Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4764-4775

  Curreli, Francesca ^a   Choudhury, Spreeha ^a   Pyatkin, Ilya ^b   Zagorodnikov, Victor P ^b   Bulay, Anna Khulianova ^b   Altieri, Andrea ^b   Kwon, Young Do ^c   Kwong, Peter D ^c   Debnath, Asim K ^a  

^a NEW YORK BLOOD CENTER   (United States)

^b Asinex Ltd   (Russian Federation)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLORO 3 FLUOROPHENYLAMINO) 2 OXOACETIC ACID; ANTIVIRUS AGENT; ARGININE; ASPARAGINE; CD4 ANTIGEN; ETHYL 2 (4 CHLORO 3 FLUOROPHENYLAMINO) 2 OXOACETATE; GLYCOPROTEIN GP 120; LEAD; METHYL 4 (2 (4 CHLOROPHENYLAMINO) 2 OXOACETAMIDO) 5 PHENYLPYRROLIDINE 2 CARBOXYLATE; MICROBICIDE; N' (4 CHLORO 3 FLUOROPHENYL) N2((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YL) (PIPERIDIN 2 YL) METHYL)OXALAMIDE 2 HYDROCHLORIDE; N1 ((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YL)(PIPERIDIN 2 YL)METHYL) N2 (4 (TRIFLUOROMETHYL)PHENYL)OXALAMIDE HYDROCHLORIDE; N1 (2,4 DIFLUOROPHENYL) N2 ((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YL) ((PIPERIDIN 2 YL)METHYL)OXALAMIDE HYDROCHLORIC ACID; N1 (4 CHLOROPHENYL) N2 ((1S,2S) 1 MORPHOLINO 1 PHENYLPROPAN 2 YL)OXALAMIDE; N1 (4 CHLOROPHENYL) N2 ((5 (2 HYDROXYETHYL) 4 METHYLTHIAZOL 2 YL) (1 METHYLPIPERIDIN 2 YL)METHYL)OXALAMIDE; N1 (4 CHLOROPHENYL) N2 ((5 (2 HYDROXYETHYL) 4 METHYLTHIAZOL 2 YL) (PIPERIDIN 2 YL)METHYL)OXALAMIDE FORMIC ACID; N1 (4 CHLOROPHENYL) N2 ((5 (2 HYDROXYETHYL) 4 METHYLTHIAZOL 2 YL) (PYRROLIDIN 2 YL)METHYL)OXALAMIDE FORMIC ACID; N1 (4 CHLOROPHENYL) N2 ((5 (2 HYDROXYETHYL) 4 METHYLTHIZOL 2 YL) (PIPERIDIN 3 YLL)METHYL)OXALAMIDE HYDROCHLORIC ACID; N1 (4 CHLOROPHENYL) N2 ((5 (2 HYDROXYETHYL) 4 METHYLTHIZOL 2 YL) (PIPERIDIN 4 YL)METHYL)OXALAMIDE HYDROCHLORIC ACID; N1 (4 CHLOROPHENYL) N2 ((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YL) (PIPERIDIN 4 YL)METHYL)OXALAMIDE HYDROCHLORIC ACID; N1 (4 CHLOROPHENYL) N2 ((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YL) (PYRROLIDIN 2 YL)METHYL)OXALAMIDE FORMIC ACID; N1 (4 CHLOROPHENYL) N2 ((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YL)(PIPERIDIN 3 YL)METHYL)OXALAMIDE HYDROCHLORIC ACID; N1 (4 CHLOROPHENYL) N2 ((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2YL) (4 CHLOROPHENYL) N2 ((5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YL) ( PIPERIDIN 2 YL)METHYL)OXALAMIDE HYDROCHLORIDE; N1 (4 CHLOROPHENYL) N2 (1 (5 (2 HYDROXYETHYL) 4 METHYLTHIAZOL 2 YL) 2 (METHYLAMINO)ETHYL)OXALAMIDE HYDROCHLORIC ACID; N1 (4 CHLOROPHENYL) N2 (1 ETHYL 1H PYRAZOL 4 YL)OXALAMIDE; PHENYL GROUP; PHENYLALANINE; PIPERIDINE DERIVATIVE; TERT BUTYL 2 ((2 (4 CHLORO 3 FLUOROPHENYLAMINO) 2 OXOACETAMIDO)(5 (HYDROXYMETHYL) 4 METHYLTHIAZOL 2 YLMETHYL)PIPERIDINE 1 CARBOXYLATE 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTI-HIV AGENTS; ANTIGENS, CD4; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; DRUG DESIGN; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MODELS, MOLECULAR; OXALIC ACIDS; PIPERIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VIRUS INTERNALIZATION;

EID: 84861496877     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3002247     Document Type: Article

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