The relationship among restless legs syndrome (Willis-Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular disease

Journal of Neurology

Volumn 261, Issue 6, 2014, Pages 1051-1068

  Ferini Strambi, Luigi ^a   Walters, Arthur S ^b   Sica, Domenic ^c  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Cardiovascular disease; Prehypertension; Restless legs syndrome; Sleep disturbance; Stroke; Vascular disease

Indexed keywords

BRAIN METABOLISM; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CASE STUDY; CEREBROVASCULAR DISEASE; CIRCADIAN RHYTHM; COMORBIDITY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; HUMAN; HYPERTENSION; HYPOTHALAMUS; INFLAMMATORY CELL; INSOMNIA; MEDLINE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESTLESS LEGS SYNDROME; REVIEW; SLEEP DISORDER; SLEEP DISORDERED BREATHING; VASCULAR DISEASE; COMPLICATION;

CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; HUMANS; HYPERTENSION; RESTLESS LEGS SYNDROME;

EID: 84903587631     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-013-7065-1     Document Type: Review

References (145)

1. Al-Alawi A, Mulgrew A, Tench E, Ryan CF (2006) Prevalence, risk factors and impact on daytime sleepiness and hypertension of periodic leg movements with arousals in patients with obstructive sleep apnea. J Clin Sleep Med 2:281-287
2. Alattar M, Harrington JJ, Mitchell CM, Sloane P (2007) Sleep problems in primary care: a North Carolina Family Practice Research Network (NC-FP-RN) study. J Am Board Fam Med 20:365-374
3. Ali NJ, Davies RJ, Fleetham JA, Stradling JR (1991) Periodic movements of the legs during sleep associated with rises in systemic blood pressure. Sleep 14:163-165
4. Allen RP, Bharmal M, Calloway M (2011) Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States. Mov Disord 26:114-120
5. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101-119
6. Allen RP, Walters AS, Montplaisir J, Hening W, Myers A, Bell TJ, Ferini-Strambi L (2005) Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165:1286-1292
7. Anderson KN, Bhatia KP, Losseff NA (2005) A case of restless legs syndrome in association with stroke. Sleep 28:147-148
8. Angriman M, Bruni O, Cortese S (2013) Does Restless Legs Syndrome increase cardiovascular risk in Attention-Deficit/Hyperactivity Disorder? Med Hypotheses 80:39-42
9. Barone DA, Krieger AC (2013) Stroke and obstructive sleep apnea: a review. Current Atheroscler Rep 15:334
10. Batool-Anwar S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X (2011) Restless legs syndrome and hypertension in middle-aged women. Hypertension 58:791-796
11. Bekci TT, Kayrak M, Kiyici A, Ari H, Teke T, Maden E, Akilli H (2012) The relation between Lp-PLA2 levels with periodic limb movements. Sleep Breath 16:117-122
12. Belaidi E, Joyeux-Faure M, Ribuot C, Launois SH, Levy P, Godin-Ribuot D (2009) Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. J Am Coll Cardiol 53:1309-1317
13. Benbir G, Karadeniz D (2012) Periodic leg movements in sleep in patients with supratentorial cerebral infarction. Acta Neurol Belg 112:27-32
14. Benediktsdottir B, Janson C, Lindberg E, Arnardottir ES, Olafsson I, Cook E, Thorarinsdottir EH, Gislason T (2010) Prevalence of restless legs syndrome among adults in Iceland and Sweden: lung function, comorbidity, ferritin, biomarkers and quality of life. Sleep Med 11:1043-1048
15. Bergamaschi G, Di Sabatino A, Albertini R, Ardizzone S, Biancheri P, Bonetti E, Cassinotti A, Cazzola P, Markopoulos K, Massari A, Rosti V, Porro GB, Corazza GR (2010) Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-alpha treatment. Haematologica 95:199-205
16. Berger K, Luedemann J, Trenkwalder C, John U, Kessler C (2004) Sex and the risk of restless legs syndrome in the general population. Arch Intern Med 164:196-202
17. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, Marcus CL, Mehra R, Parthasarathy S, Quan SF, Redline S, Strohl KP, Davidson Ward SL, Tangredi MM (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine. J Clin Sleep Med 8:597-619
18. Billars L, Hicks A, Bliwise DL, Sigmundsson T, Sigurdsson A, Krisjansson K, Gulcher J, Stefansson K, Rye D (2007) Hypertension risk and PLMS in restless legs syndrome. Sleep 30(Suppl):A297 (abstr 0869)
19. Boulos MI, Pettersen JA, Nguyen L, Jewell DR, Shammi P, Black S, Murray BJ (2012) Nocturnal limb movements are correlated with cerebral white matter hyperintensities and fronto-executive deficits. Sleep 35(Suppl):A261 (abstr 0775)
20. Calhoun DA, Harding SM (2010) Sleep and hypertension. Chest 138:434-443
21. Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM (2008) Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation 117:e510-e526
22. Cao JJ, Arnold AM, Manolio TA, Polak JF, Psaty BM, Hirsch CH, Kuller LH, Cushman M (2007) Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. Circulation 116:32-38
23. Cheung BM, Ong KL, Man YB, Lam KS, Lau CP (2006) Prevalence, awareness, treatment, and control of hypertension: United States National Health and Nutrition Examination Survey 2001-2002. J Clin Hypertens (Greenwich) 8:93-98
24. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ (2003) Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42:1206-1252
25. Chokroverty S (2010) Overview of sleep & sleep disorders. Indian J Med Res 131:126-140
26. Clemens S, Rye D, Hochman S (2006) Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology 67:125-130
27. Coelho FM, Georgsson H, Narayansingh M, Swartz RH, Murray BJ (2010) Higher prevalence of periodic limb movements of sleep in patients with history of stroke. J Clin Sleep Med 6:428-430
28. Connor JR, Ponnuru P, Lee BY, Podskalny GD, Alam S, Allen RP, Earley CJ, Yang QX (2011) Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome. Sleep Med 12:614-619
29. Connor JR, Wang XS, Allen RP, Beard JL, Wiesinger JA, Felt BT, Earley CJ (2009) Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain 132:2403-2412
30. Cosentino FI, Aricò D, Lanuzza B, Raggi A, Sciortino G, Tripodi M, Bella R, Zucconi M, Ferri R (2011) Absence of cardiovascular disease risk factors in restless legs syndrome. Acta Neurol Scand 125:319-325
31. de la Sierra A, Segura J, Gorostidi M, Banegas JR, de la Cruz JJ, Ruilope LM (2010) Diurnal blood pressure variation, risk categories and antihypertensive treatment. Hypertens Res 33:767-771
32. Debette S, Markus HS (2010) The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 341:c3666
33. Earley CJ, Allen RP, Hening W (2011) Restless legs syndrome and periodic leg movements in sleep. Handb Clin Neurol 99:913-948
34. Earley CJ, Silber MH (2010) Restless legs syndrome: understanding its consequences and the need for better treatment. Sleep Med 11:807-815
35. Egan BM, Zhao Y, Axon RN, Brzezinski WA, Ferdinand KC (2011) Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008. Circulation 124:1046-1058
36. Ekstedt M, Akerstedt T, Söderström M (2004) Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure. Psychosom Med 66:925-931
37. Elwood P, Hack M, Pickering J, Hughes J, Gallacher J (2006) Sleep disturbance, stroke, and heart disease events: evidence from the Caerphilly cohort. J Epidemiol Community Health 60:69-73
38. Erden EC, Erden I, Turker Y, Sivri N, Dikici S, Ozsahin M (2012) Incremental effects of restless legs syndrome on nocturnal blood pressure in hypertensive patients and normotensive individuals. Blood Press Monit 17:231-234
39. Espinar-Sierra J, Vela-Bueno A, Luque-Otero M (1997) Periodic leg movements in sleep in essential hypertension. Psychiatry Clin Neurosci 51:103-107
40. Foley D, Ancoli-Israel S, Britz P, Walsh J (2004) Sleep disturbances and chronic disease in older adults: results of the 2003 national sleep foundation sleep in America survey. J Psychosom Res 56:497-502
41. Folsom AR (2013) Classical and novel biomarkers for cardiovascular risk prediction in the United States. J Epidemiol 23:158-162
42. Fujikawa T, Tochikubo O, Kura N, Umemura S (2009) Factors related to elevated 24-h blood pressure in young adults. Clin Exp Hypertens 31:705-712
43. Gami AS, Hodge DO, Herges RM, Olson EJ, Nykodym J, Kara T, Somers VK (2007) Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. J Am Coll Cardiol 49:565-571
44. Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Pickering TG, Rundle AG, Zammit GK, Malaspina D (2006) Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey. Hypertension 47:833-839
45. Gao X, Schwarzschild MA, Wang H, Ascherio A (2009) Obesity and restless legs syndrome in men and women. Neurology 72:1255-1261
46. Giannaki CD, Zigoulis P, Karatzaferi C, Hadjigeorgiou GM, George KP, Gourgoulianis K, Koutedakis Y, Stefanidis I, Sakkas GK (2013) Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. J Clin Sleep Med 9:147-153
47. Grimaldi D, Provini F, Calandra-Buonaura G, Barletta G, Cecere A, Pierangeli G, Cortelli P (2013) Cardiovascular-sleep interaction in drug-naive patients with essential grade I hypertension. Chronobiology Int 30:31-42
48. Guo X, Zou L, Zhang X, Li J, Zheng L, Sun Z, Hu J, Wong ND, Sun Y (2011) Prehypertension: a meta-analysis of the epidemiology, risk factors, and predictors of progression. Tex Heart Inst J 38:643-652
49. Gupta R, Deedwania PC, Achari V, Bhansali A, Gupta BK, Gupta A, Mahanta TG, Asirvatham AJ, Gupta S, Maheshwari A, Saboo B, Jali MV, Singh J, Guptha S, Sharma KK (2013) Normotension, prehypertension, and hypertension in urban middle-class subjects in India: prevalence, awareness, treatment, and control. Am J Hyperten 26:83-94
50. Haack M, Sanchez E, Mullington JM (2007) Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep 30:1145-1152
51. Hanly P, Zuberi N (1992) Periodic leg movements during sleep before and after heart transplantation. Sleep 15:489-492
52. Hanly PJ, Zuberi-Khokhar N (1996) Periodic limb movements during sleep in patients with congestive heart failure. Chest 109:1497-1502
53. Hening WA, Walters AS, Wagner M, Rosen R, Chen V, Kim S, Shah M, Thai O (1999) Circadian rhythm of motor restlessness and sensory symptoms in the idiopathic restless legs syndrome. Sleep 22:901-912
54. Hoevenaar-Blom MP, Spijkerman AM, Kromhout D, van den Berg JF, Verschuren WM (2011) Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study. Sleep 34:1487-1492
55. Högl B, Kiechl S, Willeit J, Saletu M, Frauscher B, Seppi K, Müller J, Rungger G, Gasperi A, Wenning G, Poewe W (2005) Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology 64:1920-1924
56. Hornyak M, Feige B, Voderholzer U, Philipsen A, Riemann D (2007) Polysomnography findings in patients with restless legs syndrome and in healthy controls: a comparative observational study. Sleep 30:861-865
57. Innes KE, Selfe TK, Agarwal P (2011) Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review. Sleep Med Rev 16:309-339
58. International Restless Legs Syndrome Study Group (2011) 2011 Revised IRLSSG Diagnostic Criteria for RLS. http://irlssg.org/diagnostic-criteria/. Accessed July 2, 2013.
59. Javaheri S (2006) Sleep disorders in systolic heart failure: a prospective study of 100 male patients. The final report. Int J Cardiol 106:21-28
60. Javaheri S, Abraham WT, Brown C, Nishiyama H, Giesting R, Wagoner LE (2004) Prevalence of obstructive sleep apnoea and periodic limb movement in 45 subjects with heart transplantation. Eur Heart J 25:260-266
61. Juuti AK, Laara E, Rajala U, Laakso M, Harkonen P, Keinanen-Kiukaanniemi S, Hiltunen L (2010) Prevalence and associated factors of restless legs in a 57-year-old urban population in northern Finland. Acta Neurol Scand 122:63-69
62. Kang SY, Sohn YH, Lee IK, Kim JS (2004) Unilateral periodic limb movement in sleep after supratentorial cerebral infarction. Parkinsonism Relat Dis 10:429-431
63. Kim JS, Lee SB, Park SK, Han SR, Kim YI, Lee KS (2003) Periodic limb movement during sleep developed after pontine lesion. Mov Disord 18:1403-1405
64. Kizilay F, Ozkaynak S, Hatipoglu E, Annac C, Gungor H, Uysal H (2010) Periodic limb movement during sleep following cerebellar infarct. Acta Neurol Belg 110:284-286
65. Koo B, Mehra R, Blackwell T, Ancoli-Israel S, Stone KL, Redline S (2012) Periodic limb movements during sleep and nocturnal cardiac arrhythmia: Outcomes of sleep disorders in older men (MROS) study. Sleep 35 Abstract Suppl A259 (abstr 0770)
66. Koo BB, Blackwell T, Ancoli-Israel S, Stone KL, Stefanick ML, Redline S (2011) Association of incident cardiovascular disease with periodic limb movements during sleep in older men: outcomes of sleep disorders in older men (MrOS) study. Circulation 124:1223-1231
67. Lanfranchi PA, Pennestri MH, Fradette L, Dumont M, Morin CM, Montplaisir J (2009) Nighttime blood pressure in normotensive subjects with chronic insomnia: implications for cardiovascular risk. Sleep 32:760-766
68. Lavie P, Herer P, Hoffstein V (2000) Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study. BMJ 320:479-482
69. Lavie P, Hoffstein V (2001) Sleep apnea syndrome: a possible contributing factor to resistant. Sleep 24:721-725
70. Lee DS, Massaro JM, Wang TJ, Kannel WB, Benjamin EJ, Kenchaiah S, Levy D, D'Agostino RB Sr, Vasan RS (2007) Antecedent blood pressure, body mass index, and the risk of incident heart failure in later life. Hypertension 50:869-876
71. Lee HB, Hening WA, Allen RP, Earley CJ, Eaton WW, Lyketsos CG (2006) Race and restless legs syndrome symptoms in an adult community sample in east Baltimore. Sleep Med 7:642-645
72. Lee JS, Lee PH, Huh K (2005) Periodic limb movements in sleep after a small deep subcortical infarct. Mov Disord 20:260-261
73. Lee SJ, Kim JS, Song IU, An JY, Kim YI, Lee KS (2009) Poststroke restless legs syndrome and lesion location: anatomical considerations. Mov Disord 24:77-84
74. Li Y, Walters AS, Chiuve SE, Rimm EB, Winkelman JW, Gao X (2012) Prospective study of restless legs syndrome and coronary heart disease among women. Circulation 126:1689-1694
75. Li Y, Wang W, Winkelman JW, Malhotra A, Ma J, Gao X (2013) Prospective study of restless legs syndrome and mortality among men. Neurology 81:52-59
76. Lindner A, Fornadi K, Lazar AS, Czira ME, Dunai A, Zoller R, Veber O, Szentkiralyi A, Kiss Z, Toronyi E, Mucsi I, Novak M, Molnar MZ (2012) Periodic limb movements in sleep are associated with stroke and cardiovascular risk factors in patients with renal failure. J Sleep Res 21:297-307
77. Lopez-Jimenez F, Sert Kuniyoshi FH, Gami A, Somers VK (2008) Obstructive sleep apnea: implications for cardiac and vascular disease. Chest 133:793-804
78. Mallon L, Broman JE, Hetta J (2008) Restless legs symptoms with sleepiness in relation to mortality: 20-year follow-up study of a middle-aged Swedish population. Psychiatry Clin Neurosci 62:457-463
79. Manconi M, Ferri R, Zucconi M, Clemens S, Rundo F, Oldani A, Ferini-Strambi L (2011) Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep. Sleep Med 12:47-55
80. Medeiros CA, de Bruin PF, Paiva TR, Coutinho WM, Ponte RP, de Bruin VM (2011) Clinical outcome after acute ischaemic stroke: the influence of restless legs syndrome. Eur J Neurol 18:144-149
81. Minai OA, Malik N, Foldvary N, Bair N, Golish JA (2008) Prevalence and characteristics of restless legs syndrome in patients with pulmonary hypertension. J Heart Lung Transpl 27:335-340
82. Mirza M, Shen WK, Sofi A, Jahangir A, Mori N, Tajik AJ, Jahangir A (2013) Frequent periodic leg movement during sleep is associated with left ventricular hypertrophy and adverse cardiovascular outcomes. J Am Soc Echocardiogr 26(7):783-790
83. Miura K, Daviglus ML, Dyer AR, Liu K, Garside DB, Stamler J, Greenland P (2001) Relationship of blood pressure to 25-year mortality due to coronary heart disease, cardiovascular diseases, and all causes in young adult men: the Chicago Heart Association Detection Project in Industry. Arch Intern Med 161:1501-1508
84. Moller C, Wetter TC, Koster J, Stiasny-Kolster K (2010) Differential diagnosis of unpleasant sensations in the legs: prevalence of restless legs syndrome in a primary care population. Sleep Med 11:161-166
85. Mutafova-Yambolieva VN, Westfall DP (1998) Inhibitory and facilitatory presynaptic effects of endothelin on sympathetic cotransmission in the rat isolated tail artery. Br J Pharmacol 123:136-142
86. Noda A, Yasuma F, Okada T, Yokota M (1998) Circadian rhythm of autonomic activity in patients with obstructive sleep apnea syndrome. Clin Cardiol 21:271-276
87. Ohayon MM, Roth T (2002) Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res 53:547-554
88. Ong KL, Cheung BM, Man YB, Lau CP, Lam KS (2007) Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 49:69-75
89. Park JH, Han SW, Baik JS (2012) Carotid intima-media thickness in patients with idiopathic restless legs syndrome. Eur Neurol 67:321-325
90. Patton SM, Ponnuru P, Snyder AM, Podskalny GD, Connor JR (2011) Hypoxia-inducible factor pathway activation in restless legs syndrome patients. Eur J Neurol 18:1329-1335
91. Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR (2006) Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 577:705-716
92. Pennestri MH, Montplaisir J, Colombo R, Lavigne G, Lanfranchi PA (2007) Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology 68:1213-1218
93. Pennestri MH, Montplaisir J, Fradette L, Lavigne G, Colombo R, Lanfranchi PA (2013) Blood pressure changes associated with periodic leg movements during sleep in healthy subjects. Sleep Med 14:555-561
94. Pennestri MH, Whittom S, Adam B, Petit D, Carrier J, Montplaisir J (2006) PLMS and PLMW in healthy subjects as a function of age: prevalence and interval distribution. Sleep 29:1183-1187
95. Peppard PE, Young T, Palta M, Skatrud J (2000) Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342:1378-1384
96. Persell SD (2011) Prevalence of resistant hypertension in the United States, 2003-2008. Hypertension 57:1076-1080
97. Phillips B, Hening W, Britz P, Mannino D (2006) Prevalence and correlates of restless legs syndrome: results from the 2005 National Sleep Foundation Poll. Chest 129:76-80
98. Portaluppi F, Tiseo R, Smolensky MH, Hermida RC, Ayala DE, Fabbian F (2012) Circadian rhythms and cardiovascular health. Sleep Med Rev 16:151-166
99. Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O'Connor GT, Rapoport DM, Redline S, Resnick HE, Robbins JA, Shahar E, Unruh ML, Samet JM (2009) Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med 6:e1000132
100. Qureshi AI, Suri MF, Kirmani JF, Divani AA, Mohammad Y (2005) Is prehypertension a risk factor for cardiovascular diseases? Stroke 36:1859-1863
101. Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K (2000) Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in Augsburg elderly. Neurology 54:1064-1068
102. Rudic RD, Fulton DJ (2009) Pressed for time: the circadian clock and hypertension. J Appl Physiol 107:1328-1338
103. Rye DB, Trotti LM (2012) Restless legs syndrome and periodic leg movements of sleep. Neurologic Clin 30:1137-1166
104. Sabbatini M, Minale B, Crispo A, Pisani A, Ragosta A, Esposito R, Cesaro A, Cianciaruso B, Andreucci VE (2002) Insomnia in maintenance haemodialysis patients. Nephrol Dial Transpl 17:852-856
105. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA (2010) Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci USA 107:20541-20546
106. Schuiling WJ, Rinkel GJ, Walchenbach R, de Weerd AW (2005) Disorders of sleep and wake in patients after subarachnoid hemorrhage. Stroke 36:578-582
107. Scofield H, Roth T, Drake C (2008) Periodic limb movements during sleep: population prevalence, clinical correlates, and racial differences. Sleep 31:1221-1227
108. Sechi G, Agnetti V, Galistu P, Murgia B, Marrosu F, Puligheddu M, Conti M, Paulus KS (2008) Restless legs syndrome and periodic limb movements after ischemic stroke in the right lenticulostriate region. Parkinsonism Rel Dis 14:157-160
109. Semenza GL (2007) Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J 405:1-9
110. Siddiqui F, Strus J, Ming X, Lee IA, Chokroverty S, Walters AS (2007) Rise of blood pressure with periodic limb movements in sleep and wakefulness. Clin Neurophysiol 118:1923-1930
111. Skomro R, Silva R, Alves R, Figueiredo A, Lorenzi-Filho G (2009) The prevalence and significance of periodic leg movements during sleep in patients with congestive heart failure. Sleep Breath 13:43-47
112. Solem CA, Loftus EV Jr, Tremaine WJ, Harmsen WS, Zinsmeister AR, Sandborn WJ (2005) Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease. Inflamm Bowel Dis 11:707-712
113. Somers VK, Dyken ME, Clary MP, Abboud FM (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96:1897-1904
114. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T (2008) Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118:1080-1111
115. Szentkiralyi A, Volzke H, Hoffmann W, Happe S, Berger K (2013) A time sequence analysis of the relationship between cardiovascular risk factors, vascular diseases and restless legs syndrome in the general population. J Sleep Res 22(4):434-442
116. Szentkiralyi A, Winter AC, Schurks M, Volzke H, Hoffmann W, J EB, Gaziano JM, Kurth T, Berger K (2012) Restless legs syndrome and all-cause mortality in four prospective cohort studies. BMJ Open 2: e001652
117. Takaki J, Nishi T, Nangaku M, Shimoyama H, Inada T, Matsuyama N, Kumano H, Kuboki T (2003) Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis. Am J Kidney Dis 41:833-839
118. Trenkwalder C, Hening WA, Walters AS, Campbell SS, Rahman K, Chokroverty S (1999) Circadian rhythm of periodic limb movements and sensory symptoms of restless legs syndrome. Mov Disord 14:102-110
119. Trotti L, Rye DB, De Staercke C, Hooper C, Quyyumi A, Bliwise DL (2011) Elevated C-reactive protein (CRP), but not interleukin-6 (IL-6) or tumor necrosis factor (TNF-A), is associated with periodic limb movements (PLMS). Sleep 34(Suppl):A199 (abstr 0579)
120. Trotti LM, Rye DB, Staercke CD, Hooper WC, Quyyumi A, Bliwise DL (2012) Elevated C-reactive protein is associated with severe periodic leg movements of sleep in patients with restless legs syndrome. Brain Behav Immun 26:1239-1243
121. Ulfberg J, Nyström B, Carter N, Edling C (2001) Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 16:1159-1163
122. Unrath A, Kassubek J (2006) Symptomatic restless leg syndrome after lacunar stroke: a lesion study. Mov Disord 21:2027-2028
123. van Leeuwen WM, Lehto M, Karisola P, Lindholm H, Luukkonen R, Sallinen M, Härmä M, Porkka-Heiskanen T, Alenius H (2009) Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. PLoS ONE 4:e4589
124. Vermeire S, Van Assche G, Rutgeerts P (2004) C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis 10:661-665
125. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, Chrousos GP (2004) Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89:2119-2126
126. Walters AS, Moussouttas M, Siddiqui F, Silveira DC, Fuentes K, Wang L, Berger K (2010) Prevalence of stroke in restless legs syndrome: initial results point to the need for more sophisticated studies. Open Neurol J 4:73-77
127. Walters AS, Rye DB (2009) Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Sleep 32:589-597
128. Weinstock LB, Bosworth BP, Scherl EJ, Li E, Iroku U, Munsell MA, Mullen GE, Walters AS (2010) Crohn's disease is associated with restless legs syndrome. Inflamm Bowel Dis 16:275-279
129. Weinstock LB, Walters AS (2011) Restless legs syndrome is associated with irritable bowel syndrome and small intestinal bacterial overgrowth. Sleep Med 12:610-613
130. Weinstock LB, Walters AS, Mullin GE, Duntley SP (2010) Celiac disease is associated with restless legs syndrome. Dig Dis Sci 55:1667-1673
131. Weinstock LB, Walters AS, Paueksakon P (2012) Restless legs syndrome-theoretical roles of inflammatory and immune mechanisms. Sleep Med Rev 16:341-354
132. Wesstrom J, Nilsson S, Sundstrom-Poromaa I, Ulfberg J (2008) Restless legs syndrome among women: prevalence, co-morbidity and possible relationship to menopause. Climacteric 11:422-428
133. Whitworth JA (2003) 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 21:1983-1992
134. Wing YK, Zhang J, Ho CK, Au CT, Li AM (2010) Periodic limb movement during sleep is associated with nocturnal hypertension in children. Sleep 33:759-765
135. Winkelman JW (1999) The evoked heart rate response to periodic leg movements of sleep. Sleep 22:575-580
136. Winkelman JW, Finn L, Young T (2006) Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort. Sleep Med 7:545-552
137. Winkelman JW, Shahar E, Sharief I, Gottlieb DJ (2008) Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study. Neurology 70:35-42
138. Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Dauvilliers Y, Polo O, Hogl B, Berger K, Fuhs A, Gross N, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Xiong L, Montplaisir J, Rouleau GA, Fietze I, Vavrova J, Kemlink D, Sonka K, Nevsimalova S, Lin SC, Wszolek Z, Vilarino-Guell C, Farrer MJ, Gschliesser V, Frauscher B, Falkenstetter T, Poewe W, Allen RP, Earley CJ, Ondo WG, Le WD, Spieler D, Kaffe M, Zimprich A, Kettunen J, Perola M, Silander K, Cournu-Rebeix I, Francavilla M, Fontenille C, Fontaine B, Vodicka P, Prokisch H, Lichtner P, Peppard P, Faraco J, Mignot E, Gieger C, Illig T, Wichmann HE, Muller-Myhsok B, Meitinger T (2011) Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet 7:e1002171
139. Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, Trenkwalder C, Paulus W, Peglau I, Eisensehr I, Illig T, Wichmann HE, Pfister H, Golic J, Bettecken T, Putz B, Holsboer F, Meitinger T, Muller-Myhsok B (2008) Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. Mov Disord 23:350-358
140. Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Putz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Muller-Myhsok B, Meitinger T (2007) Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genet 39:1000-1006
141. Winter AC, Berger K, Glynn RJ, Buring JE, Gaziano JM, Schurks M, Kurth T (2013) Vascular risk factors, cardiovascular disease, and restless legs syndrome in men. Am J Med 126:228-235 235 e221-222
142. Winter AC, Schurks M, Glynn RJ, Buring JE, Gaziano JM, Berger K, Kurth T (2013) Vascular risk factors, cardiovascular disease, and restless legs syndrome in women. Am J Med 126:220-227 227 e221-222
143. Winter AC, Schürks M, Glynn RJ, Buring JE, Gaziano JM, Berger K, Kurth T (2012) Restless legs syndrome and risk of incident cardiovascular disease in women and men: prospective cohort study. BMJ Open 2:e000866
144. Worsnop CJ, Naughton MT, Barter CE, Morgan TO, Anderson AI, Pierce RJ (1998) The prevalence of obstructive sleep apnea in hypertensives. Am J Respir Crit Care Med 157:111-115
145. Zhang W, Li N (2011) Prevalence, risk factors, and management of prehypertension. Int J Hypertens 2011:605359