Morris PG, Hudis CA: Trastuzumab-related cardiotoxicity following anthracycline-based adjuvant chemotherapy: how worried should we be? J. Clin. Oncol. 28(21), 3407-3410 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.21
, pp. 3407-3410
-
-
Morris, P.G.1
Hudis, C.A.2
-
46
-
-
77953259617
-
HER2 testing in gastric cancer. What is different in comparison to breast cancer?
-
Rüschoff J, Nagelmeier I, Baretton G et al.: HER2 testing in gastric cancer. What is different in comparison to breast cancer? Pathologe 31(3), 208-217 (2010).
-
(2010)
Pathologe
, vol.31
, Issue.3
, pp. 208-217
-
-
Rüschoff, J.1
Nagelmeier, I.2
Baretton, G.3
-
47
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D et al.: Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N. Engl. J. Med. 355(26), 2733-2743 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
48
-
-
79952156952
-
A Phase III study of CapeOx ± lapatinib in FISH-positive HER2 Locally advanced/metastatic upper gastrointestinal adenocarcinoma: Interim safety results
-
Presented at: Berlin, Germany, 20-24 September
-
Hecht JR, Bang YJ, Sobrero A et al.: A Phase III study of CapeOx ± lapatinib in FISH-positive HER2 Locally advanced/metastatic upper gastrointestinal adenocarcinoma: interim safety results. Presented at: European Cancer Organisation 15/ European Society for Medical Oncology 34. Berlin, Germany, 20-24 September 2009.
-
(2009)
European Cancer Organisation 15/ European Society for Medical Oncology 34
-
-
Hecht, J.R.1
Bang, Y.J.2
Sobrero, A.3
-
49
-
-
79952142204
-
Interim safety analysis from TYTAN: A Phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer
-
Presented at
-
Satoh T, Bang Y, Wang J et al.: Interim safety analysis from TYTAN: a Phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer. Presented at: 2010 American Society of Clinical Oncology (ASCO) Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
-
2010 American Society of Clinical Oncology (ASCO) Annual Meeting. Chicago, IL, USA, 4-8 June 2010
-
-
Satoh, T.1
Bang, Y.2
Wang, J.3
-
50
-
-
51049123872
-
Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor
-
Gonzales AJ, Hook KE, Althaus IW et al.: Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor. Mol. Cancer Ther. 7(7), 1880-1889 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, Issue.7
, pp. 1880-1889
-
-
Gonzales, A.J.1
Hook, K.E.2
Althaus, I.W.3
-
51
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
Sergina NV, Rausch M, Wang D et al.: Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 445(7126), 437-441 (2007).
-
(2007)
Nature
, vol.445
, Issue.7126
, pp. 437-441
-
-
Sergina, N.V.1
Rausch, M.2
Wang, D.3
-
52
-
-
67649472398
-
Novel anticancer targets: Revisiting ERBB2 and discovering ERBB3
-
Baselga J, Swain SM: Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat. Rev. Cancer 9(7), 463-475 (2009). •• Excellent review describing HER signaling and anti-HER therapies.
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.7
, pp. 463-475
-
-
Baselga, J.1
Swain, S.M.2
-
53
-
-
34547871259
-
Targeting HER proteins in cancer therapy and the role of the non-target HER3
-
Hsieh AC, Moasser MM: Targeting HER proteins in cancer therapy and the role of the non-target HER3. Br. J. Cancer 97(4), 453-457 (2007).
-
(2007)
Br. J. Cancer
, vol.97
, Issue.4
, pp. 453-457
-
-
Hsieh, A.C.1
Moasser, M.M.2
-
55
-
-
0029814271
-
A hierarchical network of interreceptor interactions determines signal transduction by neu differentiation factor/neuregulin and epidermal growth factor
-
Tzahar E, Waterman H, Chen X et al.: A hierarchical network of interreceptor interactions determines signal transduction by neu differentiation factor/neuregulin and epidermal growth factor. Mol. Cell Biol. 16(10), 5276-5287 (1996).
-
(1996)
Mol. Cell Biol.
, vol.16
, Issue.10
, pp. 5276-5287
-
-
Tzahar, E.1
Waterman, H.2
Chen, X.3
-
56
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 5(4), 317-328 (2004).
-
(2004)
Cancer Cell
, vol.5
, Issue.4
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
Leahy, D.J.4
De Vos, A.M.5
Sliwkowski, M.X.6
-
57
-
-
67651174452
-
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization
-
Hughes JB, Berger C, Rodland MS, Hasmann M, Stang E, Madshus IH: Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization. Mol. Cancer Ther. 8(7), 1885-1892 (2009).
-
(2009)
Mol. Cancer Ther.
, vol.8
, Issue.7
, pp. 1885-1892
-
-
Hughes, J.B.1
Berger, C.2
Rodland, M.S.3
Hasmann, M.4
Stang, E.5
Madshus, I.H.6
-
58
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD et al.: Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2(2), 127-137 (2002).
-
(2002)
Cancer Cell
, vol.2
, Issue.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
59
-
-
1942474587
-
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
-
Nahta R, Hung MC, Esteva FJ: The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 64(7), 2343-2346 (2004).
-
(2004)
Cancer Res.
, vol.64
, Issue.7
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.C.2
Esteva, F.J.3
-
60
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
Scheuer W, Friess T, Burtscher H, Bossenmaier B, Endl J, Hasmann M: Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 69(24), 9330-9336 (2009).
-
(2009)
Cancer Res.
, vol.69
, Issue.24
, pp. 9330-9336
-
-
Scheuer, W.1
Friess, T.2
Burtscher, H.3
Bossenmaier, B.4
Endl, J.5
Hasmann, M.6
-
61
-
-
79952157284
-
Pertuzumab in combination with trastuzumab enhanced the anti-tumor activity in HER2-positive human gastric cancers
-
Presented at
-
Yamashita Y, Yorozu K, Kurasawa M, Fujimoto-Ouchi K: Pertuzumab in combination with trastuzumab enhanced the anti-tumor activity in HER2-positive human gastric cancers. Presented at: 101st Annual Meeting of the American Association for Cancer Research. Washington, DC, USA, 17-21 April 2010.
-
101st Annual Meeting of the American Association for Cancer Research. Washington, DC, USA, 17-21 April 2010
-
-
Yamashita, Y.1
Yorozu, K.2
Kurasawa, M.3
Fujimoto-Ouchi, K.4
-
62
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Baselga J, Gelmon KA, Verma S et al.: Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J. Clin. Oncol. 28(7), 1138-1144 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.7
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.A.2
Verma, S.3
-
64
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips GD, Li G, Dugger DL et al.: Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 68(22), 9280-9290 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.22
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
Li, G.2
Dugger, D.L.3
-
65
-
-
79952165404
-
Efficacy against HER2-positive trastuzumab-insensitive breast cancer models and enhanced response in trastuzumab-sensitive models
-
Presented at
-
Parsons K, Crocker L, Leipold D et al.: Efficacy against HER2-positive trastuzumab-insensitive breast cancer models and enhanced response in trastuzumab-sensitive models. Presented at: American Association for Cancer Research Annual Meeting. Los Angeles, CA, USA, 14-18 April 2007.
-
American Association for Cancer Research Annual Meeting. Los Angeles, CA, USA, 14-18 April 2007
-
-
Parsons, K.1
Crocker, L.2
Leipold, D.3
-
66
-
-
78651447411
-
A Phase II study of trastuzumab-DM1 (T-DM1), a novel HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab
-
Presented at
-
Krop I, LoRusso P, Miller D et al.: A Phase II study of trastuzumab-DM1 (T-DM1), a novel HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab. Presented at: 33rd Annual San Antonio Breast Cancer Symposium (SABCS). San Antonio, TX, USA, 10-13 December 2009.
-
33rd Annual San Antonio Breast Cancer Symposium (SABCS). San Antonio, TX, USA, 10-13 December 2009
-
-
Krop, I.1
LoRusso, P.2
Miller, D.3
-
67
-
-
84864016108
-
+ metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab
-
Presented at
-
+ metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab. Presented at: 35th European Society for Medical Oncology (ESMO) Congress. Milan, Italy, 8-12 October 2010.
-
35th European Society for Medical Oncology (ESMO) Congress. Milan, Italy, 8-12 October 2010
-
-
Krop, I.1
LoRusso, P.2
Miller, K.D.3
-
68
-
-
79952126606
-
Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cancer patients with no prior chemotherapy for metastatic disease: Preliminary results of a randomized, multicenter, open-label Phase 2 study
-
Presented at
-
Perez EA, Dirix L, Kocsis J et al.: Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cancer patients with no prior chemotherapy for metastatic disease: preliminary results of a randomized, multicenter, open-label Phase 2 study. Presented at: 35th European Society for Medical Oncology (ESMO) Congress. Milan, Italy, 8-12 October 2010.
-
35th European Society for Medical Oncology (ESMO) Congress. Milan, Italy, 8-12 October 2010
-
-
Perez, E.A.1
Dirix, L.2
Kocsis, J.3
-
69
-
-
77956895978
-
HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
-
Rüschoff J, Dietel M, Baretton G et al.: HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing. Virchows Arch. 457(3), 299-307 (2010).
-
(2010)
Virchows Arch.
, vol.457
, Issue.3
, pp. 299-307
-
-
Rüschoff, J.1
Dietel, M.2
Baretton, G.3
-
70
-
-
42949171158
-
-
American Cancer Society: Global Cancer Facts and Figures 2007 www.cancer.org/acs/groups/content/@nho/documents/document/caff2007pwsecuredpdf. pdf
-
(2007)
Global Cancer Facts and Figures
-
-
-
71
-
-
0347492085
-
-
National Cancer Institute. Bethesda, MD, USA
-
SEER Cancer Statistics Review, 1975-2006, National Cancer Institute. Bethesda, MD, USA http://seer.cancer.gov/csr/1975-2006
-
(1975)
SEER Cancer Statistics Review
-
-
|