Activation of NF-κB in the mouse spinal cord following sciatic nerve transection

Experimental Brain Research

Volumn 165, Issue 4, 2005, Pages 470-477

  Pollock, G ^a   Pennypacker, K R ^a   Memet S ^b   Israel A ^b   Saporta, S ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

Axotomy; NF B; Spinal cord; Transgenic

Indexed keywords

BETA GALACTOSIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, MOUSE; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; MALE; MOUSE; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SCIATIC NERVE; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPINAL CORD VENTRAL HORN; UPREGULATION; ANIMAL; ANTERIOR HORN CELL; BIOSYNTHESIS; CELL COUNT; DENERVATION; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; LACTOSE OPERON; METABOLISM; NERVE FIBER TRANSECTION; PHYSIOLOGY; POSTERIOR HORN CELL; TRANSGENIC MOUSE;

ANIMALS; ANTERIOR HORN CELLS; AXOTOMY; BETA-GALACTOSIDASE; CELL COUNT; DENERVATION; FLUORESCENT ANTIBODY TECHNIQUE; LAC OPERON; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NF-KAPPA B; POSTERIOR HORN CELLS; SCIATIC NERVE; SPINAL CORD; UP-REGULATION;

EID: 24044485650     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-005-2318-6     Document Type: Article

References (54)

1. Arvidsson J, Ygge J, Grant G (1986) Cell loss in lumbar dorsal root ganglia and transganglionic degeneration after sciatic nerve resection in the rat. Brain Res 373:15-21
2. Baeuerle P, Henkel T (1994) Function and activation of NF-κB in the immune system. Annu Rev Immunol 12:141-179
3. Beg A, Baltimore D (1996) An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274:782-784
4. Beg A, Ruben M, Scheinman R, Haskill S, Rosen C, Baldwin A (1992) IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention. Genes Dev 6:1899-1913
5. Bethea J, Castro M, Keane R, Lee T, Dietrich WD, Yezierski R (1998) Traumatic spinal cord injury induces nuclear factor-κB activation. J Neurosci 18:3251-3260
6. Bhakar A, Tannis L, Zeindler C, Russo M, Jobin C, Park D, Macpherson S, Barker P (2002) Constitutive nuclear factor-κB activity is required for central neuron survival. J Neurosci 22:8466-8475
7. Chiarugi A (2002) Characterization of the molecular events following impairment of NF-κB-driven transcription in neurons. Mol Brain Res 109:179-188
8. Choi J, Kim J, Kim D, Chun M, Gwag B, Yoon S, Joo C (2000) Failure to activate NF-κB promotes apoptosis of retinal ganglion cells following optic nerve transection. Brain Res 883:60-68
9. Camandola S, Mattson M (2000) Pro-apoptotic action of par-4 involves inhibition of NF-κB activity and suppression of Bcl-2 expression. J Neurosci Res 61:134-139
10. De Moissac D, Mustapha S, Greenberg A, Kirshenbaum L (1998) Bcl-2 activates the transcription factor NF-κB through degradation of the cytoplasmic inhibitor IκBα. J Biol Chem 273:23946-23951
11. Deveraux Q, Reed J (1999) IAP family proteins - suppressors of apoptosis. Genes Dev 13:239-252
12. Doyle C, Hunt S (1997) Reduced nuclear factor κB (p65) expression in rat primary sensory neurons after peripheral nerve injury. Neuroreport 8:2937-2942
13. Fridmacher V, Kaltschmidt B, Goudeau B, Ndiaye D, Mattia Rossi F, Pfeiffer J, Kaltschmidt C, Israël, Mémet S (2003) Forebrain-specific neuronal inhibition of nuclear factor-κB activity leads to loss of neuroprotection. J Neurosci 23:9403-9408
14. Ganchi P, Sun S, Greene W, Ballard D (1992) IκB/MAD-3 masks the nuclear localization signal of NF-κB p65 and requires the transactivation domain to inhibit NF-κB p65 DNA binding. Mol Biol Cell 3:1339-1352
15. Gilmore S, Kane C (1998) Microglia, but not astrocytes, react to sciatic nerve injury in aging rats. Brain Res 806(1):113-116
16. s and BALB/c mice. Exp Neurol 146:587-595
17. Kaltschmidt B, Kaltschmidt C (2000) Constitutive NF-κB activity is modulated via neuron-astroglia interaction. Exp Brain Res 130:100-104
18. Kaltschmidt C, Kaltschmidt B, Lannes-Vieira J, Kreutzberg G, Wekerle H, Baeuerle P, Gehrmann J (1994) Transcription factor NF-κB is activated in microglia during experimental autoimmune encephalomyelitis. J Neuroimmunol 55:99-106
19. Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle P (1994) Constitutive NF-κB activity in neurons. Mol Cell Biol 14:3981-3992
20. Kashihara Y, Kuno M, Miyata Y (1987) Cell death of axotomized motoneurons in neonatal rats, and its prevention by peripheral reinnervation. J Physiol 386:135-148
21. Kassed C, Butler T, Patton G, Demesquita D, Navidomskis M, Memet S, Israel A, Pennypacker K (2004) Injury-induced NF-kappaB activation in the hippocampus: implications for neuronal survival. FASEB J 18:723-724
22. Kassed C, Willing A, Garbouza-Davis S, Sanberg P, Pennypacker K (2002) Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning. Exp Neurol 176:277-288
23. Koulich E, Nguyen T, Johnson K, Giardina C, D'Mello S (2001) NF-κB is involved in the survival of cerebellar granule neurons: association of IκB phosphorylation with cell survival. J Neurochem 76:1188-1198
24. Kovács A, Chakraborty-Sett S, Ramirez S, Sniderhan L, Williamson A, Maggirwar S (2004) Mechanism of NF-κB inactivation induced by survival signal withdrawal in cerebellar granule neurons. Eur J Neurosci 20:345-352
25. Li L, Houenou LJ, Wu W, Lei M, Prevette D, Oppenheim R (1998) Characterization of spinal motoneuron degeneration following different types of peripheral nerve injury in neonatal and adult mice. J Comp Neurol 396:158-168
26. Li L, Oppenheim R, Lei M, Houenou LJ (1994) Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J Neurobiol 25:759-766
27. Libermann T, Baltimore D (1990) Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol Cell Biol 10:2327-2334
28. Liu L, Persson J, Svensson M, Aldskogius H (1998) Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection. Glia 23:231-238
29. Liu L, Rudin M, Kozlova E (2000) Glial cell proliferation in the spinal cord after dorsal rhizotomy or sciatic nerve transection in the adult rat. Exp Brain Res 131:64-73
30. Ma W, Bisby M (1998) Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries. Brain Res 797:243-254
31. Makarov S (2000) NF-κB as a therapeutic target in chronic inflammation: recent advances. Mol Med Today 6:441-448
32. Mattson M, Culmsee C, Yu Z, Camandola S (2000) Roles of nuclear factor κB in neuronal survival and plasticity. J Neurochem 74:443-456
33. Mattson M, Goodman Y, Luo H, Fu W, Furukawa K (1997) Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49:681-697
34. Noven SV, Wallace N, Muccio D, Turtz A, Pinter MJ (1993) Adult spinal motoneurons remain viable despite prolonged absence of functional synaptic contact with muscle. Exp Neurol 123:147-156
35. Oliveira A, Risling M, Deckner M, Lindholm T, Langone F, Cullheim S (1997) Neonatal sciatic nerve transaction induces TUNEL labeling of neurons in the rat spinal cord and DRG. Neuroreport 8:2837-40
36. O'Neill L, Kaltschmidt C (1997) NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 20:252-258
37. Pahl H (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18:6853-6866
38. Pennypacker K, Kassed C, Eidizadeh S, Saporta S, Sanberg P, Willing A (2001) NF-κB p50 is increased in neurons surviving hippocampal injury. Exp Neurol 172:307-319
39. Pollin MM, McHanwell S, Slater CR (1991) The effect of age on motor neurone death following axotomy in the mouse. Development 112:83-89
40. Schmidt-Ullrich R, Mémet S, Lilienbaum A, Feuillard J, Raphael M, Israël A (1996) NF-kappa B activity in transgenic mice: developmental regulation and tissue specificity. Development 122:2117-2128
41. Sen R, Baltimore D (1986a) Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism. Cell 47:921-928
42. Sen R, Baltimore D (1986b) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705-716
43. Sugimoto T, Bennett G, Kajander K (1990) Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine. Pain 42:205-213
44. Sun S, Ganchi P, Ballard D, Greene W (1993) NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259:1912-1915
45. Tamatani M, Mitsuda N, Matsuzaki H, Okado H, Miyake S, Vitek M, Yamaguchi A, Tohyama M (2000) A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2. J Neurochem 75:683-693
46. Van Antwerp D, Martin S, Kafri T, Green D, Verma I (1996) Suppression of TNF-α-induced apoptosis by NF-κB. Science 274:787-789
47. Verma I, Stevenson J, Schwartz E, Van Antwerp D, Miyamoto S (1995) Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev 9:2723-2735
48. Wang C, Guttridge D, Mayo M, Baldwin A (1999) NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 19:5923-5929
49. Wang C, Mayo M, Baldwin A (1996) TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784-787
50. Wang C, Mayo M, Korneluk R, Goeddel D, Baldwin A (1998) NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683
51. Whiteside GT, Munglani R (2001) Cell death in the superficial dorsal horn in a model of neuropathic pain. J Neurosci Res 64:168-173
52. Wu M, Lee H, Bellas R, Schauer S, Arsura M, Katz D, Fitzgerald M, Rothstein T, Sherr D, Sonenshein G (1996) Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO 15:4682-4690
53. Zabel U, Henkel T, Silva M, Baeuerle P (1993) Nuclear uptake control of NF-κB by MAD-3, an IκB protein present in the nucleus. EMBO J 12:201-211
54. Zhu Y, Dulmsee C, Klumpp S, Krieglstein J (2004) Neuroprotection by transforming growth factor-β1 involves activation of nuclear factor-κB through phosphotidylinositol-3-OH kinase/AKT and mitogen activated protein kinase-extracellular-signal regulated kinasel, 2 signaling pathways. Neuroscience 123:897-906