Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia

Pharmacological Reports

Volumn 66, Issue 5, 2014, Pages 845-851

  Popiolek Barczyk, Katarzyna ^a   Makuch, Wioletta ^a   Rojewska, Ewelina ^a   Pilat, Dominika ^a   Mika, Joanna ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Morphine; Neuropathic pain; Opioid receptors; Parthenolide; U0126

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; DELTA OPIATE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAPPA OPIATE RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MORPHINE; MU OPIATE RECEPTOR; PARTHENOLIDE; 1,3 BUTADIENE DERIVATIVE; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT; NITRILE; SESQUITERPENE;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; GENE EXPRESSION REGULATION; HYPERALGESIA; INTRACELLULAR SIGNALING; MALE; NEUROPATHIC PAIN; NONHUMAN; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; INJURIES; METABOLISM; NEURALGIA; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCIATIC NERVE; SIGNAL TRANSDUCTION; WISTAR RAT;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; BUTADIENES; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; HYPERALGESIA; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MORPHINE; NEURALGIA; NF-KAPPA B; NITRILES; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCIATIC NERVE; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 84903577068     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2014.05.001     Document Type: Article

References (39)

1. R.H. Dworkin, A.B. O'Connor, J. Audette, R. Baron, G.K. Gourlay, and M.L. Haanpää et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update Mayo Clin Proc 85 2010 3 14
2. E. Kalso, J.E. Edwards, R.A. Moore, and H.J. McQuay Opioids in chronic non-cancer pain: systematic review of efficacy and safety Pain 112 2004 372 380 (Pubitemid 39550738)
3. G. Pollock, K.R. Pennypacker, S. Mémet, A. Israël, and S. Saporta Activation of NF-kappaB in the mouse spinal cord following sciatic nerve transection Exp Brain Res 165 2005 470 477 (Pubitemid 41224988)
4. S.P. Hehner, M. Heinrich, P.M. Bork, M. Vogt, F. Ratter, and V. Lehmann et al. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta J Biol Chem 273 1998 1288 1297 (Pubitemid 28133643)
5. B.H. Kwok, B. Koh, M.I. Ndubuisi, M. Elofsson, and C.M. Crews The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase Chem Biol 8 2001 759 766 (Pubitemid 32752455)
6. P.M. Bork, M.L. Schmitz, M. Kuhnt, C. Escher, and M. Heinrich Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB FEBS Lett 402 1997 85 90 (Pubitemid 27056030)
7. L.B. Rosen, D.D. Ginty, M.J. Weber, and M.E. Greenberg Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras Neuron 12 1994 1207 1221 (Pubitemid 24186790)
8. T. Komatsu, H. Mizoguchi, M. Sasaki, C. Sakurada, M. Tsuzuki, and S. Sakurada et al. Inhibition of ERK phosphorylation by substance P N-terminal fragment decreases capsaicin-induced nociceptive response Neuropharmacology 61 2011 608 613
9. M. Han, R.Y. Huang, Y.M. Du, Z.Q. Zhao, and Y.Q. Zhang Early intervention of ERK activation in the spinal cord can block initiation of peripheral nerve injury-induced neuropathic pain in rats Sheng Li Xue Bao 63 2011 106 114
10. K. Obata, and K. Noguchi MAPK activation in nociceptive neurons and pain hypersensitivity Life Sci 74 2004 2643 2653 (Pubitemid 38369361)
11. M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110 (Pubitemid 13058546)
12. G.J. Bennett, and Y. Xie A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Pain 33 1988 87 107
13. J. Mika, E. Rojewska, W. Makuch, and B. Przewlocka Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain Neuroscience 165 2010 1420 1428
14. J. Mika, M. Osikowicz, W. Makuch, and B. Przewlocka Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain Eur J Pharmacol 560 2007 142 149 (Pubitemid 46341303)
15. T.L. Yaksh, and T.A. Rudy Analgesia mediated by a direct spinal action of narcotics Science 192 1976 1357 1358
16. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1987 156 159 (Pubitemid 17064313)
17. Y. Yamamoto, and R.B. Gaynor IkappaB kinases: key regulators of the NF-kappaB pathway Trends Biochem Sci 29 2004 72 79 (Pubitemid 38186577)
18. Z.Y. Zhuang, P. Gerner, C.J. Woolf, and R.R. Ji ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model Pain 114 2005 149 159 (Pubitemid 40279096)
19. J. Kraus, C. Börner, E. Giannini, and V. Höllt The role of nuclear factor kappaB in tumor necrosis factor-regulated transcription of the human mu-opioid receptor gene Mol Pharmacol 64 2003 876 884 (Pubitemid 37153056)
20. W. Ma, and M.A. Bisby Increased activation of nu clear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries Brain Res 797 1998 243 254 (Pubitemid 28332737)
21. A. Meunier, A. Latrémolière, E. Dominguez, A. Mauborgne, S. Philippe, and M. Hamon et al. Lentiviral-mediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat Mol Ther 15 2007 687 697 (Pubitemid 46431988)
22. Q. Sun, H. Matta, G. Lu, and P.M. Chaudhary Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation Oncogene 25 2006 2717 2726
23. V.B. Mathema, Y.S. Koh, B.C. Thakuri, and M. Sillanpää Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities Inflammation 35 2012 560 565
24. R.R. Ji, H. Baba, G.J. Brenner, and C.J. Woolf Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity Nat Neurosci 2 1999 1114 1119 (Pubitemid 30126370)
25. E.M. Fitzgerald Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway J Physiol 527 2000 433 444
26. A. Morozov, I.A. Muzzio, R. Bourtchouladze, N. Van-Strien, K. Lapidus, and D. Yin et al. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory Neuron 39 2003 309 325 (Pubitemid 36897552)
27. X.S. Song, J.L. Cao, Y.B. Xu, J.H. He, L.C. Zhang, and Y.M. Zeng Activation of ERK/CREB pathway in spinal cord contributes to chronic con-strictive injury-induced neuropathic pain in rats Acta Pharmacol Sin 26 2005 789 798
28. I. Obara, J.R. Parkitna, M. Korostynski, W. Makuch, D. Kaminska, and B. Przewlocka et al. Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain Pain 141 2009 283 291
29. T. Kohno, R.R. Ji, N. Ito, A.J. Allchorne, K. Befort, and L.A. Karchewski et al. Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord Pain 117 2005 77 87 (Pubitemid 41764774)
30. R.D. Ye Regulation of nuclear factor kappaB activation by G-protein-coupled receptors J Leukoc Biol 70 2001 839 848 (Pubitemid 33151122)
31. Q. Li, and I.M. Verma NF-kappaB regulation in the immune system Nat Rev Immunol 2 2002 725 734
32. S. Roy, R.A. Barke, and H.H. Loh MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions Brain Res Mol 61 1998 190 194 (Pubitemid 28511362)
33. Y.L. Chen, P.Y. Law, and H.H. Loh Sustained activation of phosphatidylinositol 3-kinase/akt/nuclear factor {kappa}B signaling mediates G protein-coupled {delta}-opioid receptor gene expression J Biol Chem 2006 3067 3074 (Pubitemid 43845916)
34. P.Y. Law, H.H. Loh, and L.N. Wei Insights into the receptor transcription and signaling: implications in opioid tolerance and dependence Neuropharmacology 47 Suppl. 1 2004 300 311 (Pubitemid 39298273)
35. P.Y. Law, Y.H. Wong, and H.H. Loh Molecular mechanisms and regulation of opioid receptor signaling Annu Rev Pharmacol Toxicol 40 2000 389 430 (Pubitemid 30340688)
36. T. Komatsu, C. Sakurada, M. Sasaki, K. Sanai, M. Tsuzuki, and G. Bagetta et al. Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior Neuropharmacology 52 2007 1237 1243 (Pubitemid 46527699)
37. L. Chang, and M. Karin Mammalian MAP kinase signalling cascades Nature 41 2001 37 40 (Pubitemid 32225829)
38. J. Pouysségur, and P. Lenormand Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling Eur J Biochem 270 2003 3291 3299
39. Y. Kawasaki, T. Kohno, and R.R. Ji Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats J Pharmacol Exp Ther 316 2006 601 607 (Pubitemid 43130986)