Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

Autophagy

Volumn 10, Issue 6, 2014, Pages 1120-1136

  Goodall, Megan L ^a,b   Wang, Tong ^c   Martin, Katie R ^a   Kortus, Matthew G ^a   Kauffman, Audra L ^a   Trent, Jeffrey M ^d   Gately, Stephen ^c   MacKeigan, Jeffrey P ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c Translational Drug Development Inc (TD2)   (United States)

^d TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

Antimalarial; Autophagy; Chloroquine; Lysosome; Melanoma; PLX 4032; Quinacrine; Vemurafenib

Indexed keywords

ACRIDINE DERIVATIVE; AMODIAQUINE; ANTINEOPLASTIC AGENT; ARTEMISININ; AZD 8055; B RAF KINASE; B RAF V600E PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEFLOQUINE; MITOGEN ACTIVATED PROTEIN KINASE 3; PRIMAQUINE; RAPAMYCIN; SMALL INTERFERING RNA; TACRINE DERIVATIVE; UNCLASSIFIED DRUG; VATG 027; VATG 032; VEMURAFENIB; ANTIMALARIAL AGENT; BRAF PROTEIN, HUMAN; CHLOROQUINE; INDOLE DERIVATIVE; SULFONAMIDE;

ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL VIABILITY; COLONY FORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENDOSOME; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; GENE SILENCING; HUMAN; HUMAN CELL; IC 50; IMAGE ANALYSIS; IMMUNOBLOTTING; LYSOSOME; MELANOMA; MELANOMA CELL; MOLECULE; MUTANT; ONCOGENE; PH; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; TRANSMISSION ELECTRON MICROSCOPY; TURNOVER TIME; WILD TYPE; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; MOUSE; MUTATION; PATHOLOGY; TRANSLATIONAL RESEARCH; TUMOR CELL LINE;

ACRIDINES; ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AUTOPHAGY; CELL LINE, TUMOR; CHLOROQUINE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; LYSOSOMES; MELANOMA; MICE; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRANSLATIONAL MEDICAL RESEARCH; TUMOR STEM CELL ASSAY;

EID: 84903639222     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.28594     Document Type: Article

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