Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents

Marine Drugs

Volumn 12, Issue 6, 2014, Pages 3138-3160

  Wang, Jiayi ^a   Kaiser, Marcel ^b,c   Copp, Brent R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Alkaloid; Indolglyoxamide; Malaria; Marine natural products; Plasmodium falciparum; Polyamine; Protozoa; Trypanosoma brucei rhodesiense

Indexed keywords

2 (5 METHOXY 1H INDOL 3 YL) 2 OXOACETIC ACID; 2 (6 METHOXY 1H INDOL 3 YL) 2 OXOACETIC ACID; 2 (7 METHOXY 1H INDOL 3 YL) 2 OXOACETIC ACID; 4 [2 (6 BROMO 1H INDOL 3 YL) 2 OXOACETAMIDO] N [3 [2 (6 BROMO 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]BUTAN 1 AMINIUM 2,2,2 TRIFLUOROACETATE; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; CHLOROQUINE; DI TERT BUTYL DODECANE 1,12 DIYLBIS[[3 [2 (1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL DODECANE 1,12 DIYLBIS[[3 [2 (5 METHOXY 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL DODECANE 1,12 DIYLBIS[[3 [2 (6 METHOXY 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL DODECANE 1,12 DIYLBIS[[3 [2 (7 METHOXY 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL OCTANE 1,8 DIYLBIS[[3 [2 (1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL OCTANE 1,8 DIYLBIS[[3 [2 (5 METHOXY 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL OCTANE 1,8 DIYLBIS[[3 [2 (6 BROMO 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL OCTANE 1,8 DIYLBIS[[3 [2 (6 METHOXY 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DI TERT BUTYL OCTANE 1,8 DIYLBIS[[3 [2 (7 METHOXY 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]CARBAMATE]; DIDEMNIDINE A; DIDEMNIDINE B; INDOLACETAMIDE DERIVATIVE; INDOLGLYOXAMIDE DERIVATIVE; MELARSOPROL; N1,N4 BIS[3 [2 (1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]BUTANE 1,4 DIAMINIUM 2,2,2 TRIFLUOROACETATE; N1,N4 BIS[3 [2 (5 METHOXY 1H INDOL 3 YL)ACETAMIDO]PROPYL]BUTANE 1,4 DIAMINIUM 2,2,2 TRIFLUOROACETATE; N1,N4 BIS[3 [2 (6 BROMO 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]BUTANE 1,4 DIAMINIUM 2,2,2 TRIFLUOROACETATE; N1,N4 BIS[3 [2 (6 METHOXY 1H INDOL 3 YL)ACETAMIDO]PROPYL]BUTANE 1,4 DIAMINIUM 2,2,2 TRIFLUOROACETATE; N1,N4 BIS[3 [2 (7 METHOXY 1H INDOL 3 YL)ACETAMIDO]PROPYL]BUTANE 1,4 DIAMINIUM 2,2,2 TRIFLUOROACETATE; N1,N8 BIS[3 [2 (6 BROMO 1H INDOL 3 YL) 2 OXOACETAMIDO]PROPYL]OCTANE 1,8 DIAMINIUM 2,2,2 TRIFLUOROACETATE; PODOPHYLLOTOXIN; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; POLYAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYOBLAST; NONHUMAN; PHYSICAL CHEMISTRY; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; RAT; REPEATED DRUG DOSE; STRUCTURE ACTIVITY RELATION; SURVIVAL RATE; TRYPANOSOMA RHODESIENSE; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; DRUG SENSITIVITY; IC50; METABOLISM;

ANIMALS; ANTIMALARIALS; CELL LINE; FEMALE; INHIBITORY CONCENTRATION 50; MICE; MYOBLASTS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYAMINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 84903553293     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12063138     Document Type: Article

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