-
1
-
-
0020596551
-
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
-
F. Barré-Sinoussi, J.C. Chermann, F. Rey, M.T. Nugeyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler-Blin, F. Vézinet-Brun, C. Rouzioux, W. Rozenbaum, and L. Montagnier Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) Science 220 1983 868 871
-
(1983)
Science
, vol.220
, pp. 868-871
-
-
Barré-Sinoussi, F.1
Chermann, J.C.2
Rey, F.3
Nugeyre, M.T.4
Chamaret, S.5
Gruest, J.6
Dauguet, C.7
Axler-Blin, C.8
Vézinet-Brun, F.9
Rouzioux, C.10
Rozenbaum, W.11
Montagnier, L.12
-
2
-
-
84876251512
-
-
Joint United Nations Programme on HIV/AIDS (UNAIDS)
-
Joint United Nations Programme on HIV/AIDS (UNAIDS), report on the global AIDS epidemic 2013.
-
(2013)
Report on the Global AIDS Epidemic
-
-
-
3
-
-
80051564046
-
Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: A review
-
M.P. Girard, S. Osmanov, O.M. Assossou, and M.P. Kieny Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: a review Vaccine 29 2011 6191 6218
-
(2011)
Vaccine
, vol.29
, pp. 6191-6218
-
-
Girard, M.P.1
Osmanov, S.2
Assossou, O.M.3
Kieny, M.P.4
-
5
-
-
82055192318
-
Targeting protein-protein and protein-nucleic acid interactions for anti-HIV therapy
-
M. Mori, F. Manetti, and M. Botta Targeting protein-protein and protein-nucleic acid interactions for anti-HIV therapy Curr Pharm Des 17 2011 3713 3728
-
(2011)
Curr Pharm des
, vol.17
, pp. 3713-3728
-
-
Mori, M.1
Manetti, F.2
Botta, M.3
-
7
-
-
84870670336
-
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
-
F. Christ, and Z. Debyser The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy Virology 435 2013 102 109
-
(2013)
Virology
, vol.435
, pp. 102-109
-
-
Christ, F.1
Debyser, Z.2
-
8
-
-
0034255034
-
Energetics of the HIV gp120-CD4 binding reaction
-
DOI 10.1073/pnas.97.16.9026
-
D.G. Myszka, R.W. Sweet, P. Hensley, M. Brigham-Burke, P.D. Kwong, W.A. Hendrickson, R. Wyatt, J. Sodroski, and M.L. Doyle Energetics of the HIV gp120-CD4 binding reaction Proc Natl Acad Sci U S A 97 2000 9026 9031 (Pubitemid 30626667)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.16
, pp. 9026-9031
-
-
Myszka, D.G.1
Sweet, R.W.2
Hensley, P.3
Brigham-Burke, M.4
Kwong, P.D.5
Hendrickson, W.A.6
Wyatt, R.7
Sodroski, J.8
Doyle, M.L.9
-
9
-
-
0032546844
-
The HIV-1 envelope glycoproteins: Fusogens, antigens, and immunogens
-
DOI 10.1126/science.280.5371.1884
-
R. Wyatt, and J. Sodroski The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens Science 280 1998 1884 1888 (Pubitemid 28299385)
-
(1998)
Science
, vol.280
, Issue.5371
, pp. 1884-1888
-
-
Wyatt, R.1
Sodroski, J.2
-
10
-
-
0032543307
-
Structure of an HIV gp 120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
-
DOI 10.1038/31405
-
P.D. Kwong, R. Wyatt, J. Robinson, R.W. Sweet, J. Sodroski, and W.A. Hendrickson Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody Nature 393 1998 648 659 (Pubitemid 28289647)
-
(1998)
Nature
, vol.393
, Issue.6686
, pp. 648-659
-
-
Kwong, P.D.1
Wyatt, R.2
Robinson, J.3
Sweet, R.W.4
Sodroski, J.5
Hendrickson, W.A.6
-
11
-
-
23844440296
-
Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)- oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4
-
DOI 10.1016/j.virol.2005.06.008, PII S0042682205003363
-
Q. Zhao, L. Ma, S. Jiang, H. Lu, S. Liu, Y. He, N. Strick, N. Neamati, and A.K. Debnath Identification of N-phenyl-N′-(2,2,6,6-tetramethyl- piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4 Virology 339 2005 213 225 (Pubitemid 41169789)
-
(2005)
Virology
, vol.339
, Issue.2
, pp. 213-225
-
-
Zhao, Q.1
Ma, L.2
Jiang, S.3
Lu, H.4
Liu, S.5
He, Y.6
Strick, N.7
Neamati, N.8
Debnath, A.K.9
-
12
-
-
55249083812
-
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120
-
N. Madani, A. Schon, A.M. Princiotto, J.M. Lalonde, J.R. Courter, T. Soeta, D. Ng, L. Wang, E.T. Brower, S.H. Xiang, Y.D. Kwon, C.C. Huang, R. Wyatt, P.D. Kwong, E. Freire, A.B. Smith 3rd, and J. Sodroski Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120 Structure 16 2008 1689 1701
-
(2008)
Structure
, vol.16
, pp. 1689-1701
-
-
Madani, N.1
Schon, A.2
Princiotto, A.M.3
Lalonde, J.M.4
Courter, J.R.5
Soeta, T.6
Ng, D.7
Wang, L.8
Brower, E.T.9
Xiang, S.H.10
Kwon, Y.D.11
Huang, C.C.12
Wyatt, R.13
Kwong, P.D.14
Freire, E.15
Smith III, A.B.16
Sodroski, J.17
-
13
-
-
84861496877
-
Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1
-
F. Curreli, S. Choudhury, I. Pyatkin, V.P. Zagorodnikov, A.K. Bulay, A. Altieri, Y.D. Kwon, P.D. Kwong, and A.K. Debnath Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1 J Med Chem 55 2012 4764 4775
-
(2012)
J Med Chem
, vol.55
, pp. 4764-4775
-
-
Curreli, F.1
Choudhury, S.2
Pyatkin, I.3
Zagorodnikov, V.P.4
Bulay, A.K.5
Altieri, A.6
Kwon, Y.D.7
Kwong, P.D.8
Debnath, A.K.9
-
14
-
-
78650721466
-
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening
-
J.M. Lalonde, M.A. Elban, J.R. Courter, A. Sugawara, T. Soeta, N. Madani, A.M. Princiotto, Y.D. Kwon, P.D. Kwong, A. Schon, E. Freire, J. Sodroski, and A.B. Smith 3rd Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening Bioorg Med Chem 19 2011 91 101
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 91-101
-
-
Lalonde, J.M.1
Elban, M.A.2
Courter, J.R.3
Sugawara, A.4
Soeta, T.5
Madani, N.6
Princiotto, A.M.7
Kwon, Y.D.8
Kwong, P.D.9
Schon, A.10
Freire, E.11
Sodroski, J.12
Smith III, A.B.13
-
15
-
-
84861048825
-
Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors
-
J.M. LaLonde, Y.D. Kwon, D.M. Jones, A.W. Sun, J.R. Courter, T. Soeta, T. Kobayashi, A.M. Princiotto, X. Wu, A. Schon, E. Freire, P.D. Kwong, J.R. Mascola, J. Sodroski, N. Madani, and A.B. Smith 3rd Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors J Med Chem 55 2012 4382 4396
-
(2012)
J Med Chem
, vol.55
, pp. 4382-4396
-
-
Lalonde, J.M.1
Kwon, Y.D.2
Jones, D.M.3
Sun, A.W.4
Courter, J.R.5
Soeta, T.6
Kobayashi, T.7
Princiotto, A.M.8
Wu, X.9
Schon, A.10
Freire, E.11
Kwong, P.D.12
Mascola, J.R.13
Sodroski, J.14
Madani, N.15
Smith III, A.B.16
-
16
-
-
84875155171
-
Structure-based design and synthesis of an HIV-1 entry inhibitor exploiting X-ray and thermodynamic characterization
-
J.M. Lalonde, M. Le-Khac, D.M. Jones, J.R. Courter, J. Park, A. Schon, A.M. Princiotto, X. Wu, J.R. Mascola, E. Freire, J. Sodroski, N. Madani, W.A. Hendrickson, and A.B. Smith 3rd Structure-based design and synthesis of an HIV-1 entry inhibitor exploiting X-ray and thermodynamic characterization ACS Med Chem Lett 4 2013 338 343
-
(2013)
ACS Med Chem Lett
, vol.4
, pp. 338-343
-
-
Lalonde, J.M.1
Le-Khac, M.2
Jones, D.M.3
Courter, J.R.4
Park, J.5
Schon, A.6
Princiotto, A.M.7
Wu, X.8
Mascola, J.R.9
Freire, E.10
Sodroski, J.11
Madani, N.12
Hendrickson, W.A.13
Smith III, A.B.14
-
17
-
-
84859561617
-
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
-
Y.D. Kwon, A. Finzi, X. Wu, C. Dogo-Isonagie, L.K. Lee, L.R. Moore, S.D. Schmidt, J. Stuckey, Y. Yang, T. Zhou, J. Zhu, D.A. Vicic, A.K. Debnath, L. Shapiro, C.A. Bewley, J.R. Mascola, J.G. Sodroski, and P.D. Kwong Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops Proc Natl Acad Sci U S A 109 2012 5663 5668
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 5663-5668
-
-
Kwon, Y.D.1
Finzi, A.2
Wu, X.3
Dogo-Isonagie, C.4
Lee, L.K.5
Moore, L.R.6
Schmidt, S.D.7
Stuckey, J.8
Yang, Y.9
Zhou, T.10
Zhu, J.11
Vicic, D.A.12
Debnath, A.K.13
Shapiro, L.14
Bewley, C.A.15
Mascola, J.R.16
Sodroski, J.G.17
Kwong, P.D.18
-
18
-
-
84884235855
-
Rational design of HIV-1 entry inhibitors
-
A.K. Debnath Rational design of HIV-1 entry inhibitors Methods Mol Biol 993 2013 185 204
-
(2013)
Methods Mol Biol
, vol.993
, pp. 185-204
-
-
Debnath, A.K.1
-
19
-
-
84874291643
-
Computational studies identifying entry inhibitor scaffolds targeting the Phe43 cavity of HIV-1 gp120
-
C. Tintori, M. Selvaraj, R. Badia, B. Clotet, J.A. Este, and M. Botta Computational studies identifying entry inhibitor scaffolds targeting the Phe43 cavity of HIV-1 gp120 ChemMedChem 8 2013 475 483
-
(2013)
ChemMedChem
, vol.8
, pp. 475-483
-
-
Tintori, C.1
Selvaraj, M.2
Badia, R.3
Clotet, B.4
Este, J.A.5
Botta, M.6
-
20
-
-
84901275739
-
2-aminothiazolones as anti-HIV agents which act as gp120-CD4 inhibitors
-
10.1128/AAC.02739-13
-
M. Tiberi, C. Tintori, E.R. Ceresola, R. Fazi, C. Zamperini, P. Calandro, L. Franchi, M. Selvaraj, L. Botta, M. Sampaolo, D. Saita, R. Ferrarese, M. Clementi, F. Canducci, and M. Botta 2-aminothiazolones as anti-HIV agents which act as gp120-CD4 inhibitors Antimicrob Agents Chemother 2014 10.1128/AAC.02739-13
-
(2014)
Antimicrob Agents Chemother
-
-
Tiberi, M.1
Tintori, C.2
Ceresola, E.R.3
Fazi, R.4
Zamperini, C.5
Calandro, P.6
Franchi, L.7
Selvaraj, M.8
Botta, L.9
Sampaolo, M.10
Saita, D.11
Ferrarese, R.12
Clementi, M.13
Canducci, F.14
Botta, M.15
-
21
-
-
33747330377
-
Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
-
E. Guiot, K. Carayon, O. Delelis, F. Simon, P. Tauc, E. Zubin, M. Gottikh, J.F. Mouscadet, J.C. Brochon, and E. Deprez Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity J Biol Chem 281 2006 22707 22719
-
(2006)
J Biol Chem
, vol.281
, pp. 22707-22719
-
-
Guiot, E.1
Carayon, K.2
Delelis, O.3
Simon, F.4
Tauc, P.5
Zubin, E.6
Gottikh, M.7
Mouscadet, J.F.8
Brochon, J.C.9
Deprez, E.10
-
22
-
-
0035923394
-
Peptide inhibitors of HIV-1 integrase dissociate the enzyme oligomers
-
DOI 10.1021/bi011328n
-
R.G. Maroun, S. Gayet, M.S. Benleulmi, H. Porumb, L. Zargarian, H. Merad, H. Leh, J.F. Mouscadet, F. Troalen, and S. Fermandjian Peptide inhibitors of HIV-1 integrase dissociate the enzyme oligomers Biochemistry 40 2001 13840 13848 (Pubitemid 33078852)
-
(2001)
Biochemistry
, vol.40
, Issue.46
, pp. 13840-13848
-
-
Maroun, R.G.1
Gayet, S.2
Benleulmi, M.S.3
Porumb, H.4
Zargarian, L.5
Merad, H.6
Leh, H.7
Mouscadet, J.-F.8
Troalen, F.9
Fermandjian, S.10
-
23
-
-
0037463767
-
Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization
-
DOI 10.1016/S0960-894X(03)00040-4
-
L. Zhao, M.K. O'Reilly, M.D. Shultz, and J. Chmielewski Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization Bioorg Med Chem Lett 13 2003 1175 1177 (Pubitemid 36331825)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.6
, pp. 1175-1177
-
-
Zhao, L.1
O'Reilly, M.K.2
Shultz, M.D.3
Chmielewski, J.4
-
24
-
-
84879007052
-
Inhibition of HIV-1 integrase dimerization and activity with crosslinked interfacial peptides
-
L. Zhao, and J. Chmielewski Inhibition of HIV-1 integrase dimerization and activity with crosslinked interfacial peptides Bioorg Med Chem 21 2013 4041 4044
-
(2013)
Bioorg Med Chem
, vol.21
, pp. 4041-4044
-
-
Zhao, L.1
Chmielewski, J.2
-
25
-
-
84859812848
-
Discovery of small molecule HIV-1 integrase dimerization inhibitors
-
C. Tintori, J. Demeulemeester, L. Franchi, S. Massa, Z. Debyser, F. Christ, and M. Botta Discovery of small molecule HIV-1 integrase dimerization inhibitors Bioorg Med Chem Lett 22 2012 3109 3114
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 3109-3114
-
-
Tintori, C.1
Demeulemeester, J.2
Franchi, L.3
Massa, S.4
Debyser, Z.5
Christ, F.6
Botta, M.7
-
26
-
-
84859850227
-
Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors
-
J. Demeulemeester, C. Tintori, M. Botta, Z. Debyser, and F. Christ Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors J Biomol Screen 17 2012 618 628
-
(2012)
J Biomol Screen
, vol.17
, pp. 618-628
-
-
Demeulemeester, J.1
Tintori, C.2
Botta, M.3
Debyser, Z.4
Christ, F.5
-
27
-
-
84877104776
-
The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types
-
M.E. Linde, D.R. Colquhoun, C. Ubaida Mohien, T. Kole, V. Aquino, R. Cotter, N. Edwards, J.E. Hildreth, and D.R. Graham The conserved set of host proteins incorporated into HIV-1 virions suggests a common egress pathway in multiple cell types J Proteome Res 12 2013 2045 2054
-
(2013)
J Proteome Res
, vol.12
, pp. 2045-2054
-
-
Linde, M.E.1
Colquhoun, D.R.2
Ubaida Mohien, C.3
Kole, T.4
Aquino, V.5
Cotter, R.6
Edwards, N.7
Hildreth, J.E.8
Graham, D.R.9
-
28
-
-
74849097080
-
Host proteins involved in HIV infection: New therapeutic targets
-
N. Arhel, and F. Kirchhoff Host proteins involved in HIV infection: new therapeutic targets Biochim Biophys Acta 1802 2010 313 321
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 313-321
-
-
Arhel, N.1
Kirchhoff, F.2
-
30
-
-
42949164437
-
FDA approval: Maraviroc
-
P.E. Sax FDA approval: maraviroc AIDS Clin Care 19 2007 75
-
(2007)
AIDS Clin Care
, vol.19
, pp. 75
-
-
Sax, P.E.1
-
31
-
-
84930211746
-
Targeting cellular cofactor in HIV therapy
-
10.1007/7355-2014-45
-
R. Dürr, O. Keppler, F. Christ, E. Crespan, A. Garbelli, G. Maga, and U. Dietrich Targeting cellular cofactor in HIV therapy Top Med Chem 2014 1 40 10.1007/7355-2014-45
-
(2014)
Top Med Chem
, pp. 1-40
-
-
Dürr, R.1
Keppler, O.2
Christ, F.3
Crespan, E.4
Garbelli, A.5
Maga, G.6
Dietrich, U.7
-
32
-
-
0035907306
-
Tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral Vif protein
-
G. Hassaine, M. Courcoul, G. Bessou, Y. Barthalay, C. Picard, D. Olive, Y. Collette, R. Vigne, and E. Decroly Tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral Vif protein J Biol Chem 276 2001 16885 16893
-
(2001)
J Biol Chem
, vol.276
, pp. 16885-16893
-
-
Hassaine, G.1
Courcoul, M.2
Bessou, G.3
Barthalay, Y.4
Picard, C.5
Olive, D.6
Collette, Y.7
Vigne, R.8
Decroly, E.9
-
33
-
-
79954621852
-
Structure, dynamics and Hck interaction of full-length HIV-1 Nef
-
J. Jung, I.J. Bugault, and A.M. Gronenborn Structure, dynamics and Hck interaction of full-length HIV-1 Nef Protein 79 2011 1609 1622
-
(2011)
Protein
, vol.79
, pp. 1609-1622
-
-
Jung, J.1
Bugault, I.J.2
Gronenborn, A.M.3
-
34
-
-
84858132999
-
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck
-
T. Pene-Dumitrescu, S.T. Shu, T.E. Wales, J.J. Alvarado, H. Shi, P. Narute, J.A. Moroco, J.I. Yeh, J.R. Engen, and T.E. Smithgall HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck BMC Chem Biol 12 2012 1
-
(2012)
BMC Chem Biol
, vol.12
, pp. 1
-
-
Pene-Dumitrescu, T.1
Shu, S.T.2
Wales, T.E.3
Alvarado, J.J.4
Shi, H.5
Narute, P.6
Moroco, J.A.7
Yeh, J.I.8
Engen, J.R.9
Smithgall, T.E.10
-
35
-
-
0030792141
-
SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein HIV-1
-
S.D. Briggs, M. Sharkey, M. Stevenson, and T.E. Smithgall SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein HIV-1 J Biol Chem 272 1997 17899 178902
-
(1997)
J Biol Chem
, vol.272
, pp. 17899-178902
-
-
Briggs, S.D.1
Sharkey, M.2
Stevenson, M.3
Smithgall, T.E.4
-
36
-
-
0036238473
-
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo
-
DOI 10.1038/nsb782
-
E.C. Lerner, and T.E. Smithgall SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo Nat Struct Biol 9 2002 365 369 (Pubitemid 34462555)
-
(2002)
Nature Structural Biology
, vol.9
, Issue.5
, pp. 365-369
-
-
Lerner, E.C.1
Smithgall, T.E.2
-
37
-
-
6344276677
-
Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase
-
DOI 10.1016/j.jmb.2004.09.015, PII S0022283604011441
-
H.J. Choi, and T.E. Smithgall Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of Hck tyrosine kinase J Mol Biol 343 2004 1255 1268 (Pubitemid 39387825)
-
(2004)
Journal of Molecular Biology
, vol.343
, Issue.5
, pp. 1255-1268
-
-
Choi, H.-J.1
Smithgall, T.E.2
-
38
-
-
33748751555
-
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction
-
DOI 10.1074/jbc.M601128200
-
R.P. Trible, L. Emert-Sedlak, and T.E. Smithgall HIV-1 Nef selectively activates Src family kinases Hck, Lyn and c-Src through direct SH3 domain interaction J Biol Chem 281 2006 27029 27038 (Pubitemid 44401731)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.37
, pp. 27029-27038
-
-
Trible, R.P.1
Emert-Sedlak, L.2
Smithgall, T.E.3
-
39
-
-
84881023068
-
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents
-
C. Tintori, I. Laurenzana, F. La Rocca, F. Falchi, F. Carraro, A. Ruiz, J.A. Esté, M. Kissova, E. Crespan, G. Maga, M. Biava, C. Brullo, S. Schenone, and M. Botta Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents Chem Med Chem 8 2013 1353 1360
-
(2013)
Chem Med Chem
, vol.8
, pp. 1353-1360
-
-
Tintori, C.1
Laurenzana, I.2
La Rocca, F.3
Falchi, F.4
Carraro, F.5
Ruiz, A.6
Esté, J.A.7
Kissova, M.8
Crespan, E.9
Maga, G.10
Biava, M.11
Brullo, C.12
Schenone, S.13
Botta, M.14
-
40
-
-
73449135109
-
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds
-
L. Emert-Sedlak, T. Kodama, E.C. Lerner, W. Dai, C. Foster, B.W. Day, J.S. Lazo, and T.E. Smithgall Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds ACS Chem Biol 4 2009 939 947
-
(2009)
ACS Chem Biol
, vol.4
, pp. 939-947
-
-
Emert-Sedlak, L.1
Kodama, T.2
Lerner, E.C.3
Dai, W.4
Foster, C.5
Day, B.W.6
Lazo, J.S.7
Smithgall, T.E.8
-
41
-
-
51549083054
-
The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane
-
A.B. Strasner, M. Natarajan, T. Doman, D. Key, A. August, and A.J. Henderson The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane J Immunol 181 2008 3706 3713
-
(2008)
J Immunol
, vol.181
, pp. 3706-3713
-
-
Strasner, A.B.1
Natarajan, M.2
Doman, T.3
Key, D.4
August, A.5
Henderson, A.J.6
-
42
-
-
33646552033
-
Human Immunodeficiency Virus Type-1 Infection Impairs the Formation of the Immunological Synapse
-
DOI 10.1016/j.immuni.2006.02.016, PII S1074761306002196
-
M.I. Toulouze, N. Sol-Foulon, F. Blanchet, A. Dautry-Varsat, O. Shwartz, and A. Alcover Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse Immunity 24 2006 547 561 (Pubitemid 43728159)
-
(2006)
Immunity
, vol.24
, Issue.5
, pp. 547-561
-
-
Thoulouze, M.I.1
Sol-Foulon, N.2
Blanchet, F.3
Dautry-Varsat, A.4
Schwartz, O.5
Alcover, A.6
-
43
-
-
14844337426
-
The tyrosine kinases Fyn and Hck favor the recruitment of tyrosine-phosphorylated APOBEC3G into vif-defective HIV-1 particles
-
DOI 10.1016/j.bbrc.2005.02.057
-
M. Douaisi, S. Dussart, M. Courcoul, G. Bessou, E.C. Lerner, E. Decroly, and R. Vogne The tyrosine kinases Fyn and Hck favor the recruitment of tyrosine-phosphorylated APOBEC3G into Vif-defective HIV-1 particles Biochem Biophys Res Commun 329 2005 917 924 (Pubitemid 40341364)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.329
, Issue.3
, pp. 917-924
-
-
Douaisi, M.1
Dussart, S.2
Courcoul, M.3
Bessou, G.4
Lerner, E.C.5
Decroly, E.6
Vigne, R.7
-
44
-
-
77954666282
-
Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step
-
B. Harmon, N. Campbell, and L. Ratner Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step PLoS Pathog 6 2010 e1000956
-
(2010)
PLoS Pathog
, vol.6
, pp. 1000956
-
-
Harmon, B.1
Campbell, N.2
Ratner, L.3
-
45
-
-
37549055113
-
Structural basis for the interaction between focal adhesion kinase and CD4
-
M.L. Garron, J. Arthos, J.F. Guichou, J. McNally, J. Cicala, and S.T. Arold Structural basis for the interaction between focal adhesion kinase and CD4 J Mol Biol 375 2008 1320 1328
-
(2008)
J Mol Biol
, vol.375
, pp. 1320-1328
-
-
Garron, M.L.1
Arthos, J.2
Guichou, J.F.3
McNally, J.4
Cicala, J.5
Arold, S.T.6
-
46
-
-
44349123838
-
Selective targeting of ITK blocks multiple steps of HIV replication
-
DOI 10.1073/pnas.0709659105
-
J.A. Readinger, G.M. Schiralli, J.K. Jiang, C.J. Thomas, A. August, A.J. Henderson, and P.L. Schwartzberg Selective targeting of ITK blocks multiple steps of HIV replication Proc Natl Acad Sci U S A 105 2008 6684 6689 (Pubitemid 351754567)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.18
, pp. 6684-6689
-
-
Readinger, J.A.1
Schiralli, G.M.2
Jiang, J.-K.3
Thomas, C.J.4
August, A.5
Henderson, A.J.6
Schwartzberg, P.L.7
-
47
-
-
40749092840
-
The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity
-
A. Klatt, Z. Zhang, P. Kalantari, P.A. Hankey, D.S. Gilmour, and A.J. Henderson The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity J Immunol 180 2008 1670 1677
-
(2008)
J Immunol
, vol.180
, pp. 1670-1677
-
-
Klatt, A.1
Zhang, Z.2
Kalantari, P.3
Hankey, P.A.4
Gilmour, D.S.5
Henderson, A.J.6
-
48
-
-
9144244879
-
RON receptor tyrosine kinase, a negative regulator of inflammation, inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS
-
E.S. Lee, P. Kalantari, S. Tsutsui Section, A. Klatt, J. Holden, P.H. Correl, C. Power Section, and A.J. Henderson RON receptor tyrosine kinase, a negative regulator of inflammation, inhibits HIV-1 transcription in monocytes/macrophages and is decreased in brain tissue from patients with AIDS J Immunol 173 2004 6864 6872 (Pubitemid 39541073)
-
(2004)
Journal of Immunology
, vol.173
, Issue.11
, pp. 6864-6872
-
-
Lee, E.S.1
Kalantari, P.2
Tsutsui, S.3
Klatt, A.4
Holden, J.5
Correll, P.H.6
Power, C.7
Henderson, A.J.8
-
49
-
-
0030769372
-
Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1
-
S. Mitola, S. Sozzani, W. Luini, L. Primo, A. Borsatti, H. Weich, and F. Bussolino Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1 Blood 90 1997 1365 1372 (Pubitemid 27355407)
-
(1997)
Blood
, vol.90
, Issue.4
, pp. 1365-1372
-
-
Mitola, S.1
Sozzani, S.2
Luini, W.3
Primo, L.4
Borsatti, A.5
Weich, H.6
Bussolino, F.7
-
50
-
-
84883021976
-
Cardiovascular toxicity of tyrosine kinase inhibitors
-
E. Mouhayar, J.B. Durand, and J. Cortes Cardiovascular toxicity of tyrosine kinase inhibitors Expert Opin Drug Saf 12 2013 687 696
-
(2013)
Expert Opin Drug Saf
, vol.12
, pp. 687-696
-
-
Mouhayar, E.1
Durand, J.B.2
Cortes, J.3
-
51
-
-
70350072838
-
Cardiotoxicity induced by tyrosine kinase inhibitors
-
G.S. Orphanos, G.N. Ioannidis, and A.G. Ardavanis Cardiotoxicity induced by tyrosine kinase inhibitors Acta Oncol 48 2009 964 970
-
(2009)
Acta Oncol
, vol.48
, pp. 964-970
-
-
Orphanos, G.S.1
Ioannidis, G.N.2
Ardavanis, A.G.3
-
52
-
-
84896920166
-
Novel approaches for targeting kinases: Allosteric inhibition, allosteric activation and pseudokinases
-
S.W. Cowan-Jacob, W. Jahnke, and S. Knapp Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases Future Med Chem 6 2014 541 561
-
(2014)
Future Med Chem
, vol.6
, pp. 541-561
-
-
Cowan-Jacob, S.W.1
Jahnke, W.2
Knapp, S.3
-
53
-
-
0031680710
-
Assignment of a human putative RNA helicase gene, DDX3, to human X chromosome bands p11.3→p11.23
-
S.H. Park, S.G. Lee, Y. Kim, and K. Song Assignment of a human putative RNA helicase gene, DDX3, to human X chromosome bands p11.3→p11.23 Cytogenet Cell Genet 81 1998 178 179 (Pubitemid 28431933)
-
(1998)
Cytogenetics and Cell Genetics
, vol.81
, Issue.3-4
, pp. 178-179
-
-
Park, S.H.1
Lee, S.-G.2
Kim, Y.3
Song, K.4
-
54
-
-
7044253474
-
Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function
-
DOI 10.1016/j.cell.2004.09.029, PII S0092867404008360
-
V.S. Yedavalli, C. Neuveut, Y.H. Chi, L. Kleiman, and K.T. Jeang Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function Cell 119 2004 381 392 (Pubitemid 39423840)
-
(2004)
Cell
, vol.119
, Issue.3
, pp. 381-392
-
-
Yedavalli, V.S.R.K.1
Neuveut, C.2
Chi, Y.-H.3
Kleiman, L.4
Jeang, K.-T.5
-
55
-
-
79959989133
-
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication
-
A. Garbelli, M. Radi, F. Falchi, S. Beermann, S. Zanoli, F. Manetti, U. Dietrich, M. Botta, and G. Maga Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication Curr Med Chem 18 2011 3015 3027
-
(2011)
Curr Med Chem
, vol.18
, pp. 3015-3027
-
-
Garbelli, A.1
Radi, M.2
Falchi, F.3
Beermann, S.4
Zanoli, S.5
Manetti, F.6
Dietrich, U.7
Botta, M.8
Maga, G.9
-
56
-
-
49849102544
-
Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis
-
M. Ishaq, J. Hu, X. Wu, Q. Fu, Y. Yang, Q. Liu, and D. Guo Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis Mol Biotechnol 39 2008 231 238
-
(2008)
Mol Biotechnol
, vol.39
, pp. 231-238
-
-
Ishaq, M.1
Hu, J.2
Wu, X.3
Fu, Q.4
Yang, Y.5
Liu, Q.6
Guo, D.7
-
57
-
-
49249132005
-
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3
-
C.S. Lee, A.P. Dias, M. Jedrychowski, A.H. Patel, J.L. Hsu, and R. Reed Human DDX3 functions in translation and interacts with the translation initiation factor eIF3 Nucleic Acids Res 36 2008 4708 4718
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 4708-4718
-
-
Lee, C.S.1
Dias, A.P.2
Jedrychowski, M.3
Patel, A.H.4
Hsu, J.L.5
Reed, R.6
-
58
-
-
79960658232
-
Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: Synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation
-
G. Maga, F. Falchi, M. Radi, L. Botta, G. Casaluce, M. Bernardini, H. Irannejad, F. Manetti, A. Garbelli, A. Samuele, S. Zanoli, J.A. Esté, E. Gonzalez, E. Zucca, S. Paolucci, F. Baldanti, J. De Rijck, Z. Debyser, and M. Botta Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation ChemMedChem 6 2011 1371 1389
-
(2011)
ChemMedChem
, vol.6
, pp. 1371-1389
-
-
Maga, G.1
Falchi, F.2
Radi, M.3
Botta, L.4
Casaluce, G.5
Bernardini, M.6
Irannejad, H.7
Manetti, F.8
Garbelli, A.9
Samuele, A.10
Zanoli, S.11
Esté, J.A.12
Gonzalez, E.13
Zucca, E.14
Paolucci, S.15
Baldanti, F.16
De Rijck, J.17
Debyser, Z.18
Botta, M.19
-
59
-
-
33344473656
-
The DEAD-box protein family of RNA helicases
-
DOI 10.1016/j.gene.2005.10.019, PII S0378111905006359
-
O. Cordin, J. Banroques, N.K. Tanner, and P. Linder The DEAD-box protein family of RNA helicases Gene 367 2006 17 37 (Pubitemid 43286737)
-
(2006)
Gene
, vol.367
, Issue.1-2
, pp. 17-37
-
-
Cordin, O.1
Banroques, J.2
Tanner, N.K.3
Linder, P.4
-
60
-
-
56249124011
-
Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3
-
G. Maga, F. Falchi, A. Garbelli, A. Belfiore, M. Witvrouw, F. Manetti, and M. Botta Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3 J Med Chem 51 2008 6635 6638
-
(2008)
J Med Chem
, vol.51
, pp. 6635-6638
-
-
Maga, G.1
Falchi, F.2
Garbelli, A.3
Belfiore, A.4
Witvrouw, M.5
Manetti, F.6
Botta, M.7
-
61
-
-
50249144556
-
Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication
-
V.S. Yedavalli, N. Zhang, H. Cai, P. Zhang, M.F. Starost, R.S. Hosmane, and K.T. Jeang Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication J Med Chem 51 2008 5043 5051
-
(2008)
J Med Chem
, vol.51
, pp. 5043-5051
-
-
Yedavalli, V.S.1
Zhang, N.2
Cai, H.3
Zhang, P.4
Starost, M.F.5
Hosmane, R.S.6
Jeang, K.T.7
-
62
-
-
77958568836
-
Comparative structural analysis of human DEAD-box RNA helicases
-
P. Schütz, T. Karlberg, S. van den Berg, R. Collins, L. Lehtiö, M. Högbom, L. Holmberg-Schiavone, W. Tempel, H.W. Park, M. Hammarström, M. Moche, A.G. Thorsell, and H. Schüler Comparative structural analysis of human DEAD-box RNA helicases PLoS ONE 5 2010 e12791
-
(2010)
PLoS ONE
, vol.5
, pp. 12791
-
-
Schütz, P.1
Karlberg, T.2
Van Den Berg, S.3
Collins, R.4
Lehtiö, L.5
Högbom, M.6
Holmberg-Schiavone, L.7
Tempel, W.8
Park, H.W.9
Hammarström, M.10
Moche, M.11
Thorsell, A.G.12
Schüler, H.13
-
63
-
-
33947630777
-
Phosphorylation of threonine 204 of DEAD-box RNA helicase DDX3 by cyclin B/cdc2 in vitro
-
DOI 10.1016/j.bbrc.2007.03.038, PII S0006291X07004901
-
T. Sekiguchi, Y. Kurihara, and J. Fukumura Phosphorylation of threonine 204 of DEAD-box RNA helicase DDX3 by cyclin B/cdc2 in vitro Biochem Biophys Res Commun 356 2007 668 673 (Pubitemid 46499016)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.356
, Issue.3
, pp. 668-673
-
-
Sekiguchi, T.1
Kurihara, Y.2
Fukumura, J.3
-
64
-
-
84923774899
-
-
WO/2011/039735
-
Radi M, Botta M, Maga G, Falchi F, Baldanti F, Paolucci S. Compounds with DDX3 inhibitory activity and uses thereof. WO/2011/039735.
-
Compounds with DDX3 Inhibitory Activity and Uses Thereof
-
-
Radi, M.1
Botta, M.2
Maga, G.3
Falchi, F.4
Baldanti, F.5
Paolucci, S.6
-
65
-
-
84857367885
-
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors
-
M. Radi, F. Falchi, A. Garbelli, A. Samuele, V. Bernardo, S. Paolucci, F. Baldanti, S. Schenone, F. Manetti, G. Maga, and M. Botta Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors Bioorg Med Chem Lett 22 2012 2094 2098
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 2094-2098
-
-
Radi, M.1
Falchi, F.2
Garbelli, A.3
Samuele, A.4
Bernardo, V.5
Paolucci, S.6
Baldanti, F.7
Schenone, S.8
Manetti, F.9
Maga, G.10
Botta, M.11
|