Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Marine Drugs

Volumn 11, Issue 9, 2013, Pages 3472-3499

  Lam, Cary F C ^a   Pearce, A Norrie ^a   Tan, Shen H ^d   Kaiser, Marcel ^b,c   Copp, Brent R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Alkaloid; Dioxothiazine; Malaria; Marine natural products; Plasmodium falciparum; Protozoa; Quinone; Trypanosoma brucei rhodesiense

Indexed keywords

2 (1,1 DIOXIDO 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDO)ACETIC ACID; 5,9 DIOXO 3,4,5,9 TETRAHYDRO 2H BENZOFURO[5,6 B][1,4]THIAZINE 7 CARBOXYLIC ACID 1,1 DIOXIDE; ANTIPROTOZOAL AGENT; BENZNIDAZOLE; CHLOROQUINE; MELARSOPROL; METHYL 2 (1,1 DIOXIDO 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDO)ACETATE; METHYL 2 (1,1 DIOXIDO 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDO)ACETATE; MILTEFOSINE; N (2 METHOXYETHYL) 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N (2 METHOXYETHYL) 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N (3 PHENYLPROPYL) 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N (3 PHENYLPROPYL) 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N (3,7 DIMETHYLOCTA 2,6 DIEN 1 YL) 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N (3,7 DIMETHYLOCTA 2,6 DIEN 1 YL) 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N (PROP 2 YN 1 YL) 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N (PROP 2 YN 1 YL) 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N BENZYL 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N BENZYL 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N N BUTYL 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N N BUTYL 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N N OCTYL 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N N OCTYL 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N N PENTYL 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N N PENTYL 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N PHENETHYL 5,10 DIOXO 3,4,5,10 TETRAHYDRO 2H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; N PHENETHYL 5,10 DIOXO 5,10 DIHYDRO 4H [1,4]THIAZINO[2,3 G]QUINOLINE 7 CARBOXAMIDE 1,1 DIOXIDE; PODOPHYLLOTOXIN; THIAZINOQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; LIPOPHILICITY; MOUSE; NONHUMAN; OXIDATION; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SURVIVAL TIME; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

ASCIDIA; PLASMODIUM FALCIPARUM; PROTOZOA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE;

ANTIMALARIALS; INHIBITORY CONCENTRATION 50; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; QUINONES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 84885027000     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11093472     Document Type: Article

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